Article
Clinical Neurology
Kunyi Li, Lijun Wang, Lan Wen, Jian Wang, Maolin Li
Summary: The study aimed to determine the safety and efficacy of intrathecally administered isoniazid (INH) and prednisolone in addition to systemic anti-TB therapy compared with systemic anti-TB therapy alone in adult patients with tuberculous meningitis. The addition of intrathecal INH and prednisolone to systemic anti-TB therapy may result in better outcomes for adult patients with tuberculous meningitis.
NEUROLOGICAL SCIENCES
(2022)
Article
Immunology
Stephanie Thee, Robindra Basu Roy, Daniel Blazquez-Gamero, Lola Falcon-Neyra, Olaf Neth, Antoni Noguera-Julian, Cristina Lillo, Luisa Galli, Elisabetta Venturini, Danilo Buonsenso, Florian Goetzinger, Nuria Martinez-Alier, Svetlana Velizarova, Folke Brinkmann, Steven B. Welch, Maria Tsolia, Begona Santiago-Garcia, Ralph Schilling, Marc Tebruegge, Renate Krueger
Summary: This European multicenter study provides data on the management and outcome of tuberculosis (TB) meningitis in children, highlighting that both morbidity and mortality remain high even in high-resource settings. Several key factors associated with unfavorable outcome were identified.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Biology
Edwin Ardiansyah, Julian Avila-Pacheco, Le Thanh Hoang Nhat, Sofiati Dian, Dao Nguyen Vinh, Hoang Thanh Hai, Kevin Bullock, Bachti Alisjahbana, Mihai G. Netea, Riwanti Estiasari, Trinh Thi Bich Tram, Joseph Donovan, Dorothee Heemskerk, Tran Thi Hong Chau, Nguyen Duc Bang, Ahmad Rizal Ganiem, Rovina Ruslami, Valerie A. C. M. Koeken, Raph L. Hamers, Darma Imran, Kartika Maharani, Vinod Kumar, Clary B. Clish, Reinout van Crevel, Guy Thwaites, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong
Summary: Metabolomic analysis of tuberculous meningitis patients revealed that levels of tryptophan in cerebrospinal fluid were negatively associated with survival. Additionally, downstream metabolites of tryptophan were correlated with cerebrospinal fluid inflammation and blood-cerebrospinal fluid leakage, and plasma kynurenine levels predicted mortality.
Article
Medicine, Research & Experimental
Jianhua Chen, Jie Wu, Yong Luo, Nanqu Huang
Summary: The study found that the level of NELL2 in the cerebrospinal fluid of tuberculous meningitis patients decreased significantly. Anti-tuberculosis treatment can improve the level of NELL2, which may become one of the potential markers of outcome.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Critical Care Medicine
Nick Kastenholz, Murad Megjhani, Catharina Conzen-Dilger, Walid Albanna, Michael Veldeman, Daniel Nametz, Soon Bin Kwon, Henna Schulze-Steinen, Hani Ridwan, Hans Clusmann, Gerrit Alexander Schubert, Soojin Park, Miriam Weiss
Summary: The study suggests that patients with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage may have impaired cerebral autoregulation. The Pressure Reactivity Index (PRx) and Oxygen Reactivity Index (ORx) are two different measures of autoregulation, with ORx being more sensitive in detecting local perfusion disturbances.
Article
Clinical Neurology
Carolin Beuker, Nils Werring, Nadine Bonberg, Jan-Kolja Strecker, Antje Schmidt-Pogoda, Wolfram Schwindt, Paul Stracke, Andreas Schulte-Mecklenbeck, Catharina Gross, Heinz Wiendl, Heike Minnerup, Jens Minnerup
Summary: This study characterized patients with ischemic stroke due to bacterial meningitis and found a strong association between stroke and mortality. It also discovered that ischemic stroke is caused by cerebral vasculopathy near the infection focus and has specific time courses.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Yuxuan Jiang, Xiangqin Xu, Zhuoxin Guo, Yuxin Liu, Jiahao Lin, Lijun Suo, Ying Jiang, Bo Liu, Tingting Lu
Summary: This study aimed to identify the risk factors and prognostic impact of myelitis for patients with tuberculous meningitis (TBM). The study found that myelitis was a common complication of TBM and independently predicted a poor outcome. Disease severity and cerebrospinal fluid protein level were identified as independent risk factors for myelitis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Maaike C. Swets, Fabian Termorshuizen, Nicolette F. de Keizer, Judith van Paassen, Meindert Palmen, Leonardus G. Visser, M. Sesmu Arbous, Geert H. Groeneveld
Summary: This study investigated the association between influenzalike illness seasons and prolonged mechanical ventilation and inhospital mortality in a Dutch cohort of adult elective cardiac surgery patients. It found that patients undergoing cardiac surgery during the ILI season had increased risk of inhospital mortality compared with patients in the baseline season, but no evidence was found that this difference is caused by direct postoperative pulmonary complications.
ANNALS OF THORACIC SURGERY
(2023)
Article
Nutrition & Dietetics
Jonas Ellerbrock, Esmee Hubers, Chahinda Ghossein-Doha, Veronique Schiffer, Robert-Jan Alers, Laura Jorissen, Jolijn van Neer, Maartje Zelis, Emma Janssen, Sabine Landewe-Cleuren, Annemie van Haarlem, Boris Kramer, Marc Spaanderman
Summary: This study evaluated the association between gestational diabetes mellitus (GDM), metabolic syndrome (MetS) constituents, and pregnancy outcomes. The study found that factors such as hypertension, dyslipidemia, and proteinuria were associated with an increased risk of preeclampsia and preterm birth, while obesity was not related to adverse outcomes.
Article
Clinical Neurology
Ryoji Goto, Yurino Horiuchi, Haruka Kawakami, Ayaka Chikada, Tsutomu Yasuda, Sousuke Takeuchi, Noritoshi Arai
Summary: This study investigates the association between CSF parameters and enhancement on contrast-enhanced MRI in patients with bacterial meningitis (BM) or tuberculous meningitis (TM). The findings suggest that CSF analysis is important in assessing the need for contrast-enhanced MRI, which may be useful in diagnosis, distinction, and prognosis estimation.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Clinical Neurology
Manish Ramesh Patil, Imran Rizvi, Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar, Ravi Uniyal, Shweta Pandey, Rajesh Verma, Praveen Kumar Sharma
Summary: Approximately 15.3% of patients with tuberculous meningitis needed re-hospitalization, with paradoxical neurological deterioration being the main reason. Re-hospitalization had an adverse impact on prognosis.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Surgery
Sara J. Kuik, Martin van der Heide, Janneke L. M. Bruggink, Arend F. Bos, A. A. Eduard Verhagen, Elisabeth M. W. Kooi, Jan B. F. Hulscher
Summary: Measuring r(int)SO(2), but not r(c)SO(2), seems to be helpful in estimating the survival rate of preterm infants after surgery for NEC. The levels of r(int)SO(2), C-reactive protein, lactate, and fraction of inspired oxygen differed significantly between survivors and non-survivors. Only r(int)SO(2) remained significant in the multiple regression model.
Article
Immunology
Joseph Donovan, Trinh Thi Bich Tram, Nguyen Hoan Phu, Nguyen Thi Thu Hiep, Vu Thi Thu Van, Dang Thi Hong Mui, Nguyen Thi Han Ny, Ho Dang Trung Nghia, Nguyen Ho Hong Hanh, Le Van Tan, Nguyen Thuy Thuong Thuong, Guy E. Thwaites
Summary: Active Strongyloides stercoralis coinfection in Vietnamese adults with tuberculous meningitis was significantly associated with reduced intracerebral inflammation and reduced neurological complications by three months.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Romain Deschamps, Julie Pique, Xavier Ayrignac, Nicolas Collongues, Bertrand Audoin, Helene Zephir, Jonathan Ciron, Mikael Cohen, Jennifer Aboab, Guillaume Mathey, Nathalie Derache, David Laplaud, Eric Thouvenot, Bertrand Bourre, Aurelie Ruet, Francoise Durand-Dubief, Valerie Touitou, Catherine Vignal-Clermont, Caroline Papeix, Olivier Gout, Romain Marignier, Elisabeth Maillart
Summary: The study retrospectively analyzed the long-term outcomes of 61 patients with MOG antibody-associated disease, showing that most patients achieved favorable long-term outcomes, but some experienced severe impairments, particularly visual damage.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Jianxi Zhang, Zhigang Cheng, Ying Tian, Lili Weng, Yiying Zhang, Xin Yang, Michael K. E. Schafer, Qulian Guo, Changsheng Huang
Summary: The increase in cerebral tissue oxygen saturation (SctO(2)) is associated with the emergence from propofol-remifentanil anesthesia, indicating its potential as an indicator of awakening.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Bowen Zhang, Lennart M. Roesner, Stephan Traidl, Valerie A. C. M. Koeken, Cheng-Jian Xu, Thomas Werfel, Yang Li
Summary: Single-cell analysis of atopic dermatitis and psoriasis patients revealed disease-specific T cell clusters and identified cell type-specific gene expression associated with inflammation signatures and disease severity. The study shed light on the complexity of inflammatory responses and provided valuable insights for further investigation and therapeutic approaches for these chronic inflammatory skin diseases.
Article
Biochemistry & Molecular Biology
Collins K. Boahen, S. J. C. F. M. Moorlag, Kristoffer Jarlov Jensen, Vasiliki Matzaraki, Stephanie Fanucchi, Ivan Monteiro, Charlotte de Bree, Ezio T. Fok, Musa Mhlanga, Leo A. B. Joosten, Peter Aaby, Christine Stabell Benn, Mihai G. Netea, Vinod Kumar
Summary: This study aimed to identify single-nucleotide polymorphisms (SNPs) controlling cytokine responses after microbial stimulation in infants of West-African ancestry. The researchers found 12 independent loci, with the LINC01082LINC00917 locus influencing more than half of the cytokine-stimulation pairs assessed. Functional validation confirmed the impact of several complement genes on cytokine response after BCG vaccination. These findings highlight population-specific genetic effects on cytokine production and potential opportunities for therapeutic intervention and vaccine development in African populations.
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Agronomy
Xiquan Wang, Hongyuan Zhang, Zhizhong Zhang, Chenping Zhang, Kai Zhang, Huancheng Pang, Stephen M. Bell, Yuyi Li, Ji Chen
Summary: The relationship between salt-affected soils and their adjacent river systems is important for addressing the challenges of soil salinization in agriculture. A study found that the distance along the river is closely related to the level of soil salinization, with soil salinity increasing as the distance along the river increases. This is likely due to the leaching of ions from upstream soils and their accumulation in downstream soils.
AGRICULTURAL WATER MANAGEMENT
(2023)
Article
Biochemistry & Molecular Biology
Jose Manuel Sanchez-Maldonado, Antonio Jose Cabrera-Serrano, Subhayan Chattopadhyay, Daniele Campa, Maria del Pilar Garrido, Angelica Macauda, Rob Ter Horst, Andres Jerez, Mihai G. G. Netea, Yang Li, Kari Hemminki, Federico Canzian, Asta Foersti, Juan Sainz
Summary: This study found that obesity-related genetic variants do not impact the risk of developing MM, based on genomic association studies conducted in German and Spanish populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Michelle C. Sabo, Nguyen T. T. Thuong, Xuling Chang, Edwin Ardiansyah, Trinh T. B. Tram, Hoang T. Hai, Ho D. T. Nghia, Nguyen D. Bang, Sofiati Dian, A. Rizal Ganiem, Shima Shaporifar, Vinod Kumar, Zheng Li, Martin Hibberd, Chiea Chuen Khor, Guy E. Thwaites, Dorothee Heemskerk, Arjan van Laarhoven, Reinout van Crevel, Sarah J. Dunstan, Javeed A. Shah
Summary: This study reveals an association between a polymorphism in MUC5AC gene and susceptibility to and mortality from tuberculous meningitis. MUC5AC variants may affect immune response and thus influence the outcomes of tuberculous meningitis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biology
Edwin Ardiansyah, Julian Avila-Pacheco, Le Thanh Hoang Nhat, Sofiati Dian, Dao Nguyen Vinh, Hoang Thanh Hai, Kevin Bullock, Bachti Alisjahbana, Mihai G. Netea, Riwanti Estiasari, Trinh Thi Bich Tram, Joseph Donovan, Dorothee Heemskerk, Tran Thi Hong Chau, Nguyen Duc Bang, Ahmad Rizal Ganiem, Rovina Ruslami, Valerie A. C. M. Koeken, Raph L. Hamers, Darma Imran, Kartika Maharani, Vinod Kumar, Clary B. Clish, Reinout van Crevel, Guy Thwaites, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong
Summary: Metabolomic analysis of tuberculous meningitis patients revealed that levels of tryptophan in cerebrospinal fluid were negatively associated with survival. Additionally, downstream metabolites of tryptophan were correlated with cerebrospinal fluid inflammation and blood-cerebrospinal fluid leakage, and plasma kynurenine levels predicted mortality.
Article
Biochemistry & Molecular Biology
Dong Hoon Lee, Qi Jin, Ni Shi, Fenglei Wang, Alaina M. Bever, Jun Li, Liming Liang, Frank B. Hu, Mingyang Song, Oana A. Zeleznik, Xuehong Zhang, Amit Joshi, Kana Wu, Justin Y. Jeon, Jeffrey A. Meyerhardt, Andrew T. Chan, A. Heather Eliassen, Clary B. Clish, Steven K. Clinton, Edward L. Giovannucci, Fred K. Tabung
Summary: This study aimed to evaluate the association between metabolomic profile scores related to inflammatory diets and insulinemic diets, and colorectal cancer risk. The results showed that metabolomic profiles reflecting pro-inflammatory diets and inflammation biomarkers were associated with colorectal cancer risk in men, while no association was found in women.
Article
Immunology
Konstantin Foehse, Buesra Geckin, Martijn Zoodsma, Gizem Kilic, Zhaoli Liu, Rutger J. Roering, Gijs J. Overheul, Josephine van de Maata, Ozlem Buluta, Jacobien J. Hoogerwerf, Jaap ten Oever, Elles Simonetti, Heiner Schaal, Ortwin Adams, Lisa Mueller, Philipp Niklas Ostermann, Frank L. van de Veerdonk, Leo A. B. Joosten, Bart L. Haagmans, Reinout van Crevel, Ronald P. van Rij, Corine Geurtsvankessel, Marien I. de Jonge, Yang Li, Jorge Dominguez-Andres, Mihai G. Netea
Summary: The mRNA-based BNT162b2 vaccine provides protection against severe disease and mortality caused by SARS-CoV-2 by inducing specific antibody and T-cell responses. The vaccine also modulates innate immune responses and induces long-term changes in immune cells.
CLINICAL IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nick Keur, Maria Saridaki, Isis Ricano-Ponce, Mihai G. Netea, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar
Summary: This study identified protein biomarkers associated with COVID-19 severity through the measurement of plasma protein levels. It also identified three clinical endotypes of the disease. These findings suggest that circulating proteins may be useful for predicting COVID-19 outcomes and may be applicable to other populations.
RESPIRATORY MEDICINE
(2023)
Article
Rheumatology
Lara D. Veeken, Merel A. A. Opdam, Lise M. Verhoef, Calin Popa, Reinout van Crevel, Alfons A. den Broeder
Summary: This study aims to determine the infection incidence in a large real-life population of RA patients using RTX, with special focus on (ultra-)low dosing and time since last infusion. The results showed that the risk of infection was lower with a dose of 200 mg, and infections seemed to occur more frequently in the first two months after infusion, suggesting an association with peak concentration.
Article
Cell Biology
Roeland F. Stolk, Niklas Bruse, Rob ter Horst, Aron Jansen, Isis Ricano Ponce, Jelle Gerretsen, Johannes van der Hoeven, Vinod Kumar, Mihai G. Netea, Peter Pickkers, Matthijs Kox
Summary: This study aimed to evaluate the association between common nonsynonymous variants in the beta 2-adrenergic receptor gene and norepinephrine-induced immunosuppression and dysregulated inflammatory responses. The results showed that these variants did not affect cytokine production, norepinephrine-mediated immunosuppression, or the systemic inflammatory response in healthy volunteers.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Microbiology
Ralf Stemkens, Maarten Cobussen, Wouter Hoefsloot, Erik de Laat, Reinout van Crevel, Rob E. Aarnoutse, Jakko van Ingen
Summary: Treatment of skin and soft tissue infections caused by nontuberculous mycobacteria can be challenging. Negative pressure wound therapy with instillation and dwell time of topical antibiotics can be a successful and well-tolerated treatment option.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Cell Biology
Bowen Zhang, Zhenhua Zhang, Valerie A. C. M. Koeken, Saumya Kumar, Michelle Aillaud, Hsin-Chieh Tsay, Zhaoli Liu, Anke R. M. Kraft, Chai Fen Soon, Ivan Odak, Berislav Bosnjak, Anna Vlot, Morris A. Swertz, Uwe Ohler, Robert Geffers, Thomas Illig, Jochen Huehn, Antoine-Emmanuel Saliba, Leif Erik Sander, Reinhold Foerster, Cheng-Jian Xu, Markus Cornberg, Leon N. Schulte, Yang Li
Summary: This study identifies diverse genetic and epigenetic regulators that contribute to the severity of COVID-19 through single-cell analysis of patients.