Article
Biology
Abdur Rehman, Fatima Noor, Israr Fatima, Muhammad Qasim, Mingzhi Liao
Summary: The study identifies five key compounds in Celosia cristata that may regulate target genes and serve as a promising therapeutic option for IgA nephropathy.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Weronika Frak, Joanna Kucmierz, Magdalena Szlagor, Ewelina Mlynarska, Jacek Rysz, Beata Franczyk
Summary: This paper discusses the molecular mechanisms of the development and progression of chronic kidney disease (CKD), including oxidative stress, the role of the immune system, neutrophil gelatinase-associated lipocalin, and matrix metalloproteinases. It also highlights the importance of the gut-kidney axis in CKD and discusses the therapeutic potential and future research directions for the treatment of CKD.
Article
Biochemistry & Molecular Biology
Ping Lin, Fan Yin, Nuo Shen, Na Liu, Baihui Zhang, Yuan Li, Shoudong Guo
Summary: Cordyceps militaris polysaccharide CM1 has anti-atherosclerotic effects by reducing lipid levels, decreasing lipid deposition, and regulating lipid metabolism, anti-inflammatory, and antioxidant pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Kexin Wang, Qingyuan Liu, Mingyu Tang, Guangdong Qi, Chong Qiu, Yan Huang, Weiran Yu, Wei Wang, Hualin Sun, Xuejun Ni, Yuntian Shen, Xingxing Fang
Summary: Chronic kidney disease (CKD) is a high-risk chronic catabolic disease with high morbidity and mortality. CKD is accompanied by many complications, leading to a poor quality of life and even threatening the life of patients. Muscle atrophy is a common complication of CKD.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Yaning Gao, Jian Li, Liang Chen, Zhengjun Wen
Summary: The aim of this study is to investigate the potential mechanisms of COVID-19 and asthma comorbidities. By analyzing gene expression databases, overlapping differentially expressed genes (DEGs) were identified, which were related to DNA transcription regulation, protein-protein interactions, transcription factor/microRNA-gene interactions, drug-gene interactions, and disease-gene interactions. Potential drug targets and key genes with good diagnostic performance were also discovered.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Genetics & Heredity
Yago Leira, Paulo Mascarenhas, Juan Blanco, Tomas Sobrino, Jose Joao Mendes, Vanessa Machado, Joao Botelho
Summary: The study explored the protein-protein interaction network between stroke and periodontitis using bioinformatic strategies, revealing inflammation, pro-coagulant/pro-thrombotic state, and atheroma plaque rupture as the main biological mechanisms derived from the network. These pilot results may lead to future molecular and therapeutic studies to better understand the mechanisms between these two conditions.
Article
Biochemistry & Molecular Biology
Francisco Andujar-Vera, Cristina Garcia-Fontana, Raquel Sanabria-de la Torre, Sheila Gonzalez-Salvatierra, Luis Martinez-Heredia, Ivan Iglesias-Baena, Manuel Munoz-Torres, Beatriz Garcia-Fontana
Summary: The identification of common targets in Alzheimer's disease (AD) and cardiovascular disease (CVD) has attracted great interest in recent years. This study aimed to identify common targets in the CVD/AD axis using genomic data and protein-protein interaction network analysis. The results identified important proteins in both pathologies, suggesting their potential as biomarkers or therapeutic targets.
Article
Pharmacology & Pharmacy
Cheng Zeng, Xiaoyi Yang, Lantian Wang, Huiling He, Zhe Tang
Summary: The purpose of this study was to investigate and validate the therapeutic targets of lenvatinib in hepatocellular carcinoma (HCC) using bioinformatics and in vitro experiments. The potential core targets of lenvatinib were identified through screening and analysis of various databases, and were validated using in vitro experiments. The findings revealed that lenvatinib significantly affected pro-survival signals of the MAPK signaling pathway and may act on key proteins as targets, which regulate a range of cellular activities. Results from qRT-PCR revealed that lenvatinib regulated the expressions of key genes associated with HCC. This investigation provides new insight for the further development of lenvatinib as a drug for HCC treatment.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Tao Liu, Xing Xing Zhuang, Xiu Juan Qin, Liang Bing Wei, Jia Rong Gao
Summary: IL10RA and its related hub molecules play a key role in the development of CKD and could be potential biomarkers in CKD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Alessandra Stasi, Carmela Cosola, Gianvito Caggiano, Maria Teresa Cimmarusti, Rita Palieri, Paola Maria Acquaviva, Gloria Rana, Loreto Gesualdo
Summary: Obesity is a growing epidemic with important impacts on various clinical areas, such as endocrinology, cardiology, and nephrology. It increases the risk of cardiovascular disease, cancer, diabetes, dyslipidemia, hypertension, renal diseases, and neurocognitive impairment. Obesity-related chronic kidney disease is attributed to fat accumulation and hemodynamic changes in the kidneys.
FRONTIERS IN NUTRITION
(2022)
Article
Geriatrics & Gerontology
Xiaofeng Wang, Naixu Shi, Baiao Wu, Lin Yuan, Jiapeng Chen, Cong Ye, Miao Hao
Summary: Periodontitis is a high-risk factor for Parkinson's disease (PD), and the association between these two conditions is mainly manifested in immune and dopamine-related pathways. Hub genes, such as CDSN, TH, DDC, and SLC6A3, may serve as potential biomarkers for diagnosing or detecting PD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yingchao Shi, Wenhao Liu, Yang Yang, Yali Ci, Lei Shi
Summary: The COVID-19 pandemic is associated with neurological symptoms and an increased risk of neurodegenerative diseases. Bioinformatic analysis revealed shared pathways and synaptic dysfunction as potential mechanisms for these diseases. The identification of key genes and potential drugs provides new insights and treatment strategies for preventing COVID-19 patients from developing neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Liu Xiang, Yue Lin, Xianhai Li, Qiang Tang, Fanbo Meng, Wei Chen
Summary: By using bioinformatics methods, it was discovered that key ingredients in WJYZG, such as quercetin and kaempferol, interact with core targets of AD, inhibiting inflammation and neurocyte apoptosis, regulating INS levels to treat AD.
CURRENT BIOINFORMATICS
(2022)
Article
Biology
Athina I. Amanatidou, George V. Dedoussis
Summary: Non-alcoholic fatty liver disease (NAFLD) is a complex disease that requires identification and study of new candidate proteins. This study analyzed the interaction network of human proteins associated with NAFLD to identify novel associations with other proteins involved in the disease. The computational analysis detected 77 candidate proteins with high network scores, and clustering analysis identified densely connected regions with biological significance. Additionally, gene expression analysis was conducted to validate some of the research findings, aiming to provide insights for addressing the pathogenesis and progression of NAFLD.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Genetics & Heredity
Liliya Fedulova, Ekaterina Vasilevskaya, Olga Tikhonova, Laura Kazieva, Galina Tolmacheva, Alexandr Makarenko
Summary: This study investigates the post-genomic markers associated with recovery from hemorrhagic stroke, revealing molecular factors that contribute to neuronal functional recovery and reduce damage factors. The study also identifies neurotrophic factors associated with nerve cell survival and differentiation in muscles.