Article
Chemistry, Analytical
Lu-lu Pan, Tao Chen, Min Hui, Shuo Wang, Li Fu, Cui-yun Li, Hong Zhang, Yan-hua Ding, Yong Yang, Da-fang Zhong
Summary: The study developed a sensitive and rapid LC-MS/MS method for simultaneous analysis of forsythin, KD-2Glc, and KD-2-SO3H in human plasma. The method proved to be linear and met the validation criteria recommended by the CFDA. Moreover, this method was successfully applied in a clinical study among Chinese healthy participants.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemical Research Methods
Mateusz Kacper Wozniak, Laura Banaszkiewicz, Justyna Aszyk, Marek Wiergowski, Iwona Janczewska, Jolanta Wierzba, Agata Kot-Wasik, Marek Biziuk
Summary: This study developed a method for the simultaneous extraction of FAEEs, EtG, and EtS from one meconium aliquot, demonstrating sensitivity, accuracy, efficiency, and the potential for reduced organic solvent usage compared to existing methods.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Ting Du, Rongjin Sun, Nyma Siddiqui, Linda Moatamed, Yun Zhang, Dong Liang, Ming Hu, Song Gao
Summary: The study developed and validated an LC-MS method for quantifying fenoldopam and its metabolites, which was successfully applied in a rat pharmacokinetic study. The method showed high accuracy with LLOQ values for fenoldopam and its metabolites, and appropriate extraction recovery.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Chemistry, Medicinal
Guanxuanzi Zhang, Na Zhang, Liuhan Dong, Nan Bai, Yun Cai
Summary: A LC-MS/MS method for quantifying contezolid in plasma and cerebrospinal fluid (CSF) has been developed and verified in this study. Using linezolid as the internal standard, protein precipitation was performed. The LC-MS/MS analysis was performed using an Agilent EclipsePlus C18 column and acetonitrile and water mobile phases. The method showed good linearity, precision, and recovery rates in both plasma and CSF samples.
Article
Chemistry, Analytical
Dong Xiang, Tinghui Zhao, Jue Wang, Yang Cao, Qiuxia Yu, Lu Liu, Hengyi Yu, Xiping Li, Ninghong Li, Yang Yi, Xuepeng Gong
Summary: A sensitive and robust LC-MS/MS method was developed and validated for the quantification of olverembatinib in human plasma and cerebrospinal fluid (CSF). The method involved liquid-liquid extraction and precipitation enrichment for plasma and CSF pretreatment, respectively. The detection was performed by electrospray ionization in a positive ion mode using multiple reaction monitoring. The method proved to be accurate and precise, with a successful application in measuring olverembatinib concentrations in plasma and CSF from chronic myeloid leukemia patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemical Research Methods
Stefan A. J. Buck, Peter de Bruijn, Inge M. Ghobadi-Moghaddam-Helmantel, Mei H. Lam, Ronald de Wit, Stijn L. W. Koolen, Ron H. J. Mathijssen
Summary: Currently, there are several available oral androgen receptor signalling inhibitors for the treatment of advanced prostate cancer. Quantification of plasma concentrations of these drugs is highly relevant for various purposes, such as therapeutic drug monitoring in oncology. In this study, a LC-MS/MS method was developed and validated for the simultaneous quantification of abiraterone, enzalutamide, and darolutamide. The clinical applicability of quantifying enzalutamide and darolutamide in patients with metastatic castration-resistant prostate cancer was also demonstrated.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Biochemical Research Methods
Hao Wang, Yunfeng Zhang, Enshan Fan, Fangling Wang, Beixu Li, Yulan Rao
Summary: A novel sample preparation approach based on fast-dried urine spot was established to reduce matrix effects of EtS and EtG in urine, leading to significant improvement in LC-MS/MS analysis accuracy and sensitivity.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hongjiang Xu, Yanan Li, Jing Zhang, Jinhua Zhang, Jianguang Lu, Xiquan Zhang, Ling Yang, Wenjie Zhao, Jun Feng
Summary: A rapid UHPLC-MS/MS assay method was developed for the determination of CMS E2 and colistin E2 in human plasma. The method demonstrated speed and high accuracy, and was successfully applied to the analysis of plasma samples obtained from Chinese healthy volunteers.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Haoyang Lu, Tingting Guo, Shanqing Huang, Yuandan Li, Yuguan Wen, Dewei Shang, Xin Wen
Summary: A sensitive and efficient LC-MS/MS method was developed for the determination of cinacalcet concentration in human plasma. The method utilized a stable isotope as an internal standard and employed a one-step precipitation procedure for sample extraction. Chromatographic separation was achieved using a C18 column and a methanol-water-ammonium formate system. The developed method demonstrated good accuracy and precision, allowing for the reliable quantification of cinacalcet in human plasma samples.
Article
Chemistry, Medicinal
Khurshid Shaikh, Ashish Mungantiwar, Supriya Halde, Nancy Pandita
Summary: A high-performance liquid chromatography-tandem mass spectrometric method has been developed and successfully applied for the determination of free and total dabigatran in human plasma, allowing for analysis of pharmacokinetics.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Chemistry, Analytical
Jhohann Richard de Lima Benzi, Adriana Rocha, Julia Cristina Colombari, Alef Machado Gomes Pego, Patricia Pereira dos Santos Melli, Geraldo Duarte, Vera Lucia Lanchote
Summary: This study developed and validated methods for the analysis of Furosemide (FUR) and its glucuronide metabolite (FUR-GLU) in various matrices. These methods can facilitate the investigation of UGT1A9/1A1 and the fraction unbound (fu) when FUR is used as a probe for the renal transporters OAT1 and OAT3.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Rico Schwarz, Anna Richter, Elisabeth R. D. Ito, Hugo Murua Escobar, Christian Junghanss, Burkhard Hinz
Summary: Silmitasertib is a drug currently being investigated in clinical trials for the treatment of various cancers. It inhibits CK2 protein kinase, which has proliferation-promoting and anti-apoptotic effects on cancer cells. Researchers have developed an LC-MS/MS method for quantifying silmitasertib in human plasma.
Article
Biochemical Research Methods
Thomas Meikopoulos, Olga Deda, Efstratios Karagiannidis, Georgios Sianos, Georgios Theodoridis, Helen Gika
Summary: In this study, a rapid quantitation method for acylcarnitines in human serum was developed and validated. The method was successfully applied in the analysis of samples from patients with coronary artery disease.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Food Science & Technology
Sana Khajeh pour, Cynthia Blanton, Biwash Ghimire, Ali Aghazadeh-Habashi
Summary: This study developed a method to examine the effect of piperine on the bioavailability of curcumin. The results showed that piperine significantly increased the oral absorption of curcumin, reduced its systemic clearance, and improved its bioavailability.
FOOD SCIENCE & NUTRITION
(2023)
Article
Chemistry, Analytical
Patrick Kroener, Georg Heinkele, Reinhold Kerb, Svitlana Igel, Matthias Schwab, Thomas E. Muerdter
Summary: A highly sensitive and specific UPLC-MS/MS method was established to comprehensively investigate the metabolism of clomiphene in vivo, revealing the involvement of polymorphic cytochrome P450 2D6 in high inter-individual variability. The method was successfully validated and applied to determine the pharmacokinetics of clomiphene and its metabolites in healthy subjects, proving to be an essential tool for investigating human biotransformation of clomiphene.
Article
Oncology
Khoan Vu, Chi-Heng Wu, Chen-Yen Yang, Aaron Zhan, Erika Cavallone, Wade Berry, Pamela Heeter, Laura Pincus, Matthew J. Wieduwilt, Basem M. William, Charalambos Andreadis, Lawrence K. Kaplan, Frank McCormick, Pierluigi Porcu, Jonathan E. Brammer, Weiyun Z. Ai
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Benjamin K. Tomlinson, Molly M. Gallogly, Donna M. Kane, Leland Metheny, Hillard M. Lazarus, Basem M. William, Michael D. Craig, Mark J. Levis, Brenda W. Cooper
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2020)
Article
Oncology
Aleeza Abbasi, Catherine Chung, Basem M. William
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2020)
Article
Hematology
Annie Im, Armin Rashidi, Tao Wang, Michael Hemmer, Margaret L. MacMillan, Joseph Pidala, Madan Jagasia, Steven Pavletic, Navneet S. Majhail, Daniel Weisdorf, Hisham Abdel-Azim, Vaibhav Agrawal, A. Samer Al-Homsi, Mahmoud Aljurf, Medhat Askar, Jeffery J. Auletta, Asad Bashey, Amer Beitinjaneh, Vijaya Raj Bhatt, Michael Byrne, Jean-Yves Cahn, Mitchell Cairo, Paul Castillo, Jan Cerny, Saurabh Chhabra, Hannah Choe, Stefan Ciurea, Andrew Daly, Miguel Angel Diaz Perez, Nosha Farhadfar, Shahinaz M. Gadalla, Robert Gale, Siddhartha Ganguly, Usama Gergis, Rabi Hanna, Peiman Hematti, Roger Herzig, Gerhard C. Hildebrandt, Deepesh P. Lad, Catherine Lee, Leslie Lehmann, Lazaros Lekakis, Rammurti T. Kamble, Mohamed A. Kharfan-Dabaja, Pooja Khandelwal, Rodrigo Martino, Hemant S. Murthy, Taiga Nishihori, Tracey A. O'Brien, Richard F. Olsson, Sagar S. Patel, Miguel-Angel Perales, Tim Prestidge, Muna Qayed, Rizwan Romee, Helene Schoemans, Sachiko Seo, Akshay Sharma, Melhem Solh, Roger Strair, Takanori Teshima, Alvaro Urbano-Ispizua, Marjolein Van der Poel, Ravi Vij, John L. Wagner, Basem William, Baldeep Wirk, Jean A. Yared, Steve R. Spellman, Mukta Arora, Betty K. Hamilton
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Article
Oncology
Brendan Rasor, Tyler Dickerson, Qiuhong Zhao, Patrick Elder, Jonathan E. Brammer, Karilyn Larkin, Samantha Jaglowski, Alice Mims, Sam Penza, Sumithira Vasu, Sarah A. Wall, Basem William, Ayman Saad, Julianna V. F. Roddy, Hannah Choe, Marcin Puto
Summary: The retrospective cohort study compared the efficacy and tolerability of busulfan AUC target of 16.4 mg x Hr/L per day (FluBu4K) and a conventional RIC regimen (FluBu2) in patients with AML or MDS. The results suggest that for select patients, there may be benefit in choosing FluBu4K over FluBu2, as it showed a lower cumulative incidence of relapse at 18 months.
LEUKEMIA & LYMPHOMA
(2021)
Meeting Abstract
Hematology
Christiane Querfeld, Basem M. William, Lubomir Sokol, Oleg Akilov, Brian Poligone, Jasmine Zain, Yutaka Tagaya, Nazli Azimi
Meeting Abstract
Hematology
Julio C. Chavez, Caron A. Jacobson, Alison R. Sehgal, Sattva S. Neelapu, David G. Maloney, Gilles Salles, Basem M. William, Yin Yang, Lovely Goyal, Justin Chou, Vicki Plaks, Mauro P. Avanzi
Meeting Abstract
Hematology
Julio C. Chavez, Francine M. Foss, Basem M. William, Jonathan E. Brammer, Sonali M. Smith, Anca Prica, Jasmine M. Zain, Joseph M. Tuscano, Martha Glenn, Neha Mehta-Shah, Ben X. Wang, Stephanie Zantinge, Lisa Wang, Ling Zhang, Anmarie Boutrin, Weiguang Zhao, Lily Cheng, Nathan Standifer, Gianluca Carlesso, Jeffrey Moscow, Lillian Siu
Meeting Abstract
Hematology
Nidhi Sharma, Justin Jiang, Qiuhong Zhao, Patrick Elder, Don M. Benson, Ashley Rosko, Maria Chaudhry, Naresh Bumma, Abdullah Khan, Srinivas Devarakonda, Sumithira Vasu, Samantha Jaglowski, Basem M. William, Alice S. Mims, Hannah Choe, Jonathan E. Brammer, Sarah A. Wall, Nicole Grieselhuber, Ayman Saad, Sam Penza, Audrey M. Sigmund, Yvonne A. Efebera
Meeting Abstract
Hematology
Audrey M. Sigmund, Justin Jiang, Qiuhong Zhao, Patrick Elder, Don M. Benson, Ashley Rosko, Maria Chaudhry, Naresh Bumma, Abdullah Khan, Srinivas Devarakonda, Sumithira Vasu, Samantha Jaglowski, Basem M. William, Alice S. Mims, Hannah Choe, Karilyn Larkin, Jonathan E. Brammer, Sarah A. Wall, Nicole Grieselhuber, Ayman Saad, Sam Penza, Yvonne A. Efebera, Nidhi Sharma
Meeting Abstract
Hematology
Audrey M. Sigmund, Qiuhong Zhao, Justin Jiang, Patrick Elder, Don M. Benson, Ashley Rosko, Maria Chaudhry, Naresh Bumma, Abdullah Khan, Srinivas Devarakonda, Sumithira Vasu, Samantha Jaglowski, Basem M. William, Alice S. Mims, Hannah Choe, Karilyn Larkin, Jonathan E. Brammer, Sarah A. Wall, Nicole Grieselhuber, Ayman Saad, Sam Penza, Yvonne A. Efebera, Nidhi Sharma
Meeting Abstract
Hematology
Noha N. Soror, Ashleigh Keiter, Qiuhong Zhao, Julianna Roddy, Sam Penza, Jonathan E. Brammer, Yvonne A. Efebera, Don M. Benson, Sumithra Vasu, Alice S. Mims, Bradley W. Blaser, Hannah Choe, Karilyn Larkin, Nicole Grieselhuber, Sarah A. Wall, Ayman Saad, Ashley Rosko, Patrick Elder, Maria Chaudhry, Naresh Bumma, Abdullah Khan, Srinivas Devarakonda, Samantha Jaglowski, Basem M. William
Meeting Abstract
Hematology
Brendan Rasor, Tyler Dickerson, Qiuhong Zhao, Jonathan E. Brammer, Karilyn Larkin, Samantha Jaglowski, Alice Mims, Sam Penza, Sumithira Vasu, Sarah A. Wall, Basem M. William, Ayman Saad, Julianna Roddy, Hannah Choe, Marcin Puto
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Meeting Abstract
Hematology
Nidhi Sharma, Bin Ni Ni, Qiuhong Zhao, Patrick Elder, Don M. Benson, Ashley Rosko, Maria Chaudhry, Naresh Bumma, Abdullah Khan, Srinivas Devarakonda, Sumithira Vasu, Samantha Jaglowski, Basem M. William, Alice Mims, Hannah Choe, Karilyn Larkin, Jonathan E. Brammer, Sarah A. Wall, Nicole Grieselhuber, Ayman Saad, Sam Penza, Yvonne A. Efebera
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Meeting Abstract
Hematology
Jonathan E. Brammer, Zachary Braunstein, Aashish Katapadi, Kyle Porter, Michael Biersmith, Avirup Guha, Sakima A. Smith, Sumithira Vasu, Devin Haddad, Richard Gumina, Basem M. William, Sam Penza, Ayman Saad, Nathan Denlinger, Ajay Vallakati, Ragavendra Baliga, Philip Binkley, Samantha Jaglowski, Daniel Addison
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)