期刊
KIDNEY & BLOOD PRESSURE RESEARCH
卷 43, 期 3, 页码 1010-1022出版社
KARGER
DOI: 10.1159/000490821
关键词
Exosomes; Peritoneal membrane function; Fibrosis; Angiogenesis
资金
- National Natural Science Foundation of China [81473606, 81774253]
- Jiangsu Province Natural Science Foundation [BK20171514]
- Six Talent Peaks Project in Jiangsu Province [WS-033]
Fibrosis and angiogenesis are the most common processes that result in progressive peritoneal tissue remodeling and, eventually, peritoneal membrane dysfunction. The role of exosomes, which contributes to intercellular communication, in these processes has been neglected. Various biomolecules, including DNA, mRNA, proteins, lipids, and particular certain miRNAs, can be transferred by exosomes to local, neighboring and distal cells. Upon stimulation by cytokines or other microenvironment stimuli, donor cells release a mass of exosomes to peritoneal mesothelial cells, further affecting fibrosis and angiogenesis. This important exosomes-mediated intracellular communication is thought to regulate peritoneal membrane function. Understanding the molecular mechanisms of these processes, targeting changes in exosomes and regulating exosomal miRNAs will advance therapeutic methods for protecting peritoneal membrane function. (C) 2018 The Author(s) Published by S. Karger AG, Basel
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