Article
Oncology
Dolly P. White, Allison W. Kurian, Jennifer L. Stevens, Benmei Liu, Ariel E. Brest, Valentina I. Petkov
Summary: The study found that young adult females with breast cancer generally receive guideline-concordant care, with factors associated with the receipt of care varying by cancer subtype. Sociodemographic factors and treatment facility size have different effects on guideline-concordant care depending on subtype, with tumor stage being the most significant predictor of receiving guideline-concordant care across all subtypes.
Article
Cardiac & Cardiovascular Systems
Akash H. Adhia, Joseph M. Feinglass, Cary Jo R. Schlick, Ryan P. Merkow, Karl Y. Bilimoria, David D. Odell
Summary: This study aimed to evaluate the quality of management of stage III esophageal cancer nationally and found variations in adherence rates in different aspects. Academic and high-volume institutions showed higher adherence rates in some aspects of quality, but had lower adherence rates in nodal staging.
ANNALS OF THORACIC SURGERY
(2022)
Article
Clinical Neurology
Priya Sunder, Ming -Fang Chia, Kate Filia, Craig Macneil, Melissa Hasty, Christopher Davey, Patrick McGorry, Michael Berk, Sue Cotton, Aswin Ratheesh
Summary: This study examined the impact of guideline concordance on outcomes in youth with early-stage BD-I. Higher concordance was associated with worse outcomes, but this relationship was moderated by illness characteristics, severity, and insight. More interventions or modified guidelines may be needed for youth with poor insight, greater severity, and mixed/rapid cycling features.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Oncology
Lindsay J. Collin, Ming Yan, Renjian Jiang, Keerthi Gogineni, Preeti Subhedar, Kevin C. Ward, Jeffrey M. Switchenko, Joseph Lipscomb, Jasmine Miller-Kleinhenz, Mylin A. Torres, Jolinta Lin, Lauren E. McCullough
Summary: Although receipt of guideline-concordant care is important for breast cancer outcomes, racial disparities in breast cancer mortality did not diminish with receipt of GCC; differences in mortality between Black and White patients persisted across the strata of GCC.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2021)
Article
Oncology
Michael D. Honaker, William Irish, Alexander A. Parikh, Rebecca A. Snyder
Summary: This study aimed to determine whether rural residence is associated with differences in guideline-concordant care for patients with locoregional colon cancer (CC). The results showed that rural and urban patients receive guideline-concordant care equally, suggesting that differences in cancer care delivery may not explain rural-urban disparities.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sreejata Raychaudhuri, Jaclyn M. M. Kyko, Julie J. J. Ruterbusch, Stephanie S. S. Pandolfi, Jennifer L. L. Beebe-Dimmer, Ann G. G. Schwartz, Michael S. S. Simon
Summary: This study retrospectively evaluated the relationship between pre-existing comorbidities and receipt of local and systemic therapy in Black women with breast cancer. The results showed that patients with arthritis and depression were less likely to receive local treatment, while obese patients were more likely to receive hormonal therapy. Older age and increasing comorbidity burden were associated with a lower likelihood of receiving chemotherapy.
Article
Public, Environmental & Occupational Health
Michelle B. Nadler, Ann Marie Corrado, Brooke E. Wilson, Alexandra Desnoyers, Eitan Amir, Noah Ivers, Laura Desveaux
Summary: Canadian and US Task Forces recommend against routine mammography screening for women age 40-49 at average breast cancer risk, as harms outweigh benefits. This study explores primary care professionals' perspectives on screening and how it informs clinical behaviors, aiming to improve guideline concordant breast screening for this age group.
Article
Multidisciplinary Sciences
Hasan Nadeem, John A. Romley, Shaneda Warren Andersen
Summary: Racial disparities in breast cancer treatment contribute to Black women having the worst breast cancer survival rates in the U.S. Our study found that from 2008-2010, Black women had a lower receipt of optimal locoregional treatment (OLT) compared to White women. However, from 2010-2011, there was an increase in OLT for Black women, particularly in the receipt of radiation therapy following breast-conserving surgery.
Article
Oncology
Tina W. F. Yen, Zhuping Garacci, Purushottam W. Laud, Liliana E. Pezzin, Ann B. Nattinger
Summary: This large nationwide study aimed to validate two novel composite treatment scores for breast cancer care and found that these scores had independent and combined robust effects on survival, indicating they could serve as promising tools for health services research and quality-of-care studies.
Article
Oncology
Oluwatosin A. Ayeni, Daniel S. O'Neil, Yoanna S. Pumpalova, Wenlong Carl Chen, Sarah Nietz, Boitumelo Phakathi, Ines Buccimazza, Sharon Cacala, Laura W. Stopforth, Hayley A. Farrow, Witness Mapanga, Maureen Joffe, Tobias Chirwa, Valerie McCormack, Judith S. Jacobson, Katherine D. Crew, Alfred Neugut, Paul Ruff, Herbert Cubasch
Summary: This study examined the impact of HIV infection on the overall survival of women with nonmetastatic breast cancer in South Africa. The results showed that HIV infection had a negative effect on the survival rate of breast cancer patients, which was consistent across different age groups, breast cancer stages, and estrogen/progesterone receptor status.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Ahmad Hamad, Matthew DePuccio, Bradley N. Reames, Apeksha Dave, Natasha Kurien, Jordan M. Cloyd, Chengli Shen, Timothy M. Pawlik, Allan Tsung, Ann Scheck McAlearney, Aslam Ejaz
Summary: This study examined the utilization of cancer-directed treatment for pancreatic cancer patients in the USA, revealing that less than half of patients received guideline-concordant treatment. Factors such as older age, female sex, African American race, and higher comorbidity burden were associated with a lower likelihood of receiving standard treatment, while treatment at high-volume centers and higher education levels increased the likelihood. Patients who received standard treatment had significantly better long-term oncological outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Megan E. Daly, Navneet Singh, Nofisat Ismaila, Mara B. Antonoff, Douglas A. Arenberg, Jeffrey Bradley, Elizabeth David, Frank Detterbeck, Martin Fruh, Matthew A. Gubens, Amy C. Moore, Sukhmani K. Padda, Jyoti D. Patel, Tanyanika Phillips, Angel Qin, Clifford Robinson, Charles B. Simone
Summary: This article provides evidence-based recommendations for the management of patients with stage III non-small-cell lung cancer (NSCLC). The recommendations were developed through a literature search and expert consensus, covering various aspects of evaluation, surgery, neoadjuvant and adjuvant approaches, and management of unresectable stage III NSCLC.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Letter
Oncology
Sonya Reid, Mya L. Roberson, Kenna Koehler, Tiana Shah, Anne Weidner, Jennifer G. Whisenant, Tuya Pal
Summary: This case series study investigates the differences in surgical treatment between adult females with invasive breast cancer who have pathogenic or likely pathogenic variants in genes with high vs moderate breast cancer penetrance.
Article
Oncology
Anja Zgodic, Jan M. Eberth, Benjamin D. Smith, Whitney E. Zahnd, Swann A. Adams, Brian P. McKinley, Ronnie D. Horner, Mark A. O'Rourke, Dawn W. Blackhurst, Matthew F. Hudson
Summary: This study examines the factors influencing needle biopsy receipt among women with non-metastatic breast cancer in the United States. It finds that Hispanic and Medicaid patients, as well as those receiving care at Integrated Network Cancer Programs, are more likely to receive needle biopsy. Conversely, non-metropolitan patients, those with early cancer stages, comorbidities, and those receiving care at Community Cancer Programs are less likely to receive needle biopsy. Addressing these disparities in diagnostic practices may help improve outcomes for underserved breast cancer patients.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Erin J. Aiello Bowles, Cody Ramin, Diana S. M. Buist, Heather Spencer Feigelson, Sheila Weinmann, Lene H. S. Veiga, Clara Bodelon, Rochelle E. Curtis, Jacqueline B. Vo, Amy Berrington de Gonzalez, Gretchen L. Gierach
Summary: This retrospective cohort study examined the patterns of endocrine therapy initiation among women with hormone receptor-positive breast cancer. Despite an increase in aromatase inhibitor (AI) use over time, at least one in six eligible women did not initiate endocrine therapy, suggesting opportunities for improvement in breast cancer survivors' endocrine therapy uptake.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Public, Environmental & Occupational Health
Rowida Mohamed, Zasim Siddiqui, Richard Sutphin, Kimberly M. Kelly
Summary: This study explored the differences in illness representations of VALI among non-patient adults guided by the Common-Sense Model of Self-Regulation. The results showed that e-cigarette use was associated with illness representations of VALI, with current users discounting the detrimental nature of VALI compared to former and never users. Gender and urban/rural residence moderated the association as well. Qualitative analysis revealed components of VALI perceptions, such as timeline, identity, causes, consequences, cure/control, and worry. Understanding these perceptions and contexts may contribute to interventions for e-cigarette cessation.
PSYCHOLOGY & HEALTH
(2023)
Editorial Material
Pharmacology & Pharmacy
Kimberly M. Kelly, Emily Yenser
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2023)
Article
Urology & Nephrology
Katharine L. Cheung, Deidra C. Crews, Mary Cushman, Ya Yuan, Katherine Wilkinson, D. Leann Long, Suzanne E. Judd, Michael G. Shlipak, Joachim H. Ix, Alexander L. Bullen, David G. Warnock, Orlando M. Gutierrez
Summary: This study investigated the incidence and risk factors for chronic kidney disease (CKD) in different races, genders, and regions in the United States. The results showed that Black individuals had a higher risk of developing CKD compared to White individuals, and living in the US stroke belt region was also identified as a novel risk factor for CKD. Additionally, albuminuria was found to be a stronger risk factor for CKD in Black individuals. These findings have significant implications for the prevention and treatment of CKD.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Genetics & Heredity
Nadia Falah, Alissa Terry, Amna Umer, Marlee Kastner, Kathryn L. Oliverio, Nicole Matthews, Kimberly M. Kelly, Yvonne Kellar-Guenther
Summary: Telegenetics has enabled genetic testing to be performed at the patient's home, but little is known about the completion rate of home-based genetic testing. This study compared the completion rate of home-based genetic tests before and after implementing a reminder system. The results showed a higher rate of test completion in the reminder group, although the difference between the pre-reminder and reminder groups was not statistically significant. The study suggests that reminders may be clinically meaningful in improving the completion rate of home-based genetic tests.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Hematology
Debora Kamin Mukaz, Boyi Guo, D. Leann Long, Suzanne E. Judd, Timothy B. Plante, Leslie A. McClure, Alisa S. Wolberg, Neil A. Zakai, George Howard, Mary Cushman
Summary: The reasons for increased risk of hypertension in Black compared with White people are not fully understood. D-dimer, a marker for thrombo-inflammatory processes that is higher in Black individuals, is also higher in people with hypertension. However, the impact of D-dimer on racial disparities in risk of incident hypertension has not been studied.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Megan Zhou, Katherine Wilkinson, Timothy B. Plante, Debora Kamin Mukaz, D. Leann Long, Neil A. Zakai, Mary Cushman, Nels C. Olson
Article
Endocrinology & Metabolism
Zsuzsanna Ament, Amit Patki, Varun M. Bhave, Ninad S. Chaudhary, Ana-Lucia Garcia Guarniz, Naruchorn Kijpaisalratana, Suzanne E. Judd, Mary Cushman, D. Leann Long, M. Ryan Irvin, W. Taylor Kimberly
Summary: Metabolite markers, particularly those related to gut microbial metabolism, are independently associated with incident ischemic stroke. These findings emphasize the role of diet and gut microbial metabolism in the development of ischemic stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Geriatrics & Gerontology
Amani M. Norling, Aleena Bennett, Michael Crowe, D. Leann Long, Sara A. Nolin, Terina Myers, Victor A. Del Bene, Ronald M. Lazar, Adam Gerstenecker
Summary: This study examined the relationship between anticholinergic medication use and cognitive function in middle-aged and older adults. It found that higher anticholinergic burden was associated with more rapid cognitive decline, while physical activity appeared to mitigate this effect.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Clinical Neurology
Naruchorn Kijpaisalratana, Zsuzsanna Ament, Amit Patki, Varun M. Bhave, Ana-Lucia Garcia-Guarniz, Suzanne E. Judd, Mary Cushman, D. Leann Long, M. Ryan Irvin, W. Taylor Kimberly
Summary: This study aimed to identify metabolites that explain the higher prevalence of hypertension and incident ischemic stroke among Black adults. The researchers found that gluconic acid is associated with prevalent hypertension and incident ischemic stroke in Black adults, and it is also influenced by social determinants of health such as diet, education level, and physical activity.
Article
Endocrinology & Metabolism
Katherine A. Moon, Cara M. Nordberg, Stephanie L. Orstad, Aowen Zhu, Jalal Uddin, Priscilla Lopez, Mark D. Schwartz, Victoria Ryan, Annemarie G. Hirsch, Brian S. Schwartz, April P. Carson, D. Leann Long, Melissa Meeker, Janene Brown, Gina S. Lovasi, Samranchana Adhikari, Rania Kanchi, Sanja Avramovic, Giuseppina Imperatore, Melissa N. Poulsen
Summary: This study evaluated the impact of the neighborhood socioeconomic environment on type 2 diabetes, and whether this association is mediated by access to leisure-time physical activity resources. The results showed that the density of physical activity facilities and the distance to parks did not substantially mediate the relation between the neighborhood socioeconomic environment and type 2 diabetes.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Public, Environmental & Occupational Health
Jessica Hafetz, Catherine C. Mcdonald, D. Leann Long, Carol A. Ford, Thandwa Mdluli, Andrew Weiss, Jackson Felkins, Nicole Wilson, Bradley Macdonald
Summary: The impact of young drivers' motor vehicle crashes is significant, and there is a need for interventions that target families to complement Graduated Driver Licensing (GDL) programs. The Drivingly Program is a comprehensive parent-teen intervention that aims to reduce teens' risk for a police-reported MVC in the first 12 months of licensure by delivering intervention content to both teens and their parents.
Article
Pharmacology & Pharmacy
Trupti Dhumal, Virginia G. Scott, Roxann Powers, Kimberly M. Kelly
Summary: The purpose of this study was to evaluate the impact of the Skin Cancer Awareness Now (SCAN!) pharmacy-based sun-safety intervention at follow-up. Surveys were conducted to assess SCAN's effect on skin cancer prevention before and after the intervention. The results showed significant improvements in knowledge and intentions over time.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2023)
Article
Clinical Neurology
Naruchorn Kijpaisalratana, Zsuzsanna Ament, Amit Patki, Varun M. Bhave, Alana C. Jones, Ana-Lucia Garcia Guarniz, Catharine A. Couch, Mary Cushman, D. Leann Long, M. Ryan Irvin, W. Taylor Kimberly
Summary: The objective of this study was to identify metabolite risk markers associated with recurrent stroke. The study found that acetylglutamine is associated with recurrent stroke but not with first-time stroke.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Medicine, General & Internal
Anika L. Hines, Michelle A. Albert, Jessica P. Blair, Deidra C. Crews, Lisa A. Cooper, D. Leann Long, April P. Carson
Summary: This study examined whether neighborhood- and individual-level stressors mediate the racial disparities in ideal cardiovascular health. The results showed that neighborhood physical environment, neighborhood safety, neighborhood social cohesion, and discrimination attenuated the racial disparities in cardiovascular health.
Article
Public, Environmental & Occupational Health
Jalal Uddin, Sha Zhu, Samrachana Adhikari, Cara M. Nordberg, Carrie R. Howell, Gargya Malla, Suzanne E. Judd, Andrea L. Cherrington, Pasquale E. Rummo, Priscilla Lopez, Rania Kanchi, Karen Siegel, Shanika A. De Silva, Yasemin Algur, Gina S. Lovasi, Nora L. Lee, April P. Carson, Annemarie G. Hirsch, Lorna E. Thorpe, D. Leann Long
Summary: The study examines the relationship between neighborhood socioeconomic environment (NSEE) and type 2 diabetes (T2D) risk, and finds that the impact of NSEE on T2D risk differs by sex and age within different community types.
SSM-POPULATION HEALTH
(2023)