Article
Biotechnology & Applied Microbiology
Melanie H. Hughes, Patricia I. Leonardi, Diego B. Genovese
Summary: This study investigates the effects of carrageenan concentration, salt concentration, and KCl center dot CaCl2 ratio on the gelation properties of carrageenans from Sarcopeltis skottsbergii and Sarcothalia crispata. The results show that higher concentrations of carrageenan and salt increase gel strength but also increase turbidity. Increasing the KCl fraction also increases gel strength. The optimal compositions predicted by the models are in line with the observed responses. Considering the increasing demand for carrageenan in the food industry, S. skottsbergii and S. crispata could be potential sources of these biopolymers.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Materials Science, Paper & Wood
Ivan Simkovic, Filip Gucmann, Raniero Mendichi, Alberto Giacometti Schieroni, Daniele Piovani, Edmund Dobrocka, Milos Hricovini
Summary: In this study, polysaccharide films were prepared from red algae extracts and their physical, chemical, and mechanical properties were investigated. The absence of cellulose content or crystalline form of carrageenans was observed in any of the studied polysaccharide films.
Article
Multidisciplinary Sciences
Tallyson Nogueira Barbosa, Mara Thais de Oliveira Silva, Angela Sena-Lopes, Frederico Schmitt Kremer, Fernanda Severo Sabedra Sousa, Fabiana Kommling Seixas, Tiago Veiras Collares, Claudio Martin Pereira de Pereira, Sibele Borsuk
Summary: Algal extracts from Gigartina skottsbergii have shown promising antiparasitic activity against Trichomonas vaginalis, without exhibiting cytotoxic effects on cell lines. These extracts could potentially be developed as alternative drugs for the treatment of trichomoniasis.
Article
Chemistry, Medicinal
Milena Alvarez-Vinas, Sandra Rivas, Maria Dolores Torres, Herminia Dominguez
Summary: The development of greener processes for the sustainable utilization of raw materials is increasingly demanded for environmental and economic reasons. A rapid and chemical-free technique for the extraction of hybrid kappa/iota (6/4) carrageenan from Sarcopeltis (ex Gigartina) skottsbergii was proposed. The extracted carrageenans showed suitable rheological properties for commercial uses, and the microwave-assisted hydrothermal treatment was found to be an efficient tool for carrageenan extraction without the need for chemicals.
Article
Chemistry, Multidisciplinary
Shuaidong Huo, Zhihuan Liao, Pengkun Zhao, Yu Zhou, Robert Goestl, Andreas Herrmann
Summary: Mechanochemistry-based strategies provide new avenues to improve drug selectivity and overcome side effects and drug resistance. In this study, a mechano-responsive nanoswitch was constructed for the selective activation of drugs to inhibit cancer cell proliferation.
Article
Materials Science, Multidisciplinary
Guo Dong Kwang, Kaarunya Sampathkumar, Say Chye Joachim Loo
Summary: Medication adherence is crucial for optimal treatment efficiency, and can impact economic and healthcare costs. This study proposes a biocompatible oral delivery system that can be retained in the stomach for a week and sustain the release of encapsulated drugs.
Article
Polymer Science
Farzaneh Sabbagh, Nadia Mahmoudi Khatir, Khadijeh Kiarostami
Summary: Nanocomposites were prepared by combining k-carrageenan, polyvinyl alcohol (PVA), and doped nanoparticles (MgO and MgZnO). The structure of the composites was analyzed, and active ingredient catechin was loaded. SEM and texture analysis revealed that MgZnO composites had increased entrapment efficiency and drug release. ZnO played an effective role in the structure and performance of the composites.
Review
Pharmacology & Pharmacy
Ilker S. Bayer
Summary: Polysaccharides are complex molecules with exceptional properties and can be chemically modified. They have increased application in drug encapsulation and release in nanoscale synthesis due to their biocompatibility and biodegradability. This review focuses on studying sustained drug release from nanoscale polysaccharides, particularly drug release kinetics and mathematical modeling. It highlights the importance of modeling in predicting the behavior of specific polysaccharide matrices and reducing experimental trial and error.
Article
Engineering, Environmental
Tomoya Mizushima, Ryo-ichi Nakayama, Masanao Imai, Norikazu Namiki
Summary: This study investigated the sustained release characteristics of capsanthin using kappa-carrageenan composited alginate gel beads. Results showed that the weight ratio of kappa-carrageenan, concentration of crosslinking agent, and hydrophobicity of outer organic phase affected the release rate of capsanthin from the gel beads. Surface structure also played a role in the release kinetics.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Materials Science, Multidisciplinary
Thitikarn Rungpetchanan, Nattinee Krathumkhet, Anuvat Sirivat, Nophawan Paradee
Summary: The objective of this study was to fabricate and characterize kappa and iota carrageenan cryogel matrix for controlled release of ionic and non-ionic drugs. The results showed that the swelling behavior and pore size of the cryogels were influenced by the concentration of kappa carrageenan. However, blending kappa and iota carrageenan increased the swelling behavior and decreased the pore size. The release mechanism of diclofenac and theophylline depended on the drug types, cryogels composition, and applied electric potentials. The drug release was decreased with increasing kappa carrageenan concentrations and increased with increasing electric potential, especially for anionic drugs. The amount of diclofenac released was higher than that of theophylline.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Max L. Wang, Christian F. Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P. Annes, Richard N. Zare, Amin Arbabian
Summary: On-demand drug delivery systems combined with wireless implants can control drug release, reducing dosage and side effects. Researchers designed a release system based on a modified electroresponsive polypyrrole nanoparticulate film for negatively charged compounds. They also developed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system in vivo. The feasibility of wireless, controllable drug release was demonstrated through in vitro and in vivo characterization using fluorescein as a model drug.
Article
Engineering, Biomedical
Jichuan Qiu, Jianchang Xu, Younan Xia
Summary: Nanobottles are colloidal particles with a hollow interior and a single opening, making them ideal for loading, encapsulation, release, and delivery of therapeutic agents in biomedical applications. Control of release can be achieved by varying the opening size and integrating stimuli-responsive materials. Future directions for nanomaterials include manufacturing, functionalization, and application advancements.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Amogh Kumar Baranwal, G. Keerthiga, L. Mohan, Sayan Deb Dutta, Pallavi Gupta, Ki-Taek Lim, Tuhin Subhra Santra
Summary: Titanium-dioxide nanotubes loaded with ciprofloxacin were fabricated using anodic oxidation. Coating the drug-loaded nanotubes with different thicknesses of PLGA allowed for controlled drug release, leading to better osseointegration and treatment of bone infections.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Thi Hien Nguyen, Thuy Chinh Nguyen, Thi Minh Tu Nguyen, Dinh Hoa Hoang, Do Mai Trang Tran, Dinh Thang Tran, Phuong Thai Hoang, Van Tan Le, Thi Kim Ngan Tran, Hoang Thai
Summary: The study developed microparticles loaded with alpha-mangostin extracted from Vietnamese mangosteen skin using carrageenan and chitosan. The microparticles exhibited improved release ability of alpha-mangostin into solutions, maintained its bioactivities, reduced vero cell toxicity, and showed antibacterial and antioxidant activities. The combination of chitosan and carrageenan in the microparticles enhanced the controlled release of alpha-mangostin.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Andreia Meneguin, Guilherme Pacheco, Jhonatan Miguel Silva, Francisca Pereira de Araujo, Edson Cavalcanti Silva-Filho, Luiz Carlos Bertolino, Hernane da Silva Barud
Summary: The study produced a nanocomposite based on bacterial cellulose and palygorskite clay loaded with metronidazole, demonstrating that the addition of clay improved the crystallinity and thermal stability of the composite, affecting the drug release rates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)