Article
Neurosciences
Laurence Bourgeais-Rambur, Laurianne Beynac, Jean-Charles Mariani, Mickael Tanter, Thomas Deffieux, Zsolt Lenkei, Luis Villanueva
Summary: This study explored the links between neurovascular coupling and cortical craniofacial nociceptive activities modulated by spreading depolarization (SD). The findings suggest that SD triggers strong physiological and electrophysiological responses in S1, providing a useful preclinical tool for deciphering central sensitization mechanisms involved in migraine attacks.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Medicine, Research & Experimental
Christine Nash, Keren Powell, Daniel G. Lynch, Jed A. Hartings, Chunyan Li
Summary: This review summarizes nonpharmacological techniques for modulating cortical spreading depolarization (CSD), presents their mechanisms of action, and provides insight into future directions. Both pharmacologic and nonpharmacologic interventions can mitigate the pathological impact of CSDs via shared molecular mechanisms, and nonpharmacologic interventions can also target unique mechanisms, which may have broader effects.
Article
Clinical Neurology
Chiho Kudo, Andrea M. Harriott, Michael A. Moskowitz, Christian Waeber, Cenk Ayata
Summary: This study aimed to investigate the effects of sex, gonadectomy, and female hormone supplementation and withdrawal on the susceptibility to cortical spreading depression (CSD). The results showed that female rats had a higher CSD frequency than males and ovariectomized rats. Estrogen withdrawal after prolonged treatment significantly increased CSD susceptibility in gonadectomized females. These findings have implications for estrogen-withdrawal migraine.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Anesthesiology
Agustin Melo-Carrillo, Andrew M. Strassman, Aaron J. Schain, Ron S. Broide, Brian B. Cai, Catherine Rheaume, Amy D. Brideau-Andersen, Sait Ashina, Yadira Flores-Montanez, Mitchell F. Brin, Rami Burstein
Summary: The study found that peripherally applied BoNT-A can shorten the period of spontaneous cortical activity depression following CSD, but does not prevent induction or propagation of CSD. It also found that cleaved SNAP25, a tool for determining the anatomical targeting of BoNT-A treatment, can be readily detected at injection sites and intracranial nerve fibers, but not within cortical areas affected by CSD.
Article
Biochemistry & Molecular Biology
Mamoru Shibata, Satoshi Kitagawa, Miyuki Unekawa, Tsubasa Takizawa, Jin Nakahara
Summary: Migraine is a debilitating neurovascular disorder characterized by recurrent headache attacks. Calcitonin gene-related peptide (CGRP) plays a crucial role in migraine pathogenesis. In a CSD-based mouse migraine model, CSD did not significantly change the density of CGRP mRNA-synthesizing neurons in the trigeminal ganglion (TG), but it did cause an increase in cell sizes of CGRP mRNA-synthesizing TG neurons. The findings suggest that the increase in cell size may contribute to increased disease activity and reduced responsiveness to CGRP-based therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hiromu Monai, Shinnosuke Koketsu, Yoshiaki Shinohara, Takatoshi Ueki, Peter Kusk, Natalie L. Hauglund, Andrew J. Samson, Maiken Nedergaard, Hajime Hirase
Summary: The use of AdR antagonists has been shown to decrease the recurrence of CSD waves, accelerate neural activity recovery, and reduce aberrant activity in astrocytes.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Marina Vitale, Angelita Tottene, Maral Zarin Zadeh, K. C. Brennan, Daniela Pietrobon
Summary: This study investigated the mechanisms of cortical spreading depression (CSD) initiation by applying high KCl puffs in mouse cerebral cortex slices. The results showed that the initiation of CSD requires the combined action of NMDARs and Ca-V channels, and is not determined by extracellular K+ concentration or neuronal depolarization levels.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Biochemistry & Molecular Biology
Lingdi Nie, Liwen Jiang, John P. Quinn, Blair D. Grubb, Minyan Wang
Summary: The research reveals a novel mechanism of migraine pathogenesis in which TRPA1 transmits signaling to SFKs via PKA, facilitating CSD susceptibility and sensitization of the trigeminovascular system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hanzhi T. Zhao, Mary Claire Tuohy, Daniel Chow, Mariel G. Kozberg, Sharon H. Kim, Mohammed A. Shaik, Elizabeth M. C. Hillman
Summary: Research has found that in acute brain injuries, CSD can cause vasoconstriction and ischemia, with its effects worsening with repeated CSD occurrences. This feedback loop may explain the variable but potentially devastating effects of CSD in the context of acute brain injury.
Article
Clinical Neurology
Xiaoxi Fu, Ming Chen, Jinling Lu, Pengcheng Li
Summary: This study investigated the neuronal activity of the mouse thalamus ventral posteromedial nucleus (VPM) during cortical spreading depression (CSD). The results showed that CSD induced propagating activation of the ipsilateral VPM, and the response might be affected by the location of CSD induction and anesthesia.
JOURNAL OF HEADACHE AND PAIN
(2022)
Review
Neurosciences
Ejay Nsugbe
Summary: Migraine with aura (MwA) is a common condition that affects around 30% of migraine patients. Initially considered a neurological disease, it was discovered that it is accompanied by cortical spreading depression (CSD) through electrophysiological waves. Mathematical models play a crucial role in understanding the dynamic relationship between MwA and CSD. Various biophysical mechanisms, such as ion diffusion, ionic currents, osmosis, and neurotransmission, are believed to contribute to the condition. Electrophysiological data, including EEG and fMRI, have been used to study MwA. The review emphasizes the need for further research on enhancing existing models, considering individual variability, sex and hormonal factors, and different age groups.
Article
Behavioral Sciences
Elena Gerasimova, Gulshat Burkhanova, Kseniya Chernova, Andrey Zakharov, Daniel Enikeev, Nail Khaertdinov, Rashid Giniatullin, Guzel Sitdikova
Summary: Experimental results show that rats with genetically acquired hyperhomocysteinemia display multiple features associated with migraine, such as increased cortical excitability, mechanical allodynia, photophobia, and anxiety. This provides the first experimental evidence for the higher occurrence of migraine with aura in patients with hyperhomocysteinemia.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Medicine, Research & Experimental
Oana Chever, Sarah Zerimech, Paolo Scalmani, Louisiane Lemaire, Lara Pizzamiglio, Alexandre Loucif, Marion Ayrault, Martin Krupa, Mathieu Desroches, Fabrice Duprat, Isabelle Lena, Sandrine Cestele, Massimo Mantegazza
Summary: Spreading depolarizations (SDs) are involved in various neurological conditions, with GABAergic interneurons playing a key role in the initiation of cortical spreading depression (CSD). The study found that hyperactivity of GABAergic interneurons can ignite CSD in the neocortex without the need for GABA or glutamatergic synaptic transmission. This neocortex-specific mechanism of CSD initiation is relevant to familial hemiplegic migraine type-3 (FHM3) caused by gain-of-function mutations of Na(V)1.1.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Clinical Neurology
Tzu-Ting Liu, Andreia Morais, Tsubasa Takizawa, Inge Mulder, Bruce J. Simon, Shih-Pin Chen, Shuu-Jiun Wang, Cenk Ayata, Jiin-Cherng Yen
Summary: Our study provides insight on optimal nVNS parameters to suppress CSD and suggests its benefit on CSD-induced neuroinflammation and trigeminovascular activation in migraine treatment.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Biochemistry & Molecular Biology
Chisato Iba, Miyuki Unekawa, Yoshikane Izawa, Jin Nakahara, Tsubasa Takizawa
Summary: The study found that chronic treatment with Goreisan does not affect cortical spreading depolarization (CSD) susceptibility in migraines. This suggests that the drug treats headaches via mechanisms that do not involve CSD modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Jun Zhao, Dara Bree, Michael G. Harrington, Andrew M. Strassman, Dan Levy
Review
Clinical Neurology
Dan Levy, Alejandro Labastida-Ramirez, Antoinette MaassenVanDenBrink
Article
Clinical Neurology
XiChun Zhang, Vanessa Kainz, Jun Zhao, Andrew M. Strassman, Dan Levy
ANNALS OF NEUROLOGY
(2013)
Article
Immunology
Dan Levy, Vanessa Kainz, Rami Burstein, Andrew M. Strassman
BRAIN BEHAVIOR AND IMMUNITY
(2012)
Article
Clinical Neurology
Dan Levy, Andrew M. Strassman, Rami Burstein
Article
Multidisciplinary Sciences
Michal Eger, Miaad Bader, Dara Bree, Rivka Hadar, Alina Nemerovski, Joseph Tam, Dan Levy, Chaim G. Pick, Yankel Gabet
SCIENTIFIC REPORTS
(2019)
Article
Clinical Neurology
Dan Levy, Hila Gruener, Miri Riabinin, Yelena Feingold, Shaul Schreiber, Chaim G. Pick, Ruth Defrin
Article
Clinical Neurology
Dara Bree, Kimberly Mackenzie, Jennifer Stratton, Dan Levy
Article
Clinical Neurology
Dara Bree, Jennifer Stratton, Dan Levy
Correction
Multidisciplinary Sciences
Michal Eger, Miaad Bader, Dara Bree, Rivka Hadar, Alina Nemirovski, Joseph Tam, Dan Levy, Chaim G. Pick, Yankel Gabet
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Lite Yang, Mengyi Xu, Shamsuddin A. Bhuiyan, Jia Li, Jun Zhao, Randall J. Cohrs, Justin T. Susterich, Sylvia Signorelli, Ursula Green, James R. Stone, Dan Levy, Jochen K. Lennerz, William Renthal
Summary: This study developed a cell atlas of trigeminal ganglion cells in humans and mice, providing insights into the gene expression patterns and gene regulatory elements of different cell types. The atlas identified cell types implicated in migraine and provides a valuable resource for understanding headache pathophysiology and developing more selective treatments.
Article
Cell Biology
Andrew S. Blaeser, Arthur U. Sugden, Jun Zhao, Simone Carneiro-Nascimento, Frederick B. Shipley, Hanae Carrie, Mark L. Andermann, Dan Levy
Summary: Meningeal sensory neurons not only play a role in headache pain, but also track the dynamic mechanical state of the meninges under natural conditions, being activated during locomotion.
Article
Neurosciences
Jun Zhao, Dan Levy