Article
Cardiac & Cardiovascular Systems
Christian Gerges, Anna -Maria Pistritto, Mario Gerges, Richard Friewald, Valerie Hartig, Thomas M. Hofbauer, Benedikt Reil, Leon Engel, Varius Dannenberg, Stefan P. Kastl, Nika Skoro-Sajer, Bernhard Moser, Shahrokh Taghavi, Walter Klepetko, Irene M. Lang
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by the obstruction of major pulmonary arteries with organized thrombi. The study investigated the prevalence and prognostic implications of elevated left ventricular filling pressures (LVFP) in CTEPH through diagnostic right and left heart catheterization in 593 CTEPH patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Katsuji Inoue, Faraz H. Khan, Espen W. Remme, Nobuyuki Ohte, Eusebio Garcia-Izquierdo, Michael Chetrit, Vanessa Monivas-Palomero, Susana Mingo-Santos, Oyvind S. Andersen, Einar Gude, Arne K. Andreassen, Tom Kai Ming Wang, Shohei Kikuchi, Marie Stugaard, Jong-Won Ha, Allan L. Klein, Sherif F. Nagueh, Otto A. Smiseth
Summary: The study aimed to investigate determinants of left atrial (LA) reservoir and pump strain and their ability to serve as markers of left ventricular (LV) filling pressure. The strongest determinants of LA strains were found to be LV global longitudinal strain (GLS) and LV filling pressure. Accuracy of LA strains in identifying elevated LV filling pressure was highest in patients with reduced LV systolic function, while high values of LA pump strain accurately identified normal LV filling pressure in patients with normal systolic function.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Pankaj Garg, Rebecca Gosling, Peter Swoboda, Rachel Jones, Alexander Rothman, Jim M. Wild, David G. Kiely, Robin Condliffe, Samer Alabed, Andrew J. Swift
Summary: CMR can estimate LVFP in patients with suspected HF and has prognostic power.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Giulia Iannaccone, Francesca Graziani, Marco Giuseppe Del Buono, Massimiliano Camilli, Rosa Lillo, Andrea Caffe, Francesco Moroni, Giulia La Vecchia, Daniela Pedicino, Tommaso Sanna, Carlo Trani, Antonella Lombardo, Gaetano Antonio Lanza, Massimo Massetti, Filippo Crea, Rocco A. Montone
Summary: The aim of this study was to evaluate the use of left atrial strain values as compared with traditional echocardiographic indexes in improving the non-invasive estimation of left ventricular and diastolic pressure in the acute phase of Takotsubo syndrome (TTS). The study also aimed to predict in-hospital adverse outcomes in TTS patients. Results showed that left atrial reservoir and pump strain values had a stronger correlation with LVEDP compared to other echocardiographic indexes. Furthermore, left atrial reservoir strain was an independent predictor of worse in-hospital outcomes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Rachel Jones, Frances Varian, Samer Alabed, Paul Morris, Alexander Rothman, Andrew J. Swift, Nigel Lewis, Andreas Kyriacou, James M. Wild, Abdallah Al-Mohammad, Liang Zhong, Amardeep Dastidar, Robert F. Storey, Peter P. Swoboda, Jeroen J. Bax, Pankaj Garg
Summary: The study evaluated the effectiveness of different echocardiographic indices in estimating true LVFP and found a moderate pooled association with invasively measured LVFP, which varied widely with disease state. In heart failure with preserved ejection fraction, no single echocardiography-based metric offered a reliable estimate, while in heart failure with reduced ejection fraction, mitral inflow-derived indices showed reasonable clinical applicability. An integrated approach using multiple echocardiographic metrics shows promise for reliably estimating LVFP, but further validation in larger patient-specific studies is needed.
Article
Radiology, Nuclear Medicine & Medical Imaging
T. Erdei, J. C. L. Rodrigues, R. Hartley-Davies, A. G. Dastidar, G. V. Szantho, E. C. Hart, A. K. Nightingale, N. E. Manghat, M. C. K. Hamilton
Summary: This study assessed the relationship between global longitudinal strain and left atrial and left ventricular filling and emptying. In hypertensive patients, reduced global longitudinal strain was associated with impaired left atrial function and impaired left ventricular filling and diastolic function.
CLINICAL RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Oleg F. Sharifov, Thomas S. Denney Jr, Andrew A. Girard, Himanshu Gupta, Steven G. Lloyd
Summary: The impairment of left atrial strain is associated with left ventricular diastolic dysfunction and increased left ventricular end diastolic pressure. The impact of coronary artery disease on left atrial strain and its relationship with left ventricular end diastolic pressure is not well studied.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pankaj Garg, Wasim Javed, Hosamadin Assadi, Samer Alabed, Ciaran Grafton-Clarke, Andrew J. Swift, Gareth Williams, Abdallah Al-Mohammad, Chris Sawh, Vassilios S. Vassiliou, Mohammed Y. Khanji, Fabrizio Ricci, John P. Greenwood, Sven Plein, Peter Swoboda
Summary: This study aimed to investigate whether left atrial (LA) volume and left ventricular filling pressure (LVFP) assessed by cardiovascular magnetic resonance (CMR) change during adenosine delivered myocardial hyperaemia. The results showed that at peak hyperaemic state, left atrial end ventricular systolic volume increased significantly from baseline in all cohorts, and CMR-derived LVFP also increased significantly.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Qiaobing Sun, Yu Pan, Yixiao Zhao, Yan Liu, Yinong Jiang
Summary: This study investigated the association between LA-LV-arterial coupling and nighttime systolic blood pressure (BP) as well as BP circadian rhythm in essential hypertension. The results showed that the dipping pattern of BP was related to the abnormalities of myocardial mechanics and LA-LV-arterial coupling, with the absolute nocturnal systolic BP value being more important than BP circadian profile.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Ciaran Grafton-Clarke, Gareth Matthews, Rebecca Gosling, Peter Swoboda, Alexander Rothman, Jim M. Wild, David G. Kiely, Robin Condliffe, Samer Alabed, Andrew J. Swift, Pankaj Garg, Marco Fogante
Summary: This study aimed to evaluate a simple CMR-derived model for estimating pulmonary capillary wedge pressure (PCWP) in patients with heart failure. The results showed that the model had good diagnostic accuracy and predictive value for mortality.
MEDICINA-LITHUANIA
(2023)
Article
Multidisciplinary Sciences
Roger E. Peverill, Gene-Siew Ngian, Catherine Mylrea, Joanne Sahhar, Masataka Kuwana, Masataka Kuwana, Masataka Kuwana, Masataka Kuwana
Summary: The study found that in patients with systemic sclerosis (SSc), there are associations of sex, body size, age, and disease type with left ventricular structural variables, age and heart rate with E/A, and age with both systolic and early diastolic LV long-axis velocities. Appropriate adjustment for these variables could help to resolve current uncertainties regarding the effects of SSc on the left ventricle.
Article
Cardiac & Cardiovascular Systems
Aurore Lyon, Manouk van Mourik, Laura Cruts, Jordi Heijman, Sebastiaan C. A. M. Bekkers, Ulrich Schotten, Harry J. G. M. Crijns, Dominik Linz, Joost Lumens
Summary: This study aimed to elucidate the impact of RR-interval and heart rate on left ventricular function during atrial fibrillation (AF). The research found that changes in preload and heart rate can significantly affect LV peak strain, with faster heart rates showing greater sensitivity to RR-interval changes. The simulations suggest that longer LV activation relative to the preceding RR-interval plays a key role in determining LV systolic function during AF.
Article
Multidisciplinary Sciences
Kuo-Wei Kao, Weiming Cheng, Ching-Ju Wu, Yu-Hua Fan
Summary: There is a relationship between heart disease and nocturia, with higher occurrences of bothersome nocturia in elderly patients with risk factors for heart disease. Nocturia can predict structural abnormalities in the heart.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Christopher C. Henderson, Kristen George-Durrett, Sandra Kikano, James C. Slaughter, Joshua D. Chew, David Parra, Jeffrey Weiner, Jonathan Soslow
Summary: This study aims to compare a more rapid method of obtaining left ventricular filling curves to standard methodology and report the respective data for cardiovascular magnetic resonance (CMR) diastolic function. The results show that the more rapid method produces similar results to the standard methodology, which may facilitate the use of left ventricular filling in clinical CMR reporting.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Article
Cardiac & Cardiovascular Systems
David Pham, Mark H. Drazner, Colby R. Ayers, Justin L. Grodin, Elizabeth A. Hardin, Sonia Garg, Pradeep P. A. Mammen, Alpesh Amin, Faris G. Araj, Robert M. Morlend, Jennifer T. Thibodeau
Summary: Clinical examination allows accurate detection of elevated right atrial pressure but does not allow accurate detection of discordant right-ventricular and left-ventricular filling pressures in patients with heart failure.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Francesco Maffessanti, Amit R. Patel, Mita B. Patel, James J. Walter, Anuj Mediratta, Diego Medvedofsky, Nadjia Kachenoura, Roberto M. Lang, Victor Mor-Avi
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2017)
Article
Cardiac & Cardiovascular Systems
Diego Medvedofsky, Doron Aronson, Mardi Gomberg-Maitland, Vasiliki Thomeas, Stuart Rich, Kirk Spencer, Victor Mor-Avi, Karima Addetia, Roberto M. Lang, Avinoam Shiran
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2017)
Article
Cardiac & Cardiovascular Systems
Diego Medvedofsky, Francesco Maffessanti, Lynn Weinert, David M. Tehrani, Akhil Narang, Karima Addetia, Anuj Mediratta, Stephanie A. Besser, Elad Maor, Amit R. Patel, Kirk T. Spencer, Victor Mor-Avi, Roberto M. Lang
JACC-CARDIOVASCULAR IMAGING
(2018)
Article
Cardiac & Cardiovascular Systems
Diego Medvedofsky, Victor Mor-Avi, Mihaela Amzulescu, Covadonga Fernandez-Golfin, Rocio Hinojar, Mark J. Monaghan, Kyoko Otani, Joseph Reiken, Masaaki Takeuchi, Wendy Tsang, Jean-Louis Vanoverschelde, Mathivathana Indrajith, Lynn Weinert, Jose Luis Zamorano, Roberto M. Lang
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2018)
Article
Cardiac & Cardiovascular Systems
Teruhiko Imamura, Sirtaz Adatya, Ben Chung, Ann Nguyen, Daniel Rodgers, Gabriel Sayer, Nitasha Sarswat, Gene Kim, Jayant Raikhelkar, Takeyoshi Ota, Tae Song, Colleen Juricek, Diego Medvedofsky, Valluvan Jeevanandam, Roberto Lang, Jerry D. Estep, Daniel Burkhoff, Nir Uriel
JOURNAL OF CARDIAC FAILURE
(2018)
Article
Cardiac & Cardiovascular Systems
Diego Medvedofsky, Roberto M. Lang, Eric Kruse, Brittney Guile, Lynn Weinert, Boguslawa Ciszek, Zachary Jacobson, Jacqueline Negron, Valentina Volpato, Aldo Prado, Amit R. Patel, Victor Mor-Avi
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2018)
Article
Cardiac & Cardiovascular Systems
Diego Medvedofsky, Victor Mor-Avi, Gabriel Sayer, Karima Addetia, Eric Kruse, Sirtaz Adatya, Gene Kim, Lynn Weinert, Megan Yamat, Takeyoshi Ota, Valluvan Jeevanandam, Nir Uriel, Roberto M. Lang
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Abra Guo, Hilmi Alnsasra, Hiroto Kitahara, Maria Rodrigo, Diego Medvedofsky
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Hilmi Alnsasra, Brian C. Case, Michael Yang, Toby Rogers, Lowell F. Satler, Federico M. Asch, Ron Waksman, Preetham Kumar, Itsik Ben-Dor, Diego Medvedofsky
Summary: The study found that in patients with PH, RV function indices remained unchanged after pericardiocentesis, while in non-PH patients, RV function improved postpericardiocentesis, potentially guiding management of PH patients with large pericardial effusion.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2021)
Article
Cardiac & Cardiovascular Systems
Diego Medvedofsky, Genevieve Arany-Lao-Kan, Scott McNitt, Roberto M. Lang, Roderick Tung, Scott D. Solomon, Bela Merkely, Ilan Goldenberg, Valentina Kutyifa
Summary: This study aimed to evaluate the predictive value of left ventricular global longitudinal strain (LV GLS) in HF patients with different LVEF. The results showed that higher LV GLS was associated with higher risk of VT/VF, HF/death in patients with LVEF <= 30%, but not in patients with LVEF > 30%.
Article
Cardiac & Cardiovascular Systems
Farnaz Namazi, Victoria Delgado, Stephan Mithorini Pio, Nina Ajmone Marsan, Federico M. Asch, Diego Medvedofsky, Neil J. Weissman, Zhipeng Zhou, Bjorn Redfors, JoAnn Lindenfeld, William T. Abraham, Michael J. Mack, Gregg W. Stone, Jeroen J. Bax
Summary: In patients with heart failure and severe secondary MR, a large anteroposterior mitral annular diameter and greater EROA were the strongest echocardiographic predictors of HF hospitalization and death in patients treated with GDMT alone and with the MitraClip.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Anuj Mediratta, Karima Addetia, Diego Medvedofsky, Robert J. Schneider, Eric Kruse, Atman P. Shah, Sandeep Nathan, Jonathan D. Paul, John E. Blair, Takeyoshi Ota, Husam H. Balkhy, Amit R. Patel, Victor Mor-Avi, Roberto M. Lang
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2017)
Article
Cardiac & Cardiovascular Systems
Diego Medvedofsky, Kalie Kebed, Luke Laffin, Jeremy Stone, Karima Addetia, Roberto M. Lang, Victor Mor-Avi
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2017)