Dual targeting agents for Aβ plaque/P-glycoprotein and Aβ plaque/nicotinic acetylcholine α4β2* receptors—potential approaches to facilitate Aβ plaque removal in Alzheimer’s disease brain
出版年份 2018 全文链接
标题
Dual targeting agents for Aβ plaque/P-glycoprotein and Aβ plaque/nicotinic acetylcholine α4β2* receptors—potential approaches to facilitate Aβ plaque removal in Alzheimer’s disease brain
作者
关键词
Alzheimer’s disease, Plaque removal, Ferulic acid, Curcumin, Nifene, PET imaging
出版物
MEDICINAL CHEMISTRY RESEARCH
Volume 27, Issue 6, Pages 1634-1646
出版商
Springer Nature
发表日期
2018-04-07
DOI
10.1007/s00044-018-2178-9
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Development of fluorescence imaging probes for nicotinic acetylcholine α4β2 ∗ receptors
- (2018) Gurleen K. Samra et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Enhanced Brain Amyloid-β Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease
- (2018) Hisham Qosa et al. JOURNAL OF ALZHEIMERS DISEASE
- Human brain imaging of nicotinic acetylcholine α4β2* receptors using [18 F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways
- (2017) Jogeshwar Mukherjee et al. JOURNAL OF COMPARATIVE NEUROLOGY
- The Paravascular Pathway for Brain Waste Clearance: Current Understanding, Significance and Controversy
- (2017) Andrew Bacyinski et al. Frontiers in Neuroanatomy
- Brain and Brown Adipose Tissue Metabolism in Transgenic Tg2576 Mice Models of Alzheimer Disease Assessed Using 18F-FDG PET Imaging
- (2017) Robert A. Coleman et al. Molecular Imaging
- Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients
- (2016) Eric R. Siemers et al. Alzheimers & Dementia
- Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease
- (2016) Madhuri Venigalla et al. NEUROCHEMISTRY INTERNATIONAL
- Evaluation of [11C]TAZA for amyloid β plaque imaging in postmortem human Alzheimer's disease brain region and whole body distribution in rodent PET/CT
- (2016) Min-Liang Pan et al. SYNAPSE
- Curcumin/Melatonin Hybrid 5-(4-Hydroxy-phenyl)-3-oxo-pentanoic Acid [2-(5-Methoxy-1H-indol-3-yl)-ethyl]-amide Ameliorates AD-Like Pathology in the APP/PS1 Mouse Model
- (2015) Gorka Gerenu et al. ACS Chemical Neuroscience
- Pharmacological Inhibition of BACE1 Impairs Synaptic Plasticity and Cognitive Functions
- (2015) Severin Filser et al. BIOLOGICAL PSYCHIATRY
- Clinical development of curcumin in neurodegenerative disease
- (2015) Shuxin Hu et al. Expert Review of Neurotherapeutics
- Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future
- (2015) Manuela Ariza et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Glymphatic System: A Beginner’s Guide
- (2015) Nadia Aalling Jessen et al. NEUROCHEMICAL RESEARCH
- PET-CT imaging with [18F]-gefitinib to measure Abcb1a/1b (P-gp) and Abcg2 (Bcrp1) mediated drug–drug interactions at the murine blood–brain barrier
- (2015) Maria L.H. Vlaming et al. NUCLEAR MEDICINE AND BIOLOGY
- Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model
- (2015) Gerhard Leinenga et al. Science Translational Medicine
- Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants
- (2015) Antonella Sgarbossa et al. Nutrients
- Clinical development of curcumin in neurodegenerative disease
- (2015) Shuxin Hu et al. Expert Review of Neurotherapeutics
- Synaptic activity and Alzheimer's disease: a critical update
- (2015) Davide Tampellini Frontiers in Neuroscience
- Cross-Sectional Comparison of Small Animal [18F]-Florbetaben Amyloid-PET between Transgenic AD Mouse Models
- (2015) Matthias Brendel et al. PLoS One
- A proposed role for efflux transporters in the pathogenesis of hydrocephalus
- (2014) Satish Krishnamurthy et al. CROATIAN MEDICAL JOURNAL
- Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
- (2014) Stephen Salloway et al. NEW ENGLAND JOURNAL OF MEDICINE
- Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
- (2014) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease
- (2014) Robert Vassar Alzheimers Research & Therapy
- Nicotinic Receptors in Neurodegeneration
- (2013) Inmaculada Posadas et al. Current Neuropharmacology
- Ferulic acid: Pharmacological and toxicological aspects
- (2013) Cesare Mancuso et al. FOOD AND CHEMICAL TOXICOLOGY
- 18F-Fluorodeoxyglycosylamines: Maillard reaction of18F-fluorodeoxyglucose with biological amines†
- (2013) Aparna Baranwal et al. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
- Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier
- (2012) Stina Syvänen et al. ACS Chemical Neuroscience
- Protective Effects of Ferulic Acid in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mouse Model of Alzheimer Disease
- (2012) Ji-Jing Yan et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Blood-Brain Barrier P-Glycoprotein Function in Neurodegenerative Disease
- (2012) A.L. Bartels CURRENT PHARMACEUTICAL DESIGN
- Nicotinic α4β2 receptor imaging agents. Part IV. Synthesis and Biological Evaluation of 3-(2-(S)-3,4-dehydropyrrolinyl methoxy)-5-(3′-18F-Fluoropropyl)pyridine (18F-Nifrolene) using PET
- (2012) Rama Pichika et al. NUCLEAR MEDICINE AND BIOLOGY
- Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders
- (2011) Rukhsana Sultana BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Amyloid-β imaging with PET in Alzheimer’s disease: is it feasible with current radiotracers and technologies?
- (2011) Mateen C. Moghbel et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Nicotinic α4β2 receptor imaging agents. Part III. Synthesis and biological evaluation of 3-(2-(S)-azetidinylmethoxy)-5-(3′-18F-fluoropropyl)pyridine (18F-nifzetidine)
- (2011) Rama Pichika et al. NUCLEAR MEDICINE AND BIOLOGY
- Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease
- (2009) R. Deane et al. CNS & Neurological Disorders-Drug Targets
- Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
- (2009) S. G. Aller et al. SCIENCE
- Clinico-Pathologic Function of Cerebral ABC Transporters – Implications for the Pathogenesis of Alzheimers Disease
- (2008) Jens Pahnke et al. Current Alzheimer Research
- Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration
- (2008) R. Zhao et al. DRUG METABOLISM AND DISPOSITION
- Therapeutic Strategies for Alzheimer’s Disease
- (2008) Donna M. Barten et al. MOLECULAR NEUROBIOLOGY
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