Article
Public, Environmental & Occupational Health
Sharon J. Parish, James A. Simon, Susan R. Davis, Annamaria Giraldi, Irwin Goldstein, Sue W. Goldstein, Noel N. Kim, Sheryl A. Kingsberg, Abraham Morgentaler, Rossella E. Nappi, Kwangsung Park, Cynthia A. Stuenkel, Abdulmaged M. Traish, Linda Vignozzi
Summary: This study provides a clinical practice guideline for safely prescribing testosterone to women with HSDD, including identification of appropriate patients, dosing, and monitoring. Despite substantial evidence regarding safety, efficacy, and clinical use, access to testosterone therapy for the treatment of HSDD in women remains a significant unmet need.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Medicine, General & Internal
Enav Friedmann, Julie Cwikel
Summary: This study explored the differences between men and women in their perceptions of the factors affecting women's sexual desire and the appropriate avenues for treatment. The results showed that women value interpersonal issues and physical attraction more, while men prioritize physical attraction and daily hassles as significant predictors of women's sexual desire. Additionally, women are more likely to endorse psychological help as a more appropriate treatment for HSDD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Urology & Nephrology
Sharon J. Parish, James A. Simon, Susan R. Davis, Annamaria Giraldi, Irwin Goldstein, Sue W. Goldstein, Noel N. Kim, Sheryl A. Kingsberg, Abraham Morgentaler, Rossella E. Nappi, Kwangsung Park, Cynthia A. Stuenkel, Abdulmaged M. Traish, Linda Vignozzi
Summary: This study provides a clinical practice guideline for the safe and efficacious use of testosterone in women with HSDD, including patient identification, dosing, and monitoring.
JOURNAL OF SEXUAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Sharon J. Parish, James A. Simon, Susan R. Davis, Annamaria Giraldi, Irwin Goldstein, Sue W. Goldstein, Noel N. Kim, Sheryl A. Kingsberg, Abraham Morgentaler, Rossella E. Nappi, Kwangsung Park, Cynthia A. Stuenkel, Abdulmaged M. Traish, Linda Vignozzi
Summary: This guideline provides standards for safely prescribing testosterone to women with HSDD, including patient identification, dosing, and monitoring. Despite substantial evidence regarding safety, efficacy, and clinical use, access to testosterone therapy for HSDD treatment in women remains a significant unmet need.
Article
Public, Environmental & Occupational Health
Patricia Koochaki, Dennis Revicki, Hilary Wilson, Robin Pokrzywinski, Robert Jordan, Johna Lucas, Laura A. Williams, Amama Sadiq, Julie Krop
Summary: The study showed that bremelanotide significantly improves sexual desire and related distress in women with HSDD, enhancing the quality of sexual activities and communication in partner relationships. In comparison, the placebo mainly helps in seeking treatment actively and improving communication with partners without involving improvements in physiological responses.
JOURNAL OF WOMENS HEALTH
(2021)
Review
Nursing
Jessica A. Pettigrew, Andrew M. Novick
Summary: Nearly half of women in the United States report sexual function problems, with many health care providers not asking about sexual concerns during routine clinical encounters due to various reasons. Hypoactive sexual desire disorder (HSDD) is the most commonly identified sexual problem among women, characterized by a deficiency of sexual thoughts, feelings, or receptiveness to sexual stimulation. Multiple hormones and neurotransmitters likely play a role in the physiology of HSDD, and validated screening tools are discussed for assessment and diagnosis.
JOURNAL OF MIDWIFERY & WOMENS HEALTH
(2021)
Article
Psychology, Clinical
Glen I. Spielmans
Summary: The study found that bremelanotide had modest benefits for treating hypoactive sexual desire disorder (HSDD) in women, but participants significantly preferred placebo. Kingsberg et al.'s data reporting and measurement practices were incomplete and lacked transparency.
JOURNAL OF SEX RESEARCH
(2021)
Article
Medicine, General & Internal
Theo Lerner, Vicente Renato Bagnoli, Elsa Aida Gay de Pereyra, Lucivanda Pontes Fonteles, Isabel Cristina Esposito Sorpreso, Jose Maria Soares Jr, Edmund Chada Baracat
Summary: Group CBT has been shown to be effective in treating Hypoactive Sexual Desire Disorder (HSDD), with significant improvement in sexual function observed in women undergoing therapy.
Article
Health Care Sciences & Services
Guanjian Li, Weiran Li, Bing Song, Chao Wang, Qunshan Shen, Bo Li, Dongdong Tang, Chuan Xu, Hao Geng, Yang Gao, Guanxiong Wang, Huan Wu, Zhiguo Zhang, Xiaofeng Xu, Ping Zhou, Zhaolian Wei, Xiaojin He, Yunxia Cao
Summary: This study investigated the differences in gut microbiota and fecal metabolites between women with hypoactive sexual desire disorder (HSDD) and healthy controls, identifying significant disparities in microbial and metabolic signatures. These findings offer new insights for potentially influencing sexual desire by modifying gut microbiota.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Lan Luo, Jingjing Huang, Huafang Li
Summary: An online survey was conducted to investigate the correlates of Chinese women's unwillingness to communicate sexual health, the shame of sexual health-related disorders, sexual distress, and hypoactive sexual desire disorder (HSDD). Factors such as age, knowledge about sexual health, work pressure, and economic conditions were found to influence women's psychological barriers to sexual health and related disorders. It is important to focus on providing sexual health education and services to women with older age, insufficient knowledge, intense work pressure, and poor economic conditions.
Article
Public, Environmental & Occupational Health
James A. Simon, Amod Athavale, Rahul Ravindranath, Nandini Hadker, Amama Sadiq, Michelle Lim-Watson, Laura Williams, Julie Krop
Summary: Hypoactive sexual desire disorder (HSDD) has a negative impact on patients' mental health, especially among premenopausal women. However, this disorder is often neglected or left untreated.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Endocrinology & Metabolism
E. Maseroli, N. Verde, S. Cipriani, G. Rastrelli, C. Alfaroli, S. A. Ravelli, D. Costeniero, R. Scairati, M. Minnetti, F. Petraglia, R. S. Auriemma, R. E. Nappi, M. Maggi, L. Vignozzi
Summary: This study aimed to investigate the role of prolactin (PRL) in the female sexual response and found a correlation between high PRL levels and low desire, while among women with normal PRL levels, those with lower levels demonstrated poorer desire. The study also suggested that a PRL level of <9.83 μg/L could be used as a predictor for Hypoactive Sexual Desire Disorder (HSDD) and a lower sexual inhibitory trait.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Urology & Nephrology
Charlene F. Belu, Serena Corsini-Munt, Justin P. Dube, Grace A. Wang, Natalie O. Rosen
Summary: This study found that partner responses to low desire in men with HSDD are associated with sexual satisfaction and distress for both members of the couple. When men perceived more facilitative partner responses, they and their partners reported greater sexual satisfaction. However, when men perceived more negative or avoidant partner responses, they and their partners reported lower sexual satisfaction. Additionally, when men perceived more avoidant partner responses, their partners reported greater sexual distress.
JOURNAL OF SEXUAL MEDICINE
(2023)
Article
Medicine, General & Internal
James A. Simon, Anita H. Clayton, Noel N. Kim, Sejal Patel
Summary: This study evaluated the clinically meaningful benefit of flibanserin in treating hypoactive sexual desire disorder (HSDD). The results showed that flibanserin treatment resulted in more patients reporting clinically meaningful benefit compared to placebo, with improvements in sexual desire, satisfying sexual events, and distress.
Article
Psychology, Clinical
Glen I. Spielmans, Elaine M. Ellefson
Summary: The validity of efficacy measures for treating hypoactive sexual desire disorder (HSDD) in women from the phase III (RECONNECT) bremelanotide trials was examined. The results show questionable validity of continuous efficacy measures, including Female Sexual Function Index (FSFI), Female Sexual Distress Scale-Desire/Arousal/Orgasm (FSDS-DAO), and their respective domains. Previously published categorical treatment response outcomes also lack validity evidence. Unpublished efficacy results were analyzed, showing small effect sizes. Modest apparent benefits were observed for some outcomes, but most were likely derived post-hoc. Overall, bremelanotide's benefits are statistically modest and limited to outcomes with scant validity evidence among women with HSDD.
JOURNAL OF SEX RESEARCH
(2023)
Review
Obstetrics & Gynecology
Chandima Hemachandra, Susan R. Davis, Robin J. Bell, Farhana Sultana, Rakibul M. Islam
Summary: This systematic review examines the association between endogenous DHEA/DHEAS and depression in postmenopausal women. The review concludes that there is no evidence to support a link between these hormones and depression in this population.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Obstetrics & Gynecology
Robin J. Bell, Penelope J. Robinson, Marina A. Skiba, Rakibul M. Islam, Chandima Hemachandra, Susan R. Davis
Summary: A large-scale study found that endometriosis has a significant impact on sick leave and work ability in women, including those without severe symptoms.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
M. Jahangirifar, E. Fooladi, S. R. Davis, R. M. Islam
Summary: Refugee and asylum seeker women at midlife and beyond face various health challenges, including menopausal symptoms, sexual dysfunctions, and pelvic floor disorders. However, there is limited global knowledge about the prevalence and risk factors of these neglected health issues in this population.
Article
Endocrinology & Metabolism
Jo Wrigglesworth, Ian H. Harding, Rakibul M. Islam, Phillip G. D. Ward, Robyn L. Woods, Robin J. Bell, John J. McNeil, Elsdon Storey, Gary Egan, Anne M. Murray, Ruth E. Trevaks, Stephanie A. Ward, Susan R. Davis, Joanne Ryan
Summary: This study investigated the relationship between circulating sex hormones and structural brain ageing in older women. The findings showed that women with higher levels of DHEA had higher baseline brain ageing, but this association was not significant after controlling for age and other potential confounding factors. Estrone, testosterone, and sex-hormone binding globulin were not associated with brain ageing. Further studies on circulating sex hormones and brain health in postmenopausal women are needed.
CLINICAL ENDOCRINOLOGY
(2023)
Review
Urology & Nephrology
G. Corona, G. Rastrelli, N. Bianchi, C. Sparano, A. Sforza, L. Vignozzi, M. Maggi
Summary: The present paper aims to analyze and discuss the relationship between male sexual function and elevated prolactin (PRL) levels (HPRL) using clinical data and meta-analytic approach. 4.2% of patients seeking medical care for sexual dysfunction showed PRL levels above the normal range. HPRL was found to have a negative influence on male sexual desire. Treating HPRL can improve libido, but its effect on erection is limited. The role of HPRL in erectile dysfunction remains inconclusive. Overall, the paper provides important evidence on the relationship between PRL levels and male sexual function.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Lara Tamburrino, Giulia Traini, Arianna Marcellini, Linda Vignozzi, Elisabetta Baldi, Sara Marchiani
Summary: Cryopreservation is an expanding strategy for fertility preservation, animal breeding, and endangered species preservation. Despite improvements in semen cryopreservation techniques, damage to spermatozoa and its impairment of function remain unsolved problems. Active research is needed to optimize the cryopreservation process and prevent sperm damage. This review discusses the evidence of structural, molecular, and functional damage in cryopreserved human spermatozoa and strategies to prevent it, as well as the outcomes of assisted reproduction techniques using cryopreserved spermatozoa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Susan R. Davis, Karen Magraith
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Biochemistry & Molecular Biology
Costanza Calamai, Oumaima Ammar, Viktoria Rosta, Ginevra Farnetani, Salvatore Zimmitti, Lisa Giovannelli, Linda Vignozzi, Csilla Krausz, Monica Muratori
Summary: Cancer significantly increases sperm DNA fragmentation (sDF) and oxidative stress levels. The induction of viable oxidative stress is even higher in cancer patients compared to normozoospermic subfertile patients and healthy donors. There is a correlation between sDF and viable oxidative stress in all subjects, but not in cancer patients alone. Detecting oxidative stress could help manage the reproductive issues of cancer patients.
Article
Psychology, Multidisciplinary
Marita McCabe, Manuel Alcaraz-Ibanez, Charlotte Markey, Alvaro Sicilia, Rachel F. F. Rodgers, Annie Aime, Jacinthe Dion, Giada Pietrabissa, Gianluca Lo Coco, Marie Caltabiano, Esben Strodl, Catherine Begin, Marie-Eve Blackburn, Gianluca Castelnuovo, Antonio Granero-Gallegos, Salvatore Gullo, Naomi Hayami-Chisuwa, Qiqiang He, Christoph Maiano, Gian Mauro Manzoni, David Mellor, Michel Probst, Matthew Fuller-Tyszkiewicz
Summary: This study aimed to examine the usefulness of a biopsychosocial model in explaining higher body mass index (BMI) and disordered eating. The study analyzed predictors of BMI and various measures of disordered eating in young adults from seven countries, grouped into four regions. Results showed unique patterns of association between predictors and BMI as well as different measures of disordered eating in the four geographical regions. The findings highlight the specific biopsychosocial factors that predict higher BMI and different aspects of disordered eating, emphasizing the need for caution in generalizing findings across countries.
AUSTRALIAN PSYCHOLOGIST
(2023)
Review
Obstetrics & Gynecology
S. R. Davis
Summary: Cardiovascular disease (CVD) is the leading cause of death in older women, and sex hormones, especially estrogens in women, play a crucial role in its development. Low testosterone levels in women may also have detrimental effects on cardiovascular function. Testosterone has been shown to have favorable effects on blood vessel function and blood pressure in postmenopausal women. Animal studies have demonstrated advantageous effects of testosterone on myocardial function and cardiac electrical signaling. However, there is limited human data, mainly consisting of observational and mechanistic studies, on the cardiovascular effects of testosterone in women.
Review
Obstetrics & Gynecology
S. R. Davis, S. Taylor, C. Hemachandra, K. Magraith, P. R. Ebeling, F. Jane, R. M. Islam
Summary: The Practitioner's Toolkit for Managing the Menopause has been revised to ensure that it reflects current best practice, with updated algorithms and supporting information.
Article
Biochemistry & Molecular Biology
Giulia Traini, Lara Tamburrino, Maria Emanuela Ragosta, Giulia Guarnieri, Annamaria Morelli, Linda Vignozzi, Elisabetta Baldi, Sara Marchiani
Summary: Benzo(a)pyrene (BaP) is a dangerous air pollutant that can have adverse effects on human spermatozoa, including reproductive toxicity. In vitro experiments showed that BaP reduced sperm motility and migration, increased spontaneous acrosome reaction and DNA fragmentation, but had no effects on apoptotic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Andrology
Sara Dabizzi, Costanza Calamai, Selene Degl'Innocenti, Luca Boni, Linda Vignozzi, Mario Maggi, Elisabetta Baldi, Monica Muratori
Summary: In this pilot study, researchers investigated the recoveries of sperm motility and viability in severe oligozoospermic subjects after cryopreservation using a tip-microVapour Fast Freezing procedure. The results showed that the tip-microVapour Fast Freezing method had better outcomes in terms of sperm parameters compared to the conventional Vapour Fast Freezing method with larger straws.
Article
Medicine, General & Internal
Sara Marchiani, Selene Degl'Innocenti, Sara Dabizzi, Lara Tamburrino, Maria Grazia Fino, Giulia Traini, Costanza Calamai, Mario Maggi, Linda Vignozzi, Elisabetta Baldi, Francesco Lotti
Summary: Sperm cryopreservation is recommended for male fertility preservation in cancer patients or other medical conditions. The recovery rates of motility and viability vary depending on the medical condition. Our study showed that lower sperm quality led to lower recovery rates, and donor samples had the highest recovery rates. Cut-off values for motility recovery were established based on initial semen quality. Overall, our results emphasize the importance of considering intrinsic sperm characteristics in cryopreservation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Immunology
Matteo Marconi, Gloria Riitano, Alessandra Daphne Fisher, Carlotta Cocchetti, Maria Teresa Pagano, Antonella Capozzi, Agostina Longo, Sara D'Arienzo, Linda Vignozzi, Maurizio Sorice, Elena Ortona, Marina Pierdominici
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)