期刊
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
卷 34, 期 8, 页码 423-427出版社
ELSEVIER TAIWAN
DOI: 10.1016/j.kjms.2018.03.004
关键词
Vitamin D; 25-hydroxyvitamin D; 1,25-dihydroxyvitamin D; Breast cancer
资金
- Medicine Dp. Faculty of Medicine Complutense University of Madrid Spain
Vitamin D is a fat soluble vitamin that plays a role in calcium and phosphorus homeostasis. Recently, extensive research on its extraskeletal actions has linked vitamin D deficiency to an increased risk of infection, diabetes mellitus types 1 and 2, cardiovascular disease, obesity, asthma, inflammatory bowel disease, colon, breast, prostate and ovarian cancer and some neurological diseases. There are various mechanisms by which vitamin D influences the natural history of cancer. These include the role of vitamin D in the induction of apoptosis, stimulation of cell differentiation, anti-inflammatory and antiproliferative effects and inhibition of angiogenesis, invasion and metastasis. The aim of this review is to clarify the true role of vitamin D in the onset of breast cancer and evolution of the disease after treatment. A further aim is to suggest new research directions to identify indications and requirements for vitamin D supplementation in patients with breast cancer. Copyright (C) 2018, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.
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