期刊
JOURNAL OF PATHOLOGY
卷 245, 期 1, 页码 3-5出版社
WILEY
DOI: 10.1002/path.5029
关键词
Wnt signalling; prostate cancer
资金
- Cancer Research UK
- Versus Arthritis [21139] Funding Source: researchfish
Recent next-generation sequencing studies demonstrate that multiple pathways are often deregulated in advanced and metastatic prostate cancer (PC). In a recent issue of The Journal of Pathology, an elegant study by Jefferies et al used in vivo modelling to demonstrate how activation of the PI3K, WNT, and MAPK pathway converges on mTORC1 signalling to drive aggressive disease. The study also highlights that approaches to target advanced PC require intelligent combination of agents to target single/multiple signalling pathways in combination with androgen receptor (AR) blockade. Copyright (c) 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Linked Article: Jeffries et al J Pathol 2018; DOI:
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