Article
Radiology, Nuclear Medicine & Medical Imaging
Elisabeth von Brandis, Pia K. Zadig, Derk F. M. Avenarius, Berit Flato, Per Kristian Knudsen, Vibke Lilleby, Bac Nguyen, Karen Rosendahl, Lil-Sofie Ording Mueller
Summary: This study describes the findings of T2 weighted high signal in the bone marrow of healthy and asymptomatic children and adolescents, as assessed by whole-body MRI. The results showed that non-specific bone marrow hyperintensities in the axial skeleton are frequently detected in these individuals. These findings are important for children with suspected multifocal skeletal disease.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Linda F. Boeswald, Dana Matzek, Helen Mohr, Ellen Kienzle, Bastian Popper
Summary: Body conditions can serve as indicators of nutritional status and health in animals, highlighting the importance of monitoring these conditions. Obtaining morphometric data through measurements and standardized photographs can be useful for evaluating the body condition and well-being of animals.
Review
Oncology
Jeffrey Y. C. Wong, An Liu, Chunhui Han, Savita Dandapani, Timothy Schultheiss, Joycelynne Palmer, Dongyun Yang, George Somlo, Amandeep Salhotra, Susanta Hui, Monzr M. M. Al Malki, Joseph Rosenthal, Anthony Stein
Summary: TMI utilizes IMRT to deliver organ sparing targeted radiotherapy in patients undergoing hematopoietic cell transplantation (HCT). Over 500 patients have received TMI at this center, with studies showing low toxicities and non-medullary relapse rates.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Samantha Costa, Heather Fairfield, Mariah Farrell, Connor S. Murphy, Ashley Soucy, Calvin Vary, Gill Holdsworth, Michaela R. Reagan
Summary: Scl-Ab treatment can mitigate the detrimental effects of irradiation on bone and adipose tissue by increasing bone volume and reducing bone marrow adipose tissue. The study showed that Scl-Ab significantly increased trabecular bone volume and improved cortical thickness and area in both irradiated and non-irradiated mice.
Article
Radiology, Nuclear Medicine & Medical Imaging
P. Zadig, E. von Brandis, L. S. Ording Mueller, L. Tanturri de Horatio, K. Rosendahl, D. F. M. Avenarius
Summary: This study compared the effectiveness of STIR and T2 Dixon in detecting and grading high signal intensity areas in bone marrow on whole-body MRI in healthy children. The results showed that most high signal bone marrow changes could be observed on both STIR and T2 Dixon images, highlighting the importance of using identical protocols when following bone marrow signal changes over time.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Xuetao Chen, Tingting Yuan, Maomao Wei, Boqi Yu, Nina Zhou, Hua Zhu, Zhi Yang, Xuejuan Wang
Summary: The diagnostic performance of integrated whole-body F-18-FDG PET/MRI in detecting bone marrow involvement (BMI) in indolent lymphoma is better compared to F-18-FDG PET or MRI alone. This study enrolled treatment-naive indolent lymphoma patients who underwent integrated whole-body F-18-FDG PET/MRI and bone marrow biopsy (BMB). The agreement between PET, MRI, PET/MRI, BMB, and the reference standard was assessed, and the sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) were calculated. The results showed that integrated whole-body F-18-FDG PET/MRI is an optimal method and a reliable alternative to BMB.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Mariana Nassif Kerbauy, Leonardo Javier Arcuri, Sergio Leonardo Favareto, Ana Carolina Pires de Rezende, Nelson Hamerschlak
Summary: Total body irradiation (TBI) is an important part of the conditioning regimen in hematopoietic cell transplantation. However, higher doses of TBI can result in more significant toxicities. To overcome this, total marrow irradiation and total marrow and lymphoid irradiation have been developed to deliver targeted radiotherapy while sparing organs. Studies have shown that these techniques can be safely administered with different chemotherapy conditioning regimens, especially in situations such as multiple myeloma, high-risk hematologic malignancies, relapsed or refractory leukemias, and elderly or frail patients, with low transplant-related mortality rates.
FRONTIERS IN MEDICINE
(2023)
Article
Pathology
Ayush Batra, Triet M. Bui, Jacob F. Rehring, Lenore K. Yalom, William A. Muller, David P. Sullivan, Ronen Sumagin
Summary: Peripheral monocyte-derived CX3C chemokine receptor 1 positive (CX3CR1(+)) cells have been shown to play important roles in tissue homeostasis and immune repopulation of gut and brain in response to inflammation. This study found temporal differences in immune repopulation of the gut and brain, and demonstrated that gut inflammation can impact immune responses within the brain.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sajeev Wagle, Hyun-Jaung Sim, Govinda Bhattarai, Ki-Choon Choi, Sung-Ho Kook, Jeong-Chae Lee, Young-Mi Jeon
Summary: Ferulic acid, as a dietary antioxidant, can protect against systemic damages caused by TBI by restoring disorders in bone formation, osteoclast activation, and adipocyte activation, thereby preventing stem cell senescence and bone mass loss.
Article
Medicine, Research & Experimental
Muemtaz Koeksal, Jonathan Baumert, Felix Schoroth, Davide Scafa, David Koch, Christina Leitzen, Gustavo R. Sarria, Frank A. Giordano, Georgios Chatzikonstantinou, Leonard C. Schmeel
Summary: Using helical tomotherapy (HT) to spare lung tissue is an effective method for reducing pulmonary complications in patients undergoing total body irradiation (TBI) for allogenic stem cell or bone marrow transplantation. This planning adjustment does not compromise the prescribed dose and quality of coverage received by the ribcage, making it a feasible tool in conditioning regimens for allogeneic bone marrow transplantation.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pia K. Zadig, Elisabeth von Brandis, Berit Flato, Lil-Sofie Ording Mueller, Ellen B. Nordal, Laura Tanturri de Horatio, Karen Rosendahl, Derk F. M. Avenarius
Summary: This study describes the appearance of bone marrow in healthy and asymptomatic children and adolescents using whole-body MRI. The findings show that focal areas of high signal intensity were observed in more than half of the participants, which could potentially be concerning in a clinical setting.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura Tanturri de Horatio, Pia K. Zadig, Elisabeth von Brandis, Karen Rosendahl, Derk F. M. Avenarius
Summary: The objective of this study was to compare the efficacy of T2 Dixon fat-only and TSE T1-weighted sequences in the assessment of bone marrow high signal areas seen on T2 Dixon water-only images in healthy children and adolescents. The study found that 92.7% of the evaluated high signal areas showed low signal on both T2 Dixon fat-only and T1-weighted sequences, and 1.9% did not show low signal on either sequence. The overall agreement between the two sequences was 0.39, with a higher agreement for major findings (0.69) compared to minor findings (0.29). Therefore, T2 Dixon fat-only can replace T1-weighted sequence in whole-body MRI for bone marrow assessment in children, reducing scan time.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Biology
Francis A. Cucinotta, Olga A. Smirnova
Summary: A mathematical model is developed to describe the level of surviving lymphocytes in the blood after partial-body irradiation at ultra-high and lower dose rates. The model uses simple analytic formulas and involves physiological, biophysical, and physical parameters. The model predicts that the level of surviving blood lymphocytes increases with dose rate and approaches a limiting level. The study also proposes a hypothesis explaining the mechanisms of the abscopal effect of FLASH radiation therapy.
RADIATION RESEARCH
(2023)
Article
Oncology
Mumtaz Koeksal, Jonathan Baumert, Danny Jazmati, Felix Schoroth, Stephan Garbe, David Koch, Davide Scafa, Gustavo R. Sarria, Christina Leitzen, Gregor Massoth, Achilles Delis, Annkristin Heine, Tobias Holderried, Peter Brossart, Thomas Muedder, Leonard C. Schmeel
Summary: Intensity-modulated helical tomotherapy is a feasible method for total body irradiation in preparation for bone marrow transplantation, as it allows for dose reduction in radiosensitive organs such as the lungs and kidneys. The study emphasizes the importance of high-quality coverage and homogeneity in minimizing radiation toxicity.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Daria Kobyzeva, Larisa Shelikhova, Anna Loginova, Francheska Kanestri, Diana Tovmasyan, Michael Maschan, Rimma Khismatullina, Mariya Ilushina, Dina Baidildina, Natalya Myakova, Alexey Nechesnyuk
Summary: The combination of TBI with chemotherapy as a conditioning regimen in HSCT has shown superior survival outcomes compared to chemotherapy alone. The optimized conformal total body irradiation (OC-TBI) method allows for selective dose reduction for organs at risk, showing promise for pediatric patients undergoing HSCT.
FRONTIERS IN ONCOLOGY
(2021)