标题
Extending human IgG half-life using structure-guided design
作者
关键词
-
出版物
mAbs
Volume -, Issue -, Pages -
出版商
Informa UK Limited
发表日期
2018-06-28
DOI
10.1080/19420862.2018.1490119
参考文献
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- (2017) Rebecca F. Alford et al. Journal of Chemical Theory and Computation
- Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab
- (2017) Lorraine D. Hernandez et al. JOURNAL OF MOLECULAR BIOLOGY
- An “Fc-Silenced” IgG1 Format With Extended Half-Life Designed for Improved Stability
- (2017) M. Jack Borrok et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies
- (2017) Rong Yang et al. mAbs
- A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life
- (2017) Pernille Foged Jensen et al. MOLECULAR & CELLULAR PROTEOMICS
- Antibodies to watch in 2017
- (2016) Janice M. Reichert mAbs
- Fc receptors and their influence on efficacy of therapeutic antibodies for treatment of viral diseases
- (2015) Kuan Rong Chan et al. Expert Review of Anti-Infective Therapy
- Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor
- (2015) Benjamin T. Walters et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effect of Individual Fc Methionine Oxidation on FcRn Binding: Met252 Oxidation Impairs FcRn Binding More Profoundly than Met428 Oxidation
- (2015) Xuan Gao et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- 3D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography
- (2015) Xing Zhang et al. Scientific Reports
- Fc-Receptor Interactions Regulate Both Cytotoxic and Immunomodulatory Therapeutic Antibody Effector Functions
- (2015) D. J. DiLillo et al. Cancer Immunology Research
- Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions
- (2015) Céline Monnet et al. Frontiers in Immunology
- pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling
- (2014) M. Jack Borrok et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms
- (2014) Vaheh Oganesyan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Immunoglobulin G1 Fc Domain Motions: Implications for Fc Engineering
- (2014) Martin Frank et al. JOURNAL OF MOLECULAR BIOLOGY
- Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life
- (2014) Ranajoy Majumdar et al. mAbs
- Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody
- (2014) Céline Monnet et al. mAbs
- Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
- (2014) C. A. Diebolder et al. SCIENCE
- A Novel Investigational Fc-Modified Humanized Monoclonal Antibody, Motavizumab-YTE, Has an Extended Half-Life in Healthy Adults
- (2013) Gabriel J. Robbie et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
- (2012) Timothy A Whitehead et al. NATURE BIOTECHNOLOGY
- Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences
- (2011) W. Wang et al. DRUG METABOLISM AND DISPOSITION
- Importance of Neonatal FcR in Regulating the Serum Half-Life of Therapeutic Proteins Containing the Fc Domain of Human IgG1: A Comparative Study of the Affinity of Monoclonal Antibodies and Fc-Fusion Proteins to Human Neonatal FcR
- (2010) Takuo Suzuki et al. JOURNAL OF IMMUNOLOGY
- Enhanced antibody half-life improves in vivo activity
- (2010) Jonathan Zalevsky et al. NATURE BIOTECHNOLOGY
- Treatment with Monoclonal Antibodies againstClostridium difficileToxins
- (2010) Israel Lowy et al. NEW ENGLAND JOURNAL OF MEDICINE
- Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies
- (2007) Roxana M. Ionescu et al. JOURNAL OF PHARMACEUTICAL SCIENCES
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