期刊
KIDNEY INTERNATIONAL
卷 93, 期 6, 页码 1293-1297出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2017.11.035
关键词
ATP; calcium; phosphate; pyrophosphate; vascular calcification
资金
- Spanish Ministerio de Economia y Competitividad [SAF-2014-60669]
- Progeria Research Foundation from the United States [PRF-2016-68]
- National Institutes of Health [R01 HL130915]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL130915] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK069681] Funding Source: NIH RePORTER
Pathologic cardiovascular calcification is associated with a number of conditions and is a common complication of chronic kidney disease. Because ambient calcium and phosphate levels together with properties of the vascular matrix favor calcification even under normal conditions, endogenous inhibitors such as pyrophosphate play a key role in prevention. Genetic diseases and animal models have elucidated the metabolism of extracellular pyrophosphate and demonstrated the importance of pyrophosphate deficiency in vascular calcification. Therapies based on pyrophosphate metabolism have been effective in animal models, including renal failure, and hold promise as future therapies to prevent vascular calcification.
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