期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 86, 期 -, 页码 129-143出版社
ELSEVIER
DOI: 10.1016/j.msec.2017.12.022
关键词
Polymers; Buccal route; Pharmacokinetics; Pharmacodynamics; Drug delivery; Mucoadhesion
资金
- Sao Paulo Research Foundation-FAPESP [13/03746-3, 15/05394-2]
Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. The main difficulty for administration via the buccal route is an effective physiological removal mechanism of the oral cavity that takes way the formulation from the buccal site and decreases the bioavailability of drugs. The use of mucoadhesive polymers in buccal drug delivery shows assessing buccal drug permeation and absorption, however some studies bring an in vivo performance. This review points to the use of polymers in the manufacture of drug delivery systems (hydrogels, films and tablets) and shows the results of their in vivo performance tests.
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