Article
Cell Biology
Zi-Ning Lei, Qiu-Xu Teng, Pranav Gupta, Wei Zhang, Silpa Narayanan, Dong-Hua Yang, John N. D. Wurpel, Ying-Fang Fan, Zhe-Sheng Chen
Summary: The study demonstrates that CBZ can inhibit the ABCG2 transporter and resensitize drug-resistant cancer cells to specific drugs, showing promising reversal effects in an in vivo xenograft model.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Villafranca-Magdalena, Carina Masferrer-Ferragutcasas, Carlos Lopez-Gil, Eva Coll-de la Rubia, Marta Rebull, Genis Parra, Angel Garcia, Armando Reques, Silvia Cabrera, Eva Colas, Antonio Gil-Moreno, Cristian P. Moiola
Summary: Endometrial cancer is the second most common gynecological cancer worldwide, and limited treatment options are available for high-risk or recurrent cases. This study proposes patient-derived xenograft models to closely mimic the disease and demonstrates their ability to recapitulate histological and molecular features. Thorough characterization of preclinical models is crucial for improving the success rate of personalized medicine drug-screening assays.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Iman Hassani, Benjamin Anbiah, Peyton Kuhlers, Nicole L. Habbit, Bulbul Ahmed, Martin J. Heslin, James A. Mobley, Michael W. Greene, Elizabeth A. Lipke
Summary: The development of an in vitro tissue-engineered CRC model using PDX cells provides a cost-effective and high-throughput alternative to the in vivo model. This model demonstrates high batch-to-batch consistency and strong correlation with the originating PDX tumors, making it a valuable tool for studying disease progression and tumorigenic mechanisms.
Review
Cell Biology
Xingyu Chen, Yongyun Li, Tengteng Yao, Renbing Jia
Summary: Zebrafish are widely used in cancer research due to their low cost, quick establishment, and small sample size required. The zebrafish patient-derived xenograft (zPDX) models show promising evidence for short-term clinical treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei Jiang, Xueyan Ouyang, Chunjuan Jiang, Lina Yin, Qianlan Yao, Xuan Pei, Zhaodong Ji, Ming Li, Shaoli Song, Wentao Yang, Shenglin Huang, Huijuan Yang, Boer Shan
Summary: Peritoneal implantation and lymph node metastasis have different driving mechanisms in ovarian cancer. This study focused on elucidating the underlying mechanism of lymph node metastasis and identified NOTCH1 mutation as a driver of lymph node metastasis in ovarian cancer. The findings suggest that treating ovarian cancer lymph node metastasis with NOTCH inhibitors may be a promising therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Siriwan Sakarin, Nuntana Meesiripan, Suleeporn Sangrajrang, Nuntakan Suwanpidokkul, Piyaporn Prayakprom, Chatchada Bodhibukkana, Vipada Khaowroongrueng, Kankanit Suriyachan, Somchai Thanasittichai, Attasit Srisubat, Pattamaporn Surawongsin, Kasem Rattanapinyopituk
Summary: This study evaluated the antitumor effects of cannabinoids in a pancreatic cancer xenografted mouse model. The results showed that cannabinoids can inhibit the growth of pancreatic cancer by inducing apoptosis and inhibiting tumor cell proliferation.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Oncology
Binhua Pan, Xuyong Wei, Xiao Xu
Summary: Animal models are essential for evaluating human cancers and investigating anticancer drugs and prevention. In hepatopancreatobiliary cancer research, mouse models are widely used. While current CDX models have limitations, the emerging PDX model shows promise for precision cancer medicine in hepatopancreatobiliary cancer research.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Patricia Letrado, Holly Mole, Maria Montoya, Irene Palacios, Jorge Barriuso, Adam Hurlstone, Roberto Diez-Martinez, Julen Oyarzabal
Summary: This study provides systematic guidelines for drug screening in zebrafish embryo xenograft cancer models, aiming to facilitate the adoption of this versatile model in cancer research community.
Article
Oncology
Qiusheng Shan, Kiyofumi Takabatake, Haruka Omori, Hotaka Kawai, May Wathone Oo, Shintaro Sukegawa, Masae Fujii, Yasunori Inada, Sho Sano, Keisuke Nakano, Hitoshi Nagatsuka
Summary: This study evaluated the effects of different stromal cells on bone invasion and osteoclast activation in oral squamous cell carcinoma (OSCC). The results showed that gingival and periodontal ligament tissue-derived stromal cells promoted bone invasion, while human dermal fibroblasts inhibited bone resorption. These findings suggest a potential regulatory mechanism for bone invasion in OSCC.
Article
Plant Sciences
Ji Min Shin, Eunbi Lim, Yoon Shin Cho, Chu Won Nho
Summary: PEITC may have the potential to prevent or delay colorectal cancer growth by inhibiting the properties of CSCs, especially clonogenicity and the expression of pluripotent factors. RNA-sequencing results demonstrated that PEITC pre-treatment significantly suppressed genes related to inflammatory, immune responses, and chemokine-related signaling.
Review
Medicine, Research & Experimental
Shahrokh Abdolahi, Zeinab Ghazvinian, Samad Muhammadnejad, Mahshid Saleh, Hamid Asadzadeh Aghdaei, Kaveh Baghaei
Summary: The establishment and application of patient-derived xenograft models have played a significant role in cancer treatment. These models accurately represent the biological characteristics of different cancers and have great value in the development of anti-cancer drugs and personalized medicine.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Justyna Stefanowicz-Hajduk, Anna Hering, Magdalena Gucwa, Monika Czerwinska, J. Renata Ochocka
Summary: Steroidal saponins, such as yamogenin, exhibit cytotoxic and apoptotic effects on ovarian cancer cells. The compound induces cell death through both the extrinsic and mitochondrial-intrinsic pathways. These findings suggest that yamogenin may serve as a potential therapeutic agent for ovarian cancer.
Article
Biochemistry & Molecular Biology
Jessica Hoarau-Vechot, Morgane Blot-Dupin, Lea Pauly, Cyril Touboul, Shahin Rafii, Arash Rafii, Jennifer Pasquier
Summary: Ovarian cancer is a heterogeneous disease characterized by late diagnosis and abdominal metastases. In this study, multicellular spheroids of endothelial cells and ovarian cancer cells were developed to mimic in vivo conditions. The Akt and Notch3/Jagged1 pathways were found to play a role in angiosphere formation and peritoneal invasion. Additionally, FGF2, Pentraxin 3 (PTX3), PD-ECGF, and TIMP-1 were identified as important factors in angiosphere organization. The study also confirmed the significance of Notch3/Jagged1 in OCC-EC crosstalk and peritoneal invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Christen A. Khella, Gaurav A. Mehta, Rushabh N. Mehta, Michael L. Gatza
Summary: The molecular heterogeneity of cancer leads to varied disease progression and clinical outcomes. Advances in high-throughput proteogenomic profiling have identified new oncogenic drivers and biomarkers for predicting drug sensitivity, contributing to the development of more effective treatment strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ying Gao, Sarah L. Miles, Piyali Dasgupta, Gary O. Rankin, Stephen Cutler, Yi Charlie Chen
Summary: Trichodermin effectively inhibits the proliferation of ovarian cancer cells by inducing G0/G1 cell cycle arrest, mainly targeting c-Myc. Its anti-tumor activity was also validated in animal experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Adam James Ferrari, Ronny Drapkin, Rajan Gogna
Summary: Cell competition allows tumor cells to outcompete adjacent less fit cells. Recent studies have identified molecular fitness fingerprint, oncogenic pathways, and cell junction stability as key factors in determining the outcome of cell competition. Understanding these features may open up possibilities for new diagnostic and therapeutic approaches in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Apoorva Tangri, Kinzie Lighty, Jagadish Loganathan, Fahmi Mesmar, Ram Podicheti, Chi Zhang, Marcin Iwanicki, Ronny Drapkin, Harikrishna Nakshatri, Sumegha Mitra
Summary: The study found that the overexpression of neuronal deubiquitinating enzyme UCHL1 in HGSOC promotes tumor growth by maintaining protein homeostasis. Inhibition of UCHL1 can reduce tumor cell proliferation and invasion, as well as decrease the metastatic growth of ovarian cancer xenografts. This indicates that UCHL1 plays a crucial role in HGSOC progression through the regulation of protein homeostasis.
MOLECULAR CANCER RESEARCH
(2021)
Review
Obstetrics & Gynecology
Jose Mauro Madi, Machline Paim Paganella, Isnard Elman Litvin, Mauricio Viggiano, Eliana Marcia Wendland, Kevin M. Elias, Neil S. Horowitz, Antonio Braga, Ross S. Berkowitz
Summary: The study assessed perinatal outcomes of first pregnancy after remission from gestational trophoblastic neoplasia and found that chemotherapy did not increase the chance of unfavorable perinatal outcomes, except for a higher occurrence of spontaneous abortion in pregnancies occurring <= 6 months after chemotherapy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Oncology
Katie Lichter, Chidinma Anakwenze Akinfenwa, Emily MacDuffie, Rohini Bhatia, Christina Small, Jennifer Croke, William Small, Junzo Chino, Daniel Petereit, Surbhi Grover
Summary: Brachytherapy is an essential component of cervical cancer treatment, but its global utilization is low and there are disparities in access. This review explores the current utilization practices and efforts to address barriers to implementation, emphasizing the need to expand access to brachytherapy for women in need worldwide.
EXPERT REVIEW OF ANTICANCER THERAPY
(2022)
Review
Oncology
Rohini K. Bhatia, Katie E. Lichter, Lavanya Gurram, Emily MacDuffie, Dorothy Lombe, Gustavo R. Sarria, Surbhi Grover
Summary: The COVID-19 pandemic has had a global impact on the use of radiation therapy for gynecologic cancers. This review explores the guidelines for using radiation therapy during the pandemic and discusses how different countries have adapted to these guidelines based on their individual resources, government restrictions, and societal norms. The article also emphasizes the importance of utilizing various fractionation schemes and technologies when resources are limited.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Oncology
Rohini Bhatia, Katie E. Lichter, Lavanya Gurram, Emily MacDuffie, Dorothy Lombe, Gustavo R. Sarria, Surbhi Grover
Summary: Gynecologic malignancies pose a disproportionate burden in low- and middle-income countries, and radiation therapy plays a crucial role in their treatment. Understanding the disease epidemiology and availability of radiation therapy infrastructure is vital to improve patient care. Different geographic regions face unique challenges, including limited access to radiation equipment, geographic barriers, and lack of specialized training. Successful examples of telemedicine and cross-cultural partnerships have helped enhance access to adequate and appropriate treatment for gynecologic malignancies.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Kristin L. M. Boylan, Ashley Petersen, Timothy K. Starr, Xuan Pu, Melissa A. Geller, Robert C. Bast, Karen H. Lu, Ugo Cavallaro, Denise C. Connolly, Kevin M. Elias, Daniel W. Cramer, Tanja Pejovic, Amy P. N. Skubitz
Summary: This study aimed to develop a multiprotein classifier for detecting early stages of ovarian cancer by analyzing the levels of 92 cancer-related proteins in the blood. The combination of four proteins successfully detected over 90% of women with ovarian cancer and improved sensitivity and specificity compared to using CA125 alone. These findings suggest potential new biomarkers for early stage ovarian cancer detection.
Review
Oncology
Kristine N. Kim, Michael LaRiviere, Emily Macduffie, Caitlin A. White, Mary M. Jordan-Luft, Eleanor Anderson, Matthew Ziegler, Jacob A. Radcliff, Joshua Jones
Summary: The purpose of this review is to update our knowledge on the usage of glucocorticoids in adult cancer patients. Glucocorticoids can be highly effective in improving outcomes and quality of life in patients with cancer, mainly used for managing disease manifestations, symptoms, and complications of cancer treatment. The lowest effective dose should be used and treatment duration should be minimized. Side effects can be minimized by careful monitoring, continued assessment of benefits versus harms, and preventative measures.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Luz Angela Correa Ramirez, Izildinha Maesta, Maria Ines Bianconi, Gustavo Jankilevich, Silvina Otero, Carlos Raul Villegas Mejia, Rafael Cortes-Charry, Kevin M. Elias, Neil S. Horowitz, Michael Seckl, Ross S. Berkowitz
Summary: This study assesses the clinical presentation, treatment outcomes, and factors associated with chemoresistance in low-risk postmolar gestation trophoblastic neoplasia (GTN) treated with first-line single-agent chemotherapy in three South American centers. The overall rate of complete response to first-line chemotherapy was 80%, and a FIGO risk score of 5 or 6 was associated with the development of resistance to first-line single-agent chemotherapy.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2022)
Review
Oncology
Esha Madan, Antonio M. Palma, Vignesh Vudatha, Jose G. Trevino, Kedar Nath Natarajan, Robert A. Winn, Kyoung Jae Won, Trevor A. Graham, Ronny Drapkin, Stuart A. C. McDonald, Paul B. Fisher, Rajan Gogna
Summary: The majority of human cancers evolve through the accumulation of somatic mutations and clonal selection. The mechanisms governing clonal dynamics and selection during the early stages of tissue transformation are still unclear. Cell competition, known as "survival of the fittest" at the cellular level, can eliminate less fit cells or lead to the uncontrolled expansion of super-fit cancer cells. Recent research has highlighted the role of interclonal competition and cancer microenvironment competition in tumor progression.
Article
Medicine, General & Internal
Kevin M. Elias, Nicholas W. Ng, Kh U. Dam, Ankrish Milne, Emily R. Disler, Alison Gockley, Nicole Holub, Maya L. Seshan, George M. Church, Elizabeth S. Ginsburg, Raymond M. Anchan
Summary: This study demonstrates the potential of induced pluripotent stem cell (iPSC) transplantation for the treatment of premature ovarian insufficiency (POI) in a mouse model, as it successfully reversed the endocrine and reproductive issues caused by POI.
Article
Oncology
Thomas J. Gerton, Allen Green, Marco Campisi, Minyue Chen, Iliana Gjeci, Navin Mahadevan, Catherine A. A. Lee, Ranjan Mishra, Ha V. Vo, Koji Haratani, Ze-Hua Li, Kathleen T. Hasselblatt, Bryanna Testino, Trevor Connor, Christine G. Lian, Kevin M. Elias, Patrick Lizotte, Elena V. Ivanova, David A. Barbie, Daniela M. Dinulescu
Summary: High-grade serous ovarian cancer (HGSOC) is a leading cause of gynecology cancer-related deaths. Utilizing epigenetic modulators can maximize the effectiveness of personalized immuno-oncology treatments. The use of patient-derived tumor ascites in a 3D screening platform has shown that epigenetic priming can enhance immune checkpoint blockade therapies.
Article
Obstetrics & Gynecology
Valdete Aparecida Ribeiro da Silva, Izildinha Maesta, Roberto Antonio de Araujo Costa, Alinede Avila Campos, Antonio Braga, Neil Horowitz, Kevin M. Elias, Ross Berkowitz
Summary: This study examined the relationship between clinical status upon admission and distance traveled in women with gestational trophoblastic disease (GTD). The results showed that patients from areas outside the specialized center were more likely to have higher risk scores for hydatidiform mole and gestational trophoblastic neoplasia at admission. Long distances seemed to hinder access to specialized centers and negatively impact clinical status.
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2023)
Review
Medicine, General & Internal
Antonio Braga, Elaine Balthar, Lais Cristhine Santos Souza, Michelle Samora, Matheus Rech, Jose Mauro Madi, Joffre Amim, Jorge Rezende Filho, Kevin M. Elias, Neil S. Horowitz, Sue Yazaki Sun, Ross S. Berkowitz
Summary: This study evaluated the efficacy of immunotherapy for GTN treatment and presented 4 Brazilian cases. The results showed that immunotherapy was effective for high-risk GTN, with pembrolizumab achieving a high therapeutic response despite prior chemoresistance to multiple lines of treatment.
Article
Oncology
Heng Liu, Jianhuang Lin, Wei Zhou, Renyta Moses, Zhongping Dai, Andrew V. Kossenkov, Ronny Drapkin, Benjamin G. Bitler, Sergey Karakashev, Rugang Zhang
Summary: This study demonstrates that the extent of effector CD8+ T cell infiltration into tumors is influenced by a histone H3 demethylase (KDM5A) in epithelial ovarian cancer. KDM5A inhibits immune cell infiltration and antitumor immune responses by silencing genes involved in antigen processing and presentation. Inhibition of KDM5A restores gene expression in the antigen-presentation pathway and promotes antitumor immune responses mediated by CD8+ T cells.
CANCER IMMUNOLOGY RESEARCH
(2022)