期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 13, 页码 7276-7280出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b03273
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [23105013, JP16H01134]
- Japan Society for the Promotion of Science (JSPS) (KAKENHI) [23105013, JP16H01134, JP26282214, JP16K17897]
- A3 foresight program
- Grants-in-Aid for Scientific Research [16K17897, 17H03052, 16H01134] Funding Source: KAKEN
Prenylated indole alkaloids bearing more than one prenyl or reverse-prenyl group show various biological activities. Among them, synthesis of trisubstituted-type prenylated indoles have not been well explored because of the difficulty in regioselective introduction of multiple prenyl and reverse-prenyl groups due to steric hindrance problems. Herein, we describe a synthesis of 2,6,7-trisubstituted prenylated indole using aza-Claisen rearrangement under mild conditions to introduce a prenyl group at C7 in the presence of the prenyl group at C6.
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