Article
Pharmacology & Pharmacy
Hussein M. El-Husseiny, Eman A. Mady, Masahiro Kaneda, Kazumi Shimada, Yasumoto Nakazawa, Tatsuya Usui, Mohamed Elbadawy, Yusuke Ishihara, Moeko Hirose, Yohei Kamei, Ahmed S. Doghish, Hesham A. El-Mahdy, Walaa A. El-Dakroury, Ryou Tanaka
Summary: The use of Trypsin + TX + SDS protocol successfully decellularized bovine pericardium, porcine pericardium, and porcine tunica vaginalis, preserving extracellular matrix integrity and demonstrating good biocompatibility. The decellularized porcine pericardium showed increased elasticity, while the tensile strength of decellularized bovine pericardium and porcine tunica vaginalis remained unaffected. Decellularized tissues supported the growth of adipose stem cells and showed in vivo biocompatibility and degradability. Trypsin + TX + SDS is a successful decellularization protocol, and decellularized pericardia and tunica vaginalis are promising scaffolds for tissue engineering applications.
Article
Engineering, Multidisciplinary
Martina Todesco, Saima Jalil Imran, Tiago Moderno Fortunato, Deborah Sandrin, Giulia Borile, Filippo Romanato, Martina Casarin, Germana Giuggioli, Fabio Conte, Massimo Marchesan, Gino Gerosa, Andrea Bagno
Summary: Human and animal pericardium are commonly used materials for repairing damaged tissues in cardiovascular surgery, but they have drawbacks such as calcification and limited availability. Decellularized pericardium, which removes cellular and nuclear components, shows potential as a scaffold for cardiovascular tissue regeneration. This study evaluates the effects of a new detergent on decellularizing bovine and porcine pericardium, and finds that the decellularized pericardium retains its extracellular matrix structure without cytotoxic effects.
Article
Engineering, Biomedical
Felix Stieglmeier, Maximilian Grab, Fabian Konig, Joscha Buech, Christian Hagl, Nikolaus Thierfelder
Summary: This study aimed to identify areas of the pericardium with consistent properties and high durability, with only one area meeting these criteria. Decellularization effectively removed all cell nuclei and reduced DNA content by 84%, while most pericardia maintained durability during long-term testing.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Polymer Science
My Thi Ngoc Nguyen, Ha Le Bao Tran
Summary: This study evaluates the in-vitro endothelialization ability of heparinized bovine pericardial scaffolds and finds that the heparinized scaffolds exhibit good anti-thrombosis properties and cell compatibility, potentially improving long-term thromboresistance.
Article
Dentistry, Oral Surgery & Medicine
Hengameh Bakhtiar, Sarah Rajabi, Mohammad Pezeshki-Modaress, Mohammad Reza Ellini, Mahsa Panahinia, Solmaz Alijani, Amir Mazidi, Amir Kamali, Amir Azarpazhooh, Anil Kishen
Summary: The study aimed to characterize the effects of various decellularization protocols on bovine dental pulp ECM. Results showed successful decellularization in all groups, with protocol P7 (12E-0S-1T) demonstrating the highest retention of glycosaminoglycan and minimal DNA content. Overall, the tested treatments hold potential for producing xenogeneic dental pulp ECM scaffolds, with P7 being a promising option due to its minimal structural damage and acceptable host immune response.
JOURNAL OF ENDODONTICS
(2021)
Article
Biochemistry & Molecular Biology
Flavia Carton, Dalila Di Francesco, Luca Fusaro, Emma Zanella, Claudio Apostolo, Francesca Oltolina, Diego Cotella, Maria Prat, Francesca Boccafoschi
Summary: The study evaluated the myogenic potential of dECM substrate derived from decellularized bovine pericardium on murine muscle cells and found that dECM could support and enhance the myogenic potential of muscle cells compared to cells grown on a standard plastic surface. This suggests that extracellular matrix proteins could be a promising therapeutic strategy for skeletal muscle tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Bastien Poitier, Jeanne Rancic, Ulysse Richez, Julie Piquet, Salma El Batti, David M. M. Smadja
Summary: This study aimed to investigate whether fibrin deposition could lead to calcification in bovine pericardium tissue. The results showed that fibrin-treated tissue had higher levels of calcification and more inflammatory-like cell infiltration. The conclusion is that fibrin deposition may be one of the triggers for calcification and deterioration of heart valves.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Shengyuan Zhou, Bo Yuan, Wenmao Huang, Yifan Tang, Xiongsheng Chen
Summary: This study successfully prepared acellular tendon fiber (ATF) by lyophilizing, fiber separation, and removal of cellular components without the use of chemical detergent. ATF retained the original fibril structure and mechanical properties after decellularization, showing good support for SD rat tenocytes and biocompatibility when implanted into paraspinal muscles.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Multidisciplinary Sciences
Angelique Lewies, Lezelle Botes, Johannes Jacobus van den Heever, Pascal Maria Dohmen, Francis Edwin Smit
Summary: The effect of monomeric glutaraldehyde fixation and amino acid detoxification on the biocompatibility and tissue-guided regenerative potential of decellularized bovine pericardium was evaluated. The study found that this process adequately removes toxicity, prevents enzymatic degradation, allows for host cell infiltration and mitigates calcification, while retaining the tissue's mechanical properties.
Article
Cell Biology
L. Botes, L. Laker, P. M. Dohmen, J. J. van den Heever, C. J. Jordaan, A. Lewies, F. E. Smit
Summary: This study compared the mechanical and morphological integrity of bovine pericardium that is GA-fixated or decellularized following implantation in an ovine model. The results showed that the decellularized pericardial scaffolds demonstrated recellularization, resistance to calcification, re-endothelialization and adequate strength, and could be considered as an alternative to GA-fixed pericardial patches.
CELL AND TISSUE BANKING
(2022)
Article
Materials Science, Biomaterials
Ning Li, Xin Li, Ye Ma, Fan Qiao, Yifan Bai, Xiaohong Liu, Zhiyun Xu
Summary: The study found that the swim bladder of carp, as a raw biomaterial, has excellent biocompatibility and anti-calcification properties, making it suitable for the production of heart valves. Experimental results demonstrated its potential in bioprosthetic valve replacements.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Olimpia Ortiz-Arrabal, Ramon Carmona, Oscar-Dario Garcia-Garcia, Jesus Chato-Astrain, David Sanchez-Porras, Alberto Domezain, Roke-Inaki Oruezabal, Victor Carriel, Antonio Campos, Miguel Alaminos
Summary: Research on a novel decellularized sturgeon cartilage scaffold showed promising results in terms of biocompatibility and sustainability for chondrocytes, as well as triggering a pro-regenerative reaction. This suggests potential for further development of these cartilage substitutes for clinical translation.
Article
Biochemistry & Molecular Biology
Jaroslav Chlupac, Roman Matejka, Miroslav Konarik, Robert Novotny, Zuzana Simunkova, Iveta Mrazova, Ondrej Fabian, Milan Zapletal, Zdenek Pulda, Jan Falk Lipensky, Jana Stepanovska, Karel Hanzalek, Antonin Broz, Tomas Novak, Alena Lodererova, Ludek Voska, Theodor Adla, Jiri Fronek, Miroslav Rozkot, Serhiy Forostyak, Peter Kneppo, Lucie Bacakova, Jan Pirk
Summary: The aim of this study was to explore the in vivo bio-integration of decellularized or recellularized pericardial matrices. The results showed that decellularized pericardial matrices had good biocompatibility and recellularization helped reduce immune reactions and tissue hyperplasia. However, the method of recellularization had an impact on the integration and repair of the pericardial matrices.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Tiziana Martinello, Eylem Emek Akyurek, Gianluca Ventriglia, Marco Patruno, Roberta Sacchetto
Summary: Three-dimensional (3D) organoids are a novel approach for in vitro modeling. This study developed a muscle organoid from the bovine diaphragm, which has a unique multilayered structure with different fiber orientations. The study analyzed the anatomical structure of the bovine diaphragm, selected the appropriate portion, and presented a decellularization protocol for the multilayered muscle. Preliminary recellularization with bovine myocytes was also conducted, aiming to achieve a completely bovine-derived 3D muscle organoid.
JOURNAL OF ANATOMY
(2023)
Article
Engineering, Biomedical
Yuriy Snyder, Soumen Jana
Summary: Valvular heart diseases are commonly treated using mechanical or bioprosthetic heart valves, but these valves have limitations. Heart valve tissue engineering offers a potential solution by using scaffolds that can grow with patients and function without the need for lifelong anticoagulation medication.
Article
Immunology
Anna Aureli, Angelica Canossi, Tiziana Del Beato, Oreste Buonomo, Piero Rossi, Mario Roselli, Franco Papola, Beatrice Marziani, Giuseppe Sconocchia
IMMUNOLOGICAL INVESTIGATIONS
(2020)
Article
Biochemistry & Molecular Biology
Maria Cristina Rapanotti, Elena Campione, Tara Mayte Suarez Viguria, Giulia Spallone, Gaetana Costanza, Piero Rossi, Augusto Orlandi, Piera Valenti, Sergio Bernardini, Luca Bianchi
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Article
Medicine, General & Internal
Giovanna Del Vecchio Blanco, Rami Dwairi, Mario Giannelli, Giampiero Palmieri, Vincenzo Formica, Ilaria Portarena, Enrico Grasso, Laura Di Iorio, Michela Benassi, Emilia Anna Giudice, Antonella Nardecchia, Piero Rossi, Mario Roselli, Giuseppe Sica, Giovanni Monteleone, Omero Alessandro Paoluzi
Summary: The study findings show that the adequacy, quality, and efficiency of colonoscopy conducted with the CCP program are superior to direct prescription or colonoscopy by non-gastroenterologist physicians; the attendance rate for colonoscopy in the CCP and NGPC groups is higher than in the OAC group, with shorter waiting times and higher appropriateness.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Environmental Sciences
Clelia Buccheri, Fabiana Festucci, Marina Potesta, Valentina Roglia, Roberta Bernardini, Antonella Minutolo, Carla Montesano, Walter Adriani
Summary: This study examined the physiological properties of microvesicles extracted from Moringa oleifera seeds in a rat model characterized by dysregulation in dopamine transporter. Results showed that Moringa had effects on rat behaviors, including locomotor activity and depressive behavior, with potential implications on the dopaminergic system. Further research is needed to fully understand these preliminary findings.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yosra Toumia, Roberto Miceli, Fabio Domenici, Sophie Heymans, Bram Carlier, Madalina Cociorb, Letizia Oddo, Piero Rossi, Rolando Maria D'Angellilo, Edmond Sterpin, Emiliano D'Agostino, Koen Van den Abeele, Jan D'hooge, Gaio Paradossi
Summary: This study investigated the vaporization of phase-change ultrasound contrast agents using photon radiation for dosimetry in radiotherapy. Superheated perfluorobutane nanodroplets with a crosslinked poly(vinylalcohol) shell were studied for their physical and acoustical properties. Results showed that the nanodroplets were sensitive to photons when heated to a specific temperature, leading to effective ultrasound contrast enhancement after exposure. The study suggests that optimizing nanodroplet design can improve sensitivity to photons under physiological conditions.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2021)
Article
Oncology
Vittoria Bellato, Yongbo An, Daniele Cerbo, Michela Campanelli, Marzia Franceschilli, Krishn Khanna, Bruno Sensi, Leandro Siragusa, Piero Rossi, Giuseppe S. Sica
Summary: The study demonstrates that the adoption of the ERAS protocol in patients with T4 colorectal cancer significantly reduces their length of stay and time of tolerance to solid food diet, without affecting surgical postoperative outcomes.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Critical Care Medicine
Sara Di Carlo, Giuseppe Cavallaro, Kenia Palomeque, Maurizio Cardi, Giuseppe Sica, Piero Rossi, Simone Sibio
Summary: This report critically reviews the assessment parameters currently used in the prehospital setting to quantify blood loss in trauma. Traditional assessment parameters often lag in providing accurate blood loss assessment, supporting the need for a noninvasive, continuously monitored assessment parameter to identify early shock in the prehospital setting.
JOURNAL OF TRAUMA NURSING
(2021)
Article
Medicine, General & Internal
Gianluca Vadala, Luca Ambrosio, Caterina Cattani, Roberta Bernardini, Antonino Giacalone, Rocco Papalia, Vincenzo Denaro
Summary: The study demonstrated that intra-articular bevacizumab treatment significantly reduced cartilage degeneration and synovial OA changes, effectively arresting OA progression. The most efficacious dose was found to be 20 mg, leading to increased production of type 2 collagen and aggrecan content even higher than in healthy cartilage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Marzia Franceschilli, Sara Di Carlo, Danilo Vinci, Bruno Sensi, Leandro Siragusa, Vittoria Bellato, Roberto Caronna, Piero Rossi, Giuseppe Cavallaro, Andrea Guida, Simone Sibio
Summary: Lymphadenectomy is crucial in oncologic surgery, with CME and CVL gaining interest in recent years for colorectal cancer. Theoretical advantages of CME include improved local-relapse rates and distance recurrence rates due to its complete removal of mesocolic fascia and ligation of vessels at their origin. While laparoscopic techniques have minimized postoperative trauma and provided similar outcomes as open surgery, the technical complexity of CME may limit its minimally invasive application.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Biochemistry & Molecular Biology
Maria Cristina Rapanotti, Elisa Cugini, Marzia Nuccetelli, Alessandro Terrinoni, Cosimo Di Raimondo, Paolo Lombardo, Gaetana Costanza, Terenzio Cosio, Piero Rossi, Augusto Orlandi, Elena Campione, Sergio Bernardini, Marcel Blot-Chabaud, Luca Bianchi
Summary: Studies have shown that MCAM/MUC18/CD146 plays a crucial role in the progression of malignant melanoma, serving as a potential target and acting during the disease spreading progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Andrea M. Guida, Bruno Sensi, Vincenzo Formica, Rolando M. D'Angelillo, Mario Roselli, Giovanna Del Vecchio Blanco, Piero Rossi, Gabriella T. Capolupo, Marco Caricato, Giuseppe S. Sica
Summary: Colorectal carcinoma is the second leading cause of cancer-related deaths, with rectal cancer accounting for approximately one third of new patients. The standard treatment for rectal cancer involves a multimodality approach focusing on local disease control. Total Neoadjuvant Therapy is an emerging strategy to reduce distant metastases and enhance local control, with ongoing studies evaluating its impact on oncological outcomes.
Review
Oncology
M. Franceschilli, D. Vinci, S. Di Carlo, B. Sensi, L. Siragusa, A. Guida, P. Rossi, V. Bellato, R. Caronna, S. Sibio
Summary: The focus of this review is on central vascular ligation as a radical lymphadenectomy in upper and lower gastrointestinal cancer, the evolution of this approach over the years, and the improvement of laparoscopic techniques. It highlights the importance of scientifically-based standardization of oncologic gastrointestinal surgery, particularly in the context of minimally invasive surgery and the increasing emphasis on the idea of less is more.
Review
Oncology
Sara Di Carlo, Marzia Franceschilli, Piero Rossi, Giuseppe Cavallaro, Maurizio Cardi, Danilo Vinci, Simone Sibio
Summary: Perforated gastric cancer, more prevalent in elderly males, typically involves the distal stomach with poor prognosis and uncommon preoperative diagnosis. Patients able to undergo curative resection show better long-term survival, and emergency cases should prioritize this approach. Laparoscopic procedure may be considered as a first step in resolving peritonitis before radical gastrectomy. Balancing emergency and oncological needs is crucial for surgical decision-making on a case-by-case basis.
Letter
Dermatology
Iria Neri, Alessia Barisani, Carlotta Baraldi, Pier A. Fan Ti, Annalisa Patrizi
ITALIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Medicine, General & Internal
Leandro Siragusa, Cristine Pathirannehalage Don, Domenico Benavoli, Davide Diacinti, Guglielmo Manenti, Marco Pocci, Giampiero Palmieri, Piero Rossi
AMERICAN JOURNAL OF CASE REPORTS
(2020)
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)