期刊
JOURNAL OF NEUROSCIENCE
卷 38, 期 13, 页码 3333-3345出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2640-17.2018
关键词
aging; contextual interference; default mode network; fMRI; motor skill learning
资金
- Research Program of the Research Foundation-Flanders [Fonds Wetenschappelijk Onderzoek (FWO) [G089818N]
- Excellence of Science (MEMODYN) [30446199]
- Research Fund of KU Leuven, Belgium [C16/15/070]
- Research Foundation-Flanders (FWO)
Motor performance deteriorates with age. Hence, studying the effects of different training types on performance improvement is particularly important. Here, we investigated the neural correlates of the contextual interference (CI) effect in 32 young (YA; 16 female) and 28 older (OA; 12 female) human adults. Participants were randomly assigned to either a blocked or a random practice schedule, practiced three variations of a bimanual visuomotor task over 3 d, and were retested 6 d later. Functional magnetic resonance imaging data were acquired during the first and last training days and during retention. Although the overall performance level was lower in OA than YA, the typical CI effects were observed in both age groups, i.e., inferior performance during acquisition but superior performance during retention for random relative to blocked practice. At the neural level, blocked practice showed higher brain activity in motor-related brain regions compared with random practice across both age groups. However, although activity in these regions decreased with blocked practice in both age groups, it was either preserved (YA) or increased (OA) as a function of random practice. In contrast, random compared with blocked practice resulted in greater activations in visual processing regions across age groups. Interestingly, in OA, the more demanding random practice schedule triggered neuroplastic changes in areas of the default mode network, ultimately leading to better long-term retention. Our findings may have substantial implications for the optimization of practice schedules, and rehabilitation settings in particular.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据