In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression

Conversion of one cell type into another: implications for understanding organ development, pathogenesis of cancer and generating cells for therapy: Figure 1

(2014) James L. Corbett et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas

(2014) Hideo Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett’s metaplasia

(2014) David H. Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomic Quantification and Site-Mapping of S-Nitrosylated Proteins Using Isobaric iodoTMT Reagents

(2014) Zhe Qu et al.   JOURNAL OF PROTEOME RESEARCH

SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines

(2014) Irem Dogan et al.   LUNG CANCER

Barrett's Esophagus

(2014) Stuart J. Spechler et al.   NEW ENGLAND JOURNAL OF MEDICINE

A pSMAD/CDX2 Complex Is Essential for the Intestinalization of Epithelial Metaplasia

(2014) Luigi Mari et al.   Cell Reports

Barrett Esophagus and Risk of Esophageal Cancer

(2013) Stuart Jon Spechler   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia

(2012) Michael Quante et al.   CANCER CELL

Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells

(2012) V. Camilo et al.   CARCINOGENESIS

Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD

(2012) Edaire Cheng et al.   GUT

EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer

(2012) Sandeep Singh et al.   Molecular Cancer

SOX2 redirects the developmental fate of the intestinal epithelium toward a premature gastric phenotype

(2012) Lalini Raghoebir et al.   Journal of Molecular Cell Biology

Current Status and Future Perspectives on the Etiology of Esophageal Adenocarcinoma

(2012) Aaron P. Thrift et al.   Frontiers in Oncology

Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia

(2011) Xia Wang et al.   CELL

On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)

(2011) N. Numajiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic review: role of acid, weakly acidic and weakly alkaline reflux in gastro-oesophageal reflux disease

(2010) G. E. Boeckxstaens et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Original article: The prevalence of Barrett's esophagus in the US: estimates from a simulation model confirmed by SEER data

(2010) T. J. Hayeck et al.   DISEASES OF THE ESOPHAGUS

Acid and Bile Salt–Induced CDX2 Expression Differs in Esophageal Squamous Cells From Patients With and Without Barrett's Esophagus

(2010) Xiaofang Huo et al.   GASTROENTEROLOGY

Aberrant Epithelial–Mesenchymal Hedgehog Signaling Characterizes Barrett's Metaplasia

(2010) David H. Wang et al.   GASTROENTEROLOGY

Exogenous luminal nitric oxide exposure accelerates columnar transformation of rat esophagus

(2010) Hiroyuki Endo et al.   INTERNATIONAL JOURNAL OF CANCER

Redox Reactions Induced by Nitrosative Stress Mediate Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases

(2010) Zezong Gu et al.   MOLECULAR NEUROBIOLOGY

Phosphorylation of Sox2 Cooperates in Reprogramming to Pluripotent Stem Cells

(2010) Chul-Ho Jeong et al.   STEM CELLS

Smad, PI3K/Akt, and Wnt-Dependent Signaling Pathways Are Involved in BMP-4-Induced ESC Self-Renewal

(2009) Min Young Lee et al.   STEM CELLS

Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus

(2008) Hui Ying Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Multilayered epithelium in a rat model and human Barrett's esophagus: Similar expression patterns of transcription factors and differentiation markers

(2008) Xiaoxin Chen et al.   BMC GASTROENTEROLOGY