Review
Biochemistry & Molecular Biology
Edgar Ramos-Martinez, Ivan Ramos-Martinez, Ivan Sanchez-Betancourt, Juan Carlos Ramos-Martinez, Sheila Irais Pena-Corona, Jorge Valencia, Renata Saucedo, Ericka Karol Pamela Almeida-Aguirre, Marco Cerbon
Summary: Patients with neurodegenerative diseases have higher levels of galectins compared to healthy individuals, with different galectin expression patterns observed in different disease types.
Article
Genetics & Heredity
Veria Vacchiano, Anna Bartoletti-Stella, Giovanni Rizzo, Patrizia Avoni, Piero Parchi, Fabrizio Salvi, Rocco Liguori, Sabina Capellari
Summary: ALS and AD patients have a higher prevalence of Lewy body disease and parkinsonian features. This study found a higher frequency of Parkinson's disease-causative genes in ALS patients, suggesting their potential role in ALS pathogenesis.
Review
Biochemistry & Molecular Biology
Angelika Krol-Grzymala, Edyta Sienkiewicz-Szlapka, Ewa Fiedorowicz, Dominika Rozmus, Anna Cieslinska, Andrzej Grzybowski
Summary: This review investigates and analyzes the biomarkers for AD, PD, and MS in tears. Through analyzing the recent original studies, the biomarkers present in tears that can be used for the diagnosis and management of these diseases are shown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Zijian Tong, Guodong Chu, Chenmeng Wan, Qiaoyu Wang, Jialing Yang, Zhaoli Meng, Linna Du, Jing Yang, Hongxia Ma
Summary: Mushrooms with edible and medicinal potential have attracted attention due to their diverse biological functions, nutritional value, and delicious taste. Various bioactive substances, including proteins, carbohydrates, phenols, and vitamins, have been identified and purified from mushrooms. Furthermore, molecules derived from mushrooms have shown promise in alleviating the pathological manifestations of Alzheimer's disease (AD), making it important to identify natural products from mushrooms that can modify the progression of AD. This review summarizes recent research on the constituents isolated from mushrooms and their potential in combating AD, as well as the underlying molecular mechanisms involved.
Article
Endocrinology & Metabolism
Hai Duc Nguyen, Byung Pal Yu, Ngoc Hong Minh Hoang, Won Hee Jo, Hae Young Chung, Min-Sun Kim
Summary: PRL is a promising molecule for the treatment of neurodegenerative disorders like Alzheimer's disease and Parkinson's disease, but the mechanisms responsible for its effects are still not fully understood. Modulating PRL functions and targeting immune mechanisms are key strategies for developing preventive or therapeutic approaches.
NEUROENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jin Li, Hongni Yu, Chuan Yang, Tao Ma, Yuan Dai
Summary: This paper provides a comprehensive summary of the neuroprotective effects of Echinacoside (ECH) in the prevention and treatment of neurodegenerative diseases. It highlights the beneficial effects of ECH in protecting mitochondrial function, reducing oxidative stress, inflammation, endoplasmic reticulum stress, and regulating autophagy. The findings suggest that ECH may be an effective and safe substance for combating neurodegenerative diseases in the future.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Yi Wang, Meng-nan Lv, Wei-jiang Zhao
Summary: This review provides an overview of the role of ferroptosis in neurodegenerative diseases and its inhibition for the treatment of these diseases. The paper summarizes the features, mechanisms, and recent advances in therapeutic approaches targeting ferroptosis.
AGEING RESEARCH REVIEWS
(2023)
Review
Chemistry, Medicinal
Amanda Cano, Elena Fonseca, Miren Ettcheto, Elena Sanchez-Lopez, Itziar de Rojas, Silvia Alonso-Lana, Xavier Morato, Eliana B. Souto, Manuel Toledo, Merce Boada, Marta Marquie, Agustin Ruiz
Summary: Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. The molecular processes that trigger epileptic seizures and promote neurotoxic effects are currently focused on the glutamate pathway and influx of calcium ions into neurons. Common molecular links between epilepsy and other neurodegenerative diseases have led to investigation of antiseizure drugs for therapeutic potential in these pathologies.
Article
Environmental Sciences
Eman A. Mohamed, Hebatalla Ahmed, Heba S. Zaky, Amira M. Badr
Summary: This study aimed to investigate the protective effect of boswellic acids (BA) against aluminum-induced Alzheimer's disease, through modulation of the Wnt/beta-catenin pathway. The results showed that BA significantly improved learning and memory impairments induced by aluminum treatment, reduced acetylcholinesterase levels and amyloid-beta expression, suppressed tumor necrosis factor-alpha and interleukin-1 beta expression, inhibited lipid peroxidation, and increased total antioxidants in the brain. BA also modulated the expression of brain-derived neurotrophic factor, pGSK-3 beta (Ser 9), and beta-catenin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Endocrinology & Metabolism
Saleha Alqarni, Mashael Alsebai
Summary: The use of VGF and its derivatives for the diagnosis of PD, ALS, AD remains unclear, so further investigation of the role of VGF in neurodegenerative diseases and pathophysiology is needed to provide new insights.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Sofia Basile, Placido Bramanti, Emanuela Mazzon
Summary: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis, are major medical needs that require novel therapeutic strategies. Inosine, known for its antioxidant properties, shows potential for use in these diseases. Its antioxidant action, ability to raise urate levels and increase ATP availability make it a promising candidate. Inosine appears to be safe and well tolerated, but the formation of kidney stones needs to be monitored. Further studies are needed to explore its effectiveness and safety, as well as its use as a complementary therapy with other approved drugs.
Article
Biochemistry & Molecular Biology
Amanda Cano, Miren Ettcheto, Mireia Bernuz, Raquel Puerta, Ester Esteban de Antonio, Elena Sanchez-Lopez, Eliana B. Souto, Antonio Camins, Merce Marti, Maria Isabel Pividori, Merce Boada, Agustin Ruiz
Summary: Extracellular vesicles are secreted by cells and play important roles in intercellular communication, immune responses, human reproduction, and synaptic plasticity. They have potential as biomarkers for diseases due to their biological relevance and easy accessibility. They can also be used as mirrors of brain diseases as they can cross the blood-brain barrier. This review explores their biogenesis, functions, and potential in clinical practice, as well as their role in major human brain diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Li-Yuan Fan, Jing Yang, Ruo-Yu Liu, Ying Kong, Guang-Yu Guo, Yu-Ming Xu
Summary: In this study, we used single-cell RNA sequencing data to investigate the shared and unique molecular crosstalk among AD, PD, and MS. Key molecules such as HSPB1 and HSPA1A were identified, and a potential therapeutic drug was found.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Fatimah K. Khalaf, Jacob Connolly, Bella Khatib-Shahidi, Abdulsahib Albehadili, Iman Tassavvor, Meghana Ranabothu, Noha Eid, Prabhatchandra Dube, Samer J. Khouri, Deepak Malhotra, Steven T. Haller, David J. Kennedy
Summary: Paraoxonase enzymes are an important redox system that protect cells against oxidative stress. The PON enzymes family, consisting of PON-1, PON-2, and PON-3, play a role in preventing cardiovascular disease and are associated with neurological disorders and neurodegenerative diseases. This review summarizes the evidence on the role of PONs in these diseases and their ability to modify risk factors for neurological disorders, focusing on Alzheimer's disease, Parkinson's disease, and other neurodegenerative and neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Artem A. Venediktov, Olga Yu Bushueva, Varvara A. Kudryavtseva, Egor A. Kuzmin, Aleksandra V. Moiseeva, Anna Baldycheva, Igor Meglinski, Gennadii A. Piavchenko
Summary: This review highlights the recent progress in the study of heat shock proteins (Hsp70) in neurodegenerative diseases (NDs) and emphasizes their crucial role in pathological aggregation. The field has seen significant advancements in recent years with numerous studies being published each month. The review summarizes the role of Hsp70 in common NDs such as AD, PD, and ALS, and connects translational research and clinical trials to medical practice. It also outlines available options to regulate Hsp70 activity in NDs.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Nutrition & Dietetics
Elif Inan-Eroglu, Aylin Ayaz, Zehra Buyuktuncer
NUTRITION RESEARCH REVIEWS
(2020)
Article
Sport Sciences
Bo-Huei Huang, Elif Inan-Eroglu, Mark Hamer, Emmanuel Stamatakis
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2020)
Article
Environmental Sciences
Elif Inan-Eroglu, Lauren Powell, Mark Hamer, Gary O'Donovan, Mitch J. Duncan, Emmanuel Stamatakis
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Immunology
Matthew N. Ahmadi, Bo-Huei Huang, Elif Inan-Eroglu, Mark Hamer, Emmanuel Stamatakis
Summary: In a community-based cohort study, meeting public health guidelines or best practice recommendations for lifestyle risk factors was associated with lower mortality from infectious diseases, including pneumonia and COVID-19. There was a beneficial dose-response association with a higher lifestyle index against mortality, which was consistent across different demographic groups.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Nutrition & Dietetics
Elif Inan-Eroglu, Bo-Huei Huang, Matthew N. Ahmadi, Nathan Johnson, Emad M. El-Omar, Emmanuel Stamatakis
Summary: The study found that overweight/obese participants who consume alcohol at the same level as normal weight individuals have a higher risk of developing ALD, NAFLD, and liver disease. Overweight/obese individuals who exceed alcohol consumption guidelines also have a greater risk of liver disease incidence and mortality compared to those with a normal weight.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Andrea L. Pattinson, Radhika Seimon, Claudia Harper, Natasha Nassar, Amanda Grech, Eunike A. Santoso, Janet Franklin, Elif Inan-Eroglu, Alice A. Gibson, Amanda Sainsbury
Summary: This study compared the impact of total meal replacement and food-based weight-loss diets on diet quality, finding that both can improve diet quality but not sufficiently to meet recommendations.
JOURNAL OF NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Gary O'Donovan, Elif Inan-Eroglu, Emmanuel Stamatakis, Mark Hamer
Summary: The study found that alcohol drinking was associated with BMI in men, but not in women, independent of other lifestyle risk factors.
PREVENTIVE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Maria Parvaneh, Paul K. Witting, Jaqueline Ku, Tala Moradi, Elif Eroglu, Ben Freedman, Greg T. Sutherland, Andrew McCorkindale, Boris Guennewig, Phannaphat Choowong, Kim Bell-Anderson, Gregory Cooney, Shane R. Thomas, Joerg Eberhard
Summary: The study found that oral lavage of P. gingivalis and S. gordonii for 4 weeks induced periodontitis in ApoE(-/-) mice, accompanied by increased mRNA expression of pro-inflammatory mediators in the liver and impaired endothelial function. While no differences were detected in caecal microbiota, this is the first report providing evidence that periodontitis induces endothelial dysfunction in mice.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Carlene S. Starck, Michelle Blumfield, Tim Keighley, Skye Marshall, Peter Petocz, Elif Inan-Eroglu, Kylie Abbott, Tim Cassettari, Ajmol Ali, Carol Wham, Rozanne Kruger, Geoff Kira, Flavia Fayet-Moore
Summary: The study found that selecting nutritious, low-cost foods can improve diet quality and affordability for the population in New Zealand, particularly for low and medium socioeconomic status households. By using substitution modeling, the processing levels of foods were also evaluated, suggesting that some ultra-processed foods may provide a valuable source of low-cost nutrition for food insecure populations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Susan Paudel, Borja del Pozo Cruz, Elif Inan-Eroglu, Matthew Ahmadi, Emmanuel Stamatakis
Summary: The study found that improved physical activity had the most pronounced beneficial associations with incident obesity, regardless of changes in discretionary screen time. Improvements in physical activity or discretionary screen time mutually attenuated the deleterious effects of the other behavior's deterioration.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Joerg Eberhard, Kate Ruiz, Jian Tan, Thilini N. Jayasinghe, Shahrukh Khan, Elif Eroglu, Christina Adler, Stephen J. Simpson, David G. Le Couteur, David Raubenheimer, Laurence Macia, Alison K. Gosby, Rosilene Ribeiro
Summary: The aim of this study was to assess the effects of two macronutrient interventions on oral health. The results showed that a semi-vegetarian high-fat diet had positive effects on clinical parameters of periodontal health.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Food Science & Technology
Aylin Ayaz, Damla Dedebayraktar, Elif Inan-Eroglu, Halit Tanju Besler, Zehra Buyuktuncer
Summary: Regardless of nutrition education status, nutrition facts labels are mainly used when buying a product for the first time, an unknown brand, or comparing similar products from different companies. Participants with nutrition education showed higher use of nutrition facts labels for specific food products and had a slightly higher total score of attitudes regarding food label use compared to those without nutrition education.
NUTRITION & FOOD SCIENCE
(2021)
Review
Sport Sciences
Matthew L. Stevens, Nidhi Gupta, Elif Inan Eroglu, Patrick Joseph Crowley, Barbaros Eroglu, Adrian Bauman, Malcolm Granat, Leon Straker, Peter Palm, Sari Stenholm, Mette Aadahl, Paul Mork, Sebastien Chastin, Vegar Rangul, Mark Hamer, Annemarie Koster, Andreas Holtermann, Emmanuel Stamatakis
BMJ OPEN SPORT & EXERCISE MEDICINE
(2020)
Article
Endocrinology & Metabolism
Alice A. Gibson, Elif Eroglu, Kieron Rooney, Claudia Harper, Sally McClintock, Janet Franklin, Tania P. Markovic, Radhika Seimon, Amanda Sainsbury
OBESITY SCIENCE & PRACTICE
(2020)
Review
Food Science & Technology
Elif Inan-Eroglu, Aylin Ayaz
NUTRITION & FOOD SCIENCE
(2019)