Inhibiting and Remodeling Toxic Amyloid-Beta Oligomer Formation Using a Computationally Designed Drug Molecule That Targets Alzheimer’s Disease

1,2,3,4,6-penta- O -galloyl-β- d -glucopyranose binds to the N-terminal metal binding region to inhibit amyloid β -protein oligomer and fibril formation

(2017) Natália E.C. de Almeida et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Amyloid-β(1–42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity

(2016) Sha Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-Protein Assembly and Alzheimer’s Disease: Dodecamers of Aβ42, but Not of Aβ40, Seed Fibril Formation

(2016) Nicholas J. Economou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking

(2015) Christian A. Lang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibiting amyloid β-protein assembly: Size-activity relationships among grape seed-derived polyphenols

(2015) Eric Y. Hayden et al.   JOURNAL OF NEUROCHEMISTRY

Stabilization of Nontoxic A -Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease

(2015) T. M. Ryan et al.   JOURNAL OF NEUROSCIENCE

Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03

(2015) Xueyun Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity?

(2015) Xueyun Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

MRZ-99030 – A novel modulator of Aβ aggregation: II – Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice

(2015) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

(2014) Tomohiro Umeda et al.   ACTA NEUROPATHOLOGICA

A Cyclic KLVFF-Derived Peptide Aggregation Inhibitor Induces the Formation of Less-Toxic Off-Pathway Amyloid-β Oligomers

(2014) Tadamasa Arai et al.   CHEMBIOCHEM

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

(2014) Arun K. Ghosh et al.   CHEMICAL SOCIETY REVIEWS

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

(2014) Nicholas J. Izzo et al.   PLoS One

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

(2014) Nicholas J. Izzo et al.   PLoS One

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

(2013) Sanghyun Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion Mobility Spectrometry Reveals the Mechanism of Amyloid Formation of Aβ(25–35) and Its Modulation by Inhibitors at the Molecular Level: Epigallocatechin Gallate and Scyllo-inositol

(2013) Christian Bleiholder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Z-Phe-Ala-diazomethylketone (PADK) Disrupts and Remodels Early Oligomer States of the Alzheimer Disease Aβ42 Protein

(2012) Xueyun Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Amyloid Formation

(2012) Torleif Härd et al.   JOURNAL OF MOLECULAR BIOLOGY

Naphthoquinone-tyrptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model

(2012) R. Scherzer-Attali et al.   NEUROBIOLOGY OF DISEASE

Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability

(2011) Karen E. Marshall et al.   BIOCHEMISTRY

Development of a Proteolytically Stable Retro-Inverso Peptide Inhibitor of β-Amyloid Oligomerization as a Potential Novel Treatment for Alzheimer’s Disease

(2010) Mark Taylor et al.   BIOCHEMISTRY

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Peptide Hairpin Inhibitor of Amyloid β-Protein Oligomerization and Fibrillogenesis

(2009) Ghiam Yamin et al.   BIOCHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

 -Amyloid Monomers Are Neuroprotective

(2009) M. L. Giuffrida et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Factors associated with resistance to dementia despite high Alzheimer disease pathology

(2009) D. Erten-Lyons et al.   NEUROLOGY

Clioquinol and other hydroxyquinoline derivatives inhibit Aβ(1–42) oligomer assembly

(2009) Harry LeVine et al.   NEUROSCIENCE LETTERS