Abscopal effect in the treatment of malignant melanoma

Background. The clearance of non-irradiated tumors after localized radiation therapy is known as the abscopal effect. Case report. In the present case report we initiated a combined therapeutic approach based on sequential administration of ipilimumab plus temozolomide in combination with radiotherapy. The treatment regime was well tolerated and resulted in unusually long disease stabilization and in a complete response of brain and kidney metastases. Thus, it is speculated that the clinical response was the result of an abscopal effect. Conclusion. The present case report highlights the possible clinical benefit of the abscopal effect in the treatment of malignant melanoma.