Investigation of potential toxic components based on the identification of Genkwa Flos chemical constituents and their metabolites by high-performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectr

Systematic screening and characterization of multiple constituents in Guizhi Fuling capsule and metabolic profiling of bioactive components in rats using ultra-high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry

(2017) Yu Zhang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Identification and analysis of chemical constituents and rat serum metabolites in Suan-Zao-Ren granule using ultra high performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with multiple data processing approaches

(2017) Yiyang Du et al.   JOURNAL OF SEPARATION SCIENCE

Yuanhuapine-induced intestinal and hepatotoxicity were correlated with disturbance of amino acids, lipids, carbohydrate metabolism and gut microflora function: A rat urine metabonomic study

(2016) Yanyan Chen et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

An optimized method for neurotransmitters and their metabolites analysis in mouse hypothalamus by high performance liquid chromatography–Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry

(2016) Zong-Lin Yang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Metabolic mapping ofSchisandra sphenantheraextract and its active lignans using a metabolomic approach based on ultra high performance liquid chromatography with high-resolution mass spectrometry

(2016) Huizhen Zhang et al.   JOURNAL OF SEPARATION SCIENCE

Quantitative performance of liquid chromatography coupled to Q-Exactive high resolution mass spectrometry (HRMS) for the analysis of tetracyclines in a complex matrix

(2015) Morgan Solliec et al.   ANALYTICA CHIMICA ACTA

The development and validation of a rapid method for the determination of antimicrobial agent residues in milk and meat using ultra performance liquid chromatography coupled to quadrupole – Orbitrap mass spectrometry

(2015) Guntis Cepurnieks et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Pharmacokinetic profile and metabolite identification of yuanhuapine, a bioactive component in Daphne genkwa by ultra-high performance liquid chromatography coupled with tandem mass spectrometry

(2015) Yanyan Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Review article: herbal hepatotoxicity - an update on traditional Chinese medicine preparations

(2014) R. Teschke et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Investigation of the Chemical Changes from Crude and Processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma Herbal Pair Extracts by Using Q Exactive High-Performance Benchtop Quadrupole-Orbitrap LC-MS/MS

(2014) Gang Cao et al.   Evidence-based Complementary and Alternative Medicine

Simultaneous identification, confirmation and quantitation of illegal adulterated antidiabetics in herbal medicines and dietary supplements using high-resolution benchtop quadrupole-Orbitrap mass spectrometry

(2014) Changchuan Guo et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Evaluation of the indicative roles of seven potential biomarkers on hepato-nephrotoxicity induced by Genkwa Flos

(2014) Yu Jiang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Drug-Induced Liver Injury

(2014) Michael D. Leise et al.   MAYO CLINIC PROCEEDINGS

In VitroScreening for Antihepatic Steatosis Active Components within Coptidis Rhizoma Alkaloids Extract Using Liver Cell Extraction with HPLC Analysis and a Free Fatty Acid-Induced Hepatic Steatosis HepG2 Cell Assay

(2013) Hui Fan et al.   Evidence-based Complementary and Alternative Medicine

Rapid identification and comparative analysis of the chemical constituents and metabolites ofPhellodendri amurensiscortex and Zhibai dihuang pill by ultra-performance liquid chromatography with quadrupole TOF-MS

(2013) Huiyu Wang et al.   JOURNAL OF SEPARATION SCIENCE

Plasma pharmacochemistry combined with microdialysis to screen potential bioactive components and their metabolites inAnemarrhena asphodeloidessaponin extract using ultrahigh-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry

(2013) Zhirui Liu et al.   JOURNAL OF SEPARATION SCIENCE

Toxicity of daphnane-type diterpenoids from Genkwa Flos and their pharmacokinetic profile in rat

(2013) Yan-Yan Chen et al.   PHYTOMEDICINE

Drug-Induced Liver Disease

(2012) Timothy J. Davern   Clinics in Liver Disease

Metabonomic Study of Genkwa Flos-induced Hepatotoxicity and Effect of Herb-Processing Procedure on Toxicity

(2012) Lulu Geng et al.   PHYTOTHERAPY RESEARCH

A simple and efficient protocol for large-scale preparation of three flavonoids from the flower of Daphne genkwa by combination of macroporous resin and counter-current chromatography

(2010) Ying-Nan Li et al.   JOURNAL OF SEPARATION SCIENCE