Article
Oncology
Hanqing Wang, Sidi Zhao, Yang Liu, Fengyuan Sun, Xiaoming Huang, Tong Wu
Summary: This study demonstrates that downregulation of SOST promotes the malignant progression of uveal melanoma by activating the Wnt/beta-catenin signaling pathway. Mechanistically, SOST may exert this function by interacting with LRP5/LRP6 membrane receptors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Anatomy & Morphology
Chunyi Ji, Lijian Chen, Miaoxian Yuan, Weixin Xie, Xinyi Sheng, Qiang Yin
Summary: This study investigates the mechanism of KDM1A-regulated hepatoblastoma (HB) development. The expression levels of KDM1A and DKK3 were analyzed in HB patients, and experiments were conducted on cell lines and nude mice to study the effects of knockdown of KDM1A and DKK3. The results suggest that KDM1A stimulates HB development by activating the Wnt/beta-catenin pathway through inhibition of DKK3 transcription.
Article
Oncology
Dan Fang, Mu-Ru Wang, Jia-Lun Guan, Ying-Ying Han, Jia-Qi Sheng, De-An Tian, Pei-Yuan Li
Summary: The study found that in HCC, high expression of BRD9 was closely related to malignancy, tumor stage, tumor size, and prognosis. BRD9 promoted cell proliferation and tumor growth, and mediated its effects by activating the Wnt/beta-catenin signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Fei Song, Fei-Yu Chen, Sui-Yi Wu, Bo Hu, Xiao-liang Liang, Hao-Qin Yang, Jian-Wen Cheng, Peng-Xiang Wang, Wei Guo, Jian Zhou, Jia Fan, Zhong Chen, Xin-Rong Yang
Summary: This study revealed that the expression of MUC1 is significantly up-regulated in ICC, and is associated with the aggressiveness of tumors and patient prognosis. Further investigations showed that MUC1 promotes ICC progression by activating the Wnt/beta-catenin pathway.
Review
Cell Biology
Roozbeh Akhavanfar, Seyyed-Ghavam Shafagh, Behnood Mohammadpour, Yalda Farahmand, Mohammad Hassan Lotfalizadeh, Keihan Kookli, Ali Adili, Goli Siri, Seyed Mahmoud Eshagh Hosseini
Summary: Gastric cancer is a prevalent malignancy worldwide, with poor prognosis and management despite therapeutic advances. The Wnt/beta-catenin pathway is an important target for gastric cancer treatment. Non-coding RNAs play crucial roles in gene regulation and are involved in signaling pathways such as Wnt/beta-catenin. Understanding the role of these regulatory molecules in gastric cancer development may lead to the identification of potential therapeutic targets.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Hao Zhang, Chuanchuan Zheng, Wei Chen, Xiaoqiang Li, Jinshu Wang, Taikun Wang, Qi Zhao, Hao Huang, Yiting Li, Chengliang Yang, Kegong Xie, Shengcai Pan, Binghao Wang, Chong Wang, Yujin Tang, Kai Li, Jia Liu, Liqiang Wang
Summary: Our study demonstrates that targeting Src with PP2 can inhibit Wnt/beta-catenin signaling and activate TGF-beta/Smad signaling, thus protecting against cartilage destruction in OA. This provides a potential therapeutic target for OA treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Fei Gao, Jilai Yin, Yongcun Wang, Hao Li, Daping Wang
Summary: miR-182 overexpression is positively correlated with distant metastasis in cervical cancer patients. It promotes the growth of cervical cancer cells and affects the progression of cervical cancer through the Wnt/β-catenin axis and its downstream genes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Cell Biology
Ruiyao Xu, Xianxian Wang, Sadia Safi, Nico Braunegger, Agnes Hipgrave Ederveen, Michelle Rottmann, Joachim Wittbrodt, Manfred Wuhrer, Janine Wesslowski, Gary Davidson
Summary: Reception of Wnt signals is mediated by Frizzled receptors and a co-receptor LRP6 or LRP5. Precise control of receptor activation is crucial to regulate Wnt/beta-catenin signaling for proper cellular function. A glycosyltransferase B3GnT2-like has been identified to modify LRP6 and enhance Wnt/beta-catenin signaling. This study highlights the importance of LRP6 as a regulatory hub in Wnt signaling and provides insight into the selective targeting of a signaling pathway component by a specific glycosyltransferase.
Article
Cardiac & Cardiovascular Systems
Javier E. Sierra-Pagan, Nikita Dsouza, Satyabrata Das, Thijs A. Larson, Jacob R. Sorensen, Xiao Ma, Patricia Stan, Erik J. Wanberg, Xiaozhong Shi, Mary G. Garry, Wuming Gong, Daniel J. Garry
Summary: FOXK1 is identified as a crucial transcriptional and epigenetic regulator of cardiovascular development by repressing the Wnt/beta-catenin signaling pathway and promoting cardiac progenitor cell differentiation.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiao-Feng Luan, Lei Wang, Xue-Feng Gai
Summary: CAMTA2 is highly expressed in colon cancer and correlated with poor survival. miR-28-5p regulates CAMTA2 expression in colon cancer. The miR-28-5p/CAMTA2 axis plays a critical role in human colon cancer development and may be a potential target for diagnosis and treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Di Zhang, Xiaofeng Liu, Yun Li, Li Sun, Shu-Shu Liu, Yue Ma, Huan Zhang, Xin Wang, Yue Yu
Summary: The study revealed that miR-586 functions as an oncogene promoting breast cancer proliferation and metastasis, while LINC01189 acts as a tumor suppressor inhibiting cancer progression. The interaction and feedback loop between the two are involved in the regulation of Wnt/β-catenin signaling and breast cancer development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Yan Zou, Limin Liu, Jie Meng, Meiyu Dai
Summary: This study aimed to investigate the influence and mechanism of circular RNA hsa_circ_0068464 (circ_0068464) on the development of colorectal cancer (CRC). The study found that circ_0068464 was abnormally up-regulated in CRC cells and tissues, and its knockdown inhibited CRC cell migration and proliferation while promoting apoptosis. The mechanism involved the regulation of Wnt/beta-catenin pathway activation through targeting miR-383. This study provides new insights into the molecular mechanisms underlying the occurrence and development of CRC.
Article
Oncology
Zhi Li, Hai-Yan Yang, Xiao-Lan Zhang, Xu Zhang, Yu-Zhou Huang, Xin-Yuan Dai, Liang Shi, Guo-Ren Zhou, Ji-Fu Wei, Qiang Ding
Summary: This study revealed that KIF23 is up-regulated in TNBC and is associated with poor prognosis. KIF23 promotes TNBC proliferation, migration, and invasion by activating the Wnt/beta-catenin pathway and inducing epithelial-mesenchymal transition (EMT). The WDR5/FOXM1/KIF23/Wnt/beta-catenin axis may serve as a promising therapeutic target for TNBC treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Senwen Feng, Junhao Liu, Hailiang Li, Jianfan Wen, Yujun Zhao, Xiaofeng Li, Guankun Lu, Peng Gao, Xiancheng Zeng
Summary: RAD54B is significantly upregulated in HCC and may serve as a potential prognostic marker and therapeutic target; RAD54B promotes HCC progression mainly through modulating the Wnt/β-catenin signaling pathway; Inhibition of the Wnt/β-catenin signaling pathway can counteract the activating effects of RAD54B on the motility of HCC cells.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Cell Biology
ChuanrRong Zhu, XiaoLing Luo, JinSheng Wu, YuTing Liu, Lei Liu, ShiJie Ma, Rui Xie, ShaoChuang Wang, Wu Ji
Summary: The study reveals that TM4SF1 interacts with DVL2 to positively regulate Wnt/beta-catenin signaling, promoting growth and motility of HCC cells. TM4SF1 is upregulated in HCC and induced by Kras signaling, suggesting it may have oncogenic functions in HCC progression and could be a potential target for treatment.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Surgery
Zi-Le Shen, Zhang Liu, Wang-Fu Zang, Peng Zhang, Hong-Bo Zou, Wen-Xi Dong, Wen-Hao Chen, Xia-Lin Yan, Zhen Yu
Summary: This study aimed to evaluate the prognostic effect of thoracic sarcopenia on adverse outcomes after coronary artery bypass grafting (CABG). The results showed a significant association between thoracic sarcopenia and postoperative complications as well as long-term survival rates in patients underwent CABG. Therefore, preoperative evaluation of thoracic sarcopenia based on chest CT should be included in the risk assessment of CABG.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Shuncang Zhu, Tao Ge, Yicheng Xiong, Jing Zhang, Di Zhu, Liangdong Sun, Nan Song, Peng Zhang
Summary: Lobectomy is a better treatment option for Lung adenosquamous carcinoma (ASC) patients compared to sublobar resection, with improved overall survival and disease-free survival. This preference holds true across different stages of the disease.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemical Research Methods
Peng Zhang, Shikui Tu, Wen Zhang, Lei Xu
Summary: This paper proposes a novel encoder-decoder network named SDCNet for predicting cell line-specific synergistic drug combinations (SDCs). SDCNet learns common patterns across different cell lines as well as cell line-specific features in one model for drug combinations. It achieves this by considering the SDC graphs of different cell lines as a relational graph and constructing a relational graph convolutional network (R-GCN) as the encoder. SDCNet outperforms state-of-the-art methods and is robust when generalized to new cell lines.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Engineering, Civil
Junjun Guo, Penghui Zhang, Jingquan Wang, Shuai Li, Zhongguo Guan
Summary: A novel framework combining Box-Cox transformation and Bayesian inference is proposed for seismic fragility analysis, aiming to enhance the performance of current methodologies. By establishing a numerical model of a cable-stayed bridge within the OpenSees platform, probabilistic seismic demand models are developed using Bayesian inference for Box-Cox transformed data, and fragility models are built using binary Bayesian regression analysis. The results demonstrate that this framework can establish nonlinear probabilistic seismic demand models and improve the performance of classical methods. Furthermore, the binary Bayesian logistic regression-based fragility model eliminates assumptions made by classical analytical approaches and yields robust results. Based on the derived fragility curves, the proposed framework accurately predicts seismic demands at high intensity levels.
ENGINEERING STRUCTURES
(2023)
Article
Surgery
Zhang Liu, Wangfu Zang, Peng Zhang, Zile Shen
Summary: This study aimed to investigate the prognostic implications of malnutrition defined by the Global Leadership Initiative on Malnutrition in older patients who underwent cardiac surgery. The results showed that patients with Global Leadership Initiative on Malnutrition-defined malnutrition had higher risks of postoperative complications and poor overall survival. Therefore, the comprehensive preoperative risk assessment of cardiac surgery using the Global Leadership Initiative on Malnutrition assessment is necessary.
Article
Engineering, Biomedical
Xianglong Li, Cong Jiang, Xinlin Jia, Yuanyuan Cao, Yuanqing Mao, Ji-Na Hao, Yang Yang, Peng Zhang, Yongsheng Li
Summary: This study proposes a dual unlocking strategy to overcome the lack of blood vessels in solid tumors, using engineered hybrid nanoparticles and dexamethasone. The results show that pretreatment with dexamethasone can increase intratumoral micro-vessel density, enhance the delivery efficiency of the nanoparticles, and decrease HIF-1 alpha expression. Furthermore, the platinum in the nanoparticles can catalyze H2O2 to produce oxygen, addressing hypoxia and achieving efficient photodynamic therapy in vivo. Additionally, the nanoparticles can reverse the immunosuppressive tumor microenvironment and promote the therapeutic effect of anti-PD-L1 immunotherapy. This dual unlocking strategy provides an innovative approach to enhance nanomedicine delivery and hypoxia relief in tumor therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang, Qiu Wu, Ziyi Li, Jingxin Fu, Rongbin Zheng, Jiamin Zhang, Qin Tang, Peng Zhang, Chenfei Wang
Summary: This study performed IFNy sensitivity screens in over 40 cancer cell lines and discovered that activation of double-strand break repair genes could lead to resistance to IFNy in cancer cells. Suppression of single-strand break repair genes increased the reliance on DSB repair genes after IFNy treatment. Inhibition of the DSB repair pathway exhibited a synergistic effect with IFNy treatment both in vitro and in vivo. The relationship between the activation of DSB repair genes and IFNy resistance was further confirmed in clinical tumor profiles. This study provides comprehensive resources and evidence to elucidate a mechanism of IFNy resistance in cancer and has the potential to inform combination therapies to overcome immunotherapy resistance.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Oncology
Yicheng Xiong, Dongliang Bian, Zhida Huang, Huansha Yu, Jie Huang, Peng Zhang, Wenxin He, Hongcheng Liu
Summary: This study aimed to assess the feasibility of neoadjuvant EGFR-TKI followed by radical surgery for stage IIIB EGFR-mutant NSCLC. The results showed that neoadjuvant EGFR-TKI followed by radical surgery significantly improved progression-free survival, especially for patients with N2 disease and harboring L858R mutation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Jinglin Zou, Cong Jiang, Xianglong Li, Tianyu Zhong, Shuqi Wang, Bo Wang, Dapeng Zhang, Ji-Na Hao, Yuanyuan Cao, Mengjia Guan, Peng Zhang, Bin Dai, Yongsheng Li
Summary: Gallbladder cancer is a highly fatal and common biliary tract cancer with no uniform chemotherapy regimen. This study designed a paclitaxel-loaded nanocarrier modified with hyaluronidase to enhance the delivery and therapeutic efficiency of paclitaxel in gallbladder cancer. The nanocarrier degrades excess hyaluronic acid to soften extracellular matrix and facilitate nanomedicine penetration for chemotherapy. This study provides a promising direction for gallbladder cancer treatment.
APPLIED MATERIALS TODAY
(2023)
Article
Public, Environmental & Occupational Health
Shuzhi Peng, Juhua Zhang, Xingyue Liu, Mengyun Pei, Tingting Wang, Peng Zhang
Summary: This study investigated the factors influencing burnout among grassroots medical staff in China. The findings suggest that health conditions, working conditions, psychological consequences of the pandemic, wages, and marital status are related to job burnout among medical staff.
Article
Biochemical Research Methods
Peng Zhang, Shikui Tu
Summary: Accurate prediction of drug combination synergistic effects is important for cost reduction and the discovery of novel therapies. This paper proposes a MGAE-DC method based on multi-channel graph autoencoder for predicting drug combination synergistic effects. Experimental results demonstrate that MGAE-DC consistently outperforms existing methods on four benchmark datasets.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiaojiao Wu, Wenxue Yang, Rui Song, Zhe Li, Xiaowei Jia, Hao Zhang, Penghui Zhang, Xinyu Xue, Shenghui Li, Yuanyuan Xie, Rongfei Zhang, Jinyun Ye, Zhijin Zhou, Chenglong Wu
Summary: This study evaluated the effects of dietary soybean lecithin on the growth, haematological indices, immunities, antioxidant capabilities, and inflammatory and intestinal barrier functions in juvenile largemouth bass. The results showed that 4% dietary soybean lecithin improved growth, haematological indices, antioxidant capabilities, immune responses, and intestinal functions, while also alleviating inflammatory responses.
Article
Engineering, Civil
Mingke Li, Junjun Guo, Penghui Zhang, Zhongguo Guan
Summary: This study investigates the characteristics of vertical components in the near-fault region using 121 pairs of typical near-fault ground motions. It is found that there is a weak positive correlation between vertical and horizontal peak ground acceleration (PGA) and peak ground velocity (PGV). The ratios of vertical to horizontal PGA and PGV follow a lognormal distribution, and the vertical ground motions are stronger at lower periods. The optimal scalar IMs for horizontal and vertical seismic demands of an isolated girder bridge with friction pendulum bearings (FPB isolators) are identified. Acceleration-related scalar IMs perform better for vertical seismic demands, while velocity-related scalar IMs perform better for horizontal seismic demands. The study proposes an optimal vector-valued IM consisting of scalar horizontal and vertical IMs for horizontal seismic demands. The probabilistic seismic demand models (PSDMs) with the optimal vector-valued IMs show improved efficiency compared to the corresponding scalar IMs when considering vertical components. The study also finds that vertical effects significantly influence the shear force of piers, while slightly affecting the curvature of piers and bearing displacements.
ENGINEERING STRUCTURES
(2023)
Retraction
Medicine, Research & Experimental
Li Xu, Wei-Lin Liao, Qi-Jue Lu, Peng Zhang, Ji Zhu, Ge-Ning Jiang
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Health Care Sciences & Services
Yanmei Wang, Jianjun Yan, Peng Zhang, Pei Yang, Wenhui Zhang, Min Lu
Summary: The objective of this study was to evaluate the effects of Tai chi on improving elderly patients with type 2 diabetes. The meta-analysis found that the Tai chi group had lower glucose levels, higher activities-specific balance confidence scale scores, and higher single limb standing test scores compared to the control group. The study supports the positive role of Tai chi in improving blood glucose and life quality in diabetes patients.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2022)