Article
Genetics & Heredity
Maria Trapali, Dimitra Houhoula, Anthimia Batrinou, Anastasia Kanellou, Irini F. Strati, Argyris Siatelis, Panagiotis Halvatsiotis
Summary: The present study found that the TNF-alpha- 308G/A and leptin receptor (LEPR) Gln223Arg polymorphisms are associated with the risk of developing type 2 diabetes mellitus (T2DM).
Review
Endocrinology & Metabolism
Hyun-Jin Kim, Kwang-il Kim
Summary: This review discusses the optimal blood pressure targets for patients with diabetes mellitus and summarizes the recommendations from different guidelines. A target blood pressure of <140/90 mm Hg is recommended, and <130/80 mm Hg for patients with diabetes mellitus who have high-risk clinical features.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Endocrinology & Metabolism
Emma J. J. Bouman, Joline W. J. Beulens, Nicolette R. R. den Braver, Marieke T. T. Blom, Sharon Remmelzwaal, Petra J. M. Elders, Femke Rutters
Summary: This study assessed the associations between social jet lag and glycemic and metabolic control in people with type 2 diabetes. The results showed that high social jet lag was associated with higher blood glucose and blood pressure in working people, and lower blood glucose, blood pressure, and higher BMI in retired people. However, the prospective associations were not significant.
Review
Endocrinology & Metabolism
Li-Mei Li, Bei-Ge Jiang, Liang-Liang Sun
Summary: Diabetes is a highly heterogeneous metabolic disease with different types and clinical manifestations. Distinguishing between types and defining subtypes is a major challenge in precise treatment. T2D is the main type of diabetes, and certain gene variants have been shown to increase the risk of T2D. HNF1 alpha gene mutations can cause different types of diabetes and exhibit high polymorphism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dana Mihaela Ciobanu, Cornelia Bala, Adriana Rusu, Gabriel Cismaru, Gabriela Roman
Summary: This study found that elevated serum E-selectin is associated with increased ambulatory diastolic blood pressure variability in patients with type 2 diabetes.
Article
Endocrinology & Metabolism
Mohammed Alfaifi, Mirza Masroor Ali Beg, Mohammed Yahya Alshahrani, Irfan Ahmad, Ali Gaithan Alkhathami, Prakash C. Joshi, Osama M. Alshehri, Abdulrahman Manaa Alamri, Amit Kumar Verma
Summary: The study found increased expression of lncRNAs NKILA, NEAT1, MALAT1, and MIAT in patients with T2DM, which was significantly associated with factors like hypertension, smoking, and alcoholism. These lncRNAs may influence the disease severity and progression in patients with T2DM, contributing to diabetes-related complications.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Multidisciplinary Sciences
Yan-Peng Li, Dilare Adi, Ying-Hong Wang, Yong-Tao Wang, Xiao-Lei Li, Zhen-Yan Fu, Fen Liu, Aibibanmu Aizezi, Jialin Abuzhalihan, Mintao Gai, Xiang Ma, Xiao-mei Li, Xiang Xie, YiTong Ma
Summary: This study investigated the effects of genetic variants of the Dab2 gene on the risk of type 2 diabetes mellitus (T2DM) in the Uygur and Han populations of Xinjiang, China. The results showed that the variations in the Dab2 gene loci rs2255280 and rs2855512 were associated with the incidence of T2DM in the Uygur population, but not in the Han population. These variations were independent predictors for T2DM in the Uygur population.
Article
Biology
Nada Alqadri
Summary: This study investigated the genotyping levels of rs5210 polymorphism in the KCNJ11 gene in the older population with T2DM in Saudi Arabia. The results showed an association between the rs5210 polymorphism and allele frequencies. However, further large-scale studies are needed to determine whether KCNJ11 gene polymorphisms may serve as risk markers for T2DM in the Saudi population.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: The study found that pulse wave arterial stiffness index (ASI) is positively associated with the risk of type 2 diabetes (T2D), while the association between pulse pressure (PP) and T2D shows a nonlinear J-shaped relationship. Additionally, the association between ASI and T2D is more pronounced among individuals with higher genetic susceptibility to T2D.
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: Pulse wave arterial stiffness index (ASI) showed a dose-response association with type 2 diabetes (T2D), while pulse pressure (PP) displayed a nonlinear J-shaped association with T2D. Additionally, the association between ASI and T2D was partially strengthened by higher genetic susceptibility to T2D.
Article
Multidisciplinary Sciences
Yeonwoo Chung, Hyunju Lee
Summary: Alzheimer's disease (AD) is a complex and heterogeneous disease affected by genetic factors, with recent recognition as type 3 diabetes. Individuals with type 2 diabetes have a higher risk of developing AD, emphasizing the importance of identifying subgroups of AD patients associated with diabetes. By using non-negative matrix factorization (NMF) to identify gene correlations between AD and T2D, 241 candidate genes related to both diseases were identified, potentially impacting personalized treatment strategies.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Yin Zhang, Heru Zhao, Bin Liu, Haiyang Shu, Lulu Zhang, Mei Bao, Wenjun Yi, Yong Tan, Xinyu Ji, Chi Zhang, Ning Zhao, Guoming Pang, Dan He, Yuexi Wang, Li Li, Jianfeng Yi, Cheng Lu
Summary: The study found clear differences in metabolomic profiles between patients with T2DM and T2DM+HBP, revealing significant changes in 8 differential metabolites during disease progression, which are associated with the gamma-glutamyl cycle, tricarboxylic acid cycle, and ceramide metabolism. These novel serum biomarkers may help improve the management of T2DM and HBP complications, reducing the reliance on incorrect medical care.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Cell Biology
Ana Ferreira, Alicia Rivera, Jay G. Wohlgemuth, Jeffrey S. Dlott, L. Michael Snyder, Seth L. Alper, Jose R. Romero
Summary: Through ex vivo experiments, it was found that high blood sugar leads to increased Mg2+ efflux in red blood cells. The study also discovered a correlation between hemoglobin A(1C) values and Na+/Mg2+ exchange, indicating that higher blood sugar levels are associated with lower cellular Mg content.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Isabel Heberle, Guilherme Tadeu de Barcelos, Leonardo Mendonca Pilar Silveira, Rochelle Rocha Costa, Aline Mendes Gerage, Rodrigo Sudatti Delevatti
Summary: Aerobic training significantly reduces blood pressure in patients with type 2 diabetes, regardless of progression in training variables.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Ilias N. Migdalis, Ioannis M. Ioannidis, Nikolaos Papanas, Athanasios E. Raptis, Alexios E. Sotiropoulos, George D. Dimitriadis
Summary: This study investigated the major risk factors for the development and progression of DCKD and found that elevated triglycerides, high systolic blood pressure, and poor glycemic control are associated with an increased risk of CKD in T2DM. These risk factors should be addressed in treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
