Article
Pediatrics
Michael L. Rinke, Moonseong Heo, Lisa Saiman, David G. Bundy, Rebecca E. Rosenberg, Patricia DeLaMora, Barbara Rabin, Philip Zachariah, Parsa Mirhaji, William J. H. Ford, Oghale Obaro-Best, Michael Drasher, Elizabeth Klein, Alexandre Peshansky, Suzette O. Oyeku
Summary: The study identified a substantial incidence density of ambulatory pediatric CLABSI and its association with healthcare utilization. The type of CL, patients with low albumin, prophylactic antimicrobial agents, and placement setting may be targeted for reduction efforts.
Article
Immunology
Lorne W. Walker, Shyam Visweswaran, Andrew J. Nowalk
Summary: This study investigated central line-associated bloodstream infections (CLABSI) treated with antimicrobial lock therapy (ALT) at a pediatric hospital from 2004 to 2018. The results showed that 85% of CLABSI initially cleared, but 20% experienced recurrence. Skin and bowel bacteria played different roles in the infections. The findings provide guidance for selecting CLABSI for optimal ALT use.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Critical Care Medicine
Andrew Ward, Augustine Chemparathy, Martin Seneviratne, Shabnam Gaskari, Roshni Mathew, Matthew Wood, Lane F. Donnelly, Grace M. Lee, David Scheinker, Andrew Y. Shin
Summary: This study found that the number of daily accesses to central lines is associated with an increased risk of CLABSI. Most medications delivered through central lines can be safely administered peripherally. Efforts to reduce central line access may be an important strategy for CLABSI prevention.
CRITICAL CARE MEDICINE
(2023)
Article
Pediatrics
William J. H. Ford, David G. Bundy, Suzette Oyeku, Moonseong Heo, Lisa Saiman, Rebecca E. Rosenberg, Patricia DeLaMora, Barbara Rabin, Philip Zachariah, Parsa Mirhaji, Elizabeth Klein, Oghale Obaro-Best, Michael Drasher, Alexandre Peshansky, Michael L. Rinke
Summary: This study evaluated the salvage of CVC in pediatric patients with ambulatory CLABSI and associated risk factors for treatment failure. The results showed that CVC salvage was frequently attempted and was successful in many cases, with specific factors such as underlying diagnosis, CVC type, and absence of candidemia being associated with attempted and successful salvage.
Review
Public, Environmental & Occupational Health
Q. Guo, Z. Lv, H. Wang, L. Song, Y. Liu, H. Chen, C. Zhou
Summary: The study compared the effectiveness of different catheter lock solutions in preventing catheter-related bloodstream infections in pediatric patients, and found that taurolidine + heparin was the most effective solution for preventing CRBSI.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Infectious Diseases
Claudia Signorino, Eleonora Fusco, Luisa Galli, Elena Chiappini
Summary: ALT combined with systemic antibiotics is an effective and safe strategy for treating children with CLABSI/CRBSI episodes, according to the study. The research aimed to investigate the causes of ALT failure in the pediatric population and found that 67.6% of children achieved clinical and microbiologic success with ALT. Factors such as dwell time and use of taurolidine and MDR bacteria infections were associated with the success rate.
Article
Computer Science, Information Systems
Lorne W. Walker, Andrew J. Nowalk, Shyam Visweswaran
Summary: This study utilized machine learning to predict outcomes of salvage of infected central venous catheters in pediatric CLABSI, showing that the infection recurrence model outperformed the CVC removal model. The research illustrated the variability of predictors over time.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Medicine, General & Internal
Ceder Hildegard van den Bosch, Yvette Loeffen, Alida F. W. van der Steeg, Jan-Tom T. van der Bruggen, Florine N. J. Frakking, Marta Fiocco, Cornelis P. van de Ven, Marc H. W. A. Wijnen, Marianne D. van de Wetering
Summary: This study aims to compare the efficacy of taurolidine-citrate-heparin lock to heparin-only lock for the prevention of central line-associated bloodstream infections (CLABSIs) in paediatric oncology patients. The primary outcome is the incidence of first CLABSIs. An interim analysis will be performed with oversight from a data safety monitoring board.
Article
Health Care Sciences & Services
Ranjith Kamity, Melissa Grella, Maureen L. Kim, Meredith Akerman, Maria Lyn Quintos-Alagheband
Summary: By implementing K-card audits and family key card education, the compliance of central line maintenance bundles was increased leading to a significant reduction in CLABSI rates. This approach shows potential in improving healthcare initiatives.
BMJ QUALITY & SAFETY
(2021)
Article
Pediatrics
Brittany L. Willer, Joseph D. Tobias, Markita L. Suttle, Olubukola O. Nafiu, Christian Mpody
Summary: This retrospective cohort study analyzed data from the Pediatric Health Information System database to evaluate trends in racial and ethnic disparities of central line-associated bloodstream infections (CLABSIs) in pediatric patients over the past 5 years. The study found that the CLABSI rate was consistently higher among Black and Hispanic children compared to their White peers, highlighting the need for further exploration of the causes of these persistent disparities in pediatric patients.
Review
Critical Care Medicine
Adam G. Stewart, Kevin B. Laupland, Alexis Tabah
Summary: Primary and intravascular catheter-associated bloodstream infections (CA-BSIs) are significant clinical entities in the ICU, with high morbidity and mortality rates. Recent studies have shown that failure to remove the catheter in CA-BSI leads to higher mortality. Factors such as severity scores, duration of ICU stay, and catheter insertion increase the risk of CA-BSI. The use of prevention bundles during central venous line insertion can significantly reduce CA-BSI incidence. Differential time-to-positivity of paired blood cultures may aid in the diagnosis of CA-BSI.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Medicine, General & Internal
Sarah E. Firmani, Holly D. Maples, Archana Balamohan
Summary: Lactococcus spp. is generally considered to be of low virulence and rarely pathogenic, with few reported cases of significant infections in children, mostly outside of the United States. Limited data exists on antimicrobial susceptibility testing for Lactococcus spp. Our study presents three pediatric cases of central line bloodstream infections caused by Lactococcus spp. between 2018 and 2020, along with a review of pediatric literature.
FRONTIERS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Keyvan Rahmani, Anurag Garikipati, Gina Barnes, Jana Hoffman, Jacob Calvert, Qingqing Mao, Ritankar Das
Summary: The study developed and validated a machine learning algorithm for predicting CLABSI risk, showing high accuracy in prediction at 48 hours. This suggests that machine learning algorithms may provide effective clinical decision support for assessing CLABSI risk.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Review
Mycology
Sofia Maraki, Nikolaos Katzilakis, Ioannis Neonakis, Dimitra Stafylaki, Joseph Meletiadis, George Hamilos, Eftichia Stiakaki
Summary: This study presents a case of central line-associated bloodstream infection caused by Exophiala dermatitidis in a 4.5-year-old boy with Ewing's sarcoma. The infection was successfully treated with appropriate antifungal medication and catheter removal. The literature review highlights the clinical manifestations and challenges in diagnosing and managing pediatric infections caused by E. dermatitidis.
Review
Public, Environmental & Occupational Health
C. H. van den Bosch, B. Jeremiasse, J. T. van der Bruggen, F. N. J. Frakking, Y. G. T. Loeffen, C. P. van de Ven, A. F. W. van der Steeg, M. F. Fiocco, M. D. van de Wetering, M. H. W. A. Wijnen
Summary: This study aimed to evaluate the efficacy of taurolidine-containing lock solutions (TL) compared to other lock solutions in preventing central venous catheter (CVC)-related bloodstream infections. The results showed that TL might be a promising method for preventing CVC-related bloodstream infections, but larger randomized controlled trials are needed for more conclusive evidence.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Public, Environmental & Occupational Health
Craig H. Gilliam, Jessica Brazelton de Cardenas, Delia Carias, Gaby Maron Alfaro, Randall T. Hayden, Hana Hakim
Summary: This article describes a cluster of 6 pediatric hematopoietic cell transplant recipients who developed Lactobacillus bacteremia attributed to the use of probiotics. Whole-genome sequencing confirmed the relatedness between Lactobacillus isolates obtained from probiotics and patients' blood. Clinical studies are required to evaluate the safety of probiotic use in immunocompromised patients.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Immunology
Ruba Barbar, Jessica N. Brazelton, Karen C. Carroll, Shawna Lewis, Dimitrios Bourdas, Anita Tembo, Linda Gluck, Hana Hakim, Randall T. Hayden
Summary: Whole genome sequencing (WGS) identified a highly diverse group of Clostridioides difficile isolates among pediatric oncology and transplant patients with C. difficile infection. WGS can provide more accurate classification of CDI compared to clinical surveillance criteria.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Oncology
Hope D. Swanson, Hana Hakim, Diego R. Hijano, Ted Morton, Shane Cross, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Seth E. Karol
Summary: This study aimed to evaluate the safety of SARS-CoV-2 vaccines in patients with anti-pegaspargase antibodies. The results showed that these patients tolerated the vaccines well, which also use polyethylene glycol as a stabilizing agent, with no significant adverse reactions observed.
Editorial Material
Microbiology
R. T. Hayden
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Oncology
Thomas Lehrnbecher, Paula D. Robinson, Roland A. Ammann, Brian Fisher, Priya Patel, Robert Phillips, Melissa P. Beauchemin, Fabianne Carlesse, Elio Castagnola, Bonnie L. Davis, Caitlin W. Elgarten, Andreas H. Groll, Gabrielle M. Haeusler, Christa Koenig, Maria E. Santolaya, Wim J. E. Tissing, Joshua Wolf, Sarah Alexander, Helen Hu, L. Lee Dupuis, Lillian Sung
Summary: This article aims to update a clinical practice guideline for the management of fever and neutropenia in pediatric patients with cancer and hematopoietic cell transplantation recipients. The guideline panel reviewed new randomized controlled trials and classified the evidence quality. Changes were made based on the latest evidence.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Immunology
Diego R. Hijano, Jose A. Ferrolino, Jennifer Hidinger, Jessica N. Brazelton, Zhengming Gu, Sri Suganda, Heather L. Glasgow, Kim J. Allison, Megan Peterson, Ronald H. Dallas, Gabriela Maron, Randall T. Hayden
Summary: Immunocompromised patients are at risk of life-threatening adenoviral infection. A digital polymerase chain reaction assay was developed and evaluated to measure human adenovirus in the respiratory tract, demonstrating that a higher peak viral load is associated with disseminated infection, mechanical ventilation, and death.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Letter
Hematology
Paul Monagle, Christoph Male, Leslie Raffini
Editorial Material
Ethics
Afreen Abraham, Joshua Wolf
AMERICAN JOURNAL OF BIOETHICS
(2023)
Article
Surgery
Teagan Fink, Tony Holmes, Paul Monagle, Tony Penington
Summary: This qualitative study aims to understand surgeons' perspectives on operation report documentation. It was found that the purpose and format of an operation report will influence the detail documented, and synoptic report writing provides clearer documentation, while narrative report writing may be a more robust communication and education tool. Overall rating: 8 out of 10.
ANZ JOURNAL OF SURGERY
(2023)
Review
Immunology
Nikhil Singh, Karin Thursky, Gabriela Maron, Joshua Wolf
TRANSPLANT INFECTIOUS DISEASE
(2023)
Editorial Material
Pediatrics
John H. Mcdermott, Joshua Wolf, William G. Newman
Article
Infectious Diseases
Shaoming Xiao, Charlotte Z. Woods-Hill, Danielle Koontz, Cary Thurm, Troy Richardson, Aaron M. Milstone, Elizabeth Colantuoni, Bright STAR Authorship Grp
Summary: This study aimed to determine whether administrative data could be used as a data source to measure blood culture use in pediatric intensive care units (PICUs). The study found differences between administrative data and hospital-reported data, suggesting that the limitations of administrative data should be carefully considered when monitoring blood culture use.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Article
Oncology
Zachary Rubnitz, Yilun Sun, Asya Agulnik, Pamela Merritt, Kim Allison, Jose Ferrolino, Ronald Dallas, Li Tang, Joshua Wolf
Summary: The study aimed to evaluate the performance of existing sepsis scores in predicting adverse outcomes in children with cancer admitted to the ICU with suspected sepsis. The results showed that all evaluated scores performed poorly, and no alternative approach significantly improved prediction.