Article
Critical Care Medicine
Cho-Yi Huang, Hsin-Chung Huang, Mei-Huei Chen, Tso-Ting Lai, Hung-Chieh Chou, Chien-Yi Chen, Ting -An Yen, Wellington Cardoso, Po-Nien Tsao
Summary: This study retrospectively evaluated the respiratory outcomes of preterm infants with bronchopulmonary dysplasia who received intravitreal bevacizumab (IVB) treatment. The results showed that IVB was significantly associated with prolonged ventilatory support and a lower likelihood of being ventilator free.
Article
Biochemistry & Molecular Biology
Roopa Siddaiah, Christiana N. Oji-Mmuo, Deborah T. Montes, Nathalie Fuentes, Debra Spear, Ann Donnelly, Patricia Silveyra
Summary: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that develops in neonates as a consequence of preterm birth and inflammation. The study identified certain miRNAs in tracheal aspirates of preterm infants with severe BPD, suggesting their potential as biomarkers for disease severity in infants with BPD.
Article
Biochemistry & Molecular Biology
Tohru Ogihara, Makoto Mino
Summary: When evaluating the nutritional status of preterm infants, it is important to compare the data with healthy term infants and consider the gestational age rather than birth weight. There is limited data on the correlation between gestational age and vitamin E concentrations in preterm infants, and the oxidizability of polyunsaturated fatty acids is lower in preterm infants. Clinical trials of vitamin E supplementation in preterm infants have mostly been unsuccessful, and there is a need for further research in modern neonatal medicine.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Pediatrics
Liron Borenstein-Levin, Jarinda A. Poppe, Willem van Weteringen, H. Rob Taal, Ori Hochwald, Amir Kugelman, Irwin K. M. Reiss, Sinno H. P. Simons
Summary: The study showed that the SpO(2) histogram classification system provides an objective measure of response to doxapram therapy in preterm infants. Infants who responded to treatment within 24 hours were less likely to require invasive mechanical ventilation. The classification system allows for bedside assessment of oxygenation status changes in response to respiratory interventions within a few hours.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Yannick Regin, Andre Gie, An Eerdekens, Jaan Toelen, Anne Debeer
Summary: Ventilation and respiratory care have undergone substantial changes in extremely premature neonates. However, the impact on respiratory health remains unclear. This retrospective study investigated changes in respiratory care and disease frequency in extremely premature infants. The study found that the incidence of bronchopulmonary dysplasia (BPD) increased over time, despite advancements in treatment guidelines. There was also an increase in the use of non-invasive ventilation, and a decrease in the rates of certain non-pulmonary morbidities.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Christoph Buehrer, Guenther Heller, Ulrich H. Thome
Summary: The study in Germany from 2010 to 2017 found a moderate decline in mortality, a slight increase in severe ROP, and a steady decline in BPD. Avoiding endotracheal intubation may have contributed to the lower rates of BPD.
Article
Biochemistry & Molecular Biology
Samuel J. Gentle, Khandaker A. Ahmed, Nengjun Yi, Casey D. Morrow, Namasivayam Ambalavanan, Charitharth Lal, Rakesh P. Patel
Summary: The study found that nitrate reductase activity in the oral cavity peaked at 29 weeks' post menstrual age, and infants who developed bronchopulmonary dysplasia (BPD) had significantly lower nitrate reductase activity at this time. The oral microbiota and nitrate reductase activity may play a role in the development of BPD in extremely preterm infants.
Article
Pharmacology & Pharmacy
A. Yazici, M. Buyuktiryaki, G. K. Simsek, H. G. Kanmaz Kutman, F. E. Canpolat
Summary: This study aimed to identify factors associated with neurodevelopmental impairment (NDI) in patients with moderate to severe BPD. The study found that several conditions, such as prolonged respiratory support, prolonged hospitalization, intraventricular hemorrhage, retinopathy, and steroid therapy, were associated with poor neurodevelopmental outcomes in patients with BPD. These conditions can be avoided or prevented with strict protocols and prevention strategies.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maxwell Mathias, Jill Chang, Marta Perez, Ola Saugstad
Summary: Oxygen is crucial for cell survival, but excessive oxygen delivery can disrupt growth and development, induce inflammation, and cause oxidative damage. Newborns, especially premature infants, are particularly susceptible to hyperoxic injury due to their immature antioxidant defense system.
Article
Pediatrics
Vineet Lamba, Oscar Winners, Prem Fort
Summary: The study found that early high-dose caffeine (HD) therapy can reduce the duration of mechanical ventilation in premature infants and decrease the risk of bronchopulmonary dysplasia (BPD).
Article
Neurosciences
Seong Phil Bae, Seung Han Shin, Young Mi Yoon, Ee-Kyung Kim, Han-Suk Kim
Summary: This study found that moderate to severe bronchopulmonary dysplasia and severe retinopathy of prematurity were associated with adverse neurodevelopmental outcomes in preterm infants without severe brain injury.
Article
Pediatrics
Wen Hua Bai, Dan Feng Gu, Yun Dai, Yu Hong Chen, Zu Ming Yang, Li Jun Lu
Summary: This study retrospectively collected clinical data of premature infants in Suzhou Municipal Hospital, China, and analyzed the association between probiotic use and retinopathy of prematurity (ROP). The results showed that probiotics were associated with a reduced risk of ROP in preterm infants, but further large-scale prospective studies are needed for validation.
FRONTIERS IN PEDIATRICS
(2023)
Article
Physiology
Andrew A. Bremer, Jagteshwar Grewal, Rohan Hazra, Roberto Romero, Diana W. Bianchi
Summary: Premature birth is a major cause of morbidity and mortality, with research efforts focused on prevention and improved treatment for pre-term infants. Collaboration between intramural and extramural research institutions, including multiple institutes and centers at the National Institutes of Health, is crucial in addressing this issue.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Critical Care Medicine
Barbara Loi, Giulia Vigo, Eugenio Baraldi, Francesco Raimondi, Virgilio P. Carnielli, Fabio Mosca, Daniele De Luca
Summary: Lung ultrasound scores can be utilized to monitor lung aeration and function in extremely preterm infants, and they can predict the occurrence of bronchopulmonary dysplasia, providing a new imaging tool and predictive method.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Pediatrics
Eli Rhoads, Gregory S. Montgomery, Clement L. Ren
Summary: Wheezing is a common symptom in preterm children, whether or not they have a history of bronchopulmonary dysplasia. This article will review the mechanisms, epidemiology, and treatment of wheezing in preterm children with and without a history of bronchopulmonary dysplasia.
PEDIATRIC PULMONOLOGY
(2021)
Article
Respiratory System
Steven H. Abman, Mary P. Mullen, Lynn A. Sleeper, Eric D. Austin, Erika B. Rosenzweig, John P. Kinsella, Dunbar Ivy, Rachel K. Hopper, J. Usha Raj, Jeffrey Fineman, Roberta L. Keller, Angela Bates, Usha S. Krishnan, Catherine M. Avitabile, Alexander Davidson, Marc D. Natter, Kenneth D. Mandl
Summary: The study found a significant proportion of pediatric PH patients with Group 3 disorders, reflecting the growing recognition of PH in diverse developmental lung diseases. Greater precision of clinical phenotyping based on disease-specific characterization may further enhance care and research of pediatric PH.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Pediatrics
Claire D. Gerall, Latoya A. Stewart, Jessica Price, Sandra Kabagambe, Shelby R. Sferra, Maggie J. Schmaedick, Rebecca Hernan, Julie Khlevner, Usha S. Krishnan, Aliva De, Gudrun Aspelund, Vincent P. Duron
Summary: This study retrospectively analyzed the outcomes of patients who underwent CDH repair at our institution in a long-term multidisciplinary follow-up clinic. As the survival of CDH patients improves, long-term care and follow-up become increasingly important to ensure appropriate surveillance and optimization of long-term outcomes.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Rebecca Epstein, Usha S. Krishnan
CARDIOLOGY CLINICS
(2022)
Article
Pediatrics
Latoya A. Stewart, Rafael Klein-Cloud, Claire Gerall, Weijia Fan, Jessica Price, Rebecca R. Hernan, Usha S. Krishnan, Eva W. Cheung, William Middlesworth, Diana Vargas Chaves, Russell Miller, Lynn L. Simpson, Wendy K. Chung, Vincent P. Duron
Summary: This study retrospectively analyzed the types of complications and their impact on survival among CDH patients undergoing ECMO treatment. The results showed that CDH neonates frequently experienced complications during ECMO treatment, with metabolic and mechanical complications being the most common. Mechanical and renal complications were independently associated with mortality.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Robyn Rexwinkel, Vera W. A. van Berge Henegouwen, Maartje M. J. Singendonk, Usha Krishnan, Yvan VandenPlas, Caterina Strisciuglio, Rachel Rosen, Arnaud Lalanne, Shaman Rajindrajith, Marc A. Benninga, Merit M. Tabbers
Summary: The study aims to develop a core outcome set for clinical studies assessing gastroesophageal reflux disease (GERD) in children. Through the use of Delphi technique and OMERACT 2.0 recommendations, healthcare professionals, parents, and children identified a total of 9 important outcome measures, including adequate relief, evidence of esophagitis, feeding difficulties, heartburn, hematemesis, regurgitation, sleeping difficulties, vomiting, and adverse events. This core outcome set facilitates comparison between studies and provides recommendations for improving treatment of GERD in children.
JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Azadeh Issapour, Benjamin Frank, Sarah Crook, Michelle D. Hite, Michelle L. Dorn, Erika B. Rosenzweig, D. Dunbar Ivy, Usha S. Krishnan
Summary: This study retrospectively observed the safety and tolerability of using ambrisentan and tadalafil in pediatric pulmonary hypertension treatment. The results showed that combination therapy with ambrisentan and tadalafil was well-tolerated and had an acceptable safety profile in children, and was associated with improved exercise capacity and hemodynamics.
PEDIATRIC PULMONOLOGY
(2022)
Article
Obstetrics & Gynecology
A. Zenilman, W. Fan, R. Hernan, J. Wynn, A. Abramov, C. Farkouh-Karoleski, G. Aspelund, U. S. Krishnan, J. Khlevner, K. Azarow, T. Crombleholme, R. Cusick, D. Chung, M. E. Danko, D. Potoka, F. Y. Lim, D. J. McCulley, G. B. Mychaliska, D. Schindel, S. Soffer, A. J. Wagner, B. W. Warner, W. K. Chung, V. P. Duron
Summary: Infants with CDH who are small for gestational age (SGA) have poorer prognosis with higher mortality rates and increased oxygen requirements compared to infants who are appropriate for gestational age (AGA).
JOURNAL OF PERINATOLOGY
(2022)
Article
Pediatrics
Michael P. DiLorenzo, Kanwal M. Farooqi, Amee M. Shah, Alexandra Channing, Jamie K. Harrington, Thomas J. Connors, Karen Martirosyan, Usha S. Krishnan, Anne Ferris, Rachel J. Weller, Donna L. Farber, Joshua D. Milner, Mark Gorelik, Erika B. Rosenzweig, Brett R. Anderson
Summary: This study aimed to assess the myocardial condition of MIS-C patients 6-9 months after hospitalization. The cardiac MRI findings revealed minimal residual myocardial damage and functional impairment in these children, indicating the need for further research on long-term implications.
PEDIATRIC RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michael Di Maria, David J. Goldberg, Victor Zak, Chenwei Hu, Adam M. Lubert, Andreea Dragulescu, Andrew S. Mackie, Andrew McCrary, Angela Weingarten, Anitha Parthiban, Benjamin Goot, Bryan H. Goldstein, Carolyn Taylor, Christopher Lindblade, Christopher J. Petit, Christopher Spurney, David M. Harrild, Elaine M. Urbina, Eleanor Schuchardt, Gi Beom Kim, Ja Kyoung Yoon, Jamie N. Colombo, Matthew D. Files, Megan Schoessling, Peter Ermis, Pierre C. Wong, Ruchira Garg, Sara K. Swanson, Shaji C. Menon, Shubhika Srivastava, Thor Thorsson, Tiffanie R. Johnson, Usha S. Krishnan, Stephen M. Paridon, Peter C. Frommelt
Summary: The FUEL trial demonstrated that treatment with udenafil can significantly improve exercise capacity. This study aimed to investigate the effect of udenafil on echocardiographic measures of single ventricle function. The results showed that participants who received udenafil had significant improvements in some global and diastolic echo indices, suggesting improved pulmonary venous return and/or ventricular compliance.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Pediatrics
Kinjal Desai, Michael Di Lorenzo, Warren S. A. Zuckerman, Ezinne Emeruwa, Usha S. S. Krishnan
Summary: This is a small study on the use of sildenafil in treating left-sided heart failure. The results show that sildenafil can improve heart function, but it needs to be titrated carefully with inpatient surveillance.
Article
Pediatrics
Latoya A. Stewart, Rebecca R. Hernan, Christopher Mardy, Eunice Hahn, Wendy K. Chung, Emile A. Bacha, Ganga Krishnamurthy, Vincent P. Duron, Usha S. Krishnan
Summary: The study aims to describe the types of congenital heart disease (CHD) in a congenital diaphragmatic hernia (CDH) cohort and evaluate surgical decision making and outcomes based on complexity of CHD and associated conditions. A retrospective review found that clinically important CHD was diagnosed in 19% of CDH patients. Patients who underwent surgery for both CHD and CDH as neonates had a survival rate of 90%, while those undergoing repair for CDH alone had a survival rate of 87.5%. Nonsurvivors were more likely to have unrepaired CDH and unrepaired CHD, reflecting a decision not to offer surgery.
JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Francisca L. Chou, Denis J. Donovan, Rachel J. Weller, Michael A. Fremed, Julie S. Glickstein, Usha S. Krishnan
Summary: This study investigates the sources of medical information that families use to learn about paediatric cardiac conditions. It reveals that education level and medical insurance type are associated with the utilization of informative resources.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Cardiac & Cardiovascular Systems
Pei-Ni Jone, D. Dunbar Ivy, Amanda Hauck, Tara Karamlou, Uyen Truong, Ryan D. Coleman, Juan Pablo Sandoval, Maria Jesus del Cerro Marin, Pirooz Eghtesady, Kathryn Tillman, Usha S. Krishnan
Summary: Patients with pulmonary hypertension associated with congenital heart disease pose challenges due to underlying anatomical and hemodynamic abnormalities, and there are currently no consensus recommendations on how to manage this group of patients. This document aims to describe different subgroups of pulmonary hypertension associated with congenital heart disease, discuss imaging modalities for patient evaluation, outline medical and surgical management considerations, address disparities within this population, and identify future research needs.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Kristin T. Fujita, Michael P. DiLorenzo, Usha S. Krishnan, Mariel E. Turner, Oliver M. Barry, Alejandro J. Torres, Emile A. Bacha, David Kalfa, Matthew A. Crystal
Summary: Pulmonary vein stenosis (PVS) in children is a challenging condition with poor outcomes. Limited data is available on the outcomes of post-operative PVS. Our objective was to review our experience and assess surgical and transcatheter outcomes.
PEDIATRIC CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Francisca L. Chou, Denis J. Donovan, Rachel J. Weller, Michael Fremed, Julie S. Glickstein, Usha S. Krishnan
Article
Pediatrics
Tarun Aurora, Audrey Cole, Parul Rai, Paul Lavoie, Carrie Mcivor, Lisa M. Klesges, Guolian Kang, Janaka S. S. Liyanage, Heather M. Brandt, Jane S. Hankins
Summary: This study evaluated the effectiveness of a vaccine strategy bundle in increasing HPV vaccine initiation and completion rates in a specialty clinic setting. By implementing the bundle, which included staff education, provider incentives, offering vaccines in clinics, and verifying vaccine completion, the clinic successfully improved HPV vaccine initiation and completion rates among sickle cell disease patients.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nienke M. Halbmeijer, Wes Onland, Jeroen Dudink, Filip Cools, Anne Debeer, Anton H. van Kaam, Manon J. N. L. Benders, Niek E. van der Aa
Summary: In ventilated infants born preterm, high dose systemic hydrocortisone initiated between 7 and 14 days after birth did not have a significant impact on brain development.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Katherine Melton, Jianfang Liu, Hossein Sadeghi, Maureen George, Arlene Smaldone
Summary: This study aims to identify predictors of change in lung function and body weight during health care transition in cystic fibrosis (CF) patients. The study findings highlight the importance of CF RISE program engagement and reducing gaps in care for improving the transition of adolescents and young adults with CF.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Laura A. Duckworth, Kimberly A. Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R. Holtz, Phillip I. Tarr, Ronald C. Rubenstein
Summary: The study tested the usefulness of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and investigated the repeatability of these measures in individuals over short periods and their correlation with clinical outcomes. The results showed that elevated levels of fLcn2 in individuals with CF may predict worsened pulmonary function.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Lindsey Haack, Nikkan Das, Arvind Hoskoppal, Mark Debrunner, Tarek Alsaied, Gaurav Arora
Summary: RAE on ECG has a low positive predictive value for RAE on echocardiogram in previously healthy young patients. The highest yield for RAE on echocardiogram was observed in patients who were <1 year of age, had RAE in the anterior precordial leads, or displayed right ventricular hypertrophy on ECG.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael A. Padula, Khatija Naing, Tara L. Wenger, Irfan Ahmad, Carl H. Coghill, K. Taylor Wild, S. Alex Rottgers, Cory M. Resnick, Jeffrey Goldstein, Zarmina Ehsan, Donna Watkins, Nicole Deptula, Kuan-Chi Lai, Janet Lioy, Semsa Gogcu, Christopher M. Cielo
Summary: This study describes the spectrum of disease and burden of care in infants with congenital micrognathia. The results show that these infants commonly require surgical intervention and tube feedings, and disparities based on race and among centers were identified.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Michael P. Fundora, Manvitha Kalicheti, Guantao Zhao, Kevin O. Maher, Nicoleta Serban
Summary: This study investigated the variation of outpatient opioid prescribing in postoperative pediatric cardiac patients across the US. The results showed that there were significant differences in opioid prescribing by race, ethnicity, sex, and region.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Jia Guo, Brooklyn J. Fraser, Leigh Blizzard, Michael D. Schmidt, Terence Dwyer, Alison J. Venn, Costan G. Magnussen
Summary: There is a correlation between childhood and adulthood cardiorespiratory fitness.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Nianzhou Xiao, Michelle Starr, Adrienne Stolfi, Gilad Hamdani, Shireen Hashmat, Stefan G. Kiessling, Christina Sethna, Mahmoud Kallash, Robyn Matloff, Robert Woroniecki, Keia Sanderson, Ikuyo Yamaguchi, Stephen D. Cha, Michael G. Semanik, Rahul Chanchlani, Joseph T. Flynn, Mark Mitsnefes
Summary: This multicenter study reports that most infants diagnosed with idiopathic hypertension in the NICU will discontinue antihypertensive treatment within 2 years of discharge. Antenatal steroid treatment is associated with a decreased likelihood of needing antihypertensive therapy for more than 1 year.
JOURNAL OF PEDIATRICS
(2024)
Editorial Material
Pediatrics
Kanwaljit Singh, John Concato, Jonathan M. Davis
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Yaxing Meng, Harri Niinikoski, Suvi P. Rovio, Brooklyn J. Fraser, Feitong Wu, Antti Jula, Tapani Ronnemaa, Jorma S. A. Viikari, Olli T. Raitakari, Katja Pahkala, Costan G. Magnussen
Summary: This 26-year study shows a correlation between early-life non-HDL-C levels and future levels. Early dietary counseling can reduce the risk of high pediatric non-HDL-C, emphasizing the importance of early interventions in preventing cardiovascular risks.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kelsey A. B. Gastineau, Rebecca Bell, Allison Hanes, Sandra Mckay, Eric Sigel, Filoteia Popescu, Evan C. Sommer, Shari Barkin
Summary: This study aimed to assess the self-reported counseling outcomes for a firearm safe storage counseling training program provided by the American Academy of Pediatrics. The results demonstrated significant improvement in counseling self-efficacy and frequency one month after the training.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Kathryn E. K. Berlin, William Scott, Sara Dawson, David Brousseau, Joanne M. Lagatta
Summary: This prospective cohort study aimed to investigate the impact of bronchopulmonary dysplasia (BPD) on the health-related quality of life (HRQL) of infants from NICU hospitalization to one year post-discharge. The study found that lower HRQL during NICU stay was associated with earlier gestational age, postnatal corticosteroid usage, outborn status, and gastrostomy tube placement. Lower HRQL at 3 and 12 months post-discharge was associated with readmissions, home oxygen use, parent-reported difficulty breathing, lower developmental scores, and not playing with other children. Most parents reported similar or improved HRQL after discharge, but parents of infants with respiratory symptoms experienced less improvement. Efforts to improve parent HRQL should focus on respiratory symptoms and social isolation.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
Garett J. Griffith, Alan P. Wang, Robert I. Liem, Michael R. Carr, Tyler Corson, Kendra Ward
Summary: This study developed reference values for cardiorespiratory fitness in children aged 6-18 years without underlying heart disease, measured by peak oxygen uptake and treadmill time. Fitness levels increased with age in males but not females. Males generally exhibited higher fitness levels compared to females in the same age groups.
JOURNAL OF PEDIATRICS
(2024)
Article
Pediatrics
David S. Liu, Patricia Miller, Anna Rothenberg, Carley Vuillermin, Peter M. Waters, Andrea S. Bauer
Summary: This study aims to determine if children with elbow flexion contracture (EFC) caused by brachial plexus birth injury (BPBI) are more likely to develop shoulder contracture and undergo surgical treatment. A retrospective review was conducted on children under 2 years old with BPBI who presented to a single children's hospital. The results showed that patients with EFC had reduced shoulder range of motion and higher odds of shoulder contracture and surgical treatment. Prompt referral to a BPBI specialty clinic is recommended for evaluation and potential surgery.
JOURNAL OF PEDIATRICS
(2024)