期刊
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
卷 27, 期 10, 页码 2623-2626出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jstrokecerebrovasdis.2018.05.037
关键词
Microinfarcts; small vessel disease; cerebral amyloid; angiopathy; double inversion recovery; Ibal; cerebrovascular disease; dementia; premortem MRI; histopathology
资金
- JSPS KAKENHI [18K15446]
- Grants-in-Aid for Scientific Research [18K15446] Funding Source: KAKEN
An 85-year-old woman diagnosed with amyotrophic lateral sclerosis died of pneumonia and was autopsied. Magnetic resonance imaging (MRI) performed 16 days before death revealed an intracortical high-intensity lesion in her right temporal cortex on three-dimensional (3D)-double inversion recovery (DIR) and 3D-fluid-attenuated inversion recovery (FLAIR) images. Histopathological examination indicated a cortical microinfarct (CMI) juxtaposed to cerebral amyloid angiopathy. Recently, in vivo detection of CMIs using 3D-DIR and 3D-FLAIR on 3-tesla MRI has been reported, and postmortem MRI study confirmed the presence of CMIs. This is the first case study to compare CMI findings detected upon premortem MRI to the CMI itself discovered upon postmortem neuropathological examination.
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