The acinar regulator Gata6 suppressesKrasG12V-driven pancreatic tumorigenesis in mice

Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice

(2014) Patrick C. Hermann et al.   GASTROENTEROLOGY

The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression

(2014) Gavin Whissell et al.   NATURE CELL BIOLOGY

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

(2014) Nina Schönhuber et al.   NATURE MEDICINE

Nr5a2heterozygosity sensitises to, and cooperates with, inflammation inKRasG12V-driven pancreatic tumourigenesis

(2013) Marta Flandez et al.   GUT

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation

(2013) Guido von Figura et al.   GUT

Nkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma

(2013) Eric L. Snyder et al.   MOLECULAR CELL

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

(2012) Carolina Navas et al.   CANCER CELL

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer

(2012) Timothy R. Donahue et al.   CLINICAL CANCER RESEARCH

Gata6is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice

(2012) Paola Martinelli et al.   GUT

Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis

(2012) Shouhong Xuan et al.   JOURNAL OF CLINICAL INVESTIGATION

GATA4 and GATA6 control mouse pancreas organogenesis

(2012) Manuel Carrasco et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer

(2011) Marina Lesina et al.   CANCER CELL

Genome profiling of pancreatic adenocarcinoma

(2011) David J. Birnbaum et al.   GENES CHROMOSOMES & CANCER

Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?

(2011) Ilse Rooman et al.   GUT

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

GATA6 Activates Wnt Signaling in Pancreatic Cancer by Negatively Regulating the Wnt Antagonist Dickkopf-1

(2011) Yi Zhong et al.   PLoS One

Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma

(2010) Baojin Fu et al.   CANCER BIOLOGY & THERAPY

A Migration Signature and Plasma Biomarker Panel for Pancreatic Adenocarcinoma

(2010) S. Balasenthil et al.   Cancer Prevention Research

A Novel Gastrokine, Gkn3, Marks Gastric Atrophy and Shows Evidence of Adaptive Gene Loss in Humans

(2010) Trevelyan R. Menheniott et al.   GASTROENTEROLOGY

Replacement of Rbpj With Rbpjl in the PTF1 Complex Controls the Final Maturation of Pancreatic Acinar Cells

(2010) Toshihiko Masui et al.   GASTROENTEROLOGY

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

(2010) A. V. Pinho et al.   GUT

β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

(2010) John P. Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

(2009) Huadong Pei et al.   CANCER CELL

Loss of the Acinar-Restricted Transcription Factor Mist1 Accelerates Kras-Induced Pancreatic Intraepithelial Neoplasia

(2009) Guanglu Shi et al.   GASTROENTEROLOGY

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

Genomic Profiling Identifies GATA6 as a Candidate Oncogene Amplified in Pancreatobiliary Cancer

(2008) Kevin A. Kwei et al.   PLoS Genetics