期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 91, 期 -, 页码 201-207出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2018.05.015
关键词
Aggregation-induced emission; Dynamic phenyl borate; Fluorescent organic nanoparticles; Carbohydrate polymers; Controlled drug delivery
资金
- National Science Foundation of China [51363016, 21474057, 21564006, 21561022, 21644014, 21788102]
- Natural Science Foundation of Jiangxi Province in China [20161BAB203072, 20161BAB213066]
- National 973 Project [2011CB935700]
Aggregation-induced emission (AIE) is an abnormal phenomenon, which has been extensively explored for various applications. Taken advantage of the unique AIE feature, a number of luminescent nanoprobes with strong fluorescence intensity could thus be fabricated through different strategies; however, the fabrication of AIE-active carbohydrate polymers is still challenge owing to the poor solubility of carbohydrate polymers in most of organic solvents. In this work, a rather facile strategy has been developed for fabricating AIE-active sodium hyaluronate (Sh) through the formation of dynamic phenyl borate between the phenylboronic acid groups of AIE dye (An-B(OF)(2))) and Sh in a one-pot route. This reaction could occur under low temperature, air atmosphere and in the present water. The physicochemical properties, biocompatibility, biological imaging and drug delivery performance of the final An-Sh fluorescent organic nanoparticles (FNPs) were confirmed by different characterization techniques. Results suggested that An-Sh FNPs possess high water dispersibility, strong fluorescence, and good biocompatibility. These excellent properties make An-Sh FNPs great potential for biological imaging and controlled drug delivery applications. In conclusion, we have developed a facile one-pot strategy for the preparation of ME-active FNPs through the formation of dynamic bonds in rather mild experimental conditions. The outstanding properties and performance of An-Sh FNPs make them promising candidates for biological imaging and controlled drug delivery applications.
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