Article
Genetics & Heredity
Jia Li, Lei Sun, Xue-Liang Peng, Xiao-Ming Yu, Shao-Jun Qi, Zhi John Lu, Jing-Dong J. Han, Qin Shen
Summary: The study revealed the dynamics of early neuronal differentiation processes through transcriptome and epigenetic analyses, identifying novel coding genes and lncRNAs involved in the differentiation of early neurons. Molecular heterogeneities were found in CR neurons, categorized into three developing states along a pseudotemporal trajectory, showing genetic cascades during the establishment of CR neuron identity and function. The research shed light on the molecular mechanisms governing early differentiation steps in cortical development, specifically CR neuron differentiation.
Article
Multidisciplinary Sciences
Alba Vilchez-Acosta, Yasmina Manso, Adrian Cardenas, Alba Elias-Tersa, Magdalena Martinez-Losa, Marta Pascual, Manuel Alvarez-Dolado, Angus C. Nairn, Victor Borrell, Eduardo Soriano
Summary: The extracellular protein Reelin, derived from both CR cells and GABAergic interneurons, plays a crucial role in regulating the migration and positioning of cortical neurons during development. Disruptions in Reelin can lead to developmental disorders and neuropsychiatric disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Developmental Biology
Frederic Causeret, Matthieu X. Moreau, Alessandra Pierani, Oriane Blanquie
Summary: Cajal-Retzius neurons (CRs) are among the first-formed neurons in the developing cortex, known for controlling glutamatergic neuron migration and cortical layer formation, as well as playing various additional key roles in cortical development. Recent advancements in single-cell technologies have allowed for a greater understanding of the molecular heterogeneity of CRs and their roles in different species.
Article
Cell Biology
Ala Ahrari, Maurice Meseke, Eckart Foerster
Summary: Granule cell dispersion (GCD) is considered a pathological feature of temporal lobe epilepsy. Early epileptiform activity may be linked to the development of chronic epilepsy, and electrical activity during neuronal migration and differentiation is believed to contribute to GCD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joshua R. Enck, Eric C. Olson
Summary: This study confirms that Cajal-Retzius neurons in the cortical marginal zone can influence the development of cortical projection neurons by releasing glutamate and glycine, providing insight into the observation that many autism-linked genes are expressed in the developing cortex before the appearance of synapses and functional circuits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nasim Ramezanidoraki, Driss El Ouardi, Margaux Le, Stephanie Moriceau, Mahboubeh Ahmadi, Dossi Elena, Danae Rolland, Philippe Bun, Gwenaelle Le Pen, Guillaume Canaud, Nadia Bahi-Buisson, Nathalie Rouach, Rebecca Piskorowski, Alessandra Pierani, Pierre Billuart
Summary: Cajal-Retzius cells (CRs) are transient neurons in the mammalian cortex that play a critical role in cortical development. Their persistence in postnatal life has been detected in epilepsy-related conditions, but it is unclear if it is a cause or consequence of the diseases. The decrease in PI3K/AKT/mTOR activity in CRs primes these cells to death by possibly repressing a survival pathway, with the mTORC1 branch contributing less to the phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Fanny Lepiemme, Julie Stoufflet, Miriam Javier-Torrent, Gabriel Mazzucchelli, Carla G. Silva, Laurent Nguyen
Summary: During embryogenesis, vOPCs and cortical interneurons interact and occupy mutually exclusive territories in the forebrain. First-wave vOPCs play a crucial role in steering the migration of cortical interneurons away from blood vessels, allowing them to reach their proper cortical territories.
Article
Neurosciences
Orly Reiner, Arpan Parichha, Tamar Sapir
Summary: Advancements in understanding human neuronal migration disorders using mouse models have been significant, despite the notable differences between human and mouse genetic information and developmental processes. The development of human brain organoid models has sparked excitement in modeling human neuronal migration diseases. Differences in gene expression, morphology, and migratory routes between human and mouse brains highlight the need for further study.
CURRENT OPINION IN NEUROBIOLOGY
(2021)
Article
Cell Biology
Ana Lopez-Mengual, Miriam Segura-Feliu, Raimon Sunyer, Hector Sanz-Fraile, Jorge Otero, Francina Mesquida-Veny, Vanessa Gil, Arnau Hervera, Isidre Ferrer, Jordi Soriano, Xavier Trepat, Ramon Farre, Daniel Navajas, Jose Antonio del Rio
Summary: Evidence suggests that both chemical and mechanical cues play important roles in brain development. Cajal-Retzius cells migrate tangentially in the developing cortex, secreting molecules for correct neocortical layer formation. The motogenic properties and distribution of these cells in the marginal zone are modulated by both chemical and mechanical factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Rebekah van Bruggen, Zain H. Patel, Mi Wang, Terry R. Suk, Maxime W. C. Rousseaux, Qiumin Tan
Summary: Cajal-Retzius (CR) cells are transient neurons that have long-lasting effects on the structure and circuitry of the neocortex and hippocampus. Contrary to previous assumptions, a significant portion of these cells persist in the hippocampus throughout adulthood in rodents. The role of these surviving CR cells in the adult hippocampus is largely unknown, partly due to a lack of suitable tools to study their functions.
Article
Developmental Biology
Arpan Parichha, Debarpita Datta, Varun Suresh, Mallika Chatterjee, Michael J. Holtzman, Shubha Tole
Summary: The study reveals the importance of beta-catenin in the development of brain structures, particularly in the formation of the dentate gyrus. In mice, disruption of beta-catenin leads to disorganization of the fimbrial glial scaffold and mispositioning of Cajal-Retzius cells, resulting in the failure of the dentate gyrus to form.
Article
Cell Biology
Megan M. Nelson, J. Damon Hoff, Mya L. Zeese, Gabriel Corfas
Summary: PARP1 plays a novel role in brain development by regulating Cajal-Retzius (CR) cells, neuronal density, and cell adhesion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Erwan Leprince, Robin F. Dard, Salome Mortet, Caroline Filippi, Marie Giorgi-Kurz, Romain Bourboulou, Pierre-Pascal Lenck-Santini, Michel A. Picardo, Marco Bocchio, Agnes Baude, Rosa Cossart
Summary: The adult CA1 region of the hippocampus produces coordinated neuronal dynamics with minimal reliance on its extrinsic inputs. Neonatal CA1, on the other hand, is tightly linked to externally generated sensorimotor activity, but the circuit mechanisms underlying early synchronous activity in CA1 remain unclear. In this study, researchers use a combination of in vivo and ex vivo circuit mapping, calcium imaging, and electrophysiological recordings in mouse pups to investigate the dynamics in the ventro-intermediate CA1. They find that these dynamics are influenced by both the entorhinal (EC) and thalamic (VMT) inputs, but movement-related population bursts are exclusively driven by the EC. The differential effects reflect the different intrahippocampal targets of these inputs, suggesting distinct contributions to the development of the hippocampal microcircuit and related cognitive maps.
Review
Biochemistry & Molecular Biology
Julie Stoufflet, Sylvia Tielens, Laurent Nguyen
Summary: The cerebral cortex, responsible for processing motor and sensory information and shaping personality, relies on cell communication for development and functional organization. Disrupting this cellular crosstalk can lead to neurodevelopmental disorders. This review focuses on how the interaction between migrating cells and their environment influences various aspects of cerebral cortex development.
Review
Cell Biology
Knut Kirmse, Chuanqiang Zhang
Summary: GABAergic signaling plays a crucial role in the inhibitory stabilization and coordination of excitatory neurons in mature cortical circuits. This review examines how GABA-releasing interneurons acquire their network functions during development, focusing on the visual neocortex and hippocampus in mice and rats. The authors propose that inhibitory stabilization is not functional at the onset of patterned activity, and that glutamatergic neurons are stable by themselves. The strengthening of inhibitory synaptic transmission toward eye opening shapes cortical network dynamics and allows the developing cortex to disengage from extra-cortical synaptic drive. The framework presented in this review has implications for our understanding of human cortical development and the treatment of neonatal seizures.
Article
Information Science & Library Science
Juhyung Sun, Sun Kyong Lee
Summary: This study examines predictors and consequences of instant messaging fatigue using the stressor-strain-outcome framework, finding that communication overload and social overload are positively associated with fatigue and technostress, leading to intentions to discontinue usage. Technostress mediates the relationship between instant messaging fatigue and intention to discontinue usage.
INFORMATION TECHNOLOGY & PEOPLE
(2022)
Article
Cell Biology
Max Anstoz, Sun Kyong Lee, Gianmaria Maccaferri
Summary: Cajal-Retzius cells play a crucial role in regulating hippocampal microcircuits and specific behaviors through the release of glutamate.
Article
Communication
Juhyung Sun, Sarah Lasser, Sun Kyong Lee
Summary: This study examines the influence of cultural identification with individualism and collectivism on the interpretation and selection of emojis commonly used in South Korea by Americans. It also investigates the moderating effects of intercultural communication competence and emotional intelligence. The results show that cultural identification plays a significant role in interpreting and selecting appropriate emojis, and that intercultural communication competence and emotional intelligence also have significant moderating effects on these relationships. These findings enhance understanding of cross-cultural differences in understanding emojis in computer-mediated communication.
JOURNAL OF INTERNATIONAL AND INTERCULTURAL COMMUNICATION
(2023)
Article
Neurosciences
Astrid Rollenhagen, Max Anstoetz, Kerstin Zimmermann, Yu Kasugai, Kurt Saetzler, Elek Molnar, Francesco Ferraguti, Joachim H. R. Luebke
Summary: AMPA and NMDA glutamate receptors play essential roles in synaptic transmission and plasticity in the neocortex. The study reveals their layer- and target-specific distribution patterns in the adult rat neocortex, which contribute to the observed functional differences in synaptic transmission and plasticity.
Article
Multidisciplinary Sciences
Sun Kyong Lee, Juhyung Sun, Seulki Jang, Shane Connelly
Summary: This study examined the impact of misinformation related to COVID-19 vaccines on vaccine hesitancy and refusal. The findings suggest that exposure to conspiratorial misinformation may increase vaccine hesitancy and reduce behavioral intention to get vaccinated.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Seulki ''Rachel'' Jang, Sun Kyong Lee, Shane Connelly
Summary: This study investigates the characteristics associated with willingness and unwillingness to receive a COVID-19 vaccine among working adults in the United States. Through quantitative and qualitative data, the study examines the demographic variables and influence sources that significantly correlate with people's willingness/unwillingness to receive the vaccine. The findings highlight the most common reasons for willingness (self-protection) and unwillingness (concerns about side effects) to get vaccinated.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Communication
Sun Kyong Lee
MOBILE MEDIA & COMMUNICATION
(2023)
Article
Social Sciences, Interdisciplinary
C. Aujean Lee, Sun Kyong Lee
Summary: Social Network Analysis and Geographic Information Systems can be combined and applied in communication research to gain a better understanding of the relationship between communication networks and spatial or city characteristics. By studying the communication networks of immigrant church members, it was found that members seeking information from coethnic immigrant networks were more likely to live in cities with a concentration of white residents, while members who provided more informational support to others were less likely to live in such areas. Thus, coethnic residential choice may not always be linked with immigrant network use and strategic assimilation patterns apply more. Future communication research that involves physical locations and space can benefit from the innovative combination of Social Network Analysis and Geographic Information System techniques.
COGENT SOCIAL SCIENCES
(2022)
Article
Computer Science, Cybernetics
Sun Kyong Lee, Juhyung Sun
Summary: A theoretical model of trust in human-machine communication was tested and emotional experience and social presence were evaluated during an interaction with the intelligent virtual agent Siri. The study found that participants reported higher levels of emotional significance when interacting with Siri for functional tasks. The results also indicated that social presence and emotional experience were directly associated with trust in Siri.
BEHAVIOUR & INFORMATION TECHNOLOGY
(2022)
Article
Communication
Sun Kyong Lee, Ioana A. Cionea
Summary: This study tested the applicability of the mobile phone appropriation model in the United States and aimed to enhance the theoretical understanding of mobile communication. Using structural equation modeling and mediation analyses, the associations between theoretical constructs were examined. The study found that meta-communication was associated with all dimensions of behavioral evaluations, and normative evaluations were an important predictor of mobile phone usage aspects. These findings shed light on the MPA theoretical framework and suggest potential revisions.
WESTERN JOURNAL OF COMMUNICATION
(2023)
Article
Biochemistry & Molecular Biology
Can Tan, Pieter R. Norden, Wei Yu, Ting Liu, Naoto Ujiie, Sun Kyong Lee, Xiaocai Yan, Yaryna Dyakiv, Kazushi Aoto, Sagrario Ortega, Isabelle G. De Plaen, Venkatesh Sampath, Tsutomu Kume
Summary: FOXC1 and FOXC2 play vital roles in intestinal regeneration by stimulating CXCL12 and Wnt signaling pathways. Deletion of Foxc1, Foxc2, or both results in defects in vascular regrowth, reduced expression of CXCL12 and RSPO3 in blood endothelial cells and lymphatic endothelial cells respectively, and increased activation of Wnt signaling in intestinal stem cells. Treatment with CXCL12 and RSPO3 rescues the intestinal damage induced by ischemia-reperfusion injury in mutant mice.
Article
Psychology, Multidisciplinary
Juhyung Sun, Sun Kyong Lee
Summary: This study uses the stressor-strain-outcome framework to show that COVID-19 information overload on social media has a significant impact on people's fatigue level towards COVID-19-related messages. This feeling of message fatigue leads to message avoidance and reduces intentions to adopt protective behaviors in response to the pandemic. Information overload regarding COVID-19 on social media also indirectly affects message avoidance and protective behavioral intention against COVID-19 through the feeling of fatigue towards COVID-19 messages. This study highlights the importance of considering message fatigue as a significant barrier in delivering effective risk communication.
CURRENT PSYCHOLOGY
(2023)
Article
Computer Science, Cybernetics
Xinyi Zhang, Sun Kyong Lee, Whani Kim, Sowon Hahn
Summary: The study introduces a three-fold categorization for technical failures in human-robot interactions and explores four trust repair strategies. The online experiment with 743 participants reveals nuances in their perceptions of trust violations based on competence and integrity, indicating ontological differences between humans and machines. The analysis also demonstrates significant effects of failure types and repair methods on trust in human-robot interactions.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER STUDIES
(2023)
Article
Robotics
Xinyi Zhang, Sun Kyong Lee, Hoyoung Maeng, Sowon Hahn
Summary: System performance is critical in determining user trust in human-machine communication. This study develops a typology of performance failures in human-robot interactions and investigates how they impact user trust, with a focus on blame attributions. The results highlight the importance of logic failures and internal attribution apology as effective repair strategies. Participants also report higher levels of competence-based trust beliefs when they perceive joint control between humans and robots.
INTERNATIONAL JOURNAL OF SOCIAL ROBOTICS
(2023)
Article
Business
Cameron W. Piercy, Sun Kyong (Sunny) Lee
Summary: This study explores how job seekers perceive human and technological sources in their sociotechnical ego-networks. The findings indicate that social support, ease of access, and homophily are positively related to tie strength, while influence is negatively related to tie strength.
INTERNATIONAL JOURNAL OF BUSINESS COMMUNICATION
(2023)