Review
Physiology
Laurel A. Grisanti
Summary: Cardiovascular disease is a leading cause of death globally. Cardiomyocyte death, which occurs in heart damage and stress, contributes to cardiac dysfunction and further damages the heart. Apoptosis, a regulated form of cell death, can occur through intrinsic or extrinsic pathways. The poorly characterized TNF-related ligand TRAIL and its receptors have been found to play a role in cardiac pathology. This article aims to provide an overview of the current understanding of TRAIL and its receptors in normal and pathological conditions in the heart.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Qiang Zhou, Jianxia Yuan, Yi Liu, Yayun Wu
Summary: Cisatracurium besilate inhibits gastric cancer cell proliferation, promotes apoptosis, increases the expression of p53 and PUMA, and enhances TRAIL-induced apoptosis. However, pifithrin-alpha can reverse the synergistic effects of cisatracurium besilate and TRAIL on AGS cell activities.
Article
Immunology
A. L. Heck, S. Mishra, T. Prenzel, L. Feulner, E. Achhammer, V Saerchen, B. S. J. Blagg, W. Schneider-Brachert, S. Schuetze, J. Fritsch
Summary: The study reveals that extrinsic cell death activation via TNF or TRAIL results in HSP90 beta degradation, promoting apoptosis induction.
Article
Plant Sciences
Irum Naz, Muhammad Rashid Khan, Jawaid Ahmed Zai, Riffat Batool, Sonia Maryam, Muhammad Majid
Summary: This study evaluated the protective effects of Indigofera linifolia on CCl4-induced endoplasmic reticulum stress in rat liver. The results showed that Indigofera linifolia extract could restore liver function and reduce histopathological variations in rat liver tissues. The active constituents of Indigofera linifolia might be responsible for its antioxidant, anti-inflammatory, and gene-regulating activities.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Taeyeon Hong, Hahyun Park, Garam An, Gwonhwa Song, Whasun Lim
Summary: This study investigated the effects of ethalfluralin on the development of zebrafish embryos. The results showed that ethalfluralin decreased the survival rate, hatching ratio, and heartbeat of zebrafish embryos. It also caused edema, apoptosis, and changes in gene expression related to apoptosis, inflammation, and angiogenesis. The study suggests that ethalfluralin can induce oxidative stress and have toxic effects on the development of zebrafish embryos.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Genetics & Heredity
Atsushi Watanabe, Kunio Miyake, Koshi Akahane, Kumiko Goi, Keiko Kagami, Hideo Yagita, Takeshi Inukai
Summary: Immunotherapies specific for BCP-ALL, such as anti-CD19 CAR T-cells and blinatumomab, have significantly improved outcomes in refractory cases. The methylation status of DR4 and DR5 genes is associated with gene expression levels, cell-surface expression, and TRAIL-sensitivities, suggesting potential clinical relevance in predicting immunotherapy efficacy. Evaluating methylation status of DR4 and DR5 genes may be informative in certain cases with unfavorable karyotypes.
Article
Biochemistry & Molecular Biology
Elisa Rubino, Andrea Marcinno, Alberto Grassini, Elisa Maria Piella, Fabio Ferrandes, Fausto Roveta, Silvia Boschi, Aurora Cermelli, Salvatore Gallone, Lidia Savi, Innocenzo Rainero
Summary: Migraine is a common disorder with unsatisfactory response to acute pain-relieving therapies. Functional polymorphism in the TNF-alpha gene is associated with the efficacy of NSAID administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Najib Ben Khaled, Katharina Hammer, Liangtao Ye, Ahmed Alnatsha, Sebastian A. Widholz, Ignazio Piseddu, Simon Sirtl, Julia Schneider, Stefan Munker, Ujjwal Mukund Mahajan, Juan Jose Montero, Joscha Griger, Julia Mayerle, Florian P. Reiter, Enrico N. De Toni
Summary: Research has identified frequent changes in BRCA genes in pancreatic cancer patients, especially in BRCA2. Pancreatic cancers with alterations in BRCA genes are sensitive to treatment with PARP inhibitors. This study shows that the combination of olaparib and TRAIL can be more effective than olaparib alone in killing pancreatic cancer cells. Furthermore, the combination of olaparib and TRAIL also kills cancer cells without BRCA2 mutations. These findings suggest a potential new combination therapy for pancreatic cancer independent of BRCA2 mutations.
Article
Biochemistry & Molecular Biology
Xue Han, Xiaowen Xu, Tingting Yu, Meifeng Li, Yulong Liu, Jingli Lai, Huiling Mao, Chengyu Hu, Shanghong Wang
Summary: Exposure to Diflubenzuron resulted in cardiac developmental damage in zebrafish embryos, increased apoptotic cells and promoted the expression of apoptosis-related genes, while inhibiting the expression of some heart-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xin Xiao, Juan Xu, Xiaoan Sheng, Chao Wang, Juanjuan Dong, Xianfeng Shi
Summary: Tobacco nicotine use is a known risk factor for lung cancer, but its role in inducing drug resistance is unclear. This study found that nicotine upregulated the expression of SNHG5 and decreased caspase-3 levels, leading to TRAIL resistance in smokers with lung cancer. SNHG5 was found to interact with X-linked inhibitor of apoptosis protein, promoting TRAIL resistance. These findings demonstrate that nicotine promotes TRAIL resistance through the SNHG5/X-linked inhibitor of apoptosis protein pathway in lung cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Medicine, Research & Experimental
Wei Zhang, Shuo Li, Jinglei Lou, Hui Li, Meng Liu, Ningzheng Dong, Qingyu Wu
Summary: The study reveals the role of ANP in uterine decidualization and spiral artery remodeling, promoting TRAIL expression to induce cell death in endothelial cells and smooth muscle cells. This finding helps to uncover the underlying mechanism of uterine artery remodeling.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Regis Brion, Malika Gantier, Kevin Biteau, Julien Taurelle, Benedicte Brounais-Le Royer, Franck Verrecchia, Francoise Redini, Romain Guiho
Summary: Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors in children. Triggering the TRAIL pro-apoptotic pathway shows promise in treating these tumors, but resistance mechanisms have limited its effectiveness. This study used human cell lines and xenograft models to investigate the differences in signaling pathways between TRAIL-sensitive and TRAIL-resistant cells, and proposed two strategies to overcome resistance.
Article
Medicine, General & Internal
Haixu Yu, Wei Rong, Jie Yang, Jie Lu, Ke Ma, Zhuohui Liu, Hui Yuan, Lei Xu, Yulin Li, Zhi-Cheng Jing, Jie Du
Summary: This study found that reduced plasma TRAIL levels predict short-term adverse events in normotensive patients with acute PE. The combination of TRAIL and hs-cTnI as a biomarker-based risk stratification strategy has a similar risk classification effect in normotensive patients with acute PE.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ella Rimmer, Sadaf Rashid, Igor Kraev, Francesc Miralles, Androulla Elia
Summary: Pancreatic cancer cells release extracellular vesicles that confer resistance to gemcitabine and TRAIL treatment. Removal of these vesicles during treatment may improve the response of pancreatic cancer cells to gemcitabine and TRAIL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Antonietta Curatola, Antonio Chiaretti, Serena Ferretti, Giulia Bersani, Donatella Lucchetti, Lavinia Capossela, Alessandro Sgambato, Antonio Gatto
Summary: The study aimed to describe clinical and immunological features of children affected by COVID-19, as well as evaluate whether cytokines could predict disease severity. Higher levels of IL-6 and TNF-alpha were found in COVID-19 group compared to other infections and control groups, but these levels did not correlate with disease severity among sub-groups in the COVID-19 group. Further clinical studies in a larger pediatric population are needed to better understand the role of immune-mediated response in SARS-CoV-2 infections in children.
Article
Multidisciplinary Sciences
Hon Y. Chan, Lachlan M. Moldenhauer, Holly M. Groome, John E. Schjenken, Sarah A. Robertson
Summary: The study demonstrates that TLR4 plays a crucial role in the initiation of a controlled inflammatory response in the pre-implantation uterus, leading to the expansion of Treg cells to support pregnancy tolerance and fetal growth. Mouse models with Tlr4 mutation showed impaired reproductive outcomes and reduced expression of key factors related to immune adaptation.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
David A. Skerrett-Byrne, Brett Nixon, Elizabeth G. Bromfield, James Breen, Natalie A. Trigg, Simone J. Stanger, Ilana R. Bernstein, Amanda L. Anderson, Tessa Lord, R. John Aitken, Shaun D. Roman, Sarah A. Robertson, John E. Schjenken
Summary: The study analyzed the transcriptome of mouse seminal vesicles under normal physiological conditions and in response to the reproductive toxicant acrylamide. Acrylamide exposure resulted in differential regulation of 70 genes, with pathways related to gene and protein synthesis for cellular survival being prominently affected. Inflammation was also a key response to acrylamide, with several dysregulated genes identified. These findings suggest that seminal vesicles are sensitive to environmental insults and their response may impact fetal development and offspring health.
Article
Biochemical Research Methods
Shannon P. Smyth, Brett Nixon, Amanda L. Anderson, Heather C. Murray, Jacinta H. Martin, Lily A. MacDougall, Sarah A. Robertson, David A. Skerrett-Byrne, John E. Schjenken
Summary: This study reports a new method for preparing seminal vesicle fluid (SVF) and identifies 126 proteins in SVF, including 83 previously undetected proteins. The most abundant proteins in SVF belong to the seminal vesicle secretory protein family. Functional analysis reveals that inflammation and formation of the vaginal plug are the most prominent biological processes associated with SVF proteins. Other processes include modulation of sperm function and regulation of the female reproductive tract immune environment. These findings provide a robust methodological framework for future SVF studies and identify novel proteins with potential to influence both male and female reproductive physiology.
Review
Veterinary Sciences
Sarah A. Robertson, Graeme B. Martin
Summary: The classical view of pheromones is challenged by camelids, which have discovered that a nerve growth factor in seminal plasma can trigger ovulation. Further research has found that certain molecules in seminal fluid can enhance the female reproductive tract's receptivity to embryos, increasing the likelihood of pregnancy. This phenomenon has significant implications in the field of reproductive biology.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Obstetrics & Gynecology
Sarah A. Robertson, Lachlan M. Moldenhauer, Ella S. Green, Alison S. Care, M. Louise Hull
Summary: Immune cells play essential roles in endometrial receptivity to embryo implantation and early placental development, providing potential targets for diagnostic evaluation and therapeutic intervention in infertility by addressing the pathophysiological mechanisms of the uterine immune response.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Lachlan M. Moldenhauer, Min Jin, Jasmine J. Wilson, Ella S. Green, David J. Sharkey, Mark D. Salkeld, Thomas C. Bristow, M. Louise Hull, Gustaaf A. Dekker, Sarah A. Robertson
Summary: Research has shown that oral contraception use can impact the number and phenotype of Treg cells, leading to physiological changes and altered disease susceptibility.
Review
Biochemistry & Molecular Biology
Jelmer R. Prins, Mirthe H. Schoots, Jule I. Wessels, Marjo J. E. Campmans-Kuijpers, Gerjan J. Navis, Harry van Goor, Sarah A. Robertson, Eline M. van der Beek, Luis Sobrevia, Sanne J. Gordijn
Summary: This review aims to provide a comprehensive overview of the endogenous and exogenous exposome factors that regulate reactive species in healthy and complicated pregnancies. It also describes dietary interventions aimed at reducing reactive species to improve pregnancy outcomes.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Microbiology
Rosa C. Coldbeck-Shackley, Ornella Romeo, Sarah Rosli, Linden J. Gearing, Jodee A. Gould, San S. Lim, Kylie H. Van der Hoek, Nicholas S. Eyre, Byron Shue, Sarah A. Robertson, Sonja M. Best, Michelle D. Tate, Paul J. Hertzog, Michael R. Beard
Summary: This study investigates the role of a hormonally regulated type I interferon, IFN epsilon (IFNε), in controlling Zika virus (ZIKV) infection in the female reproductive tract. The researchers demonstrate that IFNε has anti-ZIKV properties through the use of IFNε KO mice, neutralising antibodies, and recombinant IFNε administered directly to the reproductive tract. Additionally, human cell lines derived from the reproductive tract were used to complement the in vivo studies. This work highlights the importance of IFNε as a key type I interferon in providing an antiviral environment in the female reproductive tract.
Review
Andrology
Hannah E. Lyons, Bridget M. Arman, Sarah A. Robertson, David J. Sharkey
Summary: This study systematically reviews the concentrations of immune regulatory cytokines in seminal plasma of healthy men and evaluates the impact of different quantification methodologies. The results show that the concentrations of many cytokines associated with fertility status vary greatly between studies, possibly due to different immunoassay methods and lack of validation for seminal plasma assessment. Accurate reference ranges for healthy men cannot be determined from the published data due to the large variation between studies.
Article
Medicine, Research & Experimental
Meaghan J. Griffiths, Sarah A. . Marshall, Fiona L. . Cousins, Lauren R. . Alesi, Jordan Higgins, Saranya Giridharan, Urooza C. . Sarma, Ellen Menkhorst, Wei Zhou, Alison S. . Care, Jacqueline F. . Donoghue, Sarah J. . Holdsworth-Carson, Peter A. W. . Rogers, Evdokia Dimitriadis, Caroline E. Gargett, Sarah A. Robertson, Amy L. Winship, Karla J. Hutt
Summary: Female cancer survivors are at a higher risk of infertility due to the damaging effects of chemotherapy and radiotherapy on the ovaries. However, the effects of cancer treatments on the uterus have been understudied. This study shows that total-body gamma-irradiation (TBI) damages the uterus, leading to compromised pregnancy success. The pro-apoptotic protein Puma is identified as a key mechanism in TBI-induced uterine damage, suggesting that inhibiting PUMA may be a potential fertility preservation strategy.
Article
Medicine, Research & Experimental
Ella S. Green, Lachlan M. Moldenhauer, Holly M. Groome, David J. Sharkey, Peck Y. Chin, Alison S. Care, Rebecca L. Robker, Shaun R. McColl, Sarah A. Robertson
Summary: Using a mouse model, this study found that regulatory T cells (Treg cells) play a crucial role in mediating the effects of progesterone on uterine receptivity by repairing blood vessel remodeling and placental structure, and restoring T cell imbalance in the mother, thereby alleviating fetal loss and growth restriction caused by reduced progesterone signaling.
Review
Immunology
Sharmony B. Kelly, Nhi T. Tran, Graeme R. Polglase, Rodney W. Hunt, Marcel F. Nold, Claudia A. Nold-Petry, David M. Olson, Sylvain Chemtob, Gregory A. Lodygensky, Sarah A. Robertson, Alistair J. Gunn, Robert Galinsky
Summary: Perinatal infection/inflammation is associated with neurological injury and impairment. Anti-inflammatory therapies have the potential to improve neurological outcomes. However, there are knowledge gaps and issues with study design that need to be addressed.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Immunology
Lachlan M. Moldenhauer, M. Louise Hull, Kerrie L. Foyle, Catherine D. McCormack, Sarah A. Robertson
Summary: Pregnancy depends on maternal immune tolerance mediated by regulatory T cells. The metabolic status plays an important role in regulating the expansion of these T cells. Metabolic abnormalities can lead to insufficient regulatory T cells and contribute to infertility, recurrent miscarriage, and pregnancy complications.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Tara M. Crawford, Chad C. Andersen, Nicolette A. Hodyl, Sarah A. Robertson, Michael J. Stark
Summary: This study evaluated the effect of transfusion with washed versus unwashed packed red blood cells (PRBCs) on the immune response of preterm infants born before 29 weeks' gestation. The results showed that transfusion with washed PRBCs led to a reduction in pro-inflammatory cytokines, while transfusion with unwashed PRBCs increased the levels of these cytokines. Therefore, washing PRBCs prior to transfusion may modify the immune response in preterm infants.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Article
Oncology
Xuan Sun, Sarah M. Bernhardt, Danielle J. Glynn, Leigh J. Hodson, Lucy Woolford, Andreas Evdokiou, Cong Yan, Hong Du, Sarah A. Robertson, Wendy Ingman
Summary: Attenuation of TGFB signaling in macrophages resulted in increased alveolar epithelium and macrophage abundance in the mammary gland, with altered inflammatory macrophage markers. This led to a significant decrease in mammary tumor incidence and prolonged tumor-free survival. In human non-neoplastic breast tissue, a significant inverse relationship was observed between latent TGFB1 protein and CD68-positive macrophages.
BREAST CANCER RESEARCH
(2021)