期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 74, 期 5, 页码 726-732出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gly114
关键词
Successful aging; Epidemiology; Mortality; Physiology
资金
- NIA [N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106, R01-AG-028050]
- Centre for Ageing Research and Development in Ireland within the Institute of Public Health in Ireland (IPH) - American Federation for Aging Research Paul B Beeson Career Development Awards in Aging Research for the Island of Ireland
- Wake Forest Older Americans Independence Center [P30 AG 21332]
- University of Pittsburgh Older Americans Independence Center [P30 AG024827]
- NIA (NINR) [R01-NR-012459]
Background: Baseline scores on a Healthy Aging Index (HAI), including five key physiologic domains, strongly predict health outcomes. This study aimed to characterize 9-year changes in a HAI and explore their relationship to subsequent mortality. Methods: Data are from the Health, Aging, and Body Composition study of well-functioning adults aged 70-79 years. A HAI, which ranges from 0 to 10, was constructed at years 1 and 10 of the study including systolic blood pressure, forced expiratory volume, digit symbol substitution test, cystatin C, and fasting glucose. The relationships between the HAI at years 1 and 10 and the change between years and subsequent mortality until year 17 were estimated from Cox proportional hazards models. Results: Two thousand two hundred sixty-four participants had complete data on a HAI at year 1, of these 1,122 had complete data at year 10. HAI scores tended to increase (i.e. get worse) over 9-year follow-up, from (mean [SD]) 4.3 (2.1) to 5.7 (2.1); mean within-person change 1.5 (1.6). After multivariable adjustment, HAI score was related to mortality from year 1 (hazard ratio [95% confidence interval] = 1.17 [1.13-1.21] per unit) and year 10 (1.20 [1.14-1.27] per unit). The change between years was also related to mortality (1.08 [1.02-1.15] per unit change). Conclusions: HAI scores tended to increase with advancing age and stratified mortality rates among participants remaining at year 10. The HAI may prove useful to understand changes in health with aging.
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