Article
Biochemistry & Molecular Biology
Nour Ayoub, Hiba Mantash, Hassan R. Dhaini, Abbas Mourad, Mohammad Hneino, Zeina Daher
Summary: The study found a significant association between serum cadmium levels and dyslipidemia risk, but not with diabetes and obesity outcomes. Elevated cadmium levels increase the risk of dyslipidemia and alter blood lipid profiles, but do not support a role for cadmium in diabesity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Oncology
Gulcan Bulut, Nesrin Atci
Summary: This study investigated the clinical and body composition data of early-stage breast cancer patients and found that sarcopenic obesity is important in malignancy. By analyzing the components of metabolic syndrome and muscle radiation attenuation, it was found that the Hounsfield unit average value can predict the presence of sarcopenic obesity in early-stage breast cancer patients with metabolic syndrome.
Article
Biochemistry & Molecular Biology
Kamil Cebulski, Aleksandra Piotrowska, Alicja Kmiecik, Katarzyna Haczkiewicz-Lesniak, Urszula Ciesielska, Jedrzej Grzegrzolka, Karolina Jablonska, Hanna Romanowicz, Beata Smolarz, Piotr Dziegiel, Marzenna Podhorska-Okolow, Katarzyna Nowinska
Summary: It has been discovered that FNDC5/Ir can be found in breast cancer cells and may inhibit the process of epithelial-mesenchymal transition (EMT), which has significant implications for breast cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Thua Nguyen Tran, Huu Dang Tran, Thanh Tung Tran-Huu, Duc Minh Tran, Quang Nhat Tran
Summary: This study investigated the relationship between metabolic syndrome and serum ferritin levels in a Vietnamese adult cohort. The results showed a significant increase in serum ferritin concentration in patients with metabolic syndrome.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Environmental Sciences
Tingxin Li, Xiaoyue Tang, Yuping Liu, Yun Li, Baoming He
Summary: This study investigated the prevalence of Metabolic Syndrome (MetS) among Jiarong Tibetans in Aba Plateau, identified three major dietary patterns (traditional Tibetan, urbanized, and healthy), and found a significant association between the healthy dietary pattern and a lower risk of MetS. No significant statistical association was found between the risk of MetS and the traditional Tibetan and urbanized diet patterns.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kamil Cebulski, Katarzyna Nowinska, Karolina Jablonska, Hanna Romanowicz, Beata Smolarz, Piotr Dziegiel, Marzenna Podhorska-Okolow
Summary: This study aimed to determine the expression levels of irisin in breast cancer tissues and investigate its association with clinicopathological factors and survival rate. The results showed that BC patients had higher levels of FNDC5/irisin expression compared to normal breast tissue. Higher FNDC5/irisin expression was associated with no lymph node metastases and longer overall survival in BC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Jorge Ivan Gamez-Nava, Melissa Ramirez-Villafana, Fidencio Cons-Molina, Eli Efrain Gomez-Ramirez, Yussef Esparza-Guerrero, Ana Miriam Saldana-Cruz, Esther Nerida Sanchez-Rodriguez, Heriberto Jacobo-Cuevas, Sylvia Elena Totsuka-Sutto, Edsaul Emilio Perez-Guerrero, Miguel Huerta, Xochitl Trujillo, Jose Clemente Vasquez-Jimenez, Arnulfo Hernan Nava-Zavala, Ernesto German Cardona-Munoz, Miriam Fabiola Alcaraz-Lopez, Laura Gonzalez-Lopez
Summary: This study evaluated the association of Irisin with osteoporotic vertebral fractures (VFs) in women with rheumatoid arthritis (RA). The results showed that RA patients had lower irisin levels, and lower irisin levels and the duration of RA were associated with increased risk of VFs.
Article
Nutrition & Dietetics
Luiza K. Reitz, Sheyla de L. Baptista, Elaine da S. Santos, Patricia F. Hinnig, Gabriele Rockenbach, Francilene G. K. Vieira, Maria A. A. de Assis, Edson L. da Silva, Brunna C. B. Boaventura, Patricia F. Di Pietro
Summary: The study investigated the association between diet quality and oxidative stress parameters in women undergoing adjuvant treatment for breast cancer. It found that while diet quality was related to oxidative stress levels, changes in diet during treatment were not enough to significantly impact oxidative stress levels. Further research is needed to clarify the relationship between diet and oxidative stress in women with breast cancer.
Review
Oncology
Lingling Wang, Shizhen Zhang, Xiaochen Wang
Summary: Breast cancer is a common malignancy among women worldwide, with metastasis playing a key role in treatment failure and mortality. Metabolic reprogramming in breast cancer cells varies depending on molecular subtypes and metastatic sites, influenced by both intrinsic (MYC amplification, PIK3CA, TP53 mutations) and extrinsic factors (hypoxia, oxidative stress, acidosis). Understanding the metabolic mechanisms driving breast cancer metastasis can lead to novel therapeutic approaches for metastatic breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Maci Winn, Prasoona Karra, Benjamin Haaland, Jennifer A. Doherty, Scott A. Summers, Michelle L. Litchman, Marc J. Gunter, Mary C. Playdon, Sheetal Hardikar
Summary: Metabolic dysfunction is associated with an increased risk of obesity-related cancer, particularly in young adults under 50 and among participants with one or two abnormal metabolic parameters.
Article
Nutrition & Dietetics
Dalal Alkazemi, Noora Alsouri, Tasleem Zafar, Stan Kubow
Summary: Magnesium plays a key role in the development of metabolic disorders, and hypomagnesemia may be involved in the pathogenesis of metabolic syndrome (MetS) and its components. Hypomagnesemia is significantly associated with MetS and its components in adults living in Kuwait.
Review
Chemistry, Medicinal
Tugce Aladag, Rasim Mogulkoc, Abdulkerim Kasim Baltaci
Summary: Irisin is a thermogenic hormone that converts white adipose tissue into brown adipose tissue to increase energy expenditure. Brown adipose tissue is more effective in energy expenditure and contains more mitochondria and lipid droplets, along with uncoupling protein-1 (UCP1) to regulate heat dissipation and body temperature. The discovery of irisin revealed the molecular mechanism behind exercise-induced calorie expenditure.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Kurt W. Evans, Erkan Yuca, Stephen S. Scott, Ming Zhao, Natalia Paez Arango, Christian X. Cruz Pico, Turcin Saridogan, Maryam Shariati, Caleb A. Class, Christopher A. Bristow, Christopher P. Vellano, Xiaofeng Zheng, Ana Maria Gonzalez-Angulo, Xiaoping Su, Coya Tapia, Ken Chen, Argun Akcakanat, Bora Lim, Debu Tripathy, Timothy A. Yap, Maria Emilia Di Francesco, Giulio F. Draetta, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek, Funda Meric-Bernstam
Summary: Oxidative phosphorylation is a metabolic vulnerability in triple-negative breast cancer, and inhibiting it with IACS-10759 may enhance efficacy of multiple targeted therapies.
Article
Health Care Sciences & Services
Kuikui Jiang, Danyang Zhou, Ruoxi Hong, Qianyi Lu, Fei Xu, Wen Xia, Qiufan Zheng, Shusen Wang
Summary: This survey revealed that Chinese doctors generally followed guidelines in diagnosing and treating HER2-positive metastatic breast cancer patients, but their choices were constrained by economic factors.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Pia Lopez-Jornet, Cristina Aznar, Jose Ceron, Tvarijonaviciute Asta
Summary: The study evaluated the diagnostic value of salivary biomarkers in breast cancer patients compared to controls without neoplastic disease, revealing that CA125 and sFas are potentially promising tools for breast cancer diagnosis.
SUPPORTIVE CARE IN CANCER
(2021)