Article
Microbiology
Jun Hu, Jianwei Chen, Xiaojian Xu, Qiliang Hou, Jing Ren, Xianghua Yan
Summary: This study compared the gut microbiome of seven different pig breeds and found significant differences between Congjiang miniature (CM) pigs and commercial Duroc x [Landrace x Yorkshire] (DLY) pigs. CM pigs had a stronger intestinal epithelial barrier function than DLY pigs. Fecal microbiota transplantation from CM and DLY pigs to germ-free (GF) mice confirmed the transfer of intestinal epithelial barrier characteristics, and identified Bacteroides fragilis and its metabolite 3-phenylpropionic acid as important contributors to the enhancement of the intestinal epithelial barrier.
Article
Pharmacology & Pharmacy
Xuan Li, Guowen Huang, Yanan Zhang, Yuting Ren, Ruofan Zhang, Weiyun Zhu, Kaifan Yu
Summary: This study found that the interaction between SUCNR1 receptor and succinate has a protective effect on obesity-induced intestinal barrier dysfunction. Supplementation of succinate under high-fat diet conditions can regulate intestinal immune response, promote mucus production, suppress intestinal inflammation, restore intestinal barrier function, and ultimately exert anti-obesity effects.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Microbiology
Guangmang Liu, Jiajia Lu, Weixiao Sun, Gang Jia, Hua Zhao, Xiaoling Chen, In Ho Kim, Ruinan Zhang, Jing Wang
Summary: This study aimed to investigate the effect of tryptophan (Trp) on intestinal barrier function, inflammation, antioxidant status, and microbiota in LPS-challenged piglets. The results showed that Trp supplementation improved the composition of the gut microbiota, enhanced the synthesis of short chain fatty acids, reduced inflammation, increased antioxidant capacity, and improved intestinal barrier function.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kilia Y. Liu, Cindy H. Nakatsu, Yava Jones-Hall, Ariangela Kozik, Qing Jiang
Summary: The study demonstrates that alpha-tocopherol and gamma-tocopherol-rich tocopherols can alleviate symptoms of colitis induced by DSS, protect intestinal barrier function, and have a positive impact on gut microbiota. Gamma-tocopherol-rich tocopherols show significant effects in repairing barrier function and promoting the health of gut microbiota.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Nutrition & Dietetics
Napapan Kangwan, Wasana Pratchayasakul, Aphisek Kongkaew, Komsak Pintha, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that PSO and metformin can effectively improve gut dysbiosis, inflammation, and metabolic disturbance in HFD-fed rats, with metformin showing greater benefits.
Article
Cell Biology
Caijun Zhao, Lijuan Bao, Min Qiu, Keyi Wu, Yihong Zhao, Lianjun Feng, Kaihe Xiang, Naisheng Zhang, Xiaoyu Hu
Summary: This study found that cows with mastitis had significant gut dysbiosis, characterized by enrichment of opportunistic pathogenic bacteria and depletion of commensal bacteria. Fecal microbiota transplantation from cows with mastitis to mice induced mastitis and altered gut and mammary microbiota in mice. The commensal bacteria improved mastitis symptoms by producing butyrate, limiting bacterial translocation.
Article
Nutrition & Dietetics
Huimin Zhang, Zhenxia Xu, Wenchao Chen, Fenghong Huang, Shouwen Chen, Xu Wang, Chen Yang
Summary: In this study, it was found that supplementation with algal oil could alleviate intestinal damage and inflammation induced by ceftriaxone sodium in mice. The algal oils inhibited the activity of pro-inflammatory cytokines TNF-alpha, IL-6, and MPO, increased the expression of tight junction protein ZO-1, and regulated the composition of gut microbiota.
FRONTIERS IN NUTRITION
(2023)
Article
Immunology
Linglian Kong, Zhenhua Wang, Chuanpi Xiao, Qidong Zhu, Zhigang Song
Summary: The study demonstrated that appropriate doses of glycerol monolaurate (GML) enhanced growth performance and immunity, improved intestinal morphology and barrier function in broiler chicks, and modulated the composition of cecal microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Xinxin Ren, Jia Xu, Ye Xu, Qin Wang, Kunlun Huang, Xiaoyun He
Summary: This study investigates the potential mechanism of Artemether (ART) in diet-induced intestinal injury. The results suggest that ART intervention may alleviate intestinal barrier function disorders and inflammatory responses by restoring intestinal flora balance, increasing the expression of tight junction proteins, and decreasing the expression of pro-inflammatory factors. Moreover, ART intervention inhibits the activation of the TLR4/NF-kappa B p65 pathway in colon tissue, indicating a potential protective effect of ART on intestinal inflammation.
Article
Food Science & Technology
Yanjun Tong, Qinyue Wang, Jieyu Zhang, Ruijin Yang
Summary: This study found that xylo-oligosaccharides (XOS) can alleviate diarrhea symptoms by regulating gut microbiota, reducing pro-inflammatory factors, increasing anti-inflammatory factors, and suppressing intestinal permeability in colon tissues. Dietary supplementation of XOS may be an effective choice for preventing and alleviating diarrhea.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Environmental Sciences
Zhenxin Wang, Dan Shao, Shu Wu, Zhigang Song, Shourong Shi
Summary: This study demonstrates the beneficial effects of dietary dimethylglycine (DMG) in reducing heat stress-induced intestine injury. DMG supplementation improves growth performance and repairs gut barrier integrity, while modulating the composition of gut microbiota and enhancing microbiota-gut-brain axis metabolism function. These findings provide insights into a novel mechanism by which gut microbiota can improve host health.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Agriculture, Dairy & Animal Science
Weilei Yao, Tongxin Wang, Lu Huang, Zhengxi Bao, Shu Wen, Feiruo Huang
Summary: The study demonstrated that embelin exerts protective effects against intestinal inflammation in weaned pigs by suppressing the PCAF/NF-kappa B signaling pathway, as evidenced by decreased serum D-lactate and diamine oxidase levels, increased expression of ZO-1, occludin and claudin-1 proteins in the jejunum and ileum, and downregulation of critical inflammatory molecules in the jejunal and ileal mucosa. Additionally, embelin also downregulated PCAF activity and attenuated the acetylation and activities of NF-kappa B in IPEC-1 cells with overexpression of PCAF.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Environmental Sciences
Yunhuan Liu, Weili Kang, Shuiping Liu, Jinyan Li, Jinyan Liu, Xingxiang Chen, Fang Gan, Kehe Huang
Summary: This study reveals a new mechanism of Cd-induced liver injury, in which Cd exposure leads to dysbiosis of gut microbiota, reduces fecal bile salt hydrolase activity, and increases the level of a certain substance in the intestine, thereby inhibiting intestinal FXR/FGF-15 signaling, increasing hepatic bile acid synthesis, and ultimately facilitating hepatic ductular proliferation, inflammation, and injury in mice.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Nutrition & Dietetics
Qingwei Meng, Yiming Zhang, Jibo Li, Baoming Shi, Qingquan Ma, Anshan Shan
Summary: Supplementation of lycopene can improve intestinal barrier function, regulate intestinal antioxidant signaling, and improve gut microbiota in weaned piglets.
JOURNAL OF NUTRITION
(2022)
Article
Chemistry, Applied
Bowei Zhang, Yingchuan Xu, Huan Lv, Wenwen Pang, Jin Wang, Hui Ma, Shuo Wang
Summary: This study investigated the intestinal pharmacokinetics of resveratrol in mice using HPLC-MS/MS and found that resveratrol and its metabolites were present in significant amounts in the entire intestinal tract and feces, with a peak concentration at 4 hours post-administration. The study also demonstrated the promotion of Lactobacillus reuteri growth by resveratrol-3-O-sulfate during in vitro fermentation and the up-regulation of tight junction and mucin-related proteins mRNA expressions by resveratrol-3-O-sulfate during incubation with Caco-2 cells.
Article
Psychology, Biological
Zachary I. Grunewald, Sunhye Lee, Rebecca Kirkland, Matthew Ross, Claire B. de La Serre
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Nutrition & Dietetics
Elizabeth A. Klingbeil, Carolina Cawthon, Rebecca Kirkland, Claire B. de La Serre
Article
Nutrition & Dietetics
Sunhye Lee, Rebecca Kirkland, Zachary I. Grunewald, Qingshen Sun, Louise Wicker, Claire B. de La Serre
Editorial Material
Neurosciences
Arashdeep Singh, Claire de la Serre, Guillaume de Lartigue
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Nutrition & Dietetics
Sunhye Lee, Michael Goodson, Wendie Vang, Karen Kalanetra, Daniela Barile, Helen Raybould
Article
Physiology
Molly McDougle, Danielle Quinn, Charlene Diepenbroek, Arashdeep Singh, Claire de la Serre, Guillaume de Lartigue
Summary: The study found that selective ablation of sensory vagal neurones innervating the gut plays a crucial role in the control of food intake, energy expenditure, and glucose homeostasis in response to different diets. This suggests that intact sensory vagal neurones prevent overeating and weight gain in response to a high-fat high-sugar diet by promoting lipid-mediated satiation.
Article
Psychology, Biological
J. S. Kim, R. A. Kirkland, S. H. Lee, C. R. Cawthon, K. W. Rzepka, D. M. Minaya, G. de Lartigue, K. Czaja, C. B. de La Serre
PHYSIOLOGY & BEHAVIOR
(2020)
Article
Biochemistry & Molecular Biology
Carolina R. Cawthon, Claire B. de La Serre
Summary: CCK plays a crucial role in regulating feeding behavior and optimizing digestion and nutrient absorption. Diet-induced obesity results in reduced sensitivity to CCK, potentially leading to dysfunction of the CCK system.
Article
Nutrition & Dietetics
Sunhye Lee, Trina A. Knotts, Michael L. Goodson, Mariana Barboza, Elyse Wudeck, Grace England, Helen E. Raybould
Article
Psychiatry
Emily E. Noble, Christine A. Olson, Elizabeth Davis, Linda Tsan, Yen-Wei Chen, Ruth Schade, Clarissa Liu, Andrea Suarez, Roshonda B. Jones, Claire de la Serre, Xia Yang, Elaine Y. Hsiao, Scott E. Kanoski
Summary: Research indicates that excessive early life consumption of sugar negatively impacts memory function in rats during adulthood, affecting hippocampal-dependent memory function and altering the gut microbiome, including the abundance of specific Parabacteroides species. Enrichment of these bacterial taxa during adolescence impairs hippocampal-dependent memory in adulthood, while early life sugar consumption and Parabacteroides microbial enrichment lead to alterations in gene expression related to intracellular kinase, neurotransmitter signaling, metabolic function, neurodegenerative disease, and dopaminergic signaling pathways.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Nutrition & Dietetics
Allison W. Rautmann, Claire B. de la Serre
Summary: The gut microbiota plays a key role in modulating host physiology and behavior, particularly in relation to feeding behavior, energy balance, and obesity. Changes in microbiome composition due to diet can lead to weight gain, adiposity, and alterations in ingestive behavior. Research is focused on understanding the role of the microbiome in the development of obesity and using microbiome manipulation to reduce food intake and promote weight loss.
Article
Food Science & Technology
Sunhye Lee, Soyeon Jeong, Yeongju Park, Hyunji Seo, Cheongbin You, Unsik Hwang, Hoon Park, Hee-Jae Suh
Summary: The supplementation of goji berries and fermented goji berries demonstrated metabolic benefits by improving hepatic function, regulating lipid metabolism, and protecting the liver from high-fat diet-induced damages through their anti-inflammatory and antioxidant properties.
APPLIED BIOLOGICAL CHEMISTRY
(2021)
Meeting Abstract
Physiology
G. de Lartigue, M. McDougle, D. Quinn, A. Singh, C. Diepenbroek, C. de La Serre
Article
Psychology, Biological
Carolina R. Cawthon, Rebecca A. Kirkland, Shreya Pandya, Nigel A. Brinson, Claire B. de La Serre
PHYSIOLOGY & BEHAVIOR
(2020)