Review
Food Science & Technology
Qi Yan, Jun Mei, Dapeng Li, Jing Xie
Summary: Food safety and food waste are important topics of discussion in recent years. Microbial-contaminated food can lead to the infection of human pathogenic bacteria and the waste of food resources. Traditional sterilization technology has drawbacks such as changes in food flavor and high energy consumption. Sonodynamic sterilization technology, as a new non-thermal sterilization technology, shows great potential in reducing these issues. This review provides an overview of the concept, mechanism, and application of sonodynamic sterilization technology, offering scientific references for its application in the field of food sterilization.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Nanoscience & Nanotechnology
Thuy Giang Nguyen Cao, Ji Hee Kang, Jae Young You, Han Chang Kang, Won Jong Rhee, Young Tag Ko, Min Suk Shim
Summary: Utilizing exosomes as nanocarriers, this study effectively delivered the sonosensitizer ICG to tumor tissues, with surface modification using the cancer-targeting ligand FA to enhance ROS production in breast cancer cells and inhibit tumor growth. The active cancer-targeted FA-ExoICG showed superior tumor accumulation, pharmacokinetic properties, and sonotoxicity against cancer cells compared to ExoICG and free ICG, demonstrating its potential as an effective nanosonosensitizer for safe and targeted cancer treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biotechnology & Applied Microbiology
Danling Cheng, Xiaoying Wang, Xiaojun Zhou, Jingchao Li
Summary: Immunotherapy is a promising strategy for cancer treatment, but it faces challenges of low immune responses and immune-related adverse events. Sonodynamic therapy combined with immunotherapy can enhance antitumor immunity, and research on nanosonosensitizers for ROS generation is ongoing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Meng Yuan, Shuang Liang, Ying Zhou, Xiao Xiao, Bin Liu, Chunzheng Yang, Ping'an Ma, Ziyong Cheng, Jun Lin
Summary: The study demonstrates that hemoglobin (Hb) as a sonosensitizer shows great potential and has better sensitization efficiency compared to traditional sonosensitizers, effectively avoiding the low ROS quantum yield problem. By integrating with ZIF-8 to form a nanoplatform, it can effectively suppress deep-seated tumors under ultrasound irradiation.
Article
Nanoscience & Nanotechnology
Abu Raihan Sarkar, Nikhil R. Jana
Summary: Ultrasound-based sonodynamic therapy using sound-responsive materials has great potential for the wireless treatment of human diseases. This study investigated the ROS generation performance of molecular sonosensitizer-loaded polymer micelles under ultrasound, and found that singlet oxygen is the primary ROS component. The ROS generation performance depends on the molecular structure and experimental conditions. Additionally, the use of nanomicelle-based carriers greatly improves the therapeutic performance of sonodynamic therapy.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Cheng-Chung Chang, Chia-Feng Hsieh, Hsing-Ju Wu, Mohamed Ameen, Tun-Pin Hung
Summary: Sonodynamic therapy (SDT) offers a noninvasive approach for tumor treatment by using ultrasound to activate a sonosensitizer. Two synthesized phenothiazine derivatives showed potential as photosensitizers and sonosensitizers. Among them, compound MB6C exhibited superior therapeutic effects and could be a potential candidate for photodynamic therapy (PDT) and SDT.
APPLIED SCIENCES-BASEL
(2022)
Article
Acoustics
Lihua Fan, Aliyu Idris Muhammad, Balarabe Bilyaminu Ismail, Donghong Liu
Summary: Sonodynamic antimicrobial chemotherapy (SACT) combines low-intensity ultrasound with chemotherapeutic agents to effectively combat microbial burden. With its superior penetration ability and high target specificity, SACT has emerged as a promising alternative for microbial inactivation. This treatment method has attracted increasing attention in recent years.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Yi-Ching Lin, Yi-Giien Tsai, Yu-Chih Lin, Chia-Hong Kuo, Mei-Lan Tsai, Chao-Hung Kuo, Wei-Ting Liao
Summary: Acrylamide promoted mitochondria-specific ROS generation, increased gene expression of mitochondrial respiratory chain complex II SDHA, induced histone modifications and upregulated PINK1 expression, leading to a macrophage M2 polarization shift in THP-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xiaobo Feng, Liang Ma, Jie Lei, Qunle Ouyang, Yuxuan Zeng, Yue Luo, Xiaoguang Zhang, Yu Song, Gaocai Li, Lei Tan, Xiangmei Liu, Cao Yang
Summary: The successful treatment of osteomyelitis remains a challenge in the field of orthopedics. Researchers have developed a piezoelectric-enhanced sonosensitizer that effectively eliminates bone infection and suppresses inflammation and bone loss.
Article
Engineering, Biomedical
Hak Rae Lee, Dae Woo Kim, Victoria O. Jones, Yunkyu Choi, Vivian E. Ferry, Melissa A. Geller, Samira M. Azarin
Summary: In this study, a therapeutic strategy using functionalized graphene nanoribbons for targeting metastatic ovarian cancer spheroids is reported, showing effectiveness in delaying spheroid disaggregation, killing adhered spheroids, and loosening cell-cell adhesions. This material has the potential to facilitate effective chemotherapy and sonodynamic combination therapies for ovarian cancer.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yining Chen, Tianshu Zou, Gaoying Xin, Xin Liu, Yunan Yang, Liqi Wei, Biao Zhang, Pengcheng Yu, Yiping Ren, Yanlin Feng, Rui Chen, Fangfang Cao, Xiaoyuan Chen, Yan Cheng
Summary: This study presents a novel approach for tumor treatment by developing BiOCl-Au-Ag2S Z-scheme heterostructure nanoparticles loaded with tirapazamine (TPZ). These nanoparticles exhibit efficient electron-hole separation under ultrasound irradiation and have a high redox potential. The generated holes react with water to produce hydroxyl radicals, while the electrons autonomously activate TPZ, leading to synergistic sonodynamic and hypoxia-activated prodrugs therapy without the need for oxygen.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Adilet Beishenaliev, Farid Nazer Faruqu, Bey Fen Leo, Lei Cheng Lit, Yean Leng Loke, Chia-Ching Chang, Yin Yin Teo, Zamri Chik, Yiing Yee Foo, Lip Yong Chung, Lik Voon Kiew
Summary: The study reported a novel method for synthesizing biocompatible ultrasmall gold nanoparticles using sodium alginate as the stabilizing agent, which have considerable sonosensitizing properties for anti-cancer adjunctive therapy. These sub-5 nm nanoparticles show potential for in vivo applications.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Acoustics
Yean Leng Loke, Adilet Beishenaliev, Pei-Wen Wang, Chung-Yin Lin, Chia -Yu Chang, Yiing Yee Foo, Farid Nazer Faruqu, Bey Fen Leo, Misni Misran, Lip Yong Chung, Dar-Bin Shieh, Lik Voon Kiew, Chia-Ching Chang, Yin Yin Teo
Summary: Gold nanorods coated with alginate (AuNRsALG) are found to be promising nanosonosensitisers for sonodynamic therapy (SDT) due to their enhanced singlet oxygen generation and efficient cancer cell killing effect, primarily through apoptosis.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
M. Gorgizadeh, N. Zahraie, N. Behzadpour, R. Dehdari Vais, N. Sattarahmady
Summary: A carbon dots/polypyrrole nanocomposite was studied as a sonosensitizer for cancer annihilation. The results showed that the nanocomposite inhibited the growth of melanoma cancer cells and induced cell apoptosis through increased production of reactive oxygen species.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Article
Cardiac & Cardiovascular Systems
Hongmei Zhao, Hongqin Yang, Chi Geng, Yang Chen, Junling Pang, Ting Shu, Meijun Zhao, Yaqin Tang, Zhiwei Li, Baicun Li, Cuiliu Hou, Xiaomin Song, Aoxue Wu, Xiaoxiao Guo, Si Chen, Bin Liu, Chen Yan, Jing Wang
Summary: The study found that IgE plays a causative role in pathological cardiac remodeling, at least partially through activating IgE-Fc epsilon R1 signaling in cardiomyocytes and cardiac fibroblasts. Therapeutic strategies targeting the IgE-Fc epsilon R1 axis may be effective for managing IgE-mediated cardiac remodeling.
Article
Cardiac & Cardiovascular Systems
Yuxi Sun, Niuniu Wang, Xiao Li, Yanli Zhang, Jie Yang, Gary Tse, Ying Liu
Summary: The H2FPEF score is a useful tool for predicting prognosis in HFpEF patients, with higher scores being associated with higher all-cause mortality and rehospitalization rates.
Article
Cardiac & Cardiovascular Systems
Fei F. Chen, Shu F. Jiang, Chang Dong, Ying Che, Lin Y. Du, Zhi Y. Li, Zhi Q. Yang, Yi C. Zhao, Ying Liu
Summary: Primary cardiac angiosarcomas, especially those originating in the pericardium, are rare and aggressive tumors with diverse clinical presentations often masked by other comorbidities. This case report presents a patient with both pulmonary thromboembolism and pericardial tamponade ultimately diagnosed with angiosarcoma. The challenging diagnosis of this disease requires multiple imaging modalities and biopsies for accurate diagnosis and effective management.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Ya-qin Tang, Zhi-wei Li, Yu-fan Feng, Hong-qin Yang, Cui-liu Hou, Chi Geng, Pei-ran Yang, Hong-mei Zhao, Jing Wang
Summary: The study revealed that MK2206 has anti-inflammatory and anti-atherosclerotic potential, reducing vascular inflammation, atherosclerotic lesions, and inhibiting proliferation of vascular smooth muscle cell.
ACTA PHARMACOLOGICA SINICA
(2022)
Letter
Cardiac & Cardiovascular Systems
Hongmei Zhao, Chi Geng, Chen Yan, Jing Wang
Meeting Abstract
Cardiac & Cardiovascular Systems
J. S. K. Chan, J. Zhou, A. Li, M. Tan, W. T. Wong, A. Ciobanu, A. Gkouziouta, K. Letsas, T. Liu, Y. Liu, Q. Zhang, G. Tse
EUROPEAN HEART JOURNAL
(2022)
Article
Medical Laboratory Technology
C. H. Geng, Y. U. F. A. N. Feng, Y. A. N. G. Yang, H. O. N. G. Q. I. N. Yang, Z. H. I. W. E. I. LI, Y. A. Q. I. N. Tang, J. I. N. G. Wang, H. O. N. G. M. E. Zhao
Summary: Cardiovascular disease, including heart failure (HF), is a leading cause of death globally. This study explored the link between asthma and HF, and found a higher prevalence of HF among asthmatic individuals. In animal models, asthma impaired heart function and aggravated cardiac remodeling. The study also identified the involvement of immunoglobulin E (IgE) and its receptor (Fc epsilon R1) in the adverse effects of asthma on the heart. Blockage of IgE-Fc epsilon R1 prevented asthma-induced decline of cardiac function and alleviated cardiac remodeling. These findings suggest the potential use of anti-IgE therapy in treating asthma complicated with heart conditions.
TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Liangqingqing Yin, Jie Bai, Wei-Jia Yu, Ying Liu, Hui-Hua Li, Qiu-Yue Lin
Summary: The adhesion of monocytes to the vascular endothelium is an important factor in inflammatory response and contributes to hypertension and vascular remodeling. The role of VCAM-1 in Ang II-induced hypertension and vascular dysfunction is not well understood. Blocking VCAM-1 with a neutralizing antibody can alleviate these effects and represents a novel therapeutic approach for hypertension.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jiandong Zhou, Sharen Lee, Keith Sai Kit Leung, Abraham Ka Chung Wai, Tong Liu, Ying Liu, Dong Chang, Wing Tak Wong, Ian Chi Kei Wong, Bernard Man Yung Cheung, Qingpeng Zhang, Gary Tse
Summary: This study compared the rates of major cardiovascular adverse events between users of sodium-glucose cotransporter-2 inhibitors (SGLT2I) and dipeptidyl peptidase-4 inhibitors (DPP4I) in a Chinese population. The results showed that the use of SGLT2 inhibitors was associated with a significantly lower risk of new-onset heart failure, myocardial infarction, cardiovascular mortality, and all-cause mortality.
Article
Cardiac & Cardiovascular Systems
Yuxi Sun, Shuang Song, Yanli Zhang, Wenqiong Mo, Xinxin Zhang, Ning Wang, Yunlong Xia, Gary Tse, Ying Liu
Summary: This study found that compared to ACEI/ARB, ARNI has greater effects on left atrial reverse remodeling and is associated with a better prognosis in heart failure patients. For patients with mildly abnormal left atrial volume index, ARNI use can significantly reduce mortality.
Review
Cardiac & Cardiovascular Systems
Huiyu Xiao, Xiaojie Wang, Shuang Li, Ying Liu, Yijie Cui, Xiaoqin Deng
Summary: With the extended overall survival of cancer patients, the cardiovascular toxicity associated with oncology drug therapy and radiotherapy has become a focus of attention. Early identification methods for cancer treatment-related cardiac dysfunction (CTRCD) include imaging examinations and blood biomarkers. Common tumor therapies that cause CTRCD are chemotherapy, targeted therapy, immunotherapy, and radiotherapy, while emerging biomarkers show potential in predicting CTRCD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jeffrey Shi Kai Chan, Jiandong Zhou, Sharen Lee, Andrew Li, Martin Tan, Keith Sai Kit Leung, Kamalan Jeevaratnam, Tong Liu, Leonardo Roever, Ying Liu, Gary Tse, Qingpeng Zhang
Summary: fQRS in heart failure patients is an independent predictor of cardiovascular mortality, VA, and SCD. The presence of fQRS in more than 2 contiguous leads increases the risk of SCD. fQRS remains predictive of VA and SCD in heart failure patients without ischemic heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Letter
Cardiac & Cardiovascular Systems
Jeffrey Shi Kai Chan, Danish Iltaf Satti, Yan Hiu Athena Lee, Jeremy Man Ho Hui, Teddy Tai Loy Lee, Oscar Hou In Chou, Abraham Ka Chung Wai, Ana Ciobanu, Ying Liu, Tong Liu, Leonardo Roever, Giuseppe Biondi-Zoccai, Qingpeng Zhang, Bernard Man Yung Cheung, Jiandong Zhou, Gary Tse
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xinxin Zhang, Yuxi Sun, Ning Wang, Yanli Zhang, Yunlong Xia, Ying Liu
Summary: Cardio-oncology is a nascent specialty that aims to address the cardiovascular complications of cancer therapies. Some anti-tumor drugs have cardioprotective effects in addition to their cancer treatment properties. B cells participate in and promote the progression of cardiovascular diseases, suggesting novel immunomodulatory therapeutic strategies targeting B cells and their products.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Hongmei Zhao, Hongqin Yang, Chi Geng, Yang Chen, Yaqin Tang, Zhiwei Li, Junling Pang, Ting Shu, Yu Nie, Yongshuo Liu, Kegang Jia, Jing Wang
Summary: Research shows that elevated IgE promotes pathological cardiac fibrosis by modulating miR-486a-5p and downstream factors, such as Smad1, providing new targets for intervention in pathological cardiac fibrosis.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
