Article
Chemistry, Analytical
Yan Huang, Ziteng Han, Xia Zhou, Jiaxin Li, Xiangling Gu, Zhongfang Li, Wei Sun, Xueliang Niu
Summary: A facile and novel electrochemical sensing platform using a MoS2 nanoflowers-3D graphene aerogel nanocomposite as a signal amplified material is reported for the determination of quercetin. The method shows high sensitivity and reliability, and is suitable for quercetin determination in tablets and urine samples.
Article
Chemistry, Analytical
Jiasheng Wang, Decheng Zhang, Keke Xu, Ni Hui, Dongwei Wang
Summary: A dual-mode electrochemical aptasensor based on NG/PPy nanocomposite was developed for the determination of acetamiprid. The NG/PPy hybrid exhibited excellent electrocatalytic activity for nitrite oxidation. By coupling acetamiprid aptamers with the NG/PPy hybrid, a highly sensitive dual-mode biosensor for acetamiprid was easily constructed, enabling the measurement of acetamiprid concentration.
Article
Chemistry, Analytical
Andreea-Roxana Niculae, Raluca-Ioana Stefan-van Staden, Jacobus Frederick van Staden, Ramona Georgescu State
Summary: Two sensors based on sulfur-doped graphene were proposed for the determination of R-limonene in beverages. The sensors showed high detection and quantification limits, and accurate determination of R-limonene in a concentration range. They also exhibited good sensitivity and stability.
Article
Engineering, Environmental
Yu-Jen Shih, Yu-Qiao Su, Wei-Hsiang Chen, Sheng-Kai Lin, Yi-Chun He, Chin-Pao Huang
Summary: Electrochemical oxidation of anti-diabetic metformin (MTF) drug was studied on glassy carbon electrode (GCE) prepared by electroplating of copper nanoparticles (Cu NPs) on reduced graphene oxide (rGO). Results demonstrated that the crystallite size and dispersity of Cu NPs on rGO sheets controlled the redox characteristics of CuxrGO1-x. The Cu(II)/Cu(I) redox current, attributed to the complexation of biguanide Cu(II)-MTF, was observed at specific anodic potentials as a function of MTF concentration. The electrode exhibited excellent reproducibility, selectivity, and recovery in phosphate buffer solution and pH 12, with a linear relationship between anodic current and MTF concentration in the range of 2 to 70 μM.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Food Science & Technology
Venkatesh S. Manikandan, Emmanuel Boateng, Sharmila Durairaj, Aicheng Chen
Summary: Vanillin, a compound abundant in natural vanilla, is a powerful antioxidant and antimicrobial agent widely used in various industries. This study investigates the use of a selective and sensitive electrochemical sensor for the detection of vanillin, which exhibits excellent sensitivity, selectivity, and reproducibility.
Article
Chemistry, Multidisciplinary
Nguyen Quang Man, Nguyen Thi Thanh Tu, Nguyen Thi Vuong Hoan, Ho Xuan Anh Vu, Le Lam Son, Nguyen Duc Vu Quyen, Dao Ngoc Nhiem, Nguyen Hai Phong, Vo Thang Nguyen, Tran Ngoc Tuyen, Dinh Quang Khieu
Summary: A nickel-ferrite/reduced-graphene-oxide composite was synthesized and characterized. The composite material has a large surface area and consists of dispersed nickel-ferrite nanoparticles over reduced-graphene-oxide layers. It exhibits high magnetization saturation and was used to manufacture an electrochemical sensor for clenbuterol detection. The proposed method showed good sensitivity, reproducibility, and accuracy, and was successfully applied to detect clenbuterol in pig urine samples.
JOURNAL OF NANOPARTICLE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
N. Sebastian, W. -C. Yu, D. Balram, Q. Chen, A. Shiue, M. T. Noman, N. Amor
Summary: In this study, a novel ternary nanocomposite a-Fe2O3/C-Fe-gC3N4 with outstanding electrocatalytic activity was reported for the accurate detection of melatonin at nanometer level. The synthesized nanocomposite exhibited ultra-low detection limit, excellent selectivity, stability, and reproducibility, and its practical feasibility was validated in tart cherry, human urine, and melatonin tablets.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Analytical
Archana Chaudhary, Mohd Quasim Khan, Rais Ahmad Khan, Ali Alsalme, Khursheed Ahmad, Haekyoung Kim
Summary: This study successfully synthesized CeO2 nanoparticles through a facile method and applied them for the modification of an electrode for hydroquinone detection. The modified CeO2/GCE electrode exhibited good detection limit, sensitivity, and stability, as well as good selectivity and repeatability for the determination of hydroquinone.
Article
Chemistry, Analytical
Chunming He, Ru Yan, Xiang Gao, Qingwang Xue, Huaisheng Wang
Summary: A non-enzymatic electrochemical sensor based on bimetallic Cu-Co metal-organic gel (MOG) modified glassy carbon electrode (GCE) was developed for highly sensitive malathion detection. The PA-Cu-Co/GCE sensor exhibited excellent sensitivity and selectivity due to the large surface area and superior conductivity of the phytic acid-based Cu-Co bimetallic MOG, as well as the good affinity between Cu element and malathion. Under optimized conditions, the sensor showed good stability and detection performance, with a wide linear range and low detection limit.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Selvarasu Maheshwaran, Muthumariappan Akilarasan, Tse-Wei Chen, Shen-Ming Chen, Elayappan Tamilalagan, Ting-Yu Jiang, Eman A. Alabdullkarem, Mustafa Soylak
Summary: Rare metastable GO warped tetragonal phase t-lanthanum vanadate nanocomposites (GO@LaVO4-NCs) were reported for the sensitive electrochemical detection of antifungal drug Clioquinol (CQ). The hydrothermal synthesis method was used to prepare GO@LaVO4-NCs, which exhibited excellent electrochemical performance in detecting CQ with high sensitivity and low detection limit. Detection of CQ in biological media using GO@LaVO4-NCs/GCE showed promising recoveries.
Article
Chemistry, Analytical
Tayebeh Ghiasi, Shahin Ahmadi, Elahe Ahmadi, Mohamad Reza Talei Bavil Olyai, Zahra Khodadadi
Summary: A new electrochemical sensor for diazinon determination was developed based on graphene quantum dots, chitosan, and nickel molybdate nanocomposites, showing good sensitivity and selectivity. The sensor demonstrated two linear ranges and a low detection limit under optimized conditions.
MICROCHEMICAL JOURNAL
(2021)
Article
Engineering, Multidisciplinary
Yao Chen, Weibo Dai, Shuying Zhou, Xi Liu, Wenying Chen, Yucheng Zheng, Xiaoyi Chen, Geqin Sun
Summary: This study developed an electrochemical sensor for the determination of sertraline hydrochloride (SH) using carboxylated graphene oxide-modified glassy carbon electrodes and silver vanadate nanoparticles (AgVO3/c-GO/GCE). The modified electrode, made of AgVO3/c-GO nanocomposite, showed a 3D hybrid matrix with a precise surface area and increased porosity. The sensor demonstrated selective and sensitive SH sensing with a wide linear response range and accurate determination in pharmaceutical tablets.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Yu Yan, Si Zeng, Fang Xu, Yongmei Hu, Haiping Huang
Summary: In this study, FeNi alloy nanoparticles and reduced graphene oxide (rGO) were compounded to obtain FeNi/rGO nanocomposites by an ultrasonic method. The FeNi/rGO nanocomposites exhibited excellent electrocatalysis for acetaminophen determination, thanks to the catalytic activity of FeNi alloy nanoparticles and the synergy between the high specific surface area and conductivity of rGO.
ANALYTICAL LETTERS
(2023)
Article
Engineering, Multidisciplinary
Noel Nesakumar, Indhu Suresh, Gautham B. Jegadeesan, John Bosco Balaguru Rayappan, Arockia Jayalatha Kulandaiswamy
Summary: In this study, a modified Glassy Carbon Electrode (GCE) was used to detect ultra-low levels of profenofos in water. The developed sensor showed a wide linear range, low detection limit, and good stability, making it suitable for real-time water quality testing.
Article
Multidisciplinary Sciences
Balu Mahendran Gunasekaran, Ganesh Kumar Rajendran, John Bosco Balaguru Rayappan, Jothi Ramalingam Sivanesan, Noel Nesakumar, Ajit Walter Paulraj
Summary: Graphene oxide (GO) was synthesized using a standard chemical method, while reduced graphene oxide (rGO) was prepared using a greener method involving a floral extract as a green reducer. The 4-aminopyridine (4AP) molecule was covalently grafted on the rGO layer. The 4AP-rGO/SPCE nanocomposites showed potential for electrochemical lead ion sensors with high sensitivity and low detection limit.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Akhtar Atiya, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Dalia Almaghaslah, Anwar L. Bilgrami, Waleed Al Abdulmonem, Nasser M. Alorfi, Debarati DasGupta, Ghulam Md Ashraf, Anas Shamsi, Moyad Shahwan
Summary: Cardiovascular diseases are a leading cause of premature adult death. This study evaluates the inhibitory potential of lisinopril on MARK4, a protein involved in regulating cardiomyocyte contractility. Molecular docking and molecular dynamics simulations demonstrate the stable binding and therapeutic role of lisinopril in managing cardiovascular diseases.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Rashid Waseem, Anas Shamsi, Tanzeel Khan, Ayesha Anwer, Mohammad Shahid, Syed Naqui Kazim, Md. Imtaiyaz Hassan, Asimul Islam
Summary: This study monitored the formation of advanced glycation end products (AGEs) and aggregates of irisin, a clinically important protein, induced by methyl-glyoxal (MG). The results suggest that glycation of irisin leads to aggregation, and high levels of MG may contribute to reduced irisin levels in pathological conditions such as obesity, diabetes, and neurological disorders.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Nojood Altwaijry, Moneera Saud Al-Bagmi, Nouf Omar Alafaleq, Majed S. Alokail, Moyad Shahwan, Anas Shamsi
Summary: Proto-oncogene tyrosine-protein kinase ROS (ROS1) is a member of a receptor family that affects epithelial cell differentiation and is highly expressed in various tumors. This study identified two potential inhibitors of ROS1 through virtual screening of phytochemicals. The findings highlight the role of ROS1 in multiple physiological processes and suggest the potential use of phytochemicals for therapeutic development targeting ROS1-associated non-small cell lung cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Nutrition & Dietetics
Taghreed A. A. Majrashi, Saad Ali Alshehri, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Mohammad Alrouji, Asma M. M. Alshahrani, Anas Shamsi, Akhtar Atiya
Summary: Cancer is a difficult-to-treat disease with a high reoccurrence rate that has a significant impact on global health and lives. Despite the availability of various drugs on the market against cancer, challenges of chemoresistance and side effects remain. Therefore, using complementary and additional medicines from natural sources is considered the best strategy to overcome these issues.
Article
Neurosciences
Mohammed Alrouji, Ali Manouchehrinia, Jehan Aram, Abdulmajeed Alotaibi, Sharif Alhajlah, Yasir Almuhanna, Othman Alomeir, Anas Shamsi, Bruno Gran, Cris S. Constantinescu
Summary: This study quantitatively examines the effect of cigarette smoking on serum uric acid levels in people with multiple sclerosis (pwMS) before and after smoking cessation. It also investigates the possible correlation between uric acid levels and disability progression and disease severity. The results show that smokers with pwMS have significantly lower serum uric acid levels compared to non-smokers, which can be restored after smoking cessation. However, there is no correlation between serum uric acid levels and disability or disease severity in current smokers with pwMS.
Article
Chemistry, Multidisciplinary
Akhtar Atiya, Debarati Das Gupta, Abdulrhman Alsayari, Mohammed Alrouji, Abdulmajeed Alotaibi, Sharaf E. Sharaf, Waleed Al Abdulmonem, Nasser M. Alorfi, K. M. Abdullah, Anas Shamsi
Summary: Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) have a common pathophysiology, and discovering the action mechanism of anti-diabetic drugs in AD and related pathologies is in high demand. In this study, we used structure-based virtual screening to identify potential MARK4 inhibitors among FDA-approved anti-diabetic drugs. We found that linagliptin and empagliflozin have strong affinity and specificity towards the binding pocket of MARK4 and showed significant inhibition of MARK4 kinase activity.
Article
Multidisciplinary Sciences
Hina Anjum, Ghulamuddin Sofi, Moyad Shahwan, Mohd Shahnawaz Khan, Anas Shamsi, Shariq Shamsi
Summary: Panwad, Sarshaf, and Kunjad have been traditionally used for treating ringworm infection and have shown promising results. A cream containing extracts of these plants was developed and evaluated for better efficacy. The final batches of the cream demonstrated significant antifungal activity in vitro and in vivo. It can be concluded that this cream can be an alternative topical agent for treating dermatophytosis.
Article
Chemistry, Physical
Mohd Shahnawaz Khan, Moyad Shahwan, Saleha Anwar, Dharmendra Kumar Yadav, Anas Shamsi
Summary: This study comprehensively explored the interaction between thymol and transferrin (Tf) and found that thymol binds to Tf with good affinity and stability, providing a platform for the application of thymol derivatives in Alzheimer's disease therapeutics.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Neurosciences
Anas Shamsi, Moyad Shahwan, Debarati Das Gupta, K. M. Abdullah, Mohd Shahnawaz Khan
Summary: A switch from chemical molecules to natural products is currently taking place, with increasing exploration of their therapeutic potential in disease management. This study investigates the binding mechanism between caffeic acid (CA) and human transferrin (Htf) and confirms the stability of the Htf-CA complex and minimal impact on Htf's overall structure. Experimental observations support the in silico docking results.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Nutrition & Dietetics
Md. Khabeer Azhar, Saleha Anwar, Gulam Mustafa Hasan, Anas Shamsi, Asimul Islam, Suhel Parvez, Md. Imtaiyaz Hassan
Summary: Rosmarinic acid (RA) is an abundant phytochemical with anti-inflammatory and antioxidant properties, playing significant roles in cancer, neuroprotection, and diabetes.
Review
Chemistry, Multidisciplinary
Gulam Mustafa Hasan, Md. Imtaiyaz Hassan, Sukhwinder Singh Sohal, Anas Shamsi, Manzar Alam
Summary: Non-small cell lung carcinoma (NSCLC) is the most common cancer globally, and phytochemicals and small molecule inhibitors have been found to effectively prevent NSCLC and other types of cancers by regulating signaling pathways. This review focuses on the bioactive compounds and small-molecule inhibitors, such as EGCG, Perifosine, ABT-737, Thymoquinine, Quercetin, Venetoclax, Gefitinib, and Genistein, and discusses their potential in NSCLC therapy.
Article
Chemistry, Physical
Sarfraz Ahmed, Parvez Khan, Iram Irfan, Saleha Anwar, Anas Shamsi, Bhoomika Arora, Manzar Alam, Imtaiyaz Hassan, Mohammad Abid
Summary: This study synthesized vanillin-triazole derivatives and found that compounds 5a, 5g, 5h, and 5j showed significant inhibitory activity on MARK4 enzyme. Molecular docking and MD simulation studies confirmed their strong binding with MARK4 and their ability to suppress cell proliferation, migration, and induce apoptosis in hepatocellular carcinoma cells. These findings suggest that vanillin-triazole compounds, particularly compound 5g, could be potential candidates for developing MARK4-based anticancer therapies.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Moyad Shahwan, Saleha Anwar, Dharmendra Kumar Yadav, Mohd Shahnawaz Khan, Anas Shamsi
Summary: Neuroinflammation is important in the pathogenesis of Alzheimer's disease and other neurodegenerative disorders. Currently, there are no effective drugs for treating these diseases. Therefore, there is increasing interest in using anti-inflammatory compounds and antioxidants to target neuroinflammation. This study investigates the binding and dynamics of the human transferrin (HTF)-apigenin complex, and suggests that apigenin has a neuroprotective effect by binding to HTF and maintaining a stable conformation.
Article
Chemistry, Multidisciplinary
Mohd Shahnawaz Khan, Hamza Ahmad Mohammad, Moyad Shahwan, Dharmendra Kumar Yadav, Saleha Anwar, Anas Shamsi
Summary: This study identifies Dutasteride and Spironolactone as potential PDE5 inhibitors for treating conditions associated with PDE5 dysfunction, using virtual screening and molecular dynamics simulations.
Article
Biochemistry & Molecular Biology
Bandar Alharbi, Lina I. Alnajjar, Hassan H. Alhassan, Shama Khan, Talha Jawaid, Bekhzod S. Abdullaev, Nawaf Alshammari, Dharmendra Kumar Yadav, Mohd Adnan, Anas Shamsi
Summary: Mitogen-activated protein kinase 7 (MAPK7) plays a vital role in various cellular processes and its elevated expression has been connected to aggressive tumors. This study used virtual screening to identify potential MAPK7 inhibitors from natural products and identified two compounds, ZINC12296700 and ZINC02123081, with strong binding affinity and drug-like properties. Molecular dynamics simulations confirmed the stability of the docked complexes, and molecular mechanics calculations indicated considerable binding affinities. These compounds hold promise as lead candidates for developing novel MAPK7 inhibitors.
JOURNAL OF MOLECULAR RECOGNITION
(2023)