期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 83, 期 -, 页码 160-168出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2017.10.007
关键词
Hemostatic; Sponge; Self-foaming; Polysaccharide; Cationic
资金
- National Key Research and Development Program of China [2016YFC1100404]
- National Natural Science Foundation of China [51703008, 51528301, 51603008]
- Fundamental Research Funds for the Central Universities [buctrc201705]
- Beijing Natural Science Foundation [7171009]
Effective hemostatic materials are very important for treating trauma cases. Natural polysaccharides have been particularly appealing in the development of new hemostatic materials due to their unique functions in human bodies. In this work, different polysaccharide-based hemostatic porous sponges (SHDP or SHDQ) of cross-linked hyaluronic acid (HA)/cationized dextran were readily prepared by the self-foaming process of HA and poly((2-dimethyl amino)-ethyl methacrylate)-grafted dextran (Dex-PDM) or partially-quaternized Dex-PDM in the presence of sodium trimetaphosphate crosslinkers. SHDP and SHDQ sponges were investigated in terms of liquid-absorption ability, hemolysis, whole-blood clotting and hemostatic activity in hemorrhaging-liver models. Compared with HA/Dex-PDM sponges (HDP) without chemical cross-linking, SHDP and SHDQ sponges displayed higher porosity (>70.0% vs. 48.9%) and swelling ratios (>1000% vs. 520%). Meanwhile, hemolysis assay revealed the good blood compatibility of SHDP and SHDQ with low hemolysis ratio (below 0.5%). Furthermore, in vitro and in vivo hemostatic assay showed that SHDQ possessed better hemostatic properties than SHDP, owing to the higher cationic charges of partially-quaternized Dex-QPDM than Dex-PDM. The present study demonstrated that the self-foaming process of HA/Dex-PDM tinder a 'green' condition is an effective means to produce new hemostatic materials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据