Article
Chemistry, Multidisciplinary
Elise Laszlo, Gregory De Crescenzo, Alfonso Nieto-Arguello, Xavier Banquy, Davide Brambilla
Summary: This study introduced microneedle patches made of superabsorbent acrylate-based hydrogels for rapid sampling of dermal interstitial fluid, leading to the detection of 176 clinically relevant biomarkers through proteomic analysis. Through iterative optimization, the microneedle arrays were proven safe and effective in collecting up to 6 μL of dermal ISF in vivo within 10 minutes, with the ability to selectively extract specific biomarkers by tuning the composition of the patch.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biophysics
Dan Dan Zhu, Le Wen Zheng, Phan Khanh Duong, Reanne Hui Cheah, Xin Yi Liu, Jun Ren Wong, Wen Jun Wang, Steven Thng Tien Guan, Xin Ting Zheng, Peng Chen
Summary: In this study, a highly swellable microneedle patch was developed to painlessly and bloodlessly extract skin interstitial fluid (ISF) for rapid detection of multiple biomarkers through color change. The experimental results demonstrated the feasibility of this method to detect various biomarkers in ISF within minutes.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Materials Science, Multidisciplinary
Na Xu, Wenxin Xu, Manyue Zhang, Jia Yu, Guixia Ling, Peng Zhang
Summary: The traditional way of disease diagnosis faces issues such as wound infection and pain. Minimally invasive detection of biomarkers, using microneedles (MNs) to collect interstitial fluid (ISF) from the skin, has gained attention as a new method for patient monitoring and disease diagnosis. The advantages of MNs, including painless collection and patient compliance, open up new possibilities for individualized and long-term treatments.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Multidisciplinary
Daniela Oliveira, Barbara P. Correia, Sanjiv Sharma, Felismina Teixeira Coelho Moreira
Summary: Skin interstitial fluid (ISF) contains biomarkers that can be sampled in a minimally invasive manner and used for real time monitoring. This paper describes the combination of microneedle technology with molecularly imprinted polymers for transdermal electrochemical sensing. The ability to mass produce microneedle arrays and plastic antibodies allows for low-cost transdermal sensing devices.
Review
Pharmacology & Pharmacy
Shuwen Ma, Jiaqi Li, Lixia Pei, Nianping Feng, Yongtai Zhang
Summary: Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and can be used as a substitute for blood in drug analysis. However, current ISF extraction techniques are bulky, time-consuming, and complicated. Microneedles have been widely used for transdermal drug delivery and can be successfully employed for ISF extraction, facilitating subsequent analysis. The integration of microneedles with sensors enables in situ ISF analysis and specific compound monitoring, and wearable devices with monitoring and delivery functions allow real-time dose modification. This review discusses the progress, future opportunities, and challenges of drug analysis based on microneedle-assisted ISF extraction.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Review
Chemistry, Analytical
Xinyi Zhang, Wenqin Zhang, Wanhui Wu, Jianmin Chen
Summary: This paper provides an overview of the methods and applications of using microneedles for extracting interstitial fluid. Microneedles offer simplicity, speed, reliability, and minimally invasive nature as a method for disease surveillance and clinical diagnosis. The paper gives a detailed description of the preparation methods for microneedles with different structures and discusses the advantages and applications of microneedles-electrochemical sensing technology for analyzing and detecting various biomarkers in interstitial fluid.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Jiale Cheng, Jinkun Huang, Qin Xiang, Haifeng Dong
Summary: In this study, a facile yet versatile ISF analysis platform is developed by combining controllable hollow microneedles (HMNs) and elaborate microfluidic paper-based analytical devices (mu PADs). With one-touch finger operation, the HMNs enable efficient and swift sampling of sufficient ISF to the mu PADs for simultaneous detection of glucose and lactic acid. The self-programmed RGB application (APP) in smartphones is used for analysis, making it a promising point-of-care platform for accurate detection of biomolecules in ISF, with great potential in wearable device development.
ANALYTICA CHIMICA ACTA
(2023)
Article
Engineering, Environmental
Hui Huang, Moyuan Qu, Yan Zhou, Wei Cao, Xiaohui Huang, Jian Sun, Wujin Sun, Xingwu Zhou, Meimei Xu, Xing Jiang
Summary: This study designed a microneedle patch for rapid and minimally invasive extraction of interstitial fluid (ISF) for breast cancer patients. By measuring tumor markers, the patch could detect cancer earlier than other common screening methods, leading to timely treatment and prolonged survival.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Jingyu Xiao, Shuxin Zhang, Qingzhou Liu, Tailin Xu, Xueji Zhang
Summary: This study presents a microfluidic-based wearable plasmonic microneedle sensor for monitoring uric acid. The sensor shows excellent reproducibility and sensitivity, enabling fast identification of target molecules, which may contribute to efficient medical healthcare and early disease prevention.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Multidisciplinary
Muamer Dervisevic, Maria Alba, Li Yan, Mehmet Senel, Thomas R. Gengenbach, Beatriz Prieto-Simon, Nicolas H. Voelcker
Summary: The microneedle array-based transdermal sensing system offers a pain-free alternative for continuous glucose monitoring of interstitial fluid. The system demonstrates good selectivity and sensitivity, with accurate correlation to blood glucose levels measured by a commercial glucometer.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Fatemeh Keyvani, Hanjia Zheng, Md. R. Kaysir, Dragos F. Mantaila, Peyman Ghavami Nejad, Fasih A. Rahman, Joe Quadrilatero, Dayan Ban, Mahla Poudineh
Summary: This article introduces a versatile assay that combines hydrogel microneedles with a graphene oxide-nucleic acid-based fluorescence biosensor to detect biomarkers in a minimally invasive manner. The assay successfully measures four clinically important biomarkers ex vivo and accurately detects glucose and uric acid in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Agriculture, Dairy & Animal Science
Ester Perez-Martin, Almudena Coto-Vilcapoma, Juan Castilla-Silgado, Maria Rodriguez-Canon, Catuxa Prado, Gabriel Alvarez, Marco Antonio Alvarez-Vega, Benjamin Fernandez-Garcia, Manuel Menendez-Gonzalez, Cristina Tomas-Zapico
Summary: Stereotaxic surgeries are important for drug delivery to specific brain regions, but their long-term use poses challenges for animal welfare. This study proposes an optimized method for safe implantation of intrathecal devices, focusing on preoperative, intraoperative, and postoperative procedures. The refinements include modifications to device dimensions, the use of cyanoacrylate tissue adhesive and UV light-curing resin, and the development of a welfare assessment scoresheet. These refinements positively impacted animal welfare and can enhance experimental data quality and reproducibility.
Article
Multidisciplinary Sciences
Sanha Kim, Min Suk Lee, Hee Seok Yang, Jae Hwan Jung
Summary: The tilted microneedle ISF collecting system (TMICS) developed for efficient ISF extraction from rat skin in vivo shows promising results, demonstrating improved extraction efficiency and reliable collection conditions through a tilted insertion method.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Mahmood Razzaghi, Amir Seyfoori, Erik Pagan, Esfandyar Askari, Alireza Hassani Najafabadi, Mohsen Akbari
Summary: To address the need for continuous monitoring and treatment adjustments in chronic diseases, a microneedle array technique is proposed to extract interstitial skin fluid (ISF) painlessly and bloodlessly. The molecular composition of ISF resembles blood plasma, making it a good choice for biomarker identification. The integration of a multiplexed sensor in the microneedle array enables rapid biomarker detection, allowing for practical and self-administrable monitoring and management of metabolic diseases.
Article
Chemistry, Analytical
Lewen Zheng, Dandan Zhu, Wenjun Wang, Jiyang Liu, Steven Tien Guan Thng, Peng Chen
Summary: The authors developed a wire electrode embedded microneedle patch (WEMNP) for non-invasive real-time detection of glucose, which has good mechanical strength and suitable bioelectronic interface. This technology is of great significance for long-term home-based management of chronic diseases and smart agriculture.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Editorial Material
Emergency Medicine
J. K. Femling, J. T. Baca
ANNALS OF EMERGENCY MEDICINE
(2016)
Article
Oncology
Joseph M. Pomo, Robert M. Taylor, Rama R. Gullapalli
CANCER CELL INTERNATIONAL
(2016)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Alex Neuwelt, Jens Langsjoen, Thomas Byrd, Stephen Eberhardt, Gary Mlady, Justin Baca, Therese Bocklage, Cathleen Martinez, Jonathan Orner, Marisa Rivera, Laurel O. Sillerud
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2017)
Article
Biochemical Research Methods
Bao Quoc Tran, Philip R. Miller, Robert M. Taylor, Gabrielle Boyd, Phillip M. Mach, C. Nicole Rosenzweig, Justin T. Baca, Ronen Polsky, Trevor Glaros
JOURNAL OF PROTEOME RESEARCH
(2018)
Article
Chemistry, Analytical
Shane O'Sullivan, Zulfiqur Ali, Xiaoyi Jiang, Reza Abdolvand, M. Selim Unlu, Hugo Placido da Silva, Justin T. Baca, Brian Kim, Simon Scott, Mohammed Imran Sajid, Sina Moradian, Hakhamanesh Mansoorzare, Andreas Holzinger
Article
Engineering, Electrical & Electronic
Robert M. Taylor, Dilendra Maharjan, Fernando Moreu, Justin T. Baca
MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS
(2020)
Letter
Respiratory System
Justin T. Baca, Nicholas F. Parchim, Jillian Kotulski, Jon Femling, Robert M. Taylor, Silas Bussmann, Lionel Candelaria, Tatsuya Norii, Michele Moyer, Rena Laliberte, Shivan Patel, Samantha Odeesho, Richard Nowak
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2022)
Article
Biochemistry & Molecular Biology
Robert M. Taylor, Justin T. Baca
Summary: The study suggests that dermal interstitial fluid (ISF) may serve as a surrogate for blood in clinical settings for detecting ketone levels. A microneedle-based technology has been developed to extract ISF, enabling the development of wearable sensors for rapid ketosis detection.
Article
Biochemical Research Methods
Robert M. Taylor, Abdul-Mehdi S. Ali, Yiliang Zhu, Alicia M. Bolt, Justin T. Baca
Summary: This article introduces a minimally invasive technique for the extraction of interstitial fluid, which can be used for multiple extractions within weeks in animals, reducing the number of animals needed. The study also demonstrates the application of this technique for simultaneous quantification of different elements.
METHODS AND PROTOCOLS
(2022)
Article
Materials Science, Multidisciplinary
Philip R. Miller, Matthew Moorman, Ryan D. Boehm, Steven Wolfley, Victor Chavez, Justin T. Baca, Carlee Ashley, Igal Brener, Roger J. Narayan, Ronen Polsku
Article
Biology
Philip R. Miller, Robert M. Taylor, Bao Quoc Tran, Gabrielle Boyd, Trevor Glaros, Victor H. Chavez, Raga Krishnakumar, Anupama Sinha, Kunal Poorey, Kelly P. Williams, Steven S. Branda, Justin T. Baca, Ronen Polsky
COMMUNICATIONS BIOLOGY
(2018)