Review
Immunology
Wenxia Dong, Ning Wang, Zhe Qi
Summary: The prevalence of brain cancer is increasing and brings significant healthcare challenges. Immunotherapies present diagnostic imaging challenges for brain tumors. Effective neuroimaging techniques are necessary for diagnosing and monitoring brain tumors, but differentiating between tumors and necrotic lesions or inflamed tissues remains a challenge. This review summarizes recent advances in neuroimaging methods for enhancing brain tumor diagnosis and evaluating inflamed lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Benjamin Haenisch, Justine Y. Hansen, Boris C. Bernhardt, Simon B. Eickhoff, Juergen Dukart, Bratislav Misic, Sofie Louise Valk
Summary: This study investigates the role of neurotransmitter transporter and receptor molecules in the structure-function relationships in the human brain. Using positron-emission tomography imaging studies of 19 different neurotransmitter transporters and receptors, the researchers discovered three main spatial gradients of chemoarchitectural similarity in the cortical and subcortical regions of the brain. The findings show that the organization of the receptome shares similarities with functional and structural brain anatomy.
Article
Engineering, Biomedical
Zhaofeng Chen, Tianshuang Qiu, Yang Tian, Hongbo Feng, Yanjun Zhang, Hongkai Wang
Summary: The study introduces a PET/CT-based brain VOI segmentation algorithm that combines anatomical atlas, local landmarks, and dual-modality information. By incorporating local deep brain landmarks and dual-modality PET/CT image information, the algorithm improves registration accuracy and achieves accurate delineation of brain VOIs.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Review
Neurosciences
Aleksi Kokkonen, Emma A. Honkanen, Daniel T. Corp, Juho Joutsa
Summary: Deep brain stimulation (DBS) is an effective treatment for various brain disorders, but its mechanisms of action and detailed molecular effects still need further investigation.
Article
Clinical Neurology
Gavin J. B. Elias, Jurgen Germann, Alexandre Boutet, Aditya Pancholi, Michelle E. Beyn, Kartik Bhatia, Clemens Neudorfer, Aaron Loh, Sakina J. Rizvi, Venkat Bhat, Peter Giacobbe, D. Blake Woodside, Sidney H. Kennedy, Andres M. Lozano
Summary: Subcallosal cingulate deep brain stimulation can improve the clinical symptoms of patients with severe treatment-resistant depression. Imaging features can predict treatment response and may have implications for patient selection and other clinical decisions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Teng Zhang, Yuting Li, Shuilin Zhao, Yuanfan Xu, Xiaohui Zhang, Shuang Wu, Xiaofeng Dou, Congcong Yu, Jianhua Feng, Yao Ding, Junming Zhu, Zexin Chen, Hong Zhang, Mei Tian
Summary: This study developed a pediatric age-specific PET template (PAPT) and conducted a pilot study in pediatric epilepsy, demonstrating the advantages of PAPT in spatial normalization and epileptogenic focus localization. PAPT significantly improved registration similarities and achieved higher accuracy in epileptogenic focus localization in pediatric epilepsy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haodan Dang, Jinming Zhang, Ruimin Wang, Jiajin Liu, Huaping Fu, Mu Lin, Baixuan Xu
Summary: The decision-tree model of diffusion kurtosis imaging (DKI) and C-11-methionine (C-11-MET) PET shows potential in differentiating radiotherapy (RT) injury from glioblastoma recurrence. The combined model demonstrates the best diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Zhang, Duo Zhang, Zhaofeng Chen, Hongkai Wang, Weibing Miao, Wentao Zhu
Summary: The atlas-based PET brain image segmentation and quantification method proposed in this study showed higher effectiveness in patients with epilepsy than the traditional statistical parameter mapping method, accurately detecting pathologically reported epileptic defects.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Clinical Neurology
Hana Florian, Deli Wang, Steven E. Arnold, Merce Boada, Qi Guo, Ziyi Jin, Hui Zheng, Nahome Fisseha, Hari Varun Kalluri, Beatrice Rendenbach-Mueller, Kumar Budur, Michael Gold, Thomas Aware Investigators, Lealani Acosta, Thomas Ala, Sanka Amadoru, Jeffrey Apter, Steven Arnold, Merce Boada-Rovira, Anne Boerjesson-Hanson, Wendy Bond, Michael Borrie, Gabriella Bottini, Bruce Brew, Mark Brody, James Burke, Jeffrey Burns, Annalisa Chiari, Roger Clarnette, Sharon Cohen, Martin Farlow, Simon Fishman, Norman Foster, Kristian Frederiksen, Giovanni Frisoni, Nigel Gilchrist, Darren Gitelman, Ira Goodman, Marc Gordon, Neill Graff-Radford, Merja Hallikainen, Adrian Ivanoiu, Gregory Jicha, Michael Jonsson, Diana Kerwin, Dineke Koek, James Lah, Ayesha Lall, Elly Lee, Gabriel Leger, Peter Ljubenkov, Camillo Marra, Pablo Martinez-Lage, Joseph Masdeu, Scott McGinnis, Patrizia Mecocci, Philip Morris, Marshall Nash, Allison Perrin, Aimee Pierce, Robert Riesenberg, Juha Rinne, Raquel Sanchez Del Valle, Elio Scarpini, Paul Schulz, Ronald Schwartz, Amanda Smith, Bryan Spann, Sylvie Van Snick, Rik Vandenberghe, Cherian Verghese, Alberto Villarejo, Chuang-Kuo Wu
Summary: Tau accumulation in patients with Alzheimer's disease is closely related to cognitive decline. This study evaluated tilavonemab, an anti-tau monoclonal antibody, in treating patients with early Alzheimer's disease. The results showed that tilavonemab did not demonstrate efficacy in treating early Alzheimer's disease.
Article
Neurosciences
Gihwan Byeon, Min Soo Byun, Dahyun Yi, Jun Ho Lee, So Yeon Jeon, Kang Ko, Gijung Jung, Jun-Young Lee, Yu Kyeong Kim, Yun-Sang Lee, Koung Mi Kang, Chul-Ho Sohn, Dong Young Lee
Summary: The study found a synergistic effect of high blood homocysteine level and diabetes mellitus on brain damage in older adults, especially in aging-related brain regions. Strictly controlling blood glucose and lowering blood homocysteine level is important for preventing dementia or cognitive decline in older adults.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Valeria Romeo, Thomas H. Helbich, Katja Pinker
Summary: The recent introduction of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) as a promising imaging modality for breast cancer assessment has sparked extensive research on its clinical applications. This state-of-the-art review provides an overview of advanced MRI techniques, PET tracers, and the use of radiomics and artificial intelligence techniques in hybrid breast PET/MRI. The strengths and limitations of hybrid PET/MRI in the real world are also discussed.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Immunology
Rafael Roesler, Simone Afonso Dini, Gustavo R. Isolan
Summary: Brain tumors and metastases lead to changes in brain tissue remodeling, immunosuppression, and inflammatory responses, affecting invasion and metastasis. Radiotherapy may cause neuroinflammatory and necrotic lesions. GBM is the most aggressive primary malignant brain tumor in adults.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Review
Health Care Sciences & Services
Igino Simonetti, Piero Trovato, Vincenza Granata, Carmine Picone, Roberta Fusco, Sergio Venanzio Setola, Mauro Mattace Raso, Corrado Caraco, Paolo A. Ascierto, Fabio Sandomenico, Antonella Petrillo
Summary: Interval metastasis is a specific type of lymph node metastasis in patients with melanoma. Imaging techniques such as ultrasound, CT, MRI, lymphoscintigraphy, and PET are used for evaluation. Understanding these methods and collaborating with clinicians are essential for treatment and survival.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Valeria Romeo, Panagiotis Kapetas, Paola Clauser, Sazan Rasul, Renato Cuocolo, Martina Caruso, Thomas H. Helbich, Pascal A. T. Baltzer, Katja Pinker
Summary: A machine learning-based radiomics approach using hybrid 18F-FDG PET/MRI can predict axillary lymph node involvement in breast cancer. By analyzing primary cancer lesions, this approach can assess tumor heterogeneity, aggressiveness, and propensity to invade. This method can improve preoperative stratification and make PET/MRI a comprehensive tool for local and node staging in breast cancer.
Article
Veterinary Sciences
Taesik Yun, Yoonhoi Koo, Hakhyun Kim, Wonguk Lee, Soochong Kim, Dong-In Jung, Mhan-Pyo Yang, Byeong-Teck Kang
Summary: A 15.5-year-old neutered male domestic shorthair cat presented with neurologic dysfunctions, showing improvement in symptoms following treatment with hydroxyurea and prednisolone, and a hypermetabolic region was found in the lesion on F-18-FDG-PET scan.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ying Huang, Jing Huang, Qi-Xin Zhou, Chun-Xian Yang, Cui-Ping Yang, Wan-Ying Mei, Lei Zhang, Qiong Zhang, Ling Hu, Yun-Qing Hu, Ning-Ning Song, Sheng-Xi Wu, Lin Xu, Yu-Qiang Ding
Summary: The association of ZNF804A with schizophrenia has been uncovered, and ZFP804A mutant mice showed deficits in contextual fear, spatial memory, and sensorimotor gating, particularly in female mice. Changes in protein levels of hippocampal serotonin-6 receptor, GABAB1 receptor, and cortical dopamine 2 receptor were observed in female mutants. Additionally, spine density was reduced in mutant mice, while neurite morphogenesis was affected by ZFP804A knockdown and overexpression in vitro.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Ni-Ya Wang, Jin-Nan Li, Wei-Lin Liu, Qi Huang, Wen-Xing Li, Ya-Hong Tan, Fang Liu, Zi-Hua Song, Meng-Yue Wang, Ning Xie, Rong-Rong Mao, Ping Gan, Yu-Qiang Ding, Zhi Zhang, Bao-Ci Shan, Li-Dian Chen, Qi-Xin Zhou, Lin Xu
Summary: Brain capillaries play a crucial role in the pathophysiology of Alzheimer's disease, with reductions in density and diameter of hippocampal capillaries being associated with early A beta plaque deposition and spatial memory deficit. Counteracting ET1-mediated vasoconstriction can prevent these issues from occurring.
Article
Psychiatry
Ling Chen, Wan-Kun Gong, Cui-ping Yang, Chan-Chan Shao, Ning-Ning Song, Jia-Yin Chen, Li-Qiang Zhou, Kun-Shan Zhang, Siguang Li, Zhili Huang, Gal Richter-Levin, Lin Xu, Yu-Qiang Ding
Summary: The study suggests that PTEN may serve as an alternative approach for regulating 5-HT neuron activity in the brain and depressive behaviors, compared to selective serotonin reuptake inhibitors (SSRIs) commonly used in depression treatment. Elevated levels of PTEN in 5-HT neurons can induce depressive behaviors in mice, while selective deletion of Pten leads to structural plasticity in these neurons.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Immunology
Jing Wang, Qianqian Li, Qi Huang, Meng Lv, Pan Li, Jing Dai, Minjie Zhou, Jialu Xu, Faming Zhang, Jun Gao
Summary: This study revealed that long-term light stimulation can alter behaviors, composition of gut microbiota, and brain structure in tree shrews. Targeting microbiota shows promise as a treatment for neuropsychiatric disorders, including stress-related diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Neurosciences
Qi Huang, Shuhua Ren, Tianhao Zhang, Junpeng Li, Donglang Jiang, Jianfei Xiao, Fengchun Hua, Fang Xie, Yihui Guan
Summary: Using metabolic brain network, this study revealed the reorganization of brain modular architecture during aging. The modular architecture was slightly reorganized from young to old ages, with regions related to sensorimotor function more converged. The number of connector nodes was reduced, with most connector nodes localized in the temporo-occipital regions. The major gender difference was that the metabolic brain network was split into four modules in the old female group, with the sensorimotor functions divided into two modules.
BRAIN CONNECTIVITY
(2022)
Article
Cell Biology
Ling Hu, Guan-Yu Jiang, Ying-Ping Wang, Zhi-Bin Hu, Bing-Yao Zhou, Lei Zhang, Ning-Ning Song, Ying Huang, Guo-Dong Chai, Jia-Yin Chen, Bing Lang, Lin Xu, Jun-Ling Liu, Yong Li, Qing-Xiu Wang, Yu-Qiang Ding
Summary: PTEN is a tumor suppressor gene that plays a crucial role in brain development. This study reveals that PTEN is also involved in processing itch and thermal information in adult mice. PTEN deletion leads to pathological itch and enhanced itch responses, as well as enhanced thermal stimulation.
Article
Neurosciences
Ting-Ting Pan, Chao Liu, De-Min Li, Tian-Hao Zhang, Wei Zhang, Shi-Lun Zhao, Qi-Xin Zhou, Bin-Bin Nie, Gao-Hong Zhu, Lin Xu, Hua Liu
Summary: This study investigated the roles and brain network mechanisms of the retrosplenial cortex (RSC) in the encoding process of contextual fear memory in a rat model. The dysgranular (RSCd) part of the RSC was found to play a crucial role in memory retrieval, while the granular (RSCg) part had limited involvement. The hippocampus, amygdala, piriform cortex, and visual cortex were identified as hub nodes in the brain-wide network for contextual fear memory encoding in rats.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jiaxi Hu, Yiming Shi, Jiaming Zhang, Xinfeng Huang, Qian Wang, Hang Zhao, Jiawei Shen, Zhiping Chen, Wei Song, Ping Zheng, Shulu Zhan, Yanping Sun, Pengfei Cai, Kai An, Changjie Ouyang, Baizhen Zhao, Qixin Zhou, Lin Xu, Wei Xiong, Zhi Zhang, Jianjun Meng, Jutao Chen, Yuqian Ma, Huan Zhao, Mei Zhang, Kun Qu, Ji Hu, Minhua Luo, Fuqiang Xu, Xiaowei Chen, Ying Xiong, Jin Bao, Tian Xue
Summary: The early light sensation plays an important role in cortical synaptogenesis and the development of learning ability in infants, which depends on the activation of ipRGCs and the release of oxytocin.
Article
Neurosciences
Lizhu Jiang, Chao Liu, Baizhen Zhao, Chen Ma, Yan Yin, Qixin Zhou, Lin Xu, RongRong Mao
Summary: Fear memory in different species shows time-dependent alterations. This study found that training during the lower activation period of hippocampal Rac1 at night improves contextual fear memory in rats. Exogenous melatonin treatment enhances Rac1 activity and impairs fear memory acquisition during the night, while a Rac1-specific inhibitor attenuates the effect of melatonin.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yuqi Cheng, Ting Wang, Tianhao Zhang, Shu Yi, Shilun Zhao, Na Li, Yifan Yang, Fengrui Zhang, Lin Xu, Baoci Shan, Xiufeng Xu, Jian Xu
Summary: This study provides the first in vivo evidence of blood-brain barrier disruption in the thalamus of patients with schizophrenia, suggesting that blood-brain barrier dysfunction may contribute to the pathological brain structural alterations in schizophrenia.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Clinical Neurology
Ya-Bo Zhao, Xue-Fei Hou, Xin Li, Li-Su Zhu, Jing Zhu, Guo-Rui Ma, Yu-Xuan Liu, Yu-Can Miao, Qian-Yu Zhou, Lin Xu, Qi-Xin Zhou
Summary: This study explores the neurobiological mechanisms of early AD damage and finds that memory impairment occurs as early as 4 months in APP/PS1 mice and worsens with age. The findings have important implications for understanding the mechanism of early AD.
CURRENT ALZHEIMER RESEARCH
(2022)
Article
Neurosciences
Jing Dai, Ran Xie, Zhou-Na Sun, Xiao-Lin Kou, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Jing Wang, Jun Gao
Summary: Studies have shown that protein phosphorylation is important in morphine abuse, but the role of protein phosphatase 2A (PP2A) in the morphine-priming process is unclear. In this study, conditional knockout mice were used to investigate the role of hippocampal PP2A in morphine priming. The results suggest that hippocampal PP2A may be involved in morphine priming through the PP2A/HDAC4/Rack1 pathway.
Article
Neurosciences
Xue-Fei Hou, Ya-Bo Zhao, Yue-Xiong Yang, Chen Ma, Meng Li, Xin Li, Guo-Rui Ma, Li-Su Zhu, Lin Xu, Qi-Xin Zhou
Summary: This study found that learning ability in mice is negatively correlated with susceptibility to morphine use disorder (MUD), suggesting that impaired learning ability can predict SUD susceptibility. FVB mice, which showed impaired learning ability, exhibited higher sensitivity to MUDs compared to C57 mice. These findings highlight the importance of considering learning ability in identifying high-risk SUD groups.
Article
Behavioral Sciences
Xue-Fei Hou, Ya-Bo Zhao, Yue-Xiong Yang, Jing Zhu, Li-Su Zhu, Lin Xu, Qi-Xin Zhou
Summary: In this study, a simple and effective experimental model was designed to investigate the generalization memory of morphine reward. By replacing the conditioning CPP box, it was found that mice still showed a clear preference for generalized information. The establishment of this study provides a new tool for studying generalization memory in substance use disorders.
BRAIN AND BEHAVIOR
(2023)
Article
Zoology
Ting-Ting Pan, Chao Liu, De-Min Li, Bin-Bin Nie, Tian-Hao Zhang, Wei Zhang, Shi-Lun Zhao, Qi-Xin Zhou, Hua Liu, Gao-Hong Zhu, Lin Xu, Bao-Ci Shan
ZOOLOGICAL RESEARCH
(2022)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
