期刊
MEDIATORS OF INFLAMMATION
卷 2018, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2018/7373921
关键词
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资金
- Fondos de Investigacion Sanitaria (FIS)
- FEDER [PI14/01234, PIE15/00065]
- Francisco Garcia-Rio [PI13/ 01512]
Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep. Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and patients with OSA are at a higher risk of tumors. Both OSA and healthy monocytes have been found to show enhanced HIFI a expression under IH. Moreover, these cells under IH polarize toward a tumor-promoting phenotype in a HIF1 alpha-dependent manner and influence tumor growth via vascular endothelial growth factor (VEGF). Monocytes from patients with OSA increased the tumor-induced microenvironment and exhibited an impaired cytotoxicity in a 3D tumor in vitro model as a result of the increased HIF1 alpha secretion. Adequate oxygen restoration both in vivo (under continuous positive airway pressure treatment, CPAP) and in vitro leads the monocytes to revert the tumor-promoting phenotype, demonstrating the plasticity of the innate immune system and the oxygen recovery relevance in this context.
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