Article
Clinical Neurology
Shen-Jie Li, Shan-Shan Cao, Pei-Sheng Huang, Xin Nie, Yang Fu, Jian-Ren Liu
Summary: The study found that NLR is a readily available biomarker of HT and neurological outcomes in AIS patients post-thrombectomy, with higher NLR2 levels associated with increased risk of HT and unfavorable outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Minwoo Lee, Jae-Sung Lim, Chul-Ho Kim, Sang-Hwa Lee, Yerim Kim, Ju Hun Lee, Min Uk Jang, Mi Sun Oh, Byung-Chul Lee, Kyung-Ho Yu
Summary: This study found that systemic inflammation represented by NLR in the acute stage of ischemic stroke is associated with post-stroke cognitive impairment (PSCI) at 3 months after stroke, with high NLR specifically linked to cognitive dysfunction in the memory and visuospatial domains.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Xiaoming Rong, Jingjuan Chen, Dong Pan, YuKai Wang, Chengguo Zhang, Yamei Tang
Summary: This study investigates the impact of APOE alleles on the functional outcome in acute ischemic stroke (AIS) patients. It also explores the relationship between inflammation and stroke-related disability based on APOE genotypes. The results indicate that APOE e4 carriers have a worse functional outcome after AIS compared to non-e4 carriers. Additionally, the study finds that the APOE genotype may modify the relationship between neutrophil-to-lymphocyte ratio (NLR) and 3-month stroke outcome.
Article
Endocrinology & Metabolism
Xianjing Feng, Fang Yu, Minping Wei, Yunfang Luo, Tingting Zhao, Zeyu Liu, Qin Huang, Ruxin Tu, Jiaxin Li, Boxin Zhang, Liuyang Cheng, Jian Xia
Summary: This study found that neutrophil counts and neutrophil-to-lymphocyte ratio (NLR) are associated with stress hyperglycemia ratio (SHR) in patients with acute ischemic stroke (AIS). The correlation between neutrophil counts and NLR and different SHR levels varies according to TOAST classification and functional prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Farzaneh Sadeghi, Ferenc Sarkady, Katalin S. Zsori, Istvan Szegedi, Rita Orban-Kalmandi, Edina G. Szekely, Nikolett Vasas, Ervin Berenyi, Laszlo Csiba, Zsuzsa Bagoly, Amir H. Shemirani
Summary: This study demonstrated for the first time that a high NLR-low LMR combination observed at 24 hours after thrombolysis can serve as an independent predictor of poor 3-months outcome in acute ischemic stroke patients. This simple and readily available data may help clinicians to improve the prognostic estimation of patients and may provide guidance in selecting patients for personalized and intensified care post-thrombolysis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Green & Sustainable Science & Technology
Tissa Wijeratne, Carmela Sales, Rohit Menon, Leila Karimi, Mihajlo Jakovljevic
Summary: Stroke is a major cause of adult disability and death worldwide, with the immune system playing a significant role in the pathobiological process. The neutrophil to lymphocyte ratio (NLR) has been identified as a potential biomarker with implications for diagnosis, prognosis, and therapy in acute ischemic stroke (AIS). Studies have shown that an inflammatory response involving excessive neutrophils and reduced lymphocytes is associated with worse outcomes during acute interventions and recovery trajectory in stroke, highlighting the importance of a systems biology-based approach in stroke care.
Article
Oncology
Kehua Quan, Anxin Wang, Xiaoli Zhang, Xia Meng, Pan Chen, Hao Li, Yongjun Wang
Summary: The study found that a high level of NLR within the first 24 hours after admission is associated with increased risks of short- and long-term adverse clinical outcomes in patients with ischemic stroke, regardless of etiology.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Tianling Shang, Bo Ma, Yanxin Shen, Chunxiao Wei, Zicheng Wang, Weijie Zhai, Mingxi Li, Yongchun Wang, Li Sun
Summary: This study aimed to investigate the effect and predictive value of peripheral blood neutrophil percentage and neutrophil-lymphocyte ratio (NLR) in post-stroke cognitive impairment (PSCI) in patients with acute ischemic stroke (AIS). The results showed that both neutrophil percentage and NLR were independently associated with PSCI, and a high NLR was strongly associated with executive function. Additionally, neutrophil percentage and NLR had diagnostic values for PSCI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Behavioral Sciences
Chongxi Xu, Linrui Cai, Tong Yi, Xingyang Yi, Yu Hu
Summary: The objective of this research was to examine the correlation between the neutrophil-to-lymphocyte ratio (NLR) and stroke progression (SP) as well as the functional outcome following an ischemic stroke (IS). The results showed that NLR was independently associated with SP and poor functional outcomes. NLR may be a valuable prognostic indicator in clinical practice.
BRAIN AND BEHAVIOR
(2023)
Article
Immunology
Pengyu Gong, Yukai Liu, Yachi Gong, Gang Chen, Xiaohao Zhang, Siyu Wang, Feng Zhou, Rui Duan, Wenxiu Chen, Ting Huang, Meng Wang, Qiwen Deng, Hongchao Shi, Junshan Zhou, Teng Jiang, Yingdong Zhang
Summary: NLR, PLR, and LMR were shown to be associated with post-thrombolysis early neurological outcomes, with NLR and PLR potentially predicting early neurological deterioration, and NLR related to early neurological improvement.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Shinn-Kuang Lin, Pei-Ya Chen, Guei-Chiuan Chen, Po-Jen Hsu, Cheng-Lun Hsiao, Fu-Yi Yang, Chih-Yang Liu, Adam Tsou
Summary: The study found that the neutrophil-to-lymphocyte ratio (NLR) in stroke patients is associated with the hyperdense artery sign (HAS) on brain CT and clinical features. Both NLR and HAS can predict the risk of unfavorable stroke outcomes.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Medicine, General & Internal
Feng Zhu, Yan Ji, Jiang-Hua Song, Guo-Xiang Huang, Yun-Feng Zhang
Summary: This study investigates the relationship between neutrophil/lymphocyte ratio (NLR) and neutrophil/high-density lipoprotein cholesterol ratio (NHR) and acute ischemic stroke (AIS) severity and short-term prognosis. The findings suggest that NLR and NHR are independent risk factors for stroke severity and poor short-term prognosis in AIS patients. Furthermore, the combination of NLR and NHR shows a strong correlation with disease severity in AIS.
Article
Clinical Neurology
Cuiping Chen, Lei Gu, Luyun Chen, Wangwang Hu, Xiaowen Feng, Fengzhen Qiu, Zijian Fan, Qitao Chen, Jiayou Qiu, Bei Shao
Summary: The study found that both NLR and PLR are independent predictors of functional outcomes after AIS, and may help to identify high-risk patients more effectively when used together.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biology
Simona Lattanzi, Davide Norata, Serena Broggi, Stefano Meletti, Milena Switonska, Artur Slomka, Mauro Silvestrini
Summary: The worsening of neurological status shortly after acute ischemic stroke (AIS) is a serious problem, and inflammation plays a key role in stroke pathology. A study found that the neutrophil-to-lymphocyte ratio (NLR) at admission in AIS patients undergoing endovascular treatment (EVT) is associated with early neurological deterioration (END). Higher NLR values predicted a higher risk of END.
Article
Immunology
Pei-Ya Chen, Guei-Chiuan Chen, Cheng-Lun Hsiao, Po-Jen Hsu, Fu-Yi Yang, Chih-Yang Liu, Adam Tsou, Wan-Ling Chang, Hsiu-Hsun Liu, Shinn-Kuang Lin
Summary: This study compared the clinical features, immune-inflammatory markers, and outcomes between patients with in-hospital ischemic stroke (IHIS) and out-of-hospital ischemic stroke (OHIS). The results showed that patients with IHIS had more complicated clinical features, higher levels of immune-inflammatory markers, and higher mortality rates.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Nutrition & Dietetics
David L. Chan, Stephen J. Clarke, Alexander Engel, Connie I. Diakos, Nick Pavlakis, Paul J. Roach, Dale L. Bailey, Judith Bauer, Merran Findlay
Summary: The study found that sarcopenia and myosteatosis are common in NEN patients but were not associated with worsened survival outcomes in this study.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Letter
Oncology
Nyan Y. Khin, Madhawa De Silva, Stephen Clarke, Nick Pavlakis, Chris M. Rogan, Kevin Ho-Shon, Rodney J. Lane
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Derrick Ho Wai Siu, Arwa Ali, Angelina Tjokrowidjaja, Madhawa De Silva, Joanna Lee, Philip R. Clingan, Morteza Aghmesheh, Daniel Brungs, Cristina Mapagu, David Goldstein, Siobhan O'Neill, Winston S. Liauw, Katrin M. Sjoquist, David Thomas, Nick Pavlakis, Stephen J. Clarke, Connie Diakos, Lorraine A. Chantrill
Summary: This study aimed to determine the demographic, histopathological and molecular characteristics of patients with early-onset colorectal cancer (EO-CRC) in Australia, as well as their survival. The results showed that some patients already presented with metastatic disease, and pathological risk factors and molecular mutations affected the survival of the patients.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Clinical Neurology
Huynh Thi Hong Tram, Sachiko Tanaka-Mizuno, Naoyuki Takashima, Kawser Khan, Hisatomi Arima, Aya Kadota, Takako Fujii, Satoshi Shitara, Akihiro Kitamura, Naomi Miyamatsu, Yoshikuni Kita, Makoto Urushitani, Yoshihisa Nakagawa, Katsuyuki Miura, Kazuhiko Nozaki
Summary: This study aimed to investigate the effect of diabetes status at admission on long-term survival in patients with first-ever stroke. The findings suggest that stroke patients with diabetes exhibited a higher risk of all-cause mortality than those without diabetes, particularly in the overall stroke and ischemic stroke populations. Additionally, in stroke populations after 28 days of onset, high risk of long-term mortality was stated in stroke patients with poor HbA1c control.
CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Sho Takeshita, Toshiyasu Ogata, Noriko Uesugi, Kazuki Nabeshima, Hirofumi Shimada, Hisatomi Arima, Tooru Inoue, Yoshio Tsuboi
Summary: This study aimed to investigate the relationship between contrast-enhanced ultrasonography (CEUS) findings and vascular pathology obtained by carotid endarterectomy (CEA). The results showed that early phase enhancement in CEUS can help identify plaque vulnerability and predict the number of small intraplaque neovessels (INVs).
CEREBROVASCULAR DISEASES
(2023)
Article
Medicine, General & Internal
Kathleen Batty, Amelia M. Taylor, Elizabeth J. Bernard, Connie Diakos, Stephen J. Clarke, Alexander Guminski, Sally Baron-Hay, Frances Boyle, Nick Pavlakis, David L. Chan
Summary: This study retrospectively analyzed a series of patients with metastatic neuroendocrine carcinoma of the breast to investigate their clinical characteristics, treatment modalities, and prognosis. The results showed that multiple treatment modalities were used with different sequencing in different patients, but the progression-free survival with first-line therapy was short.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Medicine, General & Internal
Akira Nakao, Hiroyuki Inoue, Nobumitsu Ikeuchi, Fumiyasu Igata, Takashi Aoyama, Makoto Hamasaki, Hisatomi Arima, Masaki Fujita
Summary: This study investigated the impact of TTF-1 immunostaining on the therapeutic effect of chemotherapy in Japanese patients with nonsq NSCLC. The results showed that patients who were TTF-1-positive had significantly longer overall survival under the pemetrexed regimen compared to regimens without pemetrexed. Therefore, TTF-1 immunostaining plays an important role in predicting the prognosis of nonsq NSCLC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Johanna Bendell, Patricia LoRusso, Michael Overman, Anne M. Noonan, Dong-Wan Kim, John H. Strickler, Sang-We Kim, Stephen Clarke, Thomas J. George, Peter S. Grimison, Minal Barve, Manik Amin, Jayesh Desai, Trisha Wise-Draper, Steven Eck, Yu Jiang, Anis A. Khan, Yuling Wu, Philip Martin, Zachary A. Cooper, Nairouz Elgeioushi, Nancy Mueller, Rakesh Kumar, Sandip Pravin Patel
Summary: This study evaluated the use of oleclumab in patients with advanced colorectal cancer, pancreatic ductal adenocarcinoma, and epidermal growth factor receptor-mutant non-small-cell lung cancer. The results showed that oleclumab had a manageable safety profile and demonstrated antitumor activity.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Makiko Abe, Hisatomi Arima, Atsushi Satoh, Nagako Okuda, Hirokazu Taniguchi, Nobuo Nishi, Aya Higashiyama, Harumitsu Suzuki, Aya Kadota, Takayoshi Ohkubo, Hirotsugu Ueshima, Katsuyuki Miura, Akira Okayama
Summary: This study evaluated the association between marital status, household size, and lifestyle changes during the COVID-19 pandemic in Japan. It found that older singles living alone were more likely to experience unhealthy lifestyle changes, primarily due to decreased physical activity and increased alcohol consumption. However, there was no significant association between marital status, household size, and unhealthy changes among younger participants.
Article
Medicine, General & Internal
Claire McGee, Ann Liebert, Brian Bicknell, Vincent Pang, Vivian Isaac, Craig S. McLachlan, Hosen Kiat, Geoffrey Herkes
Summary: Emerging evidence supports the use of transcranial photobiomodulation (tPBM) for improving symptoms of neurodegenerative diseases, particularly Parkinson's disease (PD). A triple blind, randomized placebo-controlled trial was conducted to analyze the safety and efficacy of tPBM for PD motor symptoms. The results showed that tPBM is a safe treatment and improved several PD motor symptoms in patients that responded to treatment, making it an attractive non-pharmaceutical adjunct therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Tamkin Ahmadzada, Abhishek Vijayan, Fatemeh Vafaee, Ali Azimi, Glen Reid, Stephen Clarke, Steven Kao, Georges E. Grau, Elham Hosseini-Beheshti
Summary: In this study, we characterized different populations of extracellular vesicles (EVs) derived from pleural mesothelioma cell lines and identified unique cancer-specific proteomes and oncogenic cargo in each subtype. We also established a comprehensive proteomic database of cancer-associated proteins in EVs, which could serve as new targets for future biomarker studies in pleural mesothelioma.
Article
Biochemistry & Molecular Biology
Joe Q. Q. Wei, Alexander Yuile, Malinda Itchins, Benjamin Y. Y. Kong, Bob T. T. Li, Nick Pavlakis, David L. L. Chan, Stephen J. J. Clarke
Summary: Platinum-based chemotherapy combined with anti-PD-1 or PD-L1 monoclonal antibodies is the standard first-line therapy for mNSCLC patients without sensitizing driver mutations. Using network meta-analysis, we compared the efficacy of these two antibodies indirectly due to the absence of head-to-head randomized control trials. The results showed that anti-PD-1 mAb + chemotherapy had superior overall survival, progression-free survival, and objective response rate compared to anti-PD-L1 mAb + chemotherapy, with similar rates of grade 3 and higher toxicities. However, head-to-head RCTs are still needed in the future.
Article
Physiology
Koji Takahashi, Yoshihiro Nishida, Soichiro Yokota, Kazuhiro Tada, Hiroto Hiyamuta, Kenji Ito, Tetsuhiko Yasuno, Tosihki Maeda, Hisatomi Arima, Kosuke Masutani
Summary: This study aimed to examine the association between casual serum triglyceride concentrations and new-onset chronic kidney disease (CKD) in the general Japanese population. The results showed a significant association between serum triglyceride concentrations and incident CKD in Japanese men, but not in women. This study provides important insights for predicting and preventing CKD.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Stuart Keith Roberts, Ashika Maharaj, John Lubel, Eileen Lam, Paul J. Clark, Oliver Duncan, Jacob George, Gary P. Jeffrey, Lara Lipton, Howard Liu, Geoffrey McCaughan, Eu-Ling Neo, Jenny Philip, Simone I. Strasser, Katherine Stuart, Alexander Thompson, Jonathan Tibbals, Thomas Tu, Michael C. Wallace, Alan Wigg, Marnie Wood, Amany Zekry, Elysia Greenhill, Liane J. Ioannou, Golo Ahlenstiel, Kaye Bowers, Stephen J. Clarke, Anouk Dev, Mark Goodwin, Christos Karapetis, Miriam T. Levy, Kate Muller, James Patrick O'Beirne, David Pryor, James Seow, Caroline J. Tallis, Nick Butler, John K. Olynyk, John Zalcberg
Article
Gastroenterology & Hepatology
Ashika D. Maharaj, John Lubel, Eileen Lam, Paul J. Clark, Oliver Duncan, Jacob George, Gary P. Jeffrey, Lara Lipton, Howard Liu, Geoffrey McCaughan, Eu-Ling Neo, Jennifer Philip, Simone Strasser, Katherine Stuart, Alexander Thompson, Jonathan Tibballs, Thomas Tu, Michael C. Wallace, Alan Wigg, Marnie Wood, Amany Zekry, Elysia Greenhill, Liane J. Ioannou, Golo Ahlenstiel, Kaye Bowers, Stephen J. Clarke, Anouk Dev, Michael Fink, Mark Goodwin, Christos S. Karapetis, Miriam T. Levy, Kate Muller, James O'Beirne, David Pryor, James Seow, Nicholas Shackel, Caroline Tallis, Nick Butler, John K. Olynyk, Kate Reed-Cox, John R. Zalcberg, Stuart K. Roberts
Summary: This study aimed to develop a core set of quality indicators for the management of hepatocellular carcinoma (HCC). Through a Delphi consensus study, 23 specific indicators were identified, covering aspects such as diagnosis, staging, and treatment of HCC. Adherence to these indicators can improve the quality of care and patient outcomes, including survival.
HEPATOLOGY COMMUNICATIONS
(2022)