Characterisation of liver pathogenesis, human immune responses and drug testing in a humanised mouse model of HCV infection

Pluripotent stem cell-derived hepatocyte-like cells

(2014) R.E. Schwartz et al.   BIOTECHNOLOGY ADVANCES

Engrafted human stem cell–derived hepatocytes establish an infectious HCV murine model

(2014) Arnaud Carpentier et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages

(2014) Moses T. Bility et al.   PLoS Pathogens

Hepatitis C Virus Infection Induces Inflammatory Cytokines and Chemokines Mediated by the Cross Talk between Hepatocytes and Stellate Cells

(2013) H. Nishitsuji et al.   JOURNAL OF VIROLOGY

Completion of the entire hepatitis C virus life cycle in genetically humanized mice

(2013) Marcus Dorner et al.   NATURE

Human Fetal Hepatic Progenitor Cells Are Distinct from, but Closely Related to, Hematopoietic Stem/Progenitor Cells

(2013) Qingfeng Chen et al.   STEM CELLS

Too low to measure, infectious nonetheless

(2012) L. B. Dustin   BLOOD

Cytokines and HCV-Related Disorders

(2012) Poupak Fallahi et al.   Clinical & Developmental Immunology

Animal Models for the Study of Hepatitis C Virus Infection and Related Liver Disease

(2012) Jens Bukh   GASTROENTEROLOGY

Modeling hepatitis C virus infection using human induced pluripotent stem cells

(2012) R. E. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Humanized Mouse Model to Study Hepatitis C Virus Infection, Immune Response, and Liver Disease

(2011) Michael L. Washburn et al.   GASTROENTEROLOGY

T cell responses in hepatitis C: the good, the bad and the unconventional

(2011) Paul Klenerman et al.   GUT

Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus

(2011) Jean-Michel Pawlotsky   HEPATOLOGY

Interleukin-6 Protects Human Macrophages from Cellular Cholesterol Accumulation and Attenuates the Proinflammatory Response

(2011) Eric Frisdal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetically humanized mouse model for hepatitis C virus infection

(2011) Marcus Dorner et al.   NATURE

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

(2011) Nicolas Legrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

(2010) Michael A. Brehm et al.   CLINICAL IMMUNOLOGY

Soluble inflammatory markers as predictors of liver histological changes in patients with chronic hepatitis C virus infection

(2010) A. S. Moura et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

(2010) Karl-Dimiter Bissig et al.   JOURNAL OF CLINICAL INVESTIGATION

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

(2009) Nicolas Legrand et al.   Cell Host & Microbe

Occult HCV Infection: An Unexpected Finding in a Population Unselected for Hepatic Disease

(2009) Laura De Marco et al.   PLoS One

Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis

(2008) D. Sansonno et al.   BLOOD

Altered chemotactic response of myeloid and plasmacytoid dendritic cells from patients with chronic hepatitis C: role of alpha interferon

(2008) V. R. Cicinnati et al.   JOURNAL OF GENERAL VIROLOGY