Review
Infectious Diseases
Marcello Fiorani, Ege Tohumcu, Livio Enrico Del Vecchio, Serena Porcari, Giovanni Cammarota, Antonio Gasbarrini, Gianluca Ianiro
Summary: Helicobacter pylori is a bacterium that colonizes the human stomach and is associated with various gastric and extra-gastric disorders. Colonization of H. pylori affects the gastric microenvironment and gastrointestinal microbiota by regulating factors such as acidity, immune responses, antimicrobial peptides, and virulence factors. Eradication therapies for H. pylori can negatively impact the gut microbiota, but integrating probiotics into the treatment has been shown to mitigate these effects and improve eradication rates and patient compliance. This article provides an overview of the complex interaction between H. pylori and the gastrointestinal microbiota, emphasizing the consequences of eradication therapies and the benefits of probiotic supplementation.
Review
Gastroenterology & Hepatology
Lijun Du, Binrui Chen, Fangli Cheng, Jeffrey Kim, John J. Kim
Summary: The effects of H. pylori therapy on gut microbiota appear to be transient, with early changes largely resolving after one year. Probiotics may reduce the early impact of H. pylori therapy on gut microbiota.
DIGESTIVE DISEASES
(2022)
Article
Gastroenterology & Hepatology
Marcello Abbondio, Alessandro Tanca, Laura De Diego, Rosangela Sau, Stefano Bibbo, Giovanni Mario Pes, Maria Pina Dore, Sergio Uzzau
Summary: This study investigates the impact of antimicrobial therapy on the gut microbiota and host functions. The results show that antimicrobial therapy alters the taxonomic profile of the microbiota, affects the functions and biochemical pathways of acid-producing bacteria, and enhances the cross-feeding between microbes and certain compounds. Additionally, antimicrobial therapy leads to an increase in antimicrobial resistance and inflammation-related proteins in the microbiota, while decreasing inflammation and H. pylori-related carcinogenesis-related proteins in the host.
Review
Immunology
Xi Chen, Nanxi Wang, Jiannan Wang, Binyou Liao, Lei Cheng, Biao Ren
Summary: In the human body, different microbial habitats exhibit distinct microbial population patterns and play a crucial role in the development of diseases. The oral cavity and gut are complex and interdependent microbial habitats, with Helicobacter pylori being one of the most important pathogens from the digestive tract. H. pylori infections can disrupt the normal gastric environment and enhance microbial interactions between the oral cavity and gut, thus reshaping the oral and gut microbiomes. The interaction between the oral-gut axis microbiota and H. pylori plays a significant role in H. pylori's colonization, infection, and pathogenicity. The balance of the microecology of the oral-gut axis can be altered by both H. pylori infection and eradication, which can impact the occurrence and progress of related diseases. The shift of oral-gut axis microbiota and their interactions with H. pylori may serve as potential targets for the diagnosis and treatment of H. pylori infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chao Peng, Xinbo Xu, Zichuan He, Nianshuang Li, Yaobin Ouyang, Yin Zhu, Nonghua Lu, Cong He
Summary: This study found that the combination of a high-fat diet (HFD) and Helicobacter pylori infection can interact to disrupt glucose metabolism, with antibiotics able to alleviate HFD-induced insulin resistance and glucose intolerance but unable to restore H. pylori-induced hyperglycemia. The gut microbiota of the mice co-treated with H. pylori and an HFD showed a greater perturbation, and their fecal metabolome was altered, resulting in weakened restorative effects of antibiotics and persistence of glucose disorders.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Infectious Diseases
Bo Tang, Li Tang, Cheng Huang, Chuan Tian, Ling Chen, Zhijun He, Guodong Yang, Luo Zuo, Guoce Zhao, En Liu, Sumin Wang, Hui Lin, Jialin He, Shiming Yang
Summary: Probiotics supplementation may help to establish a beneficial gut microbiota profile after eradication therapy. Specific bacteria taxa are associated with the outcome of H. pylori eradication.
INFECTIOUS DISEASES AND THERAPY
(2021)
Review
Immunology
Farzaneh Fakharian, Behnoush Asgari, Ali Nabavi-Rad, Amir Sadeghi, Neda Soleimani, Abbas Yadegar, Mohammad Reza Zali
Summary: The gut microbiota plays a critical role in maintaining human health. Helicobacter pylori and antibiotic treatment have significant effects on the composition of the gut microbiota. H. pylori is essential for the early stages of gastric carcinogenesis, while a non-H. pylori microbiota may be present in later stages. The gut microbiota can produce beneficial substances that modulate inflammation and tumorigenesis pathways.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lingling Wang, Haobin Yao, Daniel C. Morgan, Kam Shing Lau, Suet Yi Leung, Joshua W. K. Ho, Wai K. Leung
Summary: The study finds that antibiotic treatment for Helicobacter pylori leads to transient alteration in gut microbiota and significantly alters the previously less known gut virome community. Recurrent treatment further leads to lower virus community diversity and altered virus-bacteria interactions, compared with treatment naive patients.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Maria Guerra-Valle, Patricio Orellana-Palma, Guillermo Petzold
Summary: This review discusses the potential impact of plant-based polyphenols on H. pylori and their role in improving gut microbiota.
Article
Immunology
Cong He, Yong Xie, Yin Zhu, Kun Zhuang, Lijuan Huo, Yong Yu, Qiang Guo, Xu Shu, Zhijuan Xiong, Zhenyu Zhang, Bin Lyu, Nonghua Lu
Summary: This study not only demonstrated the beneficial effect of probiotics implementation on side events during H. pylori eradication but also provided a comprehensive profile of microbiome alterations along the gastrointestinal tract that is modulated by probiotics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Maria Pina Dore, Rosangela Sau, Caterina Niolu, Marcello Abbondio, Alessandro Tanca, Stefano Bibbo, Mariafrancesca Loria, Giovanni Mario Pes, Sergio Uzzau
Summary: This study evaluated the impact of low-dose quadruple therapy with bismuth or Lactobacillus reuteri on gut microbiota. The results showed that both regimens had a similar effect on bacterial community complexity, but Lactobacillus reuteri was unable to significantly counteract dysbiosis induced by antibiotics.
Review
Gastroenterology & Hepatology
Chikara Iino, Tadashi Shimoyama
Summary: Several studies have shown the association between Helicobacter pylori infection and gut microbiota. Eradication of H. pylori can lead to changes in gut microbiota that may take a long time to revert to the original state. The modification of gastric acidity by long-term H. pylori infection can alter gut microbiota.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Pharmacology & Pharmacy
X. -F. Bai, D. Tian, T. -y. Wang, J. -c. Shu, Y. -j. He, M. -j. Zhu
Summary: This review examined the changes in gut microbiota after standard eradication therapy with probiotics supplementation for H. pylori. The results suggest that probiotics supplementation may have a positive impact on restoring gut microbiota during H. pylori eradication therapy, but the changes in gut microbiota remain controversial.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Eric Guillemard, Marion Poirel, Florent Schafer, Laurent Quinquis, Caroline Rossoni, Christian Keicher, Frank Wagner, Hania Szajewska, Frederic Barbut, Muriel Derrien, Peter Malfertheiner
Summary: The study showed that consumption of a multi-strain fermented milk in patients under Hp treatment can lead to a modest but significant faster recovery of the gut microbiota composition and production of short chain fatty acids, while limiting the increase of potentially pathogenic bacteria.
Review
Nutrition & Dietetics
Ludovico Abenavoli, Emidio Scarpellini, Maria Rosaria Paravati, Giuseppe Guido Maria Scarlata, Luigi Boccuto, Bruno Tilocca, Paola Roncada, Francesco Luzza
Summary: Critically ill patients often experience a hyper-inflammatory response, which can cause severe damage to tissues and organs. It has been found that this harmful inflammatory cascade can be traced back to imbalances in the gut microbiota. Understanding the dysfunction and pathophysiology of the gut microbiota in critical patients is crucial for managing the systemic inflammatory response syndrome and multiple organ dysfunction syndrome. Various studies have shown that probiotics and immunonutrition can help attenuate systemic inflammation in critically ill patients.
Article
Clinical Neurology
Jung Ha Park, Ji Hyun Moon, Hyeon Ju Kim, Mi Hee Kong, Bumjo Oh, Sunyoung Kim, Yun Hwan Oh
Summary: This study examines the relationship between weekend catch-up sleep and the risk of depression in the general middle-aged population in Korea. The findings suggest that both short and long sleep duration are associated with an increased risk of depression. However, when a shortened sleep pattern is observed, individuals who engage in weekend catch-up sleep have a lower severity and prevalence of depression.
SLEEP AND BIOLOGICAL RHYTHMS
(2023)
Article
Chemistry, Multidisciplinary
Bong-Su Kim, Ki-Jeong Hong, Tae-Hyung Kwon, Kyeong-Yeoll Lee, Byung-Ho Lee, Sung-Eun Lee
Summary: The study found that phosphine fumigation combined with cold treatment is more effective in controlling peach fruit moth larvae, improving the shelf life of apples, and resolving quarantine issues.
APPLIED SCIENCES-BASEL
(2022)
Article
Entomology
Jong-Chan Jeon, Hyun-Kyung Kim, Hyun-Na Koo, Bong-Su Kim, Jeong-Oh Yang, Gil-Hah Kim
Summary: The combination of EF fumigation and cold-temperature treatment is effective for controlling D. suzukii. Cold treatment after EF fumigation showed the best synergistic effect. The concentration of fumigant during treatment also significantly affected the insecticidal activity of the combination treatment.
Retraction
Computer Science, Information Systems
Bong-Jo Choo, Hae-Jong Joo, Bong-Soo Kim, Si-hwan Cha, Do-Hyun Myung
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Dongwook Kim, Cameron L. M. Gilchrist, Jongsik Chun, Martin Steinegger
Summary: Phylogenomics studies the evolutionary relationship of organisms using their genomic information. The UFCG database and pipeline provide a tool for genome-wide phylogenetic analysis of fungi.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Health Care Sciences & Services
Minjung Lee, Bumjo Oh, Nan -He Yoon, Shinkyeong Kim, Young-Il Jung
Summary: This study aims to evaluate the effectiveness of a communication tool for patients with underlying medical conditions who should decide whether to receive a COVID-19 vaccine. The results of this study are expected to provide valuable new insights into the potential of decision aids for supporting informed decision-making regarding COVID-19 vaccination and discovering the barriers to making informed decisions, especially among patients with underlying medical conditions.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Entomology
Dong H. Cha, Dominick Skabeikis, Bong-Soo Kim, Jana C. Lee, Man-yeon Choi
Summary: Tephritid fruit flies are highly destructive pests that can hinder international trade of fresh tropical commodities. Conventional insecticides are losing effectiveness due to resistance, so alternative methods are needed. This study found that erythritol, a non-nutritive sugar, has insecticidal effects on multiple fruit fly species, making it a potential non-toxic management tool.
Article
Gastroenterology & Hepatology
Kyoung Su Kim, Eunike Tiffany, Ji-Young Lee, Ara Oh, Hyeon-Su Jin, Ji-Sun Kim, Jung-Sook Lee, Myung Hee Nam, Soo-Jong Hong, Sowon Park, Hong Koh, Bong-Soo Kim, Yun Kyung Lee, Dong-Woo Lee
Summary: In this study, the functional modules of mucin catabolism were assessed through bioinformatics-aided functional annotation. The metabolic pathways of A. muciniphila and R. gnavus were identified and their distinct metabolic features were found to influence the host immune response and gut ecosystem.
Article
Microbiology
Ji Eun Kim, Hoonsik Nam, Ji In Park, Hyunjeong Cho, Jangwook Lee, Hyo-Eun Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Bong-Soo Kim, Sunghyouk Park, Hajeong Lee
Summary: This study investigated the relationships among gut microbial species, genes, and metabolites in diabetic mellitus nephropathy (DMN) patients. Significant elevations of six bacterial species were found in DMN patients, and differential microbial genes and metabolites were identified between DMN and control groups. Methionine and branched-chain amino acids were found to be important features in differentiating the DMN group from the control group, along with estimated glomerular filtration rate and proteinuria. The study provides insights into the gut microbial involvement in the pathogenesis of DMN and may have implications for potential therapeutic targets.
MICROBIOLOGY SPECTRUM
(2023)
Correction
Microbiology
Jihyeon Kim, Seong-In Na, Dongwook Kim, Jongsik Chun
JOURNAL OF MICROBIOLOGY
(2023)
Article
Microbiology
Seong-In Na, Michael James Bailey, Mauricio Chalita, Jae Hyoung Cho, Jongsik Chun
Summary: In the post-genomic era, phylogenomics is widely used to discover evolutionary relationships between microorganisms. This study established an up-to-date archaeal core gene set (UACG) for inferring archaeal phylogenomic trees. The UACG tool was found to be consistent with the orthoANIu dendrogram, in contrast to the 16S rRNA gene phylogeny which showed discrepancies. The UACG software tool is available at https://www.ezbiocloud.net/tools/uacg.
JOURNAL OF MICROBIOLOGY
(2023)
Correction
Microbiology
Dongwook Kim, Sein Park, Jongsik Chun
JOURNAL OF MICROBIOLOGY
(2023)
Letter
Allergy
Jinwoo Kim, Yoon Mee Park, So-Yeon Lee, Bong-Soo Kim, Yun Kyung Lee, Dong-Woo Lee, Myung Hee Nam, Soo-Jong Hong
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Joon-Young Park, Jae-Won Jo, Yu-Jeong An, Jin-Jae Lee, Bong-Soo Kim
Summary: This study analyzed the pharynx and gut microbiota in the sea urchin Mesocentrotus nudus located in a barren region along the coast of South Korea. The results showed that microbes from the surrounding habitats dispersed more to the pharynx than to the gut. The gut microbiota in sea urchins were influenced by the severity of the barren region and played different roles in host energy metabolism.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Medicine, General & Internal
Duk-Ju Kim, In Chul-Nam, Sung-Eun Park, Doo-Ri Kim, Jeong-Sub Lee, Bong-Soo Kim, Guk-Myung Choi, JeongJae Kim, Jung-Ho Won
Summary: This study evaluated the added value of CBCT in detecting HCC and feeding arteries during TACE. The results showed that CBCT can increase sensitivity for detecting HCCs and feeding arteries without significantly increasing radiation exposure.
MEDICINA-LITHUANIA
(2023)