期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 78, 期 -, 页码 480-490出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2017.12.006
关键词
Bioinspiration; Mosquito; Microneedle insertion; Skin; Stretch; Mechanical vibration
资金
- Basic Science Research Programs through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2014R1A1A1006402, 2017R1A2B4010300]
- National Research Foundation of Korea [2017R1A2B4010300, 2014R1A1A1006402] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A mosquito is known to precisely and easily insert its proboscis to the human skin by pressing down a labium and vibrating a fascicle bundle. Its advanced skin-piercing mechanisms indicate that skin resistance to the insertion of needle-like objects can be changed by the application of mechanophysical stimuli. Here, we characterize the effect of the application of mechanophysical stimuli on skin resistance to microneedle insertion to find clues for inserting a microneedle in a deep and precise fashion with low force. Microneedles with a diameter of 60-140 gm are inserted at a velocity of 0.1-2.0 mm/s to full-thickness porcine skins while either uniaxial/ equibiaxial stretch of 0-20% or mechanical vibration at a frequency of 1 to 1000 Hz and an amplitude of 1-10 pm is applied to the skins as static or dynamic mechanophysical stimulus, respectively. The values of force and depth at two events of skin puncture and maximum penetration are measured to explore changes in skin resistance induced by the application of external stimuli. The static mechanophysical stimulus applied to the skin mainly affects the precision of microneedle insertion; the application of dynamic mechanophysical stimulus controls the value and deviation of skin resistance to microneedle insertion. The application of mechanophysical stimuli, inspired from a mosquito, therefore allows a microneedle to be deeply and easily inserted to the skin in a controlled way. The findings will have broad impacts on microneedle-mediated applications and lead to an indepth understanding of skin biomechanics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据