Article
Multidisciplinary Sciences
Yi-Zhou Quan, Wei Wei, Volkan Ergin, Arun Prabhu Rameshbabu, Mingqian Huang, Chunjie Tian, Srinivas Vinod Saladi, Artur A. Indzhykulian, Zheng-Yi Chen
Summary: Strategies to overcome irreversible cochlear hair cell (HC) damage and loss in mammals are important for hearing recovery in patients with permanent hearing loss. Activation of Myc and Notch1 can promote HC regeneration and a combination of drug-like molecules has been identified to activate these pathways in mature nontransgenic cochlea.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Cell Biology
Silvia T. Erni, John C. Gill, Carlotta Palaferri, Gabriella Fernandes, Michelle Buri, Katherine Lazarides, Denis Grandgirard, Albert S. B. Edge, Stephen L. Leib, Marta Roccio
Summary: The study evaluated the otoregenerative potential of different gamma-secretase inhibitors (GSIs) in various assay models and found that GSIs induced hair cell gene expression and increased hair cell numbers, especially outer hair cells, in different models. These findings suggest the potential of targeting Notch signaling with novel GSIs for hearing restoration, paving the way for more complex animal studies and clinical research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhen Liu, Peng Chen, Yuan-Yuan Li, Meng-Wen Li, Qi Liu, Wen-Lu Pan, Dong-Ming Xu, Jing Bai, Li-Biao Zhang, Jie Tang, Peng Shi
Summary: The cochlear hair cells of echolocating bats show resistance to intense noise, preventing noise-induced hearing loss. Experimental evidence indicates that echolocating bats can maintain their hearing and cochlear health even after exposure to continuous intense noise.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Jun Li, Charles Morgan, Prathamesh T. Nadar-Ponniah, Waldemar Kolanus, Angelika Doetzlhofer
Summary: Reactivation of LIN28B and TRIM71 enhances the regenerative potential of P5 cochlear supporting cells, allowing them to dedifferentiate and form progenitor-like cells, which leads to increased hair cell formation.
Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Elijah J. Horesh, Jeremy Cheret, Ralf Paus
Summary: Research on human hair follicles has revealed interesting findings about the role of growth hormone in neurohormone physiology, showing that excessive levels of GH can lead to skin pathology. Understanding the presence of GH receptors in hair follicles opens up new possibilities for exploring the nonclassical functions of this core neurohormone in human skin physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Shan Xu, Ning Yang
Summary: Mammalian inner ear hair cells lack the ability to regenerate, leading to irreversible damage and sensorineural hearing loss caused by factors such as aging, infection, genetic factors, hypoxia, autoimmune diseases, ototoxic drugs, or noise exposure. In recent years, research on the regeneration and functional recovery of these cells has gained significant attention in the auditory field. Key scientific issues include regenerating and protecting hair cells or auditory neurons through biological methods, and rebuilding auditory circuits and functions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Sandra Diaz del Moral, Maha Benaouicha, Ramon Munoz-Chapuli, Rita Carmona
Summary: The translation introduces the importance of insulin and insulin-like growth factors during embryonic development and their role in cardiac development and cardiomyocyte proliferation. The study also discusses the clinical potential of utilizing the IGF signaling pathway for adult cardiac repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Chiara Talia, Lisa Connolly, Paul A. Fowler
Summary: This review discusses the effects of endocrine disruptors on the IGF system, focusing on different categories of EDs and their potential molecular mechanisms. While there is a lack of studies linking ED exposure to changes in IGF levels for some ED classes, this remains an area of concern that requires further research to improve reproducibility and determine the degree of risk EDs pose to the IGF system.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Neurosciences
Cheng Cheng, Jiaoyao Ma, Xiaoling Lu, Panpan Zhang, Xiaohan Wang, Luo Guo, Peifan Li, Ying Wei, Geng-Lin Li, Xia Gao, Yuqiu Zhang, Renjie Chai, Huawei Li, Shan Sun
Summary: Aminoglycoside antibiotics (AGAs) are commonly used in life-threatening infections but can cause hearing loss by accumulating in cochlear hair cells (HCs). This study demonstrated that the P2X7 receptor, which is activated by high ATP concentrations, may be involved in the entry of AGAs into HCs. Knocking out the P2X7 receptor protected HCs against neomycin-induced injury and inhibited oxidative stress and apoptosis in the cochlea. Therefore, the P2X7 receptor could be a potential therapeutic target for auditory HC protection.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Tue L. Nielsen, Tessa M. Hornsyld, Tomas Pinos, Camilla Brolin, John Vissing, Thomas O. Krag
Summary: This study found that the growth factor cocktail did not significantly improve the functional level of mdx model during treatment, despite positive effects on some muscle types at a molecular level. Additionally, histopathology at the end of the treatment revealed signs of inflammation.
Review
Neurosciences
Ying Xiao, Dan Li
Summary: The cochlea is the sensory organ in the periphery, and hair cells are its main sensory cells. Epigenetic regulation controls the structure and function of the genome in response to different cell fates during the development and survival of hair cells. Epigenetic modification also plays a significant role in the regulation of hair cell fate in response to environmental-related damage. Understanding the role of epigenetics in inner ear cell development, survival, and regeneration is crucial for hearing protection.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Otorhinolaryngology
Ippei Kishimoto, Hiroe Ohnishi, Kohei Yamahara, Takayuki Nakagawa, Masaru Yamashita, Koichi Omori, Norio Yamamoto
Summary: The study demonstrated that topical treatment with insulin-like growth factor 1 promoted the extension of tracheal epithelium in an in vitro mouse tracheal organ culture model, indicating the potential use of insulin-like growth factor 1 in aiding rapid tracheal epithelialization in patients requiring tracheal reconstruction using tissue-engineered tracheas.
AURIS NASUS LARYNX
(2021)
Article
Developmental Biology
Ryosuke Yamamoto, Hiroe Ohnishi, Koichi Omori, Norio Yamamoto
Summary: This study aimed to identify lineage-specific genes in the early developing inner ear using single-cell RNA sequencing data and discovered potential candidate genes by comparing transcriptomes between different cell clusters.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Otorhinolaryngology
Kohei Yamahara, Akifumi Mizukoshi, Kana Lee, Satoshi Ikegami
Summary: This study found a significant association between sarcopenia and systemic inflammation in head and neck cancer patients. The survival and oncological effects of sarcopenia were enhanced when the platelet-lymphocyte ratio (PLR) was high. Therefore, the combination of these two parameters may be useful for identifying HNC patients at a risk of poor survival outcomes.
AURIS NASUS LARYNX
(2021)
Article
Otorhinolaryngology
Shin-ichi Kanemaru, Rie Kanai, Koichi Omori, Norio Yamamoto, Takayuki Okano, Ippei Kishimoto, Kaoru Ogawa, Sho Kanzaki, Masato Fujioka, Naoki Oishi, Yasushi Naito, Seiji Kakehata, Hajime Nakamura, Shinobu Yamada, Kaoru Omae, Atsuhiko Kawamoto, Masanori Fukushima
Summary: The study evaluated the efficacy and safety of regenerative treatment for chronic tympanic membrane perforation using gelatin sponge, bFGF, and fibrin glue. The results showed that this treatment was safe and effective, leading to successful closure of the perforation and improvement in hearing for most patients.
AURIS NASUS LARYNX
(2021)
Article
Otorhinolaryngology
Kohei Yamahara, Akifumi Mizukoshi, Kana Lee, Satoshi Ikegami
Summary: This study aimed to evaluate nutritional/inflammatory prognostic factors before treatment in patients with early and advanced-stage head and neck cancer. The Geriatric Nutritional Risk Index was found to be statistically significantly correlated with overall survival and remained a useful prognostic factor in multivariate analysis. Study results suggest that the Geriatric Nutritional Risk Index could be a valuable tool for predicting prognosis in head and neck cancer patients.
AURIS NASUS LARYNX
(2021)
Article
Cell & Tissue Engineering
Fumihiko Kuwata, Hiroe Ohnishi, Norio Yamamoto, Toshiaki Takezawa, Masaru Yamashita, Hideaki Okuyama, Yasuyuki Hayashi, Masayoshi Yoshimatsu, Yuji Kitada, Takeshi Tada, Masayoshi Kobayashi, Koichi Omori
Summary: The nasal mucosa plays a crucial role as a biological defense mechanism against foreign substances and pathogens. Hereditary diseases can lead to severe dysfunction of the nasal mucosa, necessitating external manipulation to restore and maintain nasal epithelia. This study explores the transplantation of airway epithelial cells derived from human induced pluripotent stem cells as a potential therapeutic approach for irreversible nasal epithelial disorders.
TISSUE ENGINEERING PART A
(2022)
Article
Oncology
Chiaki Suzuki, Akihiro Nishiyama, Sachiko Arai, Shoichiro Tange, Atsushi Tajima, Azusa Tanimoto, Koji Fukuda, Yohei Takumi, Hiroshi Kotani, Shinji Takeuchi, Naohiro Yanagimura, Koushiro Ohtsubo, Norio Yamamoto, Koichi Omori, Seiji Yano
Summary: This study found that resistant mutations and alternative pathway activation may occur simultaneously in entrectinib-resistant tumors, highlighting the importance of examining resistance mechanisms and applying appropriate combination treatment.
Article
Cell & Tissue Engineering
Takeshi Tada, Hiroe Ohnishi, Norio Yamamoto, Fumihiko Kuwata, Yasuyuki Hayashi, Hideaki Okuyama, Tsunetaro Morino, Yoshiyuki Kasai, Hiromi Kojima, Koichi Omori
Summary: This study transplanted hiPSC-derived AECs into the middle ear of immunodeficient rats and found the presence of HNA-positive ciliated cells after transplantation. The percentage of HNA-positive ciliated cells in the transplanted areas increased in the 2-week postoperative group compared with the 1-week group, indicating the survival of hiPSC-derived AECs. Immunohistochemical analysis showed the presence of basal cells and goblet cells in the transplanted AECs, suggesting the regeneration of these cell types within the middle ear cavity.
REGENERATIVE THERAPY
(2022)
Article
Otorhinolaryngology
Hiroshi Yamazaki, Norio Yamamoto, Toru Sonoyama, Hayato Maruoka, Seiko Nasu, Akiko Makino, Keizo Tomonaga, Norifumi Shigemoto, Hiroki Ohge, Keizo Fujiwara, Shogo Shinohara, Sachio Takeno, Koichi Omori, Yasushi Naito
Summary: This study aimed to investigate the presence of SARS-CoV-2 in middle ear and mastoid specimens among otologic surgery patients with negative preoperative PCR test results. The results showed that all otologic specimens tested negative for SARS-CoV-2, suggesting that the transmission risk of SARS-CoV-2 in otologic surgeries is not high even when using powered instruments, provided that both clinical and laboratory tests are negative for COVID-19.
AURIS NASUS LARYNX
(2023)
Article
Engineering, Biomedical
Ichiro Furuta, Hideaki Ogita, Fukuichiro Iguchi, Takayuki Okano, Kohei Yamahara, Tatsuya Namatsu, Shuichi Kawata, Koichi Omori, Norio Yamamoto
Summary: This study aimed to develop a new bone conduction hearing device that does not require surgery and does not exert pressure on the skin. By utilizing the skin of the pinna as an electrode, this device efficiently transmits sound to the cochlea by bypassing the external auditory canal, tympanic membrane, and middle ear ossicles.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Otorhinolaryngology
Taishi Inoue, Yosuke Tona, Takayuki Okano, Koichi Omori, Norio Yamamoto
Summary: This study evaluated the importance of using mobile cone-beam computed tomography (CBCT) in detecting tip fold-over of a slim modiolar electrode during cochlear implantation surgery. The results showed that mobile CBCT was effective in detecting the tip fold-over and facilitating reinsertion before closure of the wound, eliminating the need for revision surgeries.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Cell & Tissue Engineering
Yuji Kitada, Hiroe Ohnishi, Norio Yamamoto, Fumihiko Kuwata, Masayuki Kitano, Keisuke Mizuno, Koichi Omori
Summary: In this study, the researchers investigated the transplantation of human-derived airway epithelia into the nasal mucosa to restore its function. By modifying the graft preparation method, they successfully transplanted cells that survived in the nasal mucosal epithelia and could contribute to functional recovery. This transplantation method may contribute to the development of therapeutic strategies for severe nasal mucosa dysfunction caused by hereditary diseases.
TISSUE ENGINEERING PART C-METHODS
(2023)
Article
Otorhinolaryngology
Kana Lee, Naoki Ochi, Kohei Yamahara, Kunihiko Makino, Tetsuo Ikezono
CASE REPORTS IN OTOLARYNGOLOGY
(2020)