Article
Spectroscopy
Qin Wang, Li-Bing Lu, Zhu Tao, Tao Sun, Qing Tang, Ying Huang
Summary: This study investigates the effects of pH and mercury ions on the host-guest complex between cucurbit[7]uril and Hoechst 33342. Different binding stoichiometries were observed at different pH levels, while mercury ions were found to push the formation of two different host-guest complexes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Chemistry, Multidisciplinary
Jing-Xin Liu, Kai Chen, Carl Redshaw
Summary: Since the successful separation of different cucurbit[n]uril homologues in 2001, the field of cucurbit[n]uril supramolecular chemistry has rapidly developed. The combination of Q[n] cavity size and various external stimuli has led to the creation of various Q[n]-based mechanically interlocked molecules (MIMs), including (pseudo)rotaxanes, catenanes, dendrimers, and poly(pseudo)rotaxanes. This review article highlights the important advancements in the field of Q[n]-based MIMs over the past two decades, discusses examples of heterowheel (pseudo)rotaxanes and poly(pseudo)rotaxanes involving Q[n]s, and reflects on the opportunities and challenges of constructing Q[n]-based stimuli-responsive MIMs.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Nanoscience & Nanotechnology
Obaydah Abd Alkader Alabrahim, Sherif Ashraf Fahmy, Hassan Mohamed El-Said Azzazy
Summary: Supramolecular nanovesicles are promising nanocarriers for drug delivery, with the ability to encapsulate hydrophilic and hydrophobic guest molecules. Cucurbit[n]urils (CBs) have been used as smart and multifunctional host macromolecules, with the potential for targeted delivery of chemotherapeutics.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Physical
Goutam Chakraborty, Manoj K. Choudhary, Mahesh Sundararajan, Alok K. Ray, Soumyaditya Mula, Haridas Pal
Summary: The study investigates the interaction between a molecular rotor-based BODIPY dye and a versatile macrocyclic molecule CB7 using various techniques, revealing a significant fluorescence enhancement, reduced structural flexibility, and formation of 1:1 and 1:2 dye-to-host complexes. The potential of the system in different stimuli-responsive sensor applications is also explored by examining its response to changing temperature.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Hui Zhao, Wen-Jie Chen, Hao Chen, Ji-Fu Sun, Zhong-Zheng Gao
Summary: A novel 1:1 supramolecular dye inclusion complex between inverted cucurbit[7]uril (iQ[7]) and Thioflavin T (THT) has been successfully constructed based on host-guest recognition, showing fluorescence enhancement and high sensitivity to competing guests. These results provide a new possibility for applications in the field of molecular recognition.
SUPRAMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Khaleel Assaf
Summary: The supramolecular complexation of doxepin with cucurbit[7]uril was investigated in aqueous solution, and a host-guest complex was formed. The partial encapsulation of doxepin led to the development of a supramolecular assembly at low concentration.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Polymer Science
Yanli Li, YeFang Yang, Xinqi Pei, Yu Li, Yuhui Yuan, Xiaoling Huang
Summary: The cucurbit[6]uril-derivatized copolymers exhibit an upper critical solution temperature (UCST) response in water, highly dependent on the composition of the copolymer. Additionally, the copolymers are capable of successfully capturing specific dyes and releasing them in response to temperature and pH stimuli.
POLYMER INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Lili Sun, Zejiang Wang, Juan Hou, Guozhen Fang, Jifeng Liu, Shuo Wang
Summary: Heterocyclic amines (HCA) are mutagenic factors in cooked meat products and pose a hazard to food safety. This study presents a new technique for detecting 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) using the molecular cavities of cucurbit[7]uril (CB[7]) for guest recognition. The method involves three steps: oxidation of regenerated cellulose (RC) membrane, trapping of PhIP molecules using amine-aldehyde conjugation chemistry, and quantification of PhIP through host-guest interaction with dansyl chloride-labelled CB[7] dye.
Article
Nanoscience & Nanotechnology
Hong-Guang Fu, Xin-Xin Shi, Min Liu, Hui-Juan Wang, Fanjun Zhang, Yong Chen, Yu Liu
Summary: A size-tunable nano-supramolecular assembly with reversible photoluminescent behavior has been constructed by noncovalent polymerization. This assembly shows potential applications in tumor cells' targeted imaging and anti-counterfeiting.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Organic
Sai Shradha Reddy Kommidi, Bradley D. Smith
Summary: This report investigates the complexation of azobenzenedyes with cucurbit[7]uril (CB7). The results show that CB7 encapsulates the protonated form of the azobenzene and stabilizes the dye conjugate acid, leading to an increase in pK(a). Molecular modeling suggests that this complex formation is stabilized by ion-dipole interactions, inclusion of the azobenzene ring within the CB7 cavity, and a hydrogen bond between the azo nitrogen and CB7 carbonyls. CB7 complexation not only enhances the stability and hydrophilicity of azobenzene but also offers potential applications in pigment and prodrug development, as well as creating dye displacement assays.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zhimin Yang, Richard A. Stein, Maren Pink, Peter Madzelan, Thacien Ngendahimana, Suchada Rajca, Mark A. Wilson, Sandra S. Eaton, Gareth R. Eaton, Hassane S. Mchaourab, Andrzej Rajca
Summary: We report complex formation between the chloroacetamide 2,6-diazaadamantane nitroxide radical (ClA-DZD) and cucurbit[7]uril (CB-7), which significantly immobilizes the radical and allows for reliable measurement of interspin distances. These findings have important implications for supramolecular recognition-enabled long-distance DEER measurements at near physiological temperatures.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Cheng-hui Wang, Qing Tang, Jie Zhao, Xin Xiao, Zhu Tao, Ying Huang
Summary: The supramolecular assembly between twisted cucurbit[14]uril (tQ[14]) and p-diaminoazobenzene (DAAB) can be reversibly controlled by temperature, and the tQ[14]-DAAB complex exhibits selective ultraviolet and colorimetric responses for AcO- and F-, showing potential analysis applications.
Article
Chemistry, Physical
Lubna Alrawashdeh, Bayan F. Kulaib, Khaleel I. Assaf, Musa I. El-Barghouthi, Khaled Bodoor, Osama M. Abuhasan, Ahmad A. Abdoh
Summary: Spectroscopic and computational techniques were used to study the complexation of gabapentin and its lactam form with cucurbit[7]uril in aqueous solution. The results showed that cucurbit[7]uril can form 1:1 complexes with both gabapentin and its lactam form, with a higher preference for the lactam form. The encapsulation of gabapentin within the cavity of cucurbit[7]uril also increased the rate of lactamization, as revealed by NMR spectra.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Rukayat S. Bojesomo, Khaleel Assaf, Haythem A. Saadeh, Lamia A. Siddig, Na'il Saleh
Summary: A new fluorescent dye complexed with CB7 was designed to detect carnosol, an anti-breast cancer drug, utilizing the supramolecular indicator displacement assay strategy, the CB7-assisted pK(a) shift, and the CB7-retarded photoinduced electron transfer process. The complexation was confirmed by spectroscopic methods, and a sensitive sensor for the detection of CAR in aqueous solution was achieved.
Article
Chemistry, Physical
Khaled Bodoor, Musa I. El-Barghouthi, Dima F. Alhamed, Khaleel I. Assaf, Lubna Alrawashdeh
Summary: In this study, the host-guest complexation between CB[7] and the alpha- and beta-anomers of glucosamine was investigated. The results showed that electrostatic and van der Waals interactions played important roles in the stability of the complexes. Thermodynamic integration revealed the preferred binding of specific anomers and the resulting pK(a) shift of glucosamine.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Yu Wang, Johannes B. Woehrstein, Noah Donoghue, Mingjie Dai, Maier S. Avendano, Ron C. J. Schackmann, Jason J. Zoeller, Shan Shan H. Wang, Paul W. Tillberg, Demian Park, Sylvain. W. Lapan, Edward S. Boyden, Joan S. Brugge, Pascal S. Kaeser, George M. Church, Sarit S. Agasti, Ralf Jungmann, Peng Yin
Article
Chemistry, Analytical
Ranjan Sasmal, Nilanjana Das Saha, Meenakshi Pahwa, Sushma Rao, Divyesh Joshi, Maneesha S. Inamdar, Vasu Sheeba, Sarit S. Agasti
ANALYTICAL CHEMISTRY
(2018)
Article
Materials Science, Biomaterials
Santu Sinha, Nilanjana Das Saha, Ranjan Sasmal, Divyesh Joshi, Soumya Chandrasekhar, Monica Swetha Bosco, Sarit S. Agasti
JOURNAL OF MATERIALS CHEMISTRY B
(2018)
Article
Chemistry, Inorganic & Nuclear
Arka Sarkar, Paribesh Acharyya, Ranjan Sasmal, Provas Pal, Sarit S. Agasti, Kanishka Biswas
INORGANIC CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Nilanjana Das Saha, Ranjan Sasmal, Shafeekh Kulathinte Meethal, Somya Vats, Preethi V. Gopinathan, Oishika Jash, Ravi Manjithaya, Nathalie Gagey-Eilstein, Sarit S. Agasti
Article
Chemistry, Multidisciplinary
Aritra Sarkar, Ranjan Sasmal, Charly Empereur-mot, Davide Bochicchio, Srinath V. K. Kompella, Kamna Sharma, Shikha Dhiman, Balasubramanian Sundaram, Sarit S. Agasti, Giovanni M. Pavan, Subi J. George
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Chemistry, Multidisciplinary
Aritra Sarkar, Tejmani Behera, Ranjan Sasmal, Riccardo Capelli, Charly Empereur-mot, Jaladhar Mahato, Sarit S. Agasti, Giovanni M. Pavan, Arindam Chowdhury, Subi J. George
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Editorial Material
Chemistry, Multidisciplinary
Jerrin Thomas George, Sarit S. Agasti
Article
Chemistry, Multidisciplinary
Aritra Sarkar, Ranjan Sasmal, Angshuman Das, Akhil Venugopal, Sarit S. Agasti, Subi J. George
Summary: The synthesis of supramolecular block co-polymers with small monomers and predictive sequence requires elegant molecular design and synthetic strategies. A kinetically controlled sequential seeded supramolecular polymerization method was reported to synthesize tri-component supramolecular BCPs with tunable microstructure, with the use of fluorescent pi-conjugated monomers and core-substituted naphthalene diimide derivatives. This method provides a promising platform for constructing unique functional organic heterostructures for various optoelectronic and catalytic applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Arka Som, Meenakshi Pahwa, Sumit Bawari, Nilanjana Das Saha, Ranjan Sasmal, Monica Swetha Bosco, Jagannath Mondal, Sarit S. Agasti
Summary: Modern chemical and biological studies are focusing more on understanding the fate of individual cells within apparently homogeneous populations. This has led to a need for strategies that label individual cells with unique fluorescent signatures, and one promising approach involves using optically controlled host-guest recognition to generate distinct barcodes in cells. Multiple spectrally distinct CB[7]-conjugated fluorophores can be used to perform 10-color barcoding in fixed cells and 7-color barcoding in live cells, demonstrating the potential for multiplexed applications in cellular studies.
Article
Chemistry, Multidisciplinary
Aritra Sarkar, Ranjan Sasmal, Angshuman Das, Sarit S. Agasti, Subi J. George
Summary: In this study, the synthesis of well-defined supramolecular BCPs with tunable block lengths was demonstrated by varying the monomer to seed ratio in a kinetically controlled seeded supramolecular polymerization process. Structural Illumination microscopy (SIM) and spectroscopic analyses provided structural characterization of these supramolecular BCPs, offering various possibilities as axial organic heterostructures.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Deepika Gupta, Ranjan Sasmal, Ashmeet Singh, Jojo P. Joseph, Chirag Miglani, Sarit S. Agasti, Asish Pal
Article
Chemistry, Multidisciplinary
Ranjan Sasmal, Nilanjana Das Saha, Florian Schueder, Divyesh Joshi, Vasu Sheeba, Ralf Jungmann, Sarit S. Agasti
CHEMICAL COMMUNICATIONS
(2019)
