NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass

Alpha7 Nicotine Acetylcholine Receptor Agonist PNU-282987 Attenuates Acute Lung Injury in a Cardiopulmonary Bypass Model in Rats

(2017) Jiaxi Ge et al.   SHOCK

High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen-activated protein kinase signaling pathway

(2017) Yan-Hong Zhou et al.   Experimental and Therapeutic Medicine

Protective effect of glycyrrhizin on myocardial ischemia/reperfusion injury-induced oxidative stress, inducible nitric oxide synthase and inflammatory reactions through high-mobility group box 1 and mitogen-activated protein kinase expression

(2017) Xiangna Cai et al.   Experimental and Therapeutic Medicine

Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4

(2017) Nina Van Opdenbosch et al.   Cell Reports

NLRP3 Controls the Development of Gastrointestinal CD11b + Dendritic Cells in the Steady State and during Chronic Bacterial Infection

(2017) Isabelle C. Arnold et al.   Cell Reports

NLRP3 Is Involved in Ischemia/Reperfusion Injury

(2016) Zhiliang Guo et al.   CNS & Neurological Disorders-Drug Targets

The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction

(2016) Francis M. Hughes et al.   JOURNAL OF UROLOGY

Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in Mice

(2015) Pin-Hua Pan et al.   CHINESE MEDICAL JOURNAL

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

(2015) Christina Antonopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis

(2015) Yan Geng et al.   JOURNAL OF HEPATOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

(2015) Vincent Compan et al.   JOURNAL OF IMMUNOLOGY

Macrophage endocytosis of high-mobility group box 1 triggers pyroptosis

(2014) J Xu et al.   CELL DEATH AND DIFFERENTIATION

NLRP3 Inflammasome Activation Is Essential for Paraquat-Induced Acute Lung Injury

(2014) Zhenning Liu et al.   INFLAMMATION

Cardiac Fibroblasts Contribute to Myocardial Dysfunction in Mice with Sepsis: The Role of NLRP3 Inflammasome Activation

(2014) Wenbo Zhang et al.   PLoS One

Traumatic Brain Injury: Lungs in a RAGE

(2014) M. R. Nicolls et al.   Science Translational Medicine

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

(2014) Nina Van Opdenbosch et al.   Nature Communications

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury

(2013) Naoko Kamo et al.   HEPATOLOGY

TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury

(2013) Zhongwei Yang et al.   LABORATORY INVESTIGATION

Toll-Like Receptor 4 Mediates Acute Lung Injury Induced by High Mobility Group Box-1

(2013) Yuxiao Deng et al.   PLoS One

Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome

(2012) Maria T. Kuipers et al.   ANESTHESIOLOGY

Multiple Binding Sites on the Pyrin Domain of ASC Protein Allow Self-association and Interaction with NLRP3 Protein

(2012) Parimala R. Vajjhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice

(2012) M. Kovarova et al.   JOURNAL OF IMMUNOLOGY

Analysis of cardiopulmonary bypass status in China: eight-year development trends

(2012) M Zhao et al.   PERFUSION-UK

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Critical Roles of ASC Inflammasomes in Caspase-1 Activation and Host Innate Resistance to Streptococcus pneumoniae Infection

(2011) R. Fang et al.   JOURNAL OF IMMUNOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Fibrosis during Chlamydia pneumoniae Infection Is Regulated by IL-1 and the NLRP3/ASC Inflammasome

(2010) X. He et al.   JOURNAL OF IMMUNOLOGY

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Innate Immunity: Cytoplasmic DNA Sensing by the AIM2 Inflammasome

(2009) Kate Schroder et al.   CURRENT BIOLOGY

Lung Dysfunction Following Cardiopulmonary Bypass

(2009) Efstratios Apostolakis et al.   JOURNAL OF CARDIAC SURGERY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Major cell death pathways at a glance

(2009) Linde Duprez et al.   MICROBES AND INFECTION

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

(2009) Catherine Dostert et al.   PLoS One

Cell death in the host response to infection

(2008) K Labbé et al.   CELL DEATH AND DIFFERENTIATION